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Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
ACOG Alpha Cognition	$9.10 -1.2%	$8.00	$3.75 ▼ $11.40	$147.54M	2.79	77,617 shs	43,509 shs
ALT Altimmune	$3.50 -3.0%	$5.75	$2.90 ▼ $11.16	$292.80M	0.58	3.19 million shs	19.92 million shs
SAGE Sage Therapeutics	$9.15 -1.4%	$7.38	$4.62 ▼ $13.47	$581.12M	0.18	1.29 million shs	4.68 million shs
UPB Upstream Bio	$10.93 -0.1%	$9.81	$5.14 ▼ $29.46	$588.50M	N/A	354,824 shs	3.04 million shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
ACOG Alpha Cognition	-1.19%	-0.66%	+7.95%	+64.56%	+909,999,900.00%
ALT Altimmune	-3.05%	-50.34%	-36.25%	-34.21%	-44.04%
SAGE Sage Therapeutics	-1.40%	-1.61%	+41.20%	+10.51%	-15.59%
UPB Upstream Bio	-0.09%	+0.46%	+18.55%	+59.10%	+1,092,999,900.00%

Compare MarketRank™

Company	Overall Score	Analyst's Opinion	Short Interest Score	ESG Score	News and Social Media Sentiment	Company Ownership	Earnings & Valuation
ACOG Alpha Cognition	1.9344 of 5 stars	3.5	0.0	0.0	3.3	0.8	0.0
ALT Altimmune	2.2696 of 5 stars	3.5	1.0	0.0	2.9	1.7	0.6
SAGE Sage Therapeutics	3.1526 of 5 stars	2.0	2.0	4.0	2.4	1.7	0.6
UPB Upstream Bio	1.8091 of 5 stars	3.5	0.0	0.0	1.6	0.8	0.6

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
ACOG Alpha Cognition	3.00	Buy	$20.00	119.78% Upside
ALT Altimmune	3.00	Buy	$19.00	442.86% Upside
SAGE Sage Therapeutics	2.00	Hold	$8.93	-2.37% Downside
UPB Upstream Bio	3.00	Buy	$56.50	416.93% Upside

Current Analyst Ratings Breakdown

Latest ACOG, UPB, SAGE, and ALT Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
6/27/2025	ALT Altimmune	William Blair Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Market Perform ➝ Market Perform
6/27/2025	ALT Altimmune	HC Wainwright Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$12.00
6/20/2025	SAGE Sage Therapeutics	Robert W. Baird Subscribe to MarketBeat All Access for the recommendation accuracy rating	Boost Price Target	Neutral ➝ Neutral	$7.00 ➝ $9.00
6/17/2025	SAGE Sage Therapeutics	Piper Sandler Subscribe to MarketBeat All Access for the recommendation accuracy rating	Downgrade	Strong-Buy ➝ Hold	$9.00 ➝ $8.50
6/17/2025	SAGE Sage Therapeutics	Truist Financial Subscribe to MarketBeat All Access for the recommendation accuracy rating	Set Price Target	Hold ➝ Hold	$8.00 ➝ $9.00
6/17/2025	SAGE Sage Therapeutics	HC Wainwright Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Neutral ➝ Neutral	$12.00
6/17/2025	SAGE Sage Therapeutics	Canaccord Genuity Group Subscribe to MarketBeat All Access for the recommendation accuracy rating	Boost Price Target	Hold ➝ Hold	$8.00 ➝ $8.50
6/16/2025	SAGE Sage Therapeutics	Needham & Company LLC Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Hold ➝ Hold
5/16/2025	ACOG Alpha Cognition	HC Wainwright Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$20.00 ➝ $20.00
4/25/2025	SAGE Sage Therapeutics	Needham & Company LLC Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Hold ➝ Hold
4/3/2025	ALT Altimmune	HC Wainwright Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$12.00 ➝ $12.00

(Data available from 6/28/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
ACOG Alpha Cognition	N/A	N/A	N/A	N/A	$2.59 per share	N/A
ALT Altimmune	$20K	14,194.25	N/A	N/A	$1.74 per share	2.01
SAGE Sage Therapeutics	$41.24M	13.89	N/A	N/A	$7.60 per share	1.20
UPB Upstream Bio	$2.37M	248.07	N/A	N/A	$8.77 per share	1.25

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
ACOG Alpha Cognition	-$14.64M	-$1.20	N/A	∞	N/A	N/A	-65.83%	-48.21%	8/11/2025 (Estimated)
ALT Altimmune	-$95.06M	-$1.26	N/A	N/A	N/A	-451,200.00%	-65.44%	-58.43%	8/6/2025 (Estimated)
SAGE Sage Therapeutics	-$400.67M	-$5.80	N/A	N/A	N/A	-747.63%	-68.99%	-60.67%	7/30/2025 (Estimated)
UPB Upstream Bio	-$62.81M	N/A	0.00	N/A	N/A	N/A	N/A	N/A	8/5/2025 (Estimated)

Latest ACOG, UPB, SAGE, and ALT Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
5/15/2025	Q1 2025	ACOG Alpha Cognition	-$0.58	-$0.20	+$0.38	-$0.13	$0.50 million	$2.93 million
5/13/2025	Q1 2025	ALT Altimmune	-$0.35	-$0.26	+$0.09	-$0.26	$0.00 million	$0.01 million
5/6/2025	Q1 2025	UPB Upstream Bio	-$0.49	-$0.51	-$0.02	-$0.51	$0.71 million	$0.57 million
4/29/2025	Q1 2025	SAGE Sage Therapeutics	-$0.99	-$1.01	-$0.02	-$1.01	$14.12 million	$14.06 million
3/31/2025	Q4 2024	ACOG Alpha Cognition	-$0.48	-$0.51	-$0.03	-$0.51	N/A	N/A

Compare Dividends

Company	Annual Payout	Dividend Yield	3-Year Dividend Growth	Payout Ratio	Years of Consecutive Growth
ACOG Alpha Cognition	N/A	N/A	N/A	N/A	N/A
ALT Altimmune	N/A	N/A	N/A	N/A	N/A
SAGE Sage Therapeutics	N/A	N/A	N/A	N/A	N/A
UPB Upstream Bio	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
ACOG Alpha Cognition	N/A	17.14	16.83
ALT Altimmune	N/A	15.85	15.85
SAGE Sage Therapeutics	N/A	9.13	9.13
UPB Upstream Bio	N/A	47.43	47.43

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
ACOG Alpha Cognition	N/A
ALT Altimmune	78.05%
SAGE Sage Therapeutics	99.22%
UPB Upstream Bio	N/A

Insider Ownership

Company	Insider Ownership
ACOG Alpha Cognition	14.00%
ALT Altimmune	4.10%
SAGE Sage Therapeutics	5.50%
UPB Upstream Bio	13.56%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
ACOG Alpha Cognition	N/A	16.02 million	13.78 million	N/A
ALT Altimmune	50	81.11 million	77.78 million	Optionable
SAGE Sage Therapeutics	690	62.62 million	59.18 million	Optionable
UPB Upstream Bio	38	53.79 million	46.50 million	N/A

ACOG, UPB, SAGE, and ALT Headlines

Recent News About These Companies

UPB Upstream Bio, Inc. - Seeking Alpha

3 hours ago | seekingalpha.com

Upstream Bio (NASDAQ:UPB) Trading 7.8% Higher - Should You Buy?

June 20, 2025 | marketbeat.com

Upstream Bio (NASDAQ:UPB) Shares Gap Down - What's Next?

June 18, 2025 | marketbeat.com

Upstream Bio (NASDAQ:UPB) Trading Down 3.4% - Here's What Happened

June 16, 2025 | marketbeat.com

Upstream Bio, Inc.’s Verekitug: A Promising Contender in the TSLPR Antibody Space

June 16, 2025 | tipranks.com

Upstream Bio Stock Gets A Boost As New Lung Inflammation Drug Shows Higher Potency

June 15, 2025 | msn.com

Upstream Bio Presents Pharmacology Modeling Data Supporting Verekitug's Potency over Tezepelumab at EAACI Congress

June 15, 2025 | quiverquant.comQ

Translational Data Illustrate a Mechanism of Greater Potency with Verekitug, a Novel Antibody Antagonist of the TSLP Receptor

June 15, 2025 | globenewswire.com

Upstream Bio (NASDAQ:UPB) Raised to Hold at Wall Street Zen

June 6, 2025 | marketbeat.com

Upstream Bio, Inc. to Present TSLP Receptor Targeting Data for Verekitug at EAACI Congress 2025

June 5, 2025 | quiverquant.comQ

Upstream Bio to Present Mechanistic Insights into Verekitug's Enhanced Potency via TSLP Receptor Targeting at European Academy of Allergy and Clinical Immunology (EAACI) Congress 2025

June 5, 2025 | globenewswire.com

Upstream Bio (NASDAQ:UPB) Trading Down 3.4% - Should You Sell?

June 4, 2025 | marketbeat.com

Upstream Bio to Participate in the Goldman Sachs 46th Annual Global Healthcare Conference

June 4, 2025 | globenewswire.com

Upstream Bio (NASDAQ:UPB) Trading 10.2% Higher - Here's What Happened

June 3, 2025 | marketbeat.com

1,583,154 Shares in Upstream Bio, Inc. (NASDAQ:UPB) Purchased by Wellington Management Group LLP

June 1, 2025 | marketbeat.com

Upstream Bio names new chief technology officer

May 21, 2025 | investing.com

Upstream Bio Appoints Stacy Price As CTO

May 21, 2025 | nasdaq.com

Upstream Bio, Inc. Appoints Stacy Price as Chief Technology Officer to Lead Expansion of Technical Operations

May 21, 2025 | nasdaq.com

Upstream Bio Appoints Stacy Price as Chief Technology Officer

May 20, 2025 | globenewswire.com

Upstream Bio Advances Verekitug in Clinical Trials

May 7, 2025 | tipranks.com

Upstream Bio, Inc.: Strong Buy Rating Driven by Promising Drug Progress and Solid Financial Position

May 6, 2025 | tipranks.com

New MarketBeat Followers Over Time

Media Sentiment Over Time

ACOG, UPB, SAGE, and ALT Company Descriptions

Alpha Cognition NASDAQ:ACOG

$9.10 -0.11 (-1.19%)

As of 06/27/2025 04:00 PM Eastern

Alpha Cognition, Inc. is a clinical stage biopharmaceutical company that develops treatments for underserved neurodegenerative diseases such as Alzheimer's Dementia and Amyotrophic Lateral Sclerosis. The company was founded in 2000 and is headquartered in Vancouver, Canada.

Altimmune NASDAQ:ALT

$3.50 -0.11 (-3.05%)

Closing price 06/27/2025 04:00 PM Eastern

Extended Trading

$3.47 -0.03 (-0.83%)

As of 06/27/2025 08:00 PM Eastern

Altimmune, Inc., a clinical stage biopharmaceutical company, focuses on developing treatments for obesity and liver diseases. The company's lead product candidate, pemvidutide, a GLP-1/glucagon dual receptor agonist that is in Phase 2 trial for the treatment of obesity and metabolic dysfunction-associated steatohepatitis. It is also developing HepTcell, an immunotherapeutic product candidate, which is in Phase 2 clinical trial for patients chronically infected with the hepatitis B virus. The company was formerly known as Vaxin Inc. and changed its name to Altimmune, Inc. in September 2015. Altimmune, Inc. was founded in 1997 is headquartered in Gaithersburg, Maryland.

Sage Therapeutics NASDAQ:SAGE

$9.15 -0.13 (-1.40%)

Closing price 06/27/2025 04:00 PM Eastern

Extended Trading

$9.15 0.00 (0.00%)

As of 06/27/2025 07:56 PM Eastern

Sage Therapeutics, Inc., a biopharmaceutical company, develops and commercializes brain health medicines. Its product candidates include ZULRESSO, a CIV injection for the treatment of postpartum depression (PPD) in adults; and ZURZUVAE, a neuroactive steroid, a positive allosteric modulator of GABAA receptors, targeting both synaptic and extrasynaptic GABAA receptors, for the treatment of postpartum depression. Its product pipeline also comprises SAGE-324, a compound that is in Phase II clinical trial to treat essential tremors, as well as has completed Phase I clinical trial for epilepsy and Parkinson's diseases; and SAGE-718, an oxysterol-based positive allosteric modulator of the NMDA receptor, which is in Phase II clinical trial for the treatment of depression, Huntington's disease, Parkinson's diseases, Alzheimer's disease, attention deficit hyperactivity disorder, schizophrenia, and neuropathic pain. The company has a strategic collaboration with Shionogi & Co., Ltd. for the development and commercialization of zuranolone in Japan, Taiwan, and South Korea; and a collaboration and license agreement with Biogen MA Inc. to jointly develop and commercialize SAGE-217 and SAGE-324 products. The company was formerly known as Sterogen Biopharma, Inc. and changed its name to Sage Therapeutics, Inc. in September 2011. Sage Therapeutics, Inc. was incorporated in 2010 and is headquartered in Cambridge, Massachusetts.

Upstream Bio NASDAQ:UPB

$10.93 -0.01 (-0.09%)

Closing price 06/27/2025 04:00 PM Eastern

Extended Trading

$10.94 +0.01 (+0.09%)

As of 06/27/2025 04:34 PM Eastern

Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases that focuses on severe respiratory disorders. It develops verekitug, a monoclonal antibody that targets and inhibits the thymic stromal lymphopoietin receptor. The company also develops therapies to treat severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease. Upstream Bio, Inc. was incorporated in 2021 and is based in Waltham, Massachusetts.

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Comparative Price Performance Over Time