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Stocks to Compare Sections All Sections Selected Performance Chart Price & Volume MarketRank Analyst Ratings Sales & Book Value Profitability & Earnings Dividends Debt Ownership Miscellaneous Headlines About Compare NASDAQ:COLL NASDAQ:CRNX NASDAQ:KYMR NASDAQ:PTGX On This Page Performance ChartPrice & VolumeMarketRank™Analyst RatingsSales & Book ValueProfitability & EarningsDividendsDebtOwnershipMiscellaneousHeadlinesAbout Comparison Ideas Stock Ideas Comparative Price Performance Over Time1 day7 days30 days90 days365 daysCompare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeCOLLCollegium Pharmaceutical$33.39-1.3%$36.04$23.23▼$39.95$1.07B0.65401,334 shs260,080 shsCRNXCrinetics Pharmaceuticals$42.50+2.0%$33.38$24.10▼$62.53$3.93B0.331.97 million shs5.34 million shsKYMRKymera Therapeutics$56.92-1.1%$46.20$19.44▼$59.00$4.11B2.26919,242 shs318,253 shsPTGXProtagonist Therapeutics$65.47+2.1%$58.94$33.31▼$68.26$3.99B2.21.06 million shs804,420 shsThe 10 Best AI Stocks to Own in 2025Wondering where to start (or end) with AI stocks? These 10 simple stocks can help investors build long-term wealth as artificial intelligence continues to grow into the future.Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceCOLLCollegium Pharmaceutical-1.30%-4.57%-12.87%+3.18%-16.11%CRNXCrinetics Pharmaceuticals+1.97%+2.04%+19.35%+31.46%-17.89%KYMRKymera Therapeutics-1.09%+0.57%+30.82%+25.98%+34.85%PTGXProtagonist Therapeutics+2.07%-1.45%+8.16%+25.21%+49.47%Compare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeCOLLCollegium Pharmaceutical$33.39-1.3%$36.04$23.23▼$39.95$1.07B0.65401,334 shs260,080 shsCRNXCrinetics Pharmaceuticals$42.50+2.0%$33.38$24.10▼$62.53$3.93B0.331.97 million shs5.34 million shsKYMRKymera Therapeutics$56.92-1.1%$46.20$19.44▼$59.00$4.11B2.26919,242 shs318,253 shsPTGXProtagonist Therapeutics$65.47+2.1%$58.94$33.31▼$68.26$3.99B2.21.06 million shs804,420 shsThe 10 Best AI Stocks to Own in 2025Wondering where to start (or end) with AI stocks? These 10 simple stocks can help investors build long-term wealth as artificial intelligence continues to grow into the future.Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceCOLLCollegium Pharmaceutical-1.30%-4.57%-12.87%+3.18%-16.11%CRNXCrinetics Pharmaceuticals+1.97%+2.04%+19.35%+31.46%-17.89%KYMRKymera Therapeutics-1.09%+0.57%+30.82%+25.98%+34.85%PTGXProtagonist Therapeutics+2.07%-1.45%+8.16%+25.21%+49.47%Compare Analyst ForecastsCompanyConsensus Rating ScoreConsensus RatingConsensus Price Target% Upside from Current PriceCOLLCollegium Pharmaceutical 3.00Buy$42.3326.78% UpsideCRNXCrinetics Pharmaceuticals 2.71Moderate Buy$74.4575.19% UpsideKYMRKymera Therapeutics 2.95Moderate Buy$61.267.63% UpsidePTGXProtagonist Therapeutics 2.83Moderate Buy$68.835.14% UpsideCurrent Analyst Ratings BreakdownLatest COLL, KYMR, PTGX, and CRNX Analyst RatingsDateCompanyBrokerageActionRatingPrice TargetDetails10/8/2025PTGXProtagonist TherapeuticsHC WainwrightSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingBuy$80.0010/7/2025PTGXProtagonist TherapeuticsJohnson RiceSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingSet Price Target$74.0010/1/2025KYMRKymera TherapeuticsOppenheimerSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingBoost Price TargetOutperform$53.00 ➝ $63.009/30/2025CRNXCrinetics PharmaceuticalsOppenheimerSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingBoost Price TargetOutperform$73.00 ➝ $87.009/30/2025KYMRKymera TherapeuticsTruist FinancialSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingBoost Price TargetBuy$53.00 ➝ $68.009/29/2025CRNXCrinetics PharmaceuticalsMorgan StanleySubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingBoost Price TargetOverweight$65.00 ➝ $77.009/29/2025CRNXCrinetics PharmaceuticalsLeerink PartnersSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingBoost Price TargetOutperform$80.00 ➝ $88.009/27/2025COLLCollegium PharmaceuticalWeiss RatingsSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingHold (C)9/27/2025CRNXCrinetics PharmaceuticalsWeiss RatingsSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingSell (D-)9/27/2025KYMRKymera TherapeuticsWeiss RatingsSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingSell (D-)9/27/2025PTGXProtagonist TherapeuticsWeiss RatingsSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingSell (D+)(Data available from 10/8/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)Compare Sales & Book ValueCompanyAnnual RevenuePrice/SalesCashflowPrice/CashBook ValuePrice/BookCOLLCollegium Pharmaceutical$631.45M1.67$12.19 per share2.74$7.10 per share4.70CRNXCrinetics Pharmaceuticals$1.04M3,848.70N/AN/A$14.29 per share2.97KYMRKymera Therapeutics$47.07M86.46N/AN/A$12.90 per share4.41PTGXProtagonist Therapeutics$434.43M9.38$4.61 per share14.20$11.33 per share5.78Compare Profitability & EarningsCompanyNet IncomeEPSTrailing P/E RatioForward P/E RatioP/E GrowthNet MarginsReturn on Equity (ROE)Return on Assets (ROA)Next Earnings DateCOLLCollegium Pharmaceutical$69.19M$1.0432.115.55N/A5.13%97.28%13.87%11/6/2025 (Estimated)CRNXCrinetics Pharmaceuticals-$298.41M-$4.11N/AN/AN/AN/A-32.28%-29.45%11/6/2025 (Estimated)KYMRKymera Therapeutics-$223.86M-$3.47N/AN/AN/A-616.03%-31.60%-27.12%10/30/2025 (Estimated)PTGXProtagonist Therapeutics$275.19M$0.7093.53N/AN/A24.88%8.12%7.41%11/6/2025 (Estimated)Latest COLL, KYMR, PTGX, and CRNX EarningsDateQuarterCompanyConsensus EstimateReported EPSBeat/MissGap EPSRevenue EstimateActual RevenueDetails10/30/2025Q3 2025KYMRKymera Therapeutics-$0.73N/AN/AN/AN/AN/A8/11/2025Q2 2025KYMRKymera Therapeutics-$0.83-$0.95-$0.12-$0.95$17.37 million$11.48 million8/7/2025Q2 2025CRNXCrinetics Pharmaceuticals-$1.13-$1.23-$0.10-$1.23$0.52 million$1.03 million8/6/2025Q2 2025PTGXProtagonist Therapeutics-$0.53-$0.55-$0.02-$0.55$8.32 million$5.55 millionCompare DividendsCompanyAnnual PayoutDividend Yield3-Year Dividend GrowthPayout RatioYears of Consecutive GrowthCOLLCollegium PharmaceuticalN/AN/AN/AN/AN/ACRNXCrinetics PharmaceuticalsN/AN/AN/AN/AN/AKYMRKymera TherapeuticsN/AN/AN/AN/AN/APTGXProtagonist TherapeuticsN/AN/AN/AN/AN/ACompare DebtCompanyDebt-to-Equity RatioCurrent RatioQuick RatioCOLLCollegium Pharmaceutical3.271.181.10CRNXCrinetics PharmaceuticalsN/A17.8017.80KYMRKymera TherapeuticsN/A8.328.32PTGXProtagonist TherapeuticsN/A16.9716.97Compare OwnershipInstitutional OwnershipCompanyInstitutional OwnershipCOLLCollegium PharmaceuticalN/ACRNXCrinetics Pharmaceuticals98.51%KYMRKymera TherapeuticsN/APTGXProtagonist Therapeutics98.63%Insider OwnershipCompanyInsider OwnershipCOLLCollegium Pharmaceutical2.51%CRNXCrinetics Pharmaceuticals6.00%KYMRKymera Therapeutics16.01%PTGXProtagonist Therapeutics4.90%Compare Miscellaneous StatsCompanyEmployeesShares OutstandingFree FloatOptionableCOLLCollegium Pharmaceutical21031.50 million30.71 millionOptionableCRNXCrinetics Pharmaceuticals21094.18 million88.53 millionOptionableKYMRKymera Therapeutics17071.50 million60.05 millionOptionablePTGXProtagonist Therapeutics12062.21 million59.16 millionOptionableCOLL, KYMR, PTGX, and CRNX HeadlinesRecent News About These CompaniesProtagonist Therapeutics' (PTGX) Buy Rating Reiterated at HC Wainwright1 hour ago | marketbeat.comProtagonist Therapeutics price target raised to $74 from $62 at Clear StreetOctober 7 at 7:15 PM | msn.comProtagonist Therapeutics (PTGX): Evaluating Valuation After a 65% Year-to-Date Share Price SurgeOctober 7 at 2:14 PM | finance.yahoo.comProtagonist Therapeutics, Inc. $PTGX Shares Bought by State of Alaska Department of RevenueOctober 3, 2025 | marketbeat.com14,339 Shares in Protagonist Therapeutics, Inc. $PTGX Acquired by Precision Wealth Strategies LLCOctober 2, 2025 | marketbeat.comProtagonist Therapeutics (NASDAQ:PTGX) Shares Down 5.1% - What's Next?September 29, 2025 | marketbeat.com7,530 Shares in Protagonist Therapeutics, Inc. $PTGX Acquired by Palumbo Wealth Management LLCSeptember 25, 2025 | marketbeat.comAssenagon Asset Management S.A. Increases Stock Position in Protagonist Therapeutics, Inc. $PTGXSeptember 25, 2025 | marketbeat.comProtagonist Therapeutics (NASDAQ:PTGX) Director Sells $257,000.00 in StockSeptember 24, 2025 | marketbeat.comProtagonist Therapeutics (NASDAQ:PTGX) Reaches New 12-Month High - Should You Buy?September 24, 2025 | marketbeat.comProtagonist Therapeutics, Inc. (NASDAQ:PTGX) Receives Consensus Rating of "Buy" from AnalystsSeptember 22, 2025 | marketbeat.comExchange Traded Concepts LLC Purchases 19,999 Shares of Protagonist Therapeutics, Inc. $PTGXSeptember 21, 2025 | marketbeat.comVoya Investment Management LLC Cuts Stock Position in Protagonist Therapeutics, Inc. $PTGXSeptember 21, 2025 | marketbeat.comProtagonist Therapeutics (NASDAQ:PTGX) Reaches New 12-Month High - What's Next?September 19, 2025 | marketbeat.comProtagonist Therapeutics (NASDAQ:PTGX) Upgraded by Barclays to Strong-Buy RatingSeptember 19, 2025 | marketbeat.comStrs Ohio Invests $919,000 in Protagonist Therapeutics, Inc. $PTGXSeptember 19, 2025 | marketbeat.comProtagonist Therapeutics (NASDAQ:PTGX) Given Buy Rating at HC WainwrightSeptember 18, 2025 | marketbeat.comProtagonist Therapeutics (NASDAQ:PTGX) Now Covered by BarclaysSeptember 18, 2025 | marketbeat.comBarclays Initiates Coverage of Protagonist Therapeutics (PTGX) with Overweight RecommendationSeptember 17, 2025 | msn.comDemystifying Protagonist Therapeutics: Insights From 4 Analyst ReviewsSeptember 17, 2025 | benzinga.comProtagonist Therapeutics, Inc. (PTGX): A Bull Case TheorySeptember 17, 2025 | msn.comNew MarketBeat Followers Over TimeMedia Sentiment Over Time Top HeadlinesView All HeadlinesSoundHound Breaks Critical Resistance: How High Can It Get Now?By Thomas Hughes | September 28, 2025The Fed Cut Rates: What Now for the S&P 500 and Equity Markets?By Thomas Hughes | September 18, 2025Why Datavault May Be the Penny AI Stock Investors Have Waited ForBy Nathan Reiff | September 22, 20253 Hot Tech Stocks With Bullish Charts and Ample UpsideBy Thomas Hughes | September 15, 2025GameStop Partying Like It’s 2021: What’s Behind Its 2025 Rebound?By Dan Schmidt | September 22, 2025COLL, KYMR, PTGX, and CRNX Company DescriptionsCollegium Pharmaceutical NASDAQ:COLL$33.39 -0.44 (-1.30%) Closing price 10/7/2025 04:00 PM EasternExtended Trading$33.39 0.00 (0.00%) As of 10/7/2025 04:10 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Collegium Pharmaceutical, Inc., a specialty pharmaceutical company, engages in the development and commercialization of medicines for pain management. Its portfolio includes Xtampza ER, an abuse-deterrent, extended-release, and oral formulation of oxycodone for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment; Nucynta ER and Nucynta IR, which are extended-release and immediate-release formulations of tapentadol, indicated for the management of acute, severe, and persistent pain; Belbuca, a buccal film that contains buprenorphine; and Symproic, an oral formulation of naldemedine for the treatment of opioid-induced constipation in adult patients with chronic non-cancer pain. The company was formerly known as Collegium Pharmaceuticals, Inc. and changed its name to Collegium Pharmaceutical, Inc. in October 2003. Collegium Pharmaceutical, Inc. was incorporated in 2002 and is headquartered in Stoughton, Massachusetts.Crinetics Pharmaceuticals NASDAQ:CRNX$42.50 +0.82 (+1.97%) Closing price 10/7/2025 04:00 PM EasternExtended Trading$42.02 -0.48 (-1.13%) As of 08:27 AM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Crinetics Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, focuses on the discovery, development, and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors. The company's lead product candidate is paltusotine, an oral selective nonpeptide somatostatin receptor type 2 agonist, which is in Phase 3 trial for the treatment of acromegaly; and Phase 2 trial for treating carcinoid syndrome associated with neuroendocrine tumors. It is also developing CRN04894, an investigational oral nonpeptide product candidate to antagonize the adrenocorticotrophic hormone (ACTH) receptor that has completed a Phase 1 study for the treatment of diseases caused by excess ACTH, including congenital adrenal hyperplasia and Cushing's disease. In addition, the company is developing antagonists of the parathyroid hormone (PTH) receptor for the treatment of primary hyperparathyroidism and humoral hypercalcemia of malignancy, and other diseases of excess PTH; identified investigational orally available somatostatin receptor type 3 targeted nonpeptide agonists for the treatment of autosomal dominant polycystic kidney disease; and developing thyroid-stimulating hormone receptor antagonists for the treatment of graves' disease and thyroid eye disease, as well as Oral GLP-1 and GIP nonpeptides for the treatment of diabetes and obesity. Crinetics Pharmaceuticals, Inc. was incorporated in 2008 and is headquartered in San Diego, California.Kymera Therapeutics NASDAQ:KYMR$56.92 -0.63 (-1.09%) Closing price 10/7/2025 04:00 PM EasternExtended Trading$56.92 0.00 (0.00%) As of 08:00 AM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Kymera Therapeutics, Inc., a biopharmaceutical company, focuses on discovering and developing novel small molecule therapeutics that selectively degrade disease-causing proteins by harnessing the body's own natural protein degradation system. It engages in developing IRAK4 program, which is in Phase II clinical trial for the treatment of immunology-inflammation diseases, including hidradenitis suppurativa, atopic dermatitis; STAT3 program for the treatment of hematologic malignancies and solid tumors, as well as autoimmune diseases and fibrosis; and MDM2 program to treat hematological malignancies and solid tumors. The company develops STAT6, a Type 2 inflammation in allergic diseases; and TYK2, a treatment for inflammatory bowel disease, psoriasis, psoriatic arthritis, and lupus. The company was incorporated in 2015 and is headquartered in Watertown, Massachusetts.Protagonist Therapeutics NASDAQ:PTGX$65.47 +1.33 (+2.07%) Closing price 10/7/2025 04:00 PM EasternExtended Trading$64.47 -1.00 (-1.52%) As of 08:00 AM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Protagonist Therapeutics, Inc., a biopharmaceutical company, develops peptide-based drugs for hematology and blood disorders, and inflammatory and immunomodulatory diseases. It is developing Rusfertide (PTG-300), an injectable hepcidin mimetic that completed phase 2 clinical trials for the treatment of polycythemia vera and other blood disorders; and JNJ-2113, an orally delivered investigational drug to block biological pathways that completed phase 2b clinical trials for the treatment of moderate-to-severe plaque psoriasis; and PN-943, an orally delivered, gut-restricted alpha 4 beta 7 specific integrin antagonist completed a phase 2 clinical trials in patients with moderate to severe ulcerative colitis. The company has a license and collaboration agreement with Takeda to commercialize rusfertide; and JNJ Innovative Medicines to co-develop Interleukin-23 receptor antagonist compound JNJ-2113. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California. 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