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	ACADIA Pharmaceuticals	Ascendis Pharma A/S	Ultragenyx Pharmaceutical	Ionis Pharmaceuticals	United Therapeutics
Symbol	NASDAQ:ACAD	NASDAQ:ASND	NASDAQ:RARE	NASDAQ:IONS	NASDAQ:UTHR
Price Information
Current Price	$21.50	$124.94	$107.77	$42.08	$211.93
52 Week Range	Hold	Buy	Buy	Hold	Buy
MarketRank™
Overall Score	1.9	1.5	1.6	1.6	1.5
Analysis Score	4.2	3.5	4.3	4.1	2.5
Community Score	3.2	2.6	3.3	2.3	2.2
Dividend Score	0.0	0.0	0.0	0.0	0.0
Ownership Score	1.7	0.8	0.0	1.7	1.7
Earnings & Valuation Score	0.6	0.6	0.6	0.0	1.3
Analyst Ratings
Consensus Recommendation	Hold	Buy	Buy	Hold	Buy
Consensus Price Target	$32.76	$192.22	$136.47	$57.45	$219.57
% Upside from Price Target	52.39% upside	53.85% upside	26.63% upside	36.54% upside	3.61% upside
Trade Information
Market Cap	$3.44 billion	$6.72 billion	$7.31 billion	$5.84 billion	$9.44 billion
Beta	1.44	0.77	2.19	1.42	0.52
Average Volume	2,195,594	206,189	447,912	1,228,435	385,703
Sales & Book Value
Annual Revenue	$339.08 million	$14.98 million	$103.71 million	$1.12 billion	$1.45 billion
Price / Sales	10.15	448.30	69.57	5.28	6.52
Cashflow	N/A	N/A	N/A	$1.71 per share	N/A
Price / Cash	N/A	N/A	N/A	24.55	N/A
Book Value	$4.54 per share	$15.87 per share	$11.32 per share	$11.98 per share	$63.36 per share
Price / Book	4.74	7.87	9.52	3.51	3.34
Profitability
Net Income	$-235,260,000.00	$-244,180,000.00	$-402,730,000.00	$303.26 million	$-104,500,000.00
EPS	($1.60)	($5.25)	($7.36)	$2.08	($2.39)
Trailing P/E Ratio	N/A	N/A	N/A	87.67	20.05
Forward P/E Ratio	N/A	N/A	N/A	N/A	18.29
P/E Growth	N/A	N/A	N/A	N/A	N/A
Net Margins	-63.92%	-4,042.79%	-119.19%	7.82%	33.25%
Return on Equity (ROE)	-40.35%	-55.72%	-50.69%	6.57%	15.48%
Return on Assets (ROA)	-34.72%	-49.42%	-26.87%	3.39%	11.31%
Dividend
Annual Payout	N/A	N/A	N/A	N/A	N/A
Dividend Yield	N/A	N/A	N/A	N/A	N/A
Three-Year Dividend Growth	N/A	N/A	N/A	N/A	N/A
Payout Ratio	N/A	N/A	N/A	N/A	N/A
Years of Consecutive Dividend Growth	N/A	N/A	N/A	N/A	N/A
Debt
Debt-to-Equity Ratio	N/A	N/A	N/A	0.51%	0.24%
Current Ratio	7.95%	14.80%	4.33%	10.37%	7.22%
Quick Ratio	7.86%	14.80%	4.26%	10.28%	6.88%
Ownership Information
Institutional Ownership Percentage	93.54%	N/A	N/A	84.14%	90.09%
Insider Ownership Percentage	27.70%	40.00%	8.20%	2.40%	10.90%
Miscellaneous
Employees	601	482	893	757	950
Shares Outstanding	160.05 million	53.75 million	66.95 million	140.86 million	44.54 million
Next Earnings Date	5/5/2021 (Confirmed)	5/18/2021 (Estimated)	5/5/2021 (Estimated)	5/5/2021 (Confirmed)	5/5/2021 (Estimated)
Optionable	Optionable	Optionable	Optionable	Optionable	Optionable

Source	Headline
	Pre-earnings Momentum Trade With a Technical Trigger in United Therapeutics Corp cmlviz.com - April 21 at 6:35 PM
	Wedbush Stick to Their Buy Rating for United Therapeutics investing.com - April 21 at 1:35 PM
	United Therapeutics (NASDAQ:UTHR) Shares Gap Up to $203.84 americanbankingnews.com - April 21 at 11:02 AM
	United Therapeutics takes latest step in aggressive push to launch more products bizjournals.com - April 19 at 1:59 PM
	Mannkind and United Therapeutics Reach a Milestone in the Development of Tyvaso DPI™ With New Drug Application Submitted to the FDA markets.businessinsider.com - April 19 at 8:56 AM
	Mannkind and United Therapeutics Reach a Milestone in the Development of Tyvaso DPI(TM) With New Drug Application Submitted to the FDA marketwatch.com - April 19 at 8:56 AM
	Mannkind and United Therapeutics Reach a Milestone in the Development of Tyvaso DPI™ With New ... apnews.com - April 19 at 8:56 AM
	United Therapeutics (NASDAQ:UTHR) Sets New 1-Year High at $205.52 americanbankingnews.com - April 17 at 12:12 PM
	United Therapeutics (NASDAQ:UTHR) Sets New 52-Week High on Analyst Upgrade americanbankingnews.com - April 8 at 4:22 PM
	United Therapeutics (NASDAQ:UTHR) Given New $212.00 Price Target at JPMorgan Chase & Co. americanbankingnews.com - April 8 at 10:10 AM
	JPMorgan Chase & Co. Boosts United Therapeutics (NASDAQ:UTHR) Price Target to $212.00 marketbeat.com - April 8 at 8:13 AM
	Is UTHR Stock A Buy or Sell? finance.yahoo.com - April 6 at 6:55 PM
	United Therapeutics (UTHR) Gains on Tyvaso Label Expansion finance.yahoo.com - April 5 at 12:53 PM
	This Pharma Can Breathe New Life Into Your Portfolio finance.yahoo.com - April 2 at 9:10 AM
	United Therapeutics Receives FDA Approval For Tyvaso Therapy; Shares Pop 15% finance.yahoo.com - April 2 at 9:10 AM
	United Therapeutics Target of Unusually High Options Trading (NASDAQ:UTHR) americanbankingnews.com - April 1 at 7:55 PM
	United Therapeutics Shares Rise 15% as FDA Clears Pathway to Launch Tyvaso to Treat PH-ILD streetwisereports.com - April 1 at 6:53 PM
	Wingstop, Guess rise; CarMax, Emergent BioSolutions fall marketbeat.com - April 1 at 4:31 PM
	United Therapeutics Jumps as FDA Clears Hypertension Drug thestreet.com - April 1 at 1:52 PM
	United Therapeutics (NASDAQ:UTHR) Hits New 12-Month High at $186.90 americanbankingnews.com - April 1 at 10:40 AM
	FDA approves inhaled pulmonary hypertension treatment from United Therapeutics drugdeliverybusiness.com - April 1 at 8:50 AM
	United Therapeutics: FDA Approves Tyvaso For PH-ILD - Quick Facts nasdaq.com - April 1 at 8:50 AM
	UTHR Aug 2021 160.000 put ca.finance.yahoo.com - March 27 at 3:16 PM
	UTHR May 2021 110.000 call ca.finance.yahoo.com - March 27 at 9:52 AM
	UTHR Aug 2021 200.000 put ca.finance.yahoo.com - March 27 at 9:52 AM
	Why Is United Therapeutics (UTHR) Down 0.3% Since Last Earnings Report? finance.yahoo.com - March 26 at 1:28 PM
	UTHR May 2021 75.000 put sg.finance.yahoo.com - March 18 at 9:28 AM

Date	Company	Brokerage	Action
4/13/2021	ACADIA Pharmaceuticals	The Goldman Sachs Group	Reiterated Rating
4/13/2021	ACADIA Pharmaceuticals	Jefferies Financial Group	Reiterated Rating
4/13/2021	ACADIA Pharmaceuticals	Mizuho	Reiterated Rating
4/13/2021	ACADIA Pharmaceuticals	Canaccord Genuity	Reiterated Rating
4/13/2021	ACADIA Pharmaceuticals	Morgan Stanley	Lower Price Target
4/13/2021	ACADIA Pharmaceuticals	HC Wainwright	Reiterated Rating
4/6/2021	ACADIA Pharmaceuticals	SVB Leerink	Lower Price Target
4/6/2021	ACADIA Pharmaceuticals	Cantor Fitzgerald	Boost Price Target
4/5/2021	ACADIA Pharmaceuticals	Raymond James	Downgrade
4/5/2021	ACADIA Pharmaceuticals	Needham & Company LLC	Lower Price Target
3/16/2021	ACADIA Pharmaceuticals	Bank of America	Reiterated Rating
3/15/2021	ACADIA Pharmaceuticals	Citigroup Inc. 3% Minimum Coupon Principal Protected Based Upon Russell	Reiterated Rating
3/15/2021	ACADIA Pharmaceuticals	Stifel Nicolaus	Reiterated Rating
3/15/2021	ACADIA Pharmaceuticals	Guggenheim	Reiterated Rating
3/30/2021	Ascendis Pharma A/S	Oppenheimer	Downgrade
3/17/2021	Ascendis Pharma A/S	Credit Suisse Group	Lower Price Target
12/17/2020	Ascendis Pharma A/S	Berenberg Bank	Initiated Coverage
11/12/2020	Ascendis Pharma A/S	Wells Fargo & Company	Boost Price Target
9/30/2020	Ascendis Pharma A/S	Wedbush	Boost Price Target
9/14/2020	Ascendis Pharma A/S	JPMorgan Chase & Co.	Initiated Coverage
5/20/2020	Ascendis Pharma A/S	CSFB	Boost Price Target
2/12/2021	Ultragenyx Pharmaceutical	Piper Sandler	Boost Price Target
2/12/2021	Ultragenyx Pharmaceutical	Barclays	Boost Price Target
1/11/2021	Ultragenyx Pharmaceutical	Robert W. Baird	Boost Price Target
11/24/2020	Ultragenyx Pharmaceutical	Evercore ISI	Reiterated Rating
10/28/2020	Ultragenyx Pharmaceutical	Truist	Boost Price Target
4/5/2021	Ionis Pharmaceuticals	UBS Group	Reiterated Rating
3/29/2021	Ionis Pharmaceuticals	BMO Capital Markets	Lower Price Target
3/23/2021	Ionis Pharmaceuticals	Royal Bank of Canada	Lower Price Target
12/15/2020	Ionis Pharmaceuticals	Cowen	Upgrade
1/20/2021	United Therapeutics	LADENBURG THALM/SH SH	Boost Price Target

(Data available from 4/22/2018 forward. View 10+ years of historical ratings with our analyst ratings screener.)

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