Positive News SentimentPositive NewsNASDAQ:RYTM Rhythm Pharmaceuticals (RYTM) Stock Price, News & Analysis $100.23 +0.40 (+0.40%) Closing price 04:00 PM EasternExtended Trading$100.19 -0.04 (-0.04%) As of 06:05 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock About Rhythm Pharmaceuticals Stock (NASDAQ:RYTM) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get Rhythm Pharmaceuticals alerts:Sign Up Key Stats Today's Range$99.06▼$100.9150-Day Range$84.66▼$104.5752-Week Range$45.90▼$106.52Volume428,145 shsAverage Volume656,252 shsMarket Capitalization$6.66 billionP/E RatioN/ADividend YieldN/APrice Target$106.64Consensus RatingModerate Buy Company Overview Rhythm Pharmaceuticals, Inc. is a clinical‐stage biotechnology company dedicated to developing targeted therapies for rare genetic diseases of obesity and metabolic dysfunction. The company’s research focuses on the melanocortin‐4 receptor (MC4R) pathway, which plays a central role in regulating appetite, energy expenditure and body weight. Using proprietary peptide technology, Rhythm aims to provide precision treatments to patients with specific genetic variants that disrupt normal weight regulation. The company’s lead investigational product, setmelanotide, is a selective MC4R agonist designed to restore signaling in patients with deficiencies in genes such as POMC, LEPR and PCSK1. Rhythm has advanced multiple Phase 3 clinical trials for setmelanotide and is pursuing regulatory approvals in both the United States and the European Union. In addition to its lead program, the company is exploring opportunities in related rare obesity indications and branching into other metabolic disorders tied to melanocortin pathway dysfunction. Founded in 2013 and headquartered in Boston, Massachusetts, Rhythm Pharmaceuticals is led by a management team with extensive experience in drug development, regulatory strategy and commercialization of therapies for rare diseases. The company maintains a robust intellectual property portfolio around its peptide technology and collaborates with academic institutions and patient advocacy groups to advance understanding of rare genetic forms of obesity. Rhythm’s work underscores a commitment to precision medicine approaches that address the root causes of metabolic disorders.AI Generated. May Contain Errors. Read More Rhythm Pharmaceuticals Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks71st Percentile Overall ScoreRYTM MarketRank™: Rhythm Pharmaceuticals scored higher than 71% of companies evaluated by MarketBeat, and ranked 292nd out of 942 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion3.0 / 5Analyst RatingModerate Buy Consensus RatingRhythm Pharmaceuticals has received a consensus rating of Moderate Buy. The company's average rating score is 2.94, and is based on 15 buy ratings, no hold ratings, and 1 sell rating.Upside/DownsideThe consensus price target for Rhythm Pharmaceuticals is close to its current price, suggesting limited near-term upside or downside.Amount of Analyst CoverageRhythm Pharmaceuticals has been the subject of 11 research reports in the past 90 days, demonstrating strong analyst interest in this stock.Read more about Rhythm Pharmaceuticals' stock forecast and price target. Earnings and Valuation0.6 / 5Proj. Earnings GrowthGrowing Earnings GrowthEarnings for Rhythm Pharmaceuticals are expected to grow in the coming year, from ($4.32) to ($2.58) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Rhythm Pharmaceuticals is -33.30, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Rhythm Pharmaceuticals is -33.30, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioRhythm Pharmaceuticals has a P/B Ratio of 286.37. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.Read more about Rhythm Pharmaceuticals' valuation and earnings. Short Interest1.0 / 5Short Interest LevelBearish Percentage of Shares Shorted7.86% of the outstanding shares of Rhythm Pharmaceuticals have been sold short.Short Interest Ratio / Days to CoverRhythm Pharmaceuticals has a short interest ratio ("days to cover") of 7.2.Change versus previous monthShort interest in Rhythm Pharmaceuticals has recently increased by 5.03%, indicating that investor sentiment is decreasing significantly. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldRhythm Pharmaceuticals does not currently pay a dividend.Dividend GrowthRhythm Pharmaceuticals does not have a long track record of dividend growth. Sustainability and ESG4.3 / 5Environmental Score-1.80 Percentage of Shares Shorted7.86% of the outstanding shares of Rhythm Pharmaceuticals have been sold short.Short Interest Ratio / Days to CoverRhythm Pharmaceuticals has a short interest ratio ("days to cover") of 7.2.Change versus previous monthShort interest in Rhythm Pharmaceuticals has recently increased by 5.03%, indicating that investor sentiment is decreasing significantly. News and Social Media3.7 / 5News SentimentN/A News SentimentRhythm Pharmaceuticals has a news sentiment score of 1.75. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a higher news sentiment than the 0.56 average news sentiment score of Medical companies.News Coverage This WeekMarketBeat has tracked 1 news article for Rhythm Pharmaceuticals this week, compared to 9 articles on an average week.Search Interest4 people have searched for RYTM on MarketBeat in the last 30 days. MarketBeat Follows3 people have added Rhythm Pharmaceuticals to their MarketBeat watchlist in the last 30 days. This is an increase of 200% compared to the previous 30 days. Company Ownership0.8 / 5Insider TradingSelling Shares Insider Buying vs. Insider SellingIn the past three months, Rhythm Pharmaceuticals insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $9,274,593.00 in company stock.Percentage Held by InsidersOnly 6.10% of the stock of Rhythm Pharmaceuticals is held by insiders.Read more about Rhythm Pharmaceuticals' insider trading history. 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RYTM Stock News HeadlinesShould You Expect Robust Growth Potential for Rhythm Pharmaceuticals (RYTM) Ahead?October 3, 2025 | insidermonkey.comHC Wainwright & Co. Maintains Rhythm Pharmaceuticals (RYTM) Buy RecommendationSeptember 29, 2025 | msn.comBitcoin hits $125K… but the real story is hiding elsewhereA cutting-edge drone developer just secured a U.S. Army deal to supply its Flex FPV Modular Drones and build a full FPV ecosystem — training troops, supporting operations overseas, and expanding America’s battlefield tech edge.October 8 at 2:00 AM | Weiss Ratings (Ad)Rhythm Pharmaceuticals (NASDAQ:RYTM) Stock Price Expected to Rise, JMP Securities Analyst SaysSeptember 27, 2025 | americanbankingnews.comJMP Securities Maintains Rhythm Pharmaceuticals (RYTM) Market Outperform RecommendationSeptember 26, 2025 | msn.comRhythm Pharmaceuticals price target raised to $142 from $135 at Citizens JMPSeptember 25, 2025 | msn.comRhythm Pharmaceuticals price target raised to $122 from $109 at Morgan StanleySeptember 24, 2025 | msn.comRhythm Pharmaceuticals, Inc. (RYTM) Discusses On Commercial Readiness For Acquired Hypothalamic Obesity Event Call (Transcript)September 24, 2025 | seekingalpha.comSee More Headlines RYTM Stock Analysis - Frequently Asked Questions How have RYTM shares performed this year? Rhythm Pharmaceuticals' stock was trading at $55.98 at the beginning of the year. Since then, RYTM shares have increased by 79.0% and is now trading at $100.23. How were Rhythm Pharmaceuticals' earnings last quarter? Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) released its quarterly earnings data on Tuesday, August, 5th. The company reported ($0.75) earnings per share for the quarter, missing the consensus estimate of ($0.66) by $0.09. Rhythm Pharmaceuticals's revenue was up 66.8% on a year-over-year basis. Read the conference call transcript. When did Rhythm Pharmaceuticals IPO? Rhythm Pharmaceuticals (RYTM) raised $100 million in an initial public offering (IPO) on Thursday, October 5th 2017. The company issued 6,700,000 shares at $14.00-$16.00 per share. Morgan Stanley, BofA Merrill Lynch and Cowen acted as the underwriters for the IPO and Needham was co-manager. Who are Rhythm Pharmaceuticals' major shareholders? Rhythm Pharmaceuticals' top institutional shareholders include Assenagon Asset Management S.A. (0.34%). Insiders that own company stock include David P Meeker, Hunter C Smith, Yann Mazabraud, Pamela J Cramer, Joseph Shulman, William T Roberts, Jennifer Kayden Lee, Jennifer Chien, Alastair Garfield, Lynn A Tetrault, Jennifer L Good and Christopher Paul German. View institutional ownership trends. How do I buy shares of Rhythm Pharmaceuticals? Shares of RYTM stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of Rhythm Pharmaceuticals own? Based on aggregate information from My MarketBeat watchlists, some other companies that Rhythm Pharmaceuticals investors own include NVIDIA (NVDA), Meta Platforms (META), Advanced Micro Devices (AMD), JPMorgan Chase & Co. (JPM), Netflix (NFLX), Tesla (TSLA) and Palo Alto Networks (PANW). Company Calendar Last Earnings8/05/2025Today10/08/2025Next Earnings (Estimated)11/04/2025Fiscal Year End12/31/2025Get Stock AlertsIndustry, Sector and Symbol Stock ExchangeNASDAQ SectorMedical Industry MED - BIOMED/GENE Sub-IndustryPharmaceutical Products Current SymbolNASDAQ:RYTM CIK1649904 Webwww.rhythmtx.com Phone(857) 264-4280Fax857-264-4299Employees140Year Founded2008Price Target and Rating Average Price Target for Rhythm Pharmaceuticals$106.64 High Price Target$142.00 Low Price Target$65.00 Potential Upside/Downside+6.7%Consensus RatingModerate Buy Rating Score (0-4)2.94 Research Coverage17 Analysts Profitability EPS (Trailing Twelve Months)($3.01) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$260.60 million Net Margins-117.13% Pretax Margin-117.17% Return on Equity-1,831.43% Return on Assets-48.33% Debt Debt-to-Equity RatioN/A Current Ratio2.79 Quick Ratio2.64 Sales & Book Value Annual Sales$130.13 million Price / Sales51.01 Cash FlowN/A Price / Cash FlowN/A Book Value$0.35 per share Price / Book285.53Miscellaneous Outstanding Shares66,420,000Free Float62,368,000Market Cap$6.64 billion OptionableOptionable Beta2.12 Social Links Beginner's Guide To Retirement StocksEnter your email address and we'll send you MarketBeat's list of seven best retirement stocks and why they should be in your portfolio. 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