Is BOLT or CRIS more profitable?

Curis has a net margin of -80.29% compared to Bolt Biotherapeutics' net margin of -455.15%. Curis' return on equity of 0.00% beat Bolt Biotherapeutics' return on equity. Company Net Margins Return on Equity Return on Assets Bolt Biotherapeutics -455.15% -100.89% -48.23% Curis -80.29% N/A -181.57%

Is BOLT or AMGN more profitable?

Amgen has a net margin of 20.96% compared to Bolt Biotherapeutics' net margin of -455.15%. Amgen's return on equity of 137.41% beat Bolt Biotherapeutics' return on equity. Company Net Margins Return on Equity Return on Assets Bolt Biotherapeutics -455.15% -100.89% -48.23% Amgen 20.96% 137.41% 13.28%

Bolt Biotherapeutics (BOLT) Competitors

$4.26 +0.25 (+6.23%)

As of 04:00 PM Eastern

Compare

BOLT vs. CRIS, AMGN, GILD, VRTX, and REGN

Should you buy Bolt Biotherapeutics stock or one of its competitors? MarketBeat compares Bolt Biotherapeutics with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Bolt Biotherapeutics include Curis (CRIS), Amgen (AMGN), Gilead Sciences (GILD), Vertex Pharmaceuticals (VRTX), and Regeneron Pharmaceuticals (REGN). These companies are all part of the "biotechnology" industry.

How does Bolt Biotherapeutics compare to Curis?

Bolt Biotherapeutics (NASDAQ:BOLT) and Curis (NASDAQ:CRIS) are both small-cap medical companies, but which is the better investment? We will contrast the two businesses based on the strength of their profitability, analyst recommendations, earnings, institutional ownership, dividends, valuation, risk and media sentiment.

Curis has higher revenue and earnings than Bolt Biotherapeutics. Curis is trading at a lower price-to-earnings ratio than Bolt Biotherapeutics, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Bolt Biotherapeutics	$7.70M	1.06	-$33.38M	-$16.33	N/A
Curis	$9.44M	1.49	-$7.58M	-$1.19	N/A

In the previous week, Curis had 1 more articles in the media than Bolt Biotherapeutics. MarketBeat recorded 1 mentions for Curis and 0 mentions for Bolt Biotherapeutics. Bolt Biotherapeutics' average media sentiment score of 0.00 equaled Curis'average media sentiment score.

Company	Overall Sentiment
Bolt Biotherapeutics	Neutral
Curis	Neutral

Curis has a net margin of -80.29% compared to Bolt Biotherapeutics' net margin of -455.15%. Curis' return on equity of 0.00% beat Bolt Biotherapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Bolt Biotherapeutics	-455.15%	-100.89%	-48.23%
Curis	-80.29%	N/A	-181.57%

86.7% of Bolt Biotherapeutics shares are held by institutional investors. Comparatively, 30.0% of Curis shares are held by institutional investors. 9.4% of Bolt Biotherapeutics shares are held by company insiders. Comparatively, 5.8% of Curis shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company is poised for long-term growth.

Bolt Biotherapeutics presently has a consensus target price of $34.67, suggesting a potential upside of 713.77%. Curis has a consensus target price of $17.00, suggesting a potential upside of 4,600.03%. Given Curis' higher possible upside, analysts plainly believe Curis is more favorable than Bolt Biotherapeutics.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Bolt Biotherapeutics	1 Sell rating(s)	1 Hold rating(s)	3 Buy rating(s)	0 Strong Buy rating(s)	2.40
Curis	2 Sell rating(s)	0 Hold rating(s)	1 Buy rating(s)	0 Strong Buy rating(s)	1.67

Bolt Biotherapeutics has a beta of 1.12, meaning that its stock price is 12% more volatile than the broader market. Comparatively, Curis has a beta of 3.05, meaning that its stock price is 205% more volatile than the broader market.

Summary

Curis beats Bolt Biotherapeutics on 9 of the 15 factors compared between the two stocks.

How does Bolt Biotherapeutics compare to Amgen?

Bolt Biotherapeutics (NASDAQ:BOLT) and Amgen (NASDAQ:AMGN) are both medical companies, but which is the better investment? We will compare the two businesses based on the strength of their media sentiment, earnings, profitability, risk, analyst recommendations, dividends, valuation and institutional ownership.

Amgen has a net margin of 20.96% compared to Bolt Biotherapeutics' net margin of -455.15%. Amgen's return on equity of 137.41% beat Bolt Biotherapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Bolt Biotherapeutics	-455.15%	-100.89%	-48.23%
Amgen	20.96%	137.41%	13.28%

Amgen has higher revenue and earnings than Bolt Biotherapeutics. Bolt Biotherapeutics is trading at a lower price-to-earnings ratio than Amgen, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Bolt Biotherapeutics	$7.70M	1.06	-$33.38M	-$16.33	N/A
Amgen	$36.75B	5.10	$7.71B	$14.37	24.15

Bolt Biotherapeutics has a beta of 1.12, indicating that its share price is 12% more volatile than the broader market. Comparatively, Amgen has a beta of 0.42, indicating that its share price is 58% less volatile than the broader market.

In the previous week, Amgen had 26 more articles in the media than Bolt Biotherapeutics. MarketBeat recorded 26 mentions for Amgen and 0 mentions for Bolt Biotherapeutics. Amgen's average media sentiment score of 1.32 beat Bolt Biotherapeutics' score of 0.00 indicating that Amgen is being referred to more favorably in the news media.

Company	Overall Sentiment
Bolt Biotherapeutics	Neutral
Amgen	Positive

86.7% of Bolt Biotherapeutics shares are owned by institutional investors. Comparatively, 76.5% of Amgen shares are owned by institutional investors. 9.4% of Bolt Biotherapeutics shares are owned by insiders. Comparatively, 0.9% of Amgen shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Bolt Biotherapeutics currently has a consensus target price of $34.67, indicating a potential upside of 713.77%. Amgen has a consensus target price of $354.42, indicating a potential upside of 2.14%. Given Bolt Biotherapeutics' higher possible upside, analysts plainly believe Bolt Biotherapeutics is more favorable than Amgen.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Bolt Biotherapeutics	1 Sell rating(s)	1 Hold rating(s)	3 Buy rating(s)	0 Strong Buy rating(s)	2.40
Amgen	2 Sell rating(s)	15 Hold rating(s)	12 Buy rating(s)	2 Strong Buy rating(s)	2.45

Summary

Amgen beats Bolt Biotherapeutics on 13 of the 17 factors compared between the two stocks.

How does Bolt Biotherapeutics compare to Gilead Sciences?

Bolt Biotherapeutics (NASDAQ:BOLT) and Gilead Sciences (NASDAQ:GILD) are both medical companies, but which is the better investment? We will contrast the two businesses based on the strength of their analyst recommendations, dividends, earnings, profitability, institutional ownership, media sentiment, valuation and risk.

86.7% of Bolt Biotherapeutics shares are held by institutional investors. Comparatively, 83.7% of Gilead Sciences shares are held by institutional investors. 9.4% of Bolt Biotherapeutics shares are held by insiders. Comparatively, 0.3% of Gilead Sciences shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

In the previous week, Gilead Sciences had 33 more articles in the media than Bolt Biotherapeutics. MarketBeat recorded 33 mentions for Gilead Sciences and 0 mentions for Bolt Biotherapeutics. Gilead Sciences' average media sentiment score of 1.27 beat Bolt Biotherapeutics' score of 0.00 indicating that Gilead Sciences is being referred to more favorably in the news media.

Company	Overall Sentiment
Bolt Biotherapeutics	Neutral
Gilead Sciences	Positive

Gilead Sciences has higher revenue and earnings than Bolt Biotherapeutics. Bolt Biotherapeutics is trading at a lower price-to-earnings ratio than Gilead Sciences, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Bolt Biotherapeutics	$7.70M	1.06	-$33.38M	-$16.33	N/A
Gilead Sciences	$29.44B	5.27	$8.51B	$7.34	17.04

Bolt Biotherapeutics has a beta of 1.12, suggesting that its share price is 12% more volatile than the broader market. Comparatively, Gilead Sciences has a beta of 0.31, suggesting that its share price is 69% less volatile than the broader market.

Bolt Biotherapeutics presently has a consensus target price of $34.67, suggesting a potential upside of 713.77%. Gilead Sciences has a consensus target price of $158.41, suggesting a potential upside of 26.68%. Given Bolt Biotherapeutics' higher possible upside, research analysts clearly believe Bolt Biotherapeutics is more favorable than Gilead Sciences.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Bolt Biotherapeutics	1 Sell rating(s)	1 Hold rating(s)	3 Buy rating(s)	0 Strong Buy rating(s)	2.40
Gilead Sciences	0 Sell rating(s)	4 Hold rating(s)	25 Buy rating(s)	0 Strong Buy rating(s)	2.86

Gilead Sciences has a net margin of 30.99% compared to Bolt Biotherapeutics' net margin of -455.15%. Gilead Sciences' return on equity of 48.19% beat Bolt Biotherapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Bolt Biotherapeutics	-455.15%	-100.89%	-48.23%
Gilead Sciences	30.99%	48.19%	18.28%

Summary

Gilead Sciences beats Bolt Biotherapeutics on 12 of the 16 factors compared between the two stocks.

How does Bolt Biotherapeutics compare to Vertex Pharmaceuticals?

Bolt Biotherapeutics (NASDAQ:BOLT) and Vertex Pharmaceuticals (NASDAQ:VRTX) are both medical companies, but which is the better investment? We will contrast the two businesses based on the strength of their risk, analyst recommendations, profitability, dividends, valuation, institutional ownership, media sentiment and earnings.

Bolt Biotherapeutics presently has a consensus price target of $34.67, suggesting a potential upside of 713.77%. Vertex Pharmaceuticals has a consensus price target of $555.91, suggesting a potential upside of 18.68%. Given Bolt Biotherapeutics' higher possible upside, equities analysts plainly believe Bolt Biotherapeutics is more favorable than Vertex Pharmaceuticals.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Bolt Biotherapeutics	1 Sell rating(s)	1 Hold rating(s)	3 Buy rating(s)	0 Strong Buy rating(s)	2.40
Vertex Pharmaceuticals	0 Sell rating(s)	3 Hold rating(s)	22 Buy rating(s)	0 Strong Buy rating(s)	2.88

In the previous week, Vertex Pharmaceuticals had 37 more articles in the media than Bolt Biotherapeutics. MarketBeat recorded 37 mentions for Vertex Pharmaceuticals and 0 mentions for Bolt Biotherapeutics. Vertex Pharmaceuticals' average media sentiment score of 1.14 beat Bolt Biotherapeutics' score of 0.00 indicating that Vertex Pharmaceuticals is being referred to more favorably in the news media.

Company	Overall Sentiment
Bolt Biotherapeutics	Neutral
Vertex Pharmaceuticals	Positive

Bolt Biotherapeutics has a beta of 1.12, suggesting that its share price is 12% more volatile than the broader market. Comparatively, Vertex Pharmaceuticals has a beta of 0.3, suggesting that its share price is 70% less volatile than the broader market.

86.7% of Bolt Biotherapeutics shares are owned by institutional investors. Comparatively, 91.0% of Vertex Pharmaceuticals shares are owned by institutional investors. 9.4% of Bolt Biotherapeutics shares are owned by company insiders. Comparatively, 0.2% of Vertex Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock will outperform the market over the long term.

Vertex Pharmaceuticals has a net margin of 35.51% compared to Bolt Biotherapeutics' net margin of -455.15%. Vertex Pharmaceuticals' return on equity of 23.86% beat Bolt Biotherapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Bolt Biotherapeutics	-455.15%	-100.89%	-48.23%
Vertex Pharmaceuticals	35.51%	23.86%	17.13%

Vertex Pharmaceuticals has higher revenue and earnings than Bolt Biotherapeutics. Bolt Biotherapeutics is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Bolt Biotherapeutics	$7.70M	1.06	-$33.38M	-$16.33	N/A
Vertex Pharmaceuticals	$12.00B	9.91	$3.95B	$16.86	27.78

Summary

Vertex Pharmaceuticals beats Bolt Biotherapeutics on 13 of the 16 factors compared between the two stocks.

How does Bolt Biotherapeutics compare to Regeneron Pharmaceuticals?

Bolt Biotherapeutics (NASDAQ:BOLT) and Regeneron Pharmaceuticals (NASDAQ:REGN) are both medical companies, but which is the superior stock? We will contrast the two companies based on the strength of their valuation, risk, media sentiment, dividends, institutional ownership, analyst recommendations, profitability and earnings.

86.7% of Bolt Biotherapeutics shares are held by institutional investors. Comparatively, 83.3% of Regeneron Pharmaceuticals shares are held by institutional investors. 9.4% of Bolt Biotherapeutics shares are held by insiders. Comparatively, 7.0% of Regeneron Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

Regeneron Pharmaceuticals has a net margin of 29.65% compared to Bolt Biotherapeutics' net margin of -455.15%. Regeneron Pharmaceuticals' return on equity of 13.16% beat Bolt Biotherapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Bolt Biotherapeutics	-455.15%	-100.89%	-48.23%
Regeneron Pharmaceuticals	29.65%	13.16%	10.17%

Bolt Biotherapeutics presently has a consensus target price of $34.67, suggesting a potential upside of 713.77%. Regeneron Pharmaceuticals has a consensus target price of $792.65, suggesting a potential upside of 28.25%. Given Bolt Biotherapeutics' higher probable upside, analysts plainly believe Bolt Biotherapeutics is more favorable than Regeneron Pharmaceuticals.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Bolt Biotherapeutics	1 Sell rating(s)	1 Hold rating(s)	3 Buy rating(s)	0 Strong Buy rating(s)	2.40
Regeneron Pharmaceuticals	0 Sell rating(s)	10 Hold rating(s)	15 Buy rating(s)	2 Strong Buy rating(s)	2.70

Regeneron Pharmaceuticals has higher revenue and earnings than Bolt Biotherapeutics. Bolt Biotherapeutics is trading at a lower price-to-earnings ratio than Regeneron Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Bolt Biotherapeutics	$7.70M	1.06	-$33.38M	-$16.33	N/A
Regeneron Pharmaceuticals	$14.34B	4.56	$4.50B	$41.04	15.06

Bolt Biotherapeutics has a beta of 1.12, meaning that its share price is 12% more volatile than the broader market. Comparatively, Regeneron Pharmaceuticals has a beta of 0.25, meaning that its share price is 75% less volatile than the broader market.

In the previous week, Regeneron Pharmaceuticals had 28 more articles in the media than Bolt Biotherapeutics. MarketBeat recorded 28 mentions for Regeneron Pharmaceuticals and 0 mentions for Bolt Biotherapeutics. Regeneron Pharmaceuticals' average media sentiment score of 1.55 beat Bolt Biotherapeutics' score of 0.00 indicating that Regeneron Pharmaceuticals is being referred to more favorably in the news media.

Company	Overall Sentiment
Bolt Biotherapeutics	Neutral
Regeneron Pharmaceuticals	Very Positive

Summary

Regeneron Pharmaceuticals beats Bolt Biotherapeutics on 13 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding BOLT and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.

Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.

BOLT vs. The Competition

Export

Metric	Bolt Biotherapeutics	MED Industry	Medical Sector	NASDAQ Exchange
Market Cap	$7.71M	$3.45B	$6.45B	$12.39B
Dividend Yield	N/A	2.30%	2.69%	5.83%
P/E Ratio	-0.26	11.07	21.07	22.20
Price / Sales	1.06	334.82	530.36	110.15
Price / Cash	N/A	128.56	44.82	54.51
Price / Book	0.31	8.29	10.79	6.50
Net Income	-$33.38M	$23.85M	$3.56B	$336.88M
7 Day Performance	-1.16%	5.21%	1.67%	-0.22%
1 Month Performance	-13.94%	2.19%	0.43%	0.77%
1 Year Performance	-23.93%	60.99%	32.84%	31.57%

Bolt Biotherapeutics Competitors List

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Company	MarketRank	Share Price	Analysts' Price Target	1Y Price Performance	Market Cap	Revenue	P/E Ratio	Employee Count	Indicator(s)
BOLT Bolt Biotherapeutics	2.9092 of 5 stars	$4.26 +6.2%	$34.67 +713.8%	-30.7%	$7.71M	$7.70M	N/A	90
CRIS Curis	2.2562 of 5 stars	$0.38 -8.6%	$17.00 +4,373.7%	-80.2%	$16.21M	$9.44M	N/A	60	Gap Down High Trading Volume
AMGN Amgen	4.1102 of 5 stars	$347.84 -0.8%	$354.42 +1.9%	+19.1%	$189.18B	$36.75B	24.21	31,500	Positive News
GILD Gilead Sciences	4.9193 of 5 stars	$127.23 +2.4%	$158.41 +24.5%	+15.1%	$154.33B	$29.44B	17.33	17,000	Positive News
VRTX Vertex Pharmaceuticals	4.2967 of 5 stars	$453.17 +0.6%	$555.91 +22.7%	+5.9%	$114.33B	$12.00B	26.88	6,400	Positive News Analyst Upgrade Insider Trade

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This page (NASDAQ:BOLT) was last updated on 6/23/2026 by MarketBeat.com Staff.

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Bolt Biotherapeutics (BOLT) Competitors

BOLT vs. CRIS, AMGN, GILD, VRTX, and REGN

How does Bolt Biotherapeutics compare to Curis?

Summary

How does Bolt Biotherapeutics compare to Amgen?

Summary

How does Bolt Biotherapeutics compare to Gilead Sciences?

Summary

How does Bolt Biotherapeutics compare to Vertex Pharmaceuticals?

Summary

How does Bolt Biotherapeutics compare to Regeneron Pharmaceuticals?

Summary

New MarketBeat Followers Over Time

Media Sentiment Over Time

BOLT vs. The Competition

Bolt Biotherapeutics Competitors List

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Bolt Biotherapeutics (BOLT) Competitors

BOLT vs. CRIS, AMGN, GILD, VRTX, and REGN

How does Bolt Biotherapeutics compare to Curis?

Which has preferable earnings & valuation, BOLT or CRIS?

Does the media refer more to BOLT or CRIS?

Is BOLT or CRIS more profitable?

Do institutionals & insiders hold more shares of BOLT or CRIS?

Do analysts recommend BOLT or CRIS?

Which has more volatility & risk, BOLT or CRIS?

Summary

How does Bolt Biotherapeutics compare to Amgen?

Is BOLT or AMGN more profitable?

Which has stronger valuation and earnings, BOLT or AMGN?

Which has more volatility and risk, BOLT or AMGN?

Does the media refer more to BOLT or AMGN?

Do insiders and institutionals have more ownership in BOLT or AMGN?

Do analysts prefer BOLT or AMGN?

Summary

How does Bolt Biotherapeutics compare to Gilead Sciences?

Do insiders & institutionals hold more shares of BOLT or GILD?

Does the media favor BOLT or GILD?

Which has stronger earnings and valuation, BOLT or GILD?

Which has more volatility & risk, BOLT or GILD?

Do analysts prefer BOLT or GILD?

Is BOLT or GILD more profitable?

Summary

How does Bolt Biotherapeutics compare to Vertex Pharmaceuticals?

Do analysts rate BOLT or VRTX?

Does the media refer more to BOLT or VRTX?

Which has more volatility & risk, BOLT or VRTX?

Do insiders and institutionals hold more shares of BOLT or VRTX?

Is BOLT or VRTX more profitable?

Which has higher earnings and valuation, BOLT or VRTX?

Summary

How does Bolt Biotherapeutics compare to Regeneron Pharmaceuticals?

Do insiders & institutionals have more ownership in BOLT or REGN?

Is BOLT or REGN more profitable?

Do analysts recommend BOLT or REGN?

Which has higher earnings and valuation, BOLT or REGN?

Which has more risk and volatility, BOLT or REGN?

Does the media favor BOLT or REGN?

Summary

New MarketBeat Followers Over Time

Media Sentiment Over Time

BOLT vs. The Competition

Bolt Biotherapeutics Competitors List

Related Companies and Tools

MarketBeat All Access Features

Best-in-Class Portfolio Monitoring

Stock Ideas and Recommendations

Advanced Stock Screeners and Research Tools