Is CRIS or BOLT more profitable?

Curis has a net margin of -80.29% compared to Bolt Biotherapeutics' net margin of -455.15%. Curis' return on equity of 0.00% beat Bolt Biotherapeutics' return on equity. Company Net Margins Return on Equity Return on Assets Curis -80.29% N/A -181.57% Bolt Biotherapeutics -455.15% -100.89% -48.23%

Is AMGN or BOLT more profitable?

Amgen has a net margin of 20.96% compared to Bolt Biotherapeutics' net margin of -455.15%. Amgen's return on equity of 137.41% beat Bolt Biotherapeutics' return on equity. Company Net Margins Return on Equity Return on Assets Amgen 20.96% 137.41% 13.28% Bolt Biotherapeutics -455.15% -100.89% -48.23%

Bolt Biotherapeutics (BOLT) Competitors

$3.78 0.00 (0.00%)

Closing price 07/13/2026 04:00 PM Eastern

Extended Trading

$3.81 +0.03 (+0.79%)

As of 07/13/2026 06:51 PM Eastern

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BOLT vs. SGMO, CRIS, AMGN, GILD, and VRTX

Should you buy Bolt Biotherapeutics stock or one of its competitors? MarketBeat compares Bolt Biotherapeutics with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Bolt Biotherapeutics include Sangamo Therapeutics (SGMO), Curis (CRIS), Amgen (AMGN), Gilead Sciences (GILD), and Vertex Pharmaceuticals (VRTX). These companies are all part of the "biotechnology" industry.

How does Bolt Biotherapeutics compare to Sangamo Therapeutics?

Sangamo Therapeutics (NASDAQ:SGMO) and Bolt Biotherapeutics (NASDAQ:BOLT) are both small-cap medical companies, but which is the better business? We will compare the two companies based on the strength of their valuation, institutional ownership, analyst recommendations, risk, profitability, dividends, earnings and media sentiment.

Sangamo Therapeutics currently has a consensus price target of $5.50, suggesting a potential upside of 7,332.43%. Bolt Biotherapeutics has a consensus price target of $34.67, suggesting a potential upside of 817.11%. Given Sangamo Therapeutics' higher probable upside, research analysts clearly believe Sangamo Therapeutics is more favorable than Bolt Biotherapeutics.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Sangamo Therapeutics	2 Sell rating(s)	1 Hold rating(s)	1 Buy rating(s)	0 Strong Buy rating(s)	1.75
Bolt Biotherapeutics	1 Sell rating(s)	1 Hold rating(s)	3 Buy rating(s)	0 Strong Buy rating(s)	2.40

56.9% of Sangamo Therapeutics shares are owned by institutional investors. Comparatively, 86.7% of Bolt Biotherapeutics shares are owned by institutional investors. 4.1% of Sangamo Therapeutics shares are owned by insiders. Comparatively, 9.4% of Bolt Biotherapeutics shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

Sangamo Therapeutics has a beta of 1.3, indicating that its stock price is 30% more volatile than the broader market. Comparatively, Bolt Biotherapeutics has a beta of 1.16, indicating that its stock price is 16% more volatile than the broader market.

In the previous week, Bolt Biotherapeutics had 1 more articles in the media than Sangamo Therapeutics. MarketBeat recorded 2 mentions for Bolt Biotherapeutics and 1 mentions for Sangamo Therapeutics. Bolt Biotherapeutics' average media sentiment score of 1.44 beat Sangamo Therapeutics' score of 0.00 indicating that Bolt Biotherapeutics is being referred to more favorably in the news media.

Company	Overall Sentiment
Sangamo Therapeutics	Neutral
Bolt Biotherapeutics	Positive

Sangamo Therapeutics has a net margin of -310.81% compared to Bolt Biotherapeutics' net margin of -455.15%. Bolt Biotherapeutics' return on equity of -100.89% beat Sangamo Therapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Sangamo Therapeutics	-310.81%	-2,662.06%	-132.12%
Bolt Biotherapeutics	-455.15%	-100.89%	-48.23%

Bolt Biotherapeutics has lower revenue, but higher earnings than Sangamo Therapeutics. Bolt Biotherapeutics is trading at a lower price-to-earnings ratio than Sangamo Therapeutics, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Sangamo Therapeutics	$39.55M	0.78	-$122.93M	-$0.38	N/A
Bolt Biotherapeutics	$7.70M	0.94	-$33.38M	-$16.33	N/A

Summary

Bolt Biotherapeutics beats Sangamo Therapeutics on 10 of the 16 factors compared between the two stocks.

How does Bolt Biotherapeutics compare to Curis?

Curis (NASDAQ:CRIS) and Bolt Biotherapeutics (NASDAQ:BOLT) are both small-cap medical companies, but which is the superior stock? We will contrast the two companies based on the strength of their analyst recommendations, earnings, valuation, dividends, media sentiment, risk, profitability and institutional ownership.

Curis has higher revenue and earnings than Bolt Biotherapeutics. Bolt Biotherapeutics is trading at a lower price-to-earnings ratio than Curis, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Curis	$9.44M	0.98	-$7.58M	-$23.80	N/A
Bolt Biotherapeutics	$7.70M	0.94	-$33.38M	-$16.33	N/A

Curis has a net margin of -80.29% compared to Bolt Biotherapeutics' net margin of -455.15%. Curis' return on equity of 0.00% beat Bolt Biotherapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Curis	-80.29%	N/A	-181.57%
Bolt Biotherapeutics	-455.15%	-100.89%	-48.23%

In the previous week, Curis had 1 more articles in the media than Bolt Biotherapeutics. MarketBeat recorded 3 mentions for Curis and 2 mentions for Bolt Biotherapeutics. Bolt Biotherapeutics' average media sentiment score of 1.44 beat Curis' score of 0.31 indicating that Bolt Biotherapeutics is being referred to more favorably in the news media.

Company	Overall Sentiment
Curis	Neutral
Bolt Biotherapeutics	Positive

Curis has a beta of 3.08, indicating that its stock price is 208% more volatile than the broader market. Comparatively, Bolt Biotherapeutics has a beta of 1.16, indicating that its stock price is 16% more volatile than the broader market.

Curis currently has a consensus price target of $340.00, indicating a potential upside of 7,057.89%. Bolt Biotherapeutics has a consensus price target of $34.67, indicating a potential upside of 817.11%. Given Curis' higher probable upside, equities research analysts clearly believe Curis is more favorable than Bolt Biotherapeutics.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Curis	2 Sell rating(s)	0 Hold rating(s)	1 Buy rating(s)	0 Strong Buy rating(s)	1.67
Bolt Biotherapeutics	1 Sell rating(s)	1 Hold rating(s)	3 Buy rating(s)	0 Strong Buy rating(s)	2.40

30.0% of Curis shares are owned by institutional investors. Comparatively, 86.7% of Bolt Biotherapeutics shares are owned by institutional investors. 5.8% of Curis shares are owned by company insiders. Comparatively, 9.4% of Bolt Biotherapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

Summary

Curis beats Bolt Biotherapeutics on 9 of the 16 factors compared between the two stocks.

How does Bolt Biotherapeutics compare to Amgen?

Amgen (NASDAQ:AMGN) and Bolt Biotherapeutics (NASDAQ:BOLT) are both medical companies, but which is the superior stock? We will contrast the two companies based on the strength of their valuation, profitability, risk, earnings, institutional ownership, media sentiment, analyst recommendations and dividends.

76.5% of Amgen shares are owned by institutional investors. Comparatively, 86.7% of Bolt Biotherapeutics shares are owned by institutional investors. 0.9% of Amgen shares are owned by insiders. Comparatively, 9.4% of Bolt Biotherapeutics shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

In the previous week, Amgen had 37 more articles in the media than Bolt Biotherapeutics. MarketBeat recorded 39 mentions for Amgen and 2 mentions for Bolt Biotherapeutics. Bolt Biotherapeutics' average media sentiment score of 1.44 beat Amgen's score of 1.20 indicating that Bolt Biotherapeutics is being referred to more favorably in the news media.

Company	Overall Sentiment
Amgen	Positive
Bolt Biotherapeutics	Positive

Amgen currently has a consensus price target of $356.62, indicating a potential downside of 1.06%. Bolt Biotherapeutics has a consensus price target of $34.67, indicating a potential upside of 817.11%. Given Bolt Biotherapeutics' higher possible upside, analysts plainly believe Bolt Biotherapeutics is more favorable than Amgen.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Amgen	2 Sell rating(s)	15 Hold rating(s)	11 Buy rating(s)	2 Strong Buy rating(s)	2.43
Bolt Biotherapeutics	1 Sell rating(s)	1 Hold rating(s)	3 Buy rating(s)	0 Strong Buy rating(s)	2.40

Amgen has a beta of 0.41, indicating that its share price is 59% less volatile than the broader market. Comparatively, Bolt Biotherapeutics has a beta of 1.16, indicating that its share price is 16% more volatile than the broader market.

Amgen has higher revenue and earnings than Bolt Biotherapeutics. Bolt Biotherapeutics is trading at a lower price-to-earnings ratio than Amgen, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Amgen	$36.75B	5.29	$7.71B	$14.37	25.08
Bolt Biotherapeutics	$7.70M	0.94	-$33.38M	-$16.33	N/A

Amgen has a net margin of 20.96% compared to Bolt Biotherapeutics' net margin of -455.15%. Amgen's return on equity of 137.41% beat Bolt Biotherapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Amgen	20.96%	137.41%	13.28%
Bolt Biotherapeutics	-455.15%	-100.89%	-48.23%

Summary

Amgen beats Bolt Biotherapeutics on 12 of the 17 factors compared between the two stocks.

How does Bolt Biotherapeutics compare to Gilead Sciences?

Bolt Biotherapeutics (NASDAQ:BOLT) and Gilead Sciences (NASDAQ:GILD) are both medical companies, but which is the better investment? We will contrast the two companies based on the strength of their earnings, media sentiment, risk, institutional ownership, dividends, profitability, valuation and analyst recommendations.

Bolt Biotherapeutics has a beta of 1.16, indicating that its stock price is 16% more volatile than the broader market. Comparatively, Gilead Sciences has a beta of 0.32, indicating that its stock price is 68% less volatile than the broader market.

In the previous week, Gilead Sciences had 33 more articles in the media than Bolt Biotherapeutics. MarketBeat recorded 35 mentions for Gilead Sciences and 2 mentions for Bolt Biotherapeutics. Bolt Biotherapeutics' average media sentiment score of 1.44 beat Gilead Sciences' score of 0.86 indicating that Bolt Biotherapeutics is being referred to more favorably in the media.

Company	Overall Sentiment
Bolt Biotherapeutics	Positive
Gilead Sciences	Positive

Bolt Biotherapeutics currently has a consensus price target of $34.67, suggesting a potential upside of 817.11%. Gilead Sciences has a consensus price target of $159.04, suggesting a potential upside of 21.03%. Given Bolt Biotherapeutics' higher possible upside, equities analysts plainly believe Bolt Biotherapeutics is more favorable than Gilead Sciences.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Bolt Biotherapeutics	1 Sell rating(s)	1 Hold rating(s)	3 Buy rating(s)	0 Strong Buy rating(s)	2.40
Gilead Sciences	0 Sell rating(s)	3 Hold rating(s)	26 Buy rating(s)	0 Strong Buy rating(s)	2.90

Gilead Sciences has higher revenue and earnings than Bolt Biotherapeutics. Bolt Biotherapeutics is trading at a lower price-to-earnings ratio than Gilead Sciences, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Bolt Biotherapeutics	$7.70M	0.94	-$33.38M	-$16.33	N/A
Gilead Sciences	$29.44B	5.54	$8.51B	$7.34	17.90

86.7% of Bolt Biotherapeutics shares are held by institutional investors. Comparatively, 83.7% of Gilead Sciences shares are held by institutional investors. 9.4% of Bolt Biotherapeutics shares are held by insiders. Comparatively, 0.3% of Gilead Sciences shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

Gilead Sciences has a net margin of 30.99% compared to Bolt Biotherapeutics' net margin of -455.15%. Gilead Sciences' return on equity of 48.19% beat Bolt Biotherapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Bolt Biotherapeutics	-455.15%	-100.89%	-48.23%
Gilead Sciences	30.99%	48.19%	18.28%

Summary

Gilead Sciences beats Bolt Biotherapeutics on 11 of the 16 factors compared between the two stocks.

How does Bolt Biotherapeutics compare to Vertex Pharmaceuticals?

Vertex Pharmaceuticals (NASDAQ:VRTX) and Bolt Biotherapeutics (NASDAQ:BOLT) are both medical companies, but which is the better investment? We will compare the two companies based on the strength of their earnings, analyst recommendations, institutional ownership, risk, media sentiment, valuation, dividends and profitability.

Vertex Pharmaceuticals has higher revenue and earnings than Bolt Biotherapeutics. Bolt Biotherapeutics is trading at a lower price-to-earnings ratio than Vertex Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

Company	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Vertex Pharmaceuticals	$12.00B	10.16	$3.95B	$16.86	28.48
Bolt Biotherapeutics	$7.70M	0.94	-$33.38M	-$16.33	N/A

In the previous week, Vertex Pharmaceuticals had 55 more articles in the media than Bolt Biotherapeutics. MarketBeat recorded 57 mentions for Vertex Pharmaceuticals and 2 mentions for Bolt Biotherapeutics. Bolt Biotherapeutics' average media sentiment score of 1.44 beat Vertex Pharmaceuticals' score of 0.80 indicating that Bolt Biotherapeutics is being referred to more favorably in the news media.

Company	Overall Sentiment
Vertex Pharmaceuticals	Positive
Bolt Biotherapeutics	Positive

Vertex Pharmaceuticals currently has a consensus price target of $559.61, suggesting a potential upside of 16.52%. Bolt Biotherapeutics has a consensus price target of $34.67, suggesting a potential upside of 817.11%. Given Bolt Biotherapeutics' higher probable upside, analysts clearly believe Bolt Biotherapeutics is more favorable than Vertex Pharmaceuticals.

Company	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Vertex Pharmaceuticals	0 Sell rating(s)	4 Hold rating(s)	21 Buy rating(s)	0 Strong Buy rating(s)	2.84
Bolt Biotherapeutics	1 Sell rating(s)	1 Hold rating(s)	3 Buy rating(s)	0 Strong Buy rating(s)	2.40

Vertex Pharmaceuticals has a beta of 0.29, suggesting that its stock price is 71% less volatile than the broader market. Comparatively, Bolt Biotherapeutics has a beta of 1.16, suggesting that its stock price is 16% more volatile than the broader market.

Vertex Pharmaceuticals has a net margin of 35.51% compared to Bolt Biotherapeutics' net margin of -455.15%. Vertex Pharmaceuticals' return on equity of 23.86% beat Bolt Biotherapeutics' return on equity.

Company	Net Margins	Return on Equity	Return on Assets
Vertex Pharmaceuticals	35.51%	23.86%	17.13%
Bolt Biotherapeutics	-455.15%	-100.89%	-48.23%

91.0% of Vertex Pharmaceuticals shares are held by institutional investors. Comparatively, 86.7% of Bolt Biotherapeutics shares are held by institutional investors. 0.2% of Vertex Pharmaceuticals shares are held by company insiders. Comparatively, 9.4% of Bolt Biotherapeutics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Summary

Vertex Pharmaceuticals beats Bolt Biotherapeutics on 12 of the 16 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding BOLT and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.

Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.

BOLT vs. The Competition

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Metric	Bolt Biotherapeutics	MED Industry	Medical Sector	NASDAQ Exchange
Market Cap	$7.26M	$3.71B	$7.05B	$12.61B
Dividend Yield	N/A	2.20%	2.68%	8.00%
P/E Ratio	-0.23	20.85	27.11	24.26
Price / Sales	0.94	314.01	587.92	117.88
Price / Cash	N/A	61.98	29.22	49.36
Price / Book	0.27	8.49	10.75	6.29
Net Income	-$33.38M	$23.83M	$3.58B	$330.66M
7 Day Performance	-6.67%	-3.56%	-2.06%	-1.32%
1 Month Performance	-17.11%	6.31%	3.32%	-0.64%
1 Year Performance	-36.58%	48.30%	26.35%	19.08%

Bolt Biotherapeutics Competitors List

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Company	MarketRank	Share Price	Analysts' Price Target	1Y Price Performance	Market Cap	Revenue	P/E Ratio	Employee Count	Indicator(s)
BOLT Bolt Biotherapeutics	3.8376 of 5 stars	$3.78 flat	$34.67 +817.1%	-38.9%	$7.26M	$7.70M	N/A	90	Positive News Short Interest Decrease
SGMO Sangamo Therapeutics	1.0872 of 5 stars	$0.07 flat	$5.50 +7,332.4%	N/A	$30.66M	$39.55M	N/A	480
CRIS Curis	2.5879 of 5 stars	$5.29 -10.9%	$340.00 +6,327.2%	-87.0%	$11.58M	$9.44M	N/A	60
AMGN Amgen	4.0139 of 5 stars	$368.10 +0.5%	$356.00 -3.3%	+22.1%	$197.77B	$36.75B	25.62	31,500	Positive News Analyst Forecast
GILD Gilead Sciences	4.7952 of 5 stars	$136.36 +5.2%	$159.11 +16.7%	+19.8%	$160.92B	$29.44B	18.58	17,000	Analyst Upgrade

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This page (NASDAQ:BOLT) was last updated on 7/14/2026 by MarketBeat.com Staff.

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Bolt Biotherapeutics (BOLT) Competitors

BOLT vs. SGMO, CRIS, AMGN, GILD, and VRTX

How does Bolt Biotherapeutics compare to Sangamo Therapeutics?

Summary

How does Bolt Biotherapeutics compare to Curis?

Summary

How does Bolt Biotherapeutics compare to Amgen?

Summary

How does Bolt Biotherapeutics compare to Gilead Sciences?

Summary

How does Bolt Biotherapeutics compare to Vertex Pharmaceuticals?

Summary

New MarketBeat Followers Over Time

Media Sentiment Over Time

BOLT vs. The Competition

Bolt Biotherapeutics Competitors List

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Bolt Biotherapeutics (BOLT) Competitors

BOLT vs. SGMO, CRIS, AMGN, GILD, and VRTX

How does Bolt Biotherapeutics compare to Sangamo Therapeutics?

Do analysts prefer SGMO or BOLT?

Do institutionals and insiders hold more shares of SGMO or BOLT?

Which has more volatility and risk, SGMO or BOLT?

Does the media prefer SGMO or BOLT?

Is SGMO or BOLT more profitable?

Which has preferable valuation & earnings, SGMO or BOLT?

Summary

How does Bolt Biotherapeutics compare to Curis?

Which has higher valuation & earnings, CRIS or BOLT?

Is CRIS or BOLT more profitable?

Does the media prefer CRIS or BOLT?

Which has more risk and volatility, CRIS or BOLT?

Do analysts prefer CRIS or BOLT?

Do institutionals & insiders hold more shares of CRIS or BOLT?

Summary

How does Bolt Biotherapeutics compare to Amgen?

Do institutionals & insiders have more ownership in AMGN or BOLT?

Does the media refer more to AMGN or BOLT?

Do analysts recommend AMGN or BOLT?

Which has more risk & volatility, AMGN or BOLT?

Which has better earnings and valuation, AMGN or BOLT?

Is AMGN or BOLT more profitable?

Summary

How does Bolt Biotherapeutics compare to Gilead Sciences?

Which has more volatility & risk, BOLT or GILD?

Does the media prefer BOLT or GILD?

Do analysts rate BOLT or GILD?

Which has stronger valuation and earnings, BOLT or GILD?

Do insiders and institutionals hold more shares of BOLT or GILD?

Is BOLT or GILD more profitable?

Summary

How does Bolt Biotherapeutics compare to Vertex Pharmaceuticals?

Which has stronger earnings and valuation, VRTX or BOLT?

Does the media refer more to VRTX or BOLT?

Do analysts rate VRTX or BOLT?

Which has more volatility and risk, VRTX or BOLT?

Is VRTX or BOLT more profitable?

Do insiders & institutionals believe in VRTX or BOLT?

Summary

New MarketBeat Followers Over Time

Media Sentiment Over Time

BOLT vs. The Competition

Bolt Biotherapeutics Competitors List

Related Companies and Tools

MarketBeat All Access Features

Best-in-Class Portfolio Monitoring

Stock Ideas and Recommendations

Advanced Stock Screeners and Research Tools