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Castle Biosciences (CSTL) Competitors

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$20.70 0.00 (0.00%)
Closing price 06/12/2026 04:00 PM Eastern
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$20.70 0.00 (0.00%)
As of 06/12/2026 05:34 PM Eastern
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CSTL vs. HTFL, DFTX, PGNY, SGRY, and ADUS

Should you buy Castle Biosciences stock or one of its competitors? MarketBeat compares Castle Biosciences with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Castle Biosciences include Heartflow (HTFL), Definium Therapeutics (DFTX), Progyny (PGNY), Surgery Partners (SGRY), and Addus HomeCare (ADUS). These companies are all part of the "healthcare" industry.

How does Castle Biosciences compare to Heartflow?

Castle Biosciences (NASDAQ:CSTL) and Heartflow (NASDAQ:HTFL) are both medical companies, but which is the better investment? We will compare the two businesses based on the strength of their media sentiment, institutional ownership, profitability, analyst recommendations, dividends, valuation, earnings and risk.

Castle Biosciences has higher revenue and earnings than Heartflow. Castle Biosciences is trading at a lower price-to-earnings ratio than Heartflow, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Castle Biosciences$344.23M1.82-$24.16M-$0.44N/A
Heartflow$176.03M16.28-$116.79M-$3.11N/A

Castle Biosciences has a net margin of -3.78% compared to Heartflow's net margin of -58.42%. Heartflow's return on equity of 0.00% beat Castle Biosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Castle Biosciences-3.78% -2.77% -2.30%
Heartflow -58.42%N/A -20.02%

In the previous week, Castle Biosciences had 2 more articles in the media than Heartflow. MarketBeat recorded 4 mentions for Castle Biosciences and 2 mentions for Heartflow. Castle Biosciences' average media sentiment score of 0.84 beat Heartflow's score of 0.44 indicating that Castle Biosciences is being referred to more favorably in the media.

Company Overall Sentiment
Castle Biosciences Positive
Heartflow Neutral

92.6% of Castle Biosciences shares are owned by institutional investors. 6.1% of Castle Biosciences shares are owned by insiders. Comparatively, 7.7% of Heartflow shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

Castle Biosciences presently has a consensus target price of $42.83, indicating a potential upside of 106.92%. Heartflow has a consensus target price of $37.00, indicating a potential upside of 11.31%. Given Castle Biosciences' stronger consensus rating and higher possible upside, equities research analysts plainly believe Castle Biosciences is more favorable than Heartflow.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Castle Biosciences
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
0 Strong Buy rating(s)
2.67
Heartflow
1 Sell rating(s)
2 Hold rating(s)
6 Buy rating(s)
0 Strong Buy rating(s)
2.56

Summary

Castle Biosciences beats Heartflow on 11 of the 15 factors compared between the two stocks.

How does Castle Biosciences compare to Definium Therapeutics?

Definium Therapeutics (NASDAQ:DFTX) and Castle Biosciences (NASDAQ:CSTL) are both medical companies, but which is the better investment? We will compare the two businesses based on the strength of their earnings, risk, media sentiment, analyst recommendations, institutional ownership, dividends, valuation and profitability.

In the previous week, Definium Therapeutics had 2 more articles in the media than Castle Biosciences. MarketBeat recorded 6 mentions for Definium Therapeutics and 4 mentions for Castle Biosciences. Castle Biosciences' average media sentiment score of 0.84 beat Definium Therapeutics' score of 0.47 indicating that Castle Biosciences is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Definium Therapeutics
1 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Castle Biosciences
1 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

27.9% of Definium Therapeutics shares are held by institutional investors. Comparatively, 92.6% of Castle Biosciences shares are held by institutional investors. 2.4% of Definium Therapeutics shares are held by company insiders. Comparatively, 6.1% of Castle Biosciences shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Castle Biosciences has higher revenue and earnings than Definium Therapeutics. Castle Biosciences is trading at a lower price-to-earnings ratio than Definium Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Definium TherapeuticsN/AN/A-$183.79M-$2.49N/A
Castle Biosciences$344.23M1.82-$24.16M-$0.44N/A

Definium Therapeutics currently has a consensus price target of $37.92, suggesting a potential upside of 53.22%. Castle Biosciences has a consensus price target of $42.83, suggesting a potential upside of 106.92%. Given Castle Biosciences' higher possible upside, analysts plainly believe Castle Biosciences is more favorable than Definium Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Definium Therapeutics
1 Sell rating(s)
0 Hold rating(s)
12 Buy rating(s)
2 Strong Buy rating(s)
3.00
Castle Biosciences
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
0 Strong Buy rating(s)
2.67

Definium Therapeutics has a beta of 2.37, indicating that its stock price is 137% more volatile than the broader market. Comparatively, Castle Biosciences has a beta of 1.04, indicating that its stock price is 4% more volatile than the broader market.

Definium Therapeutics has a net margin of 0.00% compared to Castle Biosciences' net margin of -3.78%. Castle Biosciences' return on equity of -2.77% beat Definium Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Definium TherapeuticsN/A -100.30% -69.22%
Castle Biosciences -3.78%-2.77%-2.30%

Summary

Castle Biosciences beats Definium Therapeutics on 9 of the 16 factors compared between the two stocks.

How does Castle Biosciences compare to Progyny?

Castle Biosciences (NASDAQ:CSTL) and Progyny (NASDAQ:PGNY) are both medical companies, but which is the superior investment? We will contrast the two companies based on the strength of their profitability, dividends, valuation, analyst recommendations, media sentiment, earnings, risk and institutional ownership.

Progyny has a net margin of 5.23% compared to Castle Biosciences' net margin of -3.78%. Progyny's return on equity of 13.34% beat Castle Biosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Castle Biosciences-3.78% -2.77% -2.30%
Progyny 5.23%13.34%9.03%

92.6% of Castle Biosciences shares are held by institutional investors. Comparatively, 94.9% of Progyny shares are held by institutional investors. 6.1% of Castle Biosciences shares are held by company insiders. Comparatively, 9.9% of Progyny shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

Progyny has higher revenue and earnings than Castle Biosciences. Castle Biosciences is trading at a lower price-to-earnings ratio than Progyny, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Castle Biosciences$344.23M1.82-$24.16M-$0.44N/A
Progyny$1.29B1.62$58.52M$0.7734.58

Castle Biosciences has a beta of 1.04, indicating that its share price is 4% more volatile than the broader market. Comparatively, Progyny has a beta of 1.03, indicating that its share price is 3% more volatile than the broader market.

In the previous week, Progyny had 1 more articles in the media than Castle Biosciences. MarketBeat recorded 5 mentions for Progyny and 4 mentions for Castle Biosciences. Progyny's average media sentiment score of 1.18 beat Castle Biosciences' score of 0.84 indicating that Progyny is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Castle Biosciences
1 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Progyny
2 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Castle Biosciences presently has a consensus target price of $42.83, suggesting a potential upside of 106.92%. Progyny has a consensus target price of $29.67, suggesting a potential upside of 11.40%. Given Castle Biosciences' higher probable upside, equities analysts clearly believe Castle Biosciences is more favorable than Progyny.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Castle Biosciences
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
0 Strong Buy rating(s)
2.67
Progyny
0 Sell rating(s)
3 Hold rating(s)
11 Buy rating(s)
0 Strong Buy rating(s)
2.79

Summary

Progyny beats Castle Biosciences on 13 of the 16 factors compared between the two stocks.

How does Castle Biosciences compare to Surgery Partners?

Castle Biosciences (NASDAQ:CSTL) and Surgery Partners (NASDAQ:SGRY) are both medical companies, but which is the superior stock? We will compare the two businesses based on the strength of their media sentiment, institutional ownership, profitability, dividends, earnings, analyst recommendations, valuation and risk.

Castle Biosciences has higher earnings, but lower revenue than Surgery Partners. Castle Biosciences is trading at a lower price-to-earnings ratio than Surgery Partners, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Castle Biosciences$344.23M1.82-$24.16M-$0.44N/A
Surgery Partners$3.31B0.61-$77.90M-$0.60N/A

Castle Biosciences presently has a consensus price target of $42.83, indicating a potential upside of 106.92%. Surgery Partners has a consensus price target of $22.18, indicating a potential upside of 44.88%. Given Castle Biosciences' higher possible upside, equities research analysts clearly believe Castle Biosciences is more favorable than Surgery Partners.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Castle Biosciences
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
0 Strong Buy rating(s)
2.67
Surgery Partners
1 Sell rating(s)
2 Hold rating(s)
8 Buy rating(s)
1 Strong Buy rating(s)
2.75

Castle Biosciences has a beta of 1.04, suggesting that its share price is 4% more volatile than the broader market. Comparatively, Surgery Partners has a beta of 1.96, suggesting that its share price is 96% more volatile than the broader market.

Surgery Partners has a net margin of -2.28% compared to Castle Biosciences' net margin of -3.78%. Surgery Partners' return on equity of 1.04% beat Castle Biosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Castle Biosciences-3.78% -2.77% -2.30%
Surgery Partners -2.28%1.04%0.41%

92.6% of Castle Biosciences shares are owned by institutional investors. 6.1% of Castle Biosciences shares are owned by company insiders. Comparatively, 2.0% of Surgery Partners shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

In the previous week, Castle Biosciences had 3 more articles in the media than Surgery Partners. MarketBeat recorded 4 mentions for Castle Biosciences and 1 mentions for Surgery Partners. Surgery Partners' average media sentiment score of 1.87 beat Castle Biosciences' score of 0.84 indicating that Surgery Partners is being referred to more favorably in the news media.

Company Overall Sentiment
Castle Biosciences Positive
Surgery Partners Very Positive

Summary

Surgery Partners beats Castle Biosciences on 10 of the 17 factors compared between the two stocks.

How does Castle Biosciences compare to Addus HomeCare?

Addus HomeCare (NASDAQ:ADUS) and Castle Biosciences (NASDAQ:CSTL) are both small-cap medical companies, but which is the superior business? We will contrast the two businesses based on the strength of their risk, media sentiment, dividends, profitability, earnings, analyst recommendations, valuation and institutional ownership.

In the previous week, Castle Biosciences had 2 more articles in the media than Addus HomeCare. MarketBeat recorded 4 mentions for Castle Biosciences and 2 mentions for Addus HomeCare. Castle Biosciences' average media sentiment score of 0.84 beat Addus HomeCare's score of 0.79 indicating that Castle Biosciences is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Addus HomeCare
0 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Positive
Castle Biosciences
1 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

95.4% of Addus HomeCare shares are owned by institutional investors. Comparatively, 92.6% of Castle Biosciences shares are owned by institutional investors. 4.1% of Addus HomeCare shares are owned by company insiders. Comparatively, 6.1% of Castle Biosciences shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.

Addus HomeCare has a beta of 0.89, indicating that its share price is 11% less volatile than the broader market. Comparatively, Castle Biosciences has a beta of 1.04, indicating that its share price is 4% more volatile than the broader market.

Addus HomeCare has a net margin of 6.89% compared to Castle Biosciences' net margin of -3.78%. Addus HomeCare's return on equity of 9.80% beat Castle Biosciences' return on equity.

Company Net Margins Return on Equity Return on Assets
Addus HomeCare6.89% 9.80% 7.34%
Castle Biosciences -3.78%-2.77%-2.30%

Addus HomeCare currently has a consensus target price of $131.00, indicating a potential upside of 40.44%. Castle Biosciences has a consensus target price of $42.83, indicating a potential upside of 106.92%. Given Castle Biosciences' higher probable upside, analysts clearly believe Castle Biosciences is more favorable than Addus HomeCare.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Addus HomeCare
1 Sell rating(s)
2 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.70
Castle Biosciences
1 Sell rating(s)
1 Hold rating(s)
7 Buy rating(s)
0 Strong Buy rating(s)
2.67

Addus HomeCare has higher revenue and earnings than Castle Biosciences. Castle Biosciences is trading at a lower price-to-earnings ratio than Addus HomeCare, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Addus HomeCare$1.42B1.22$95.91M$5.4117.24
Castle Biosciences$344.23M1.82-$24.16M-$0.44N/A

Summary

Addus HomeCare beats Castle Biosciences on 10 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding CSTL and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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CSTL vs. The Competition

MetricCastle BiosciencesMED IndustryMedical SectorNASDAQ Exchange
Market Cap$627.83M$3.39B$6.52B$12.05B
Dividend YieldN/A2.25%2.67%5.66%
P/E Ratio-47.0520.0024.0024.42
Price / Sales1.82303.98516.42110.81
Price / Cash18.5953.6127.4837.92
Price / Book1.288.3210.746.82
Net Income-$24.16M$23.94M$3.57B$337.56M
7 Day Performance2.88%1.84%0.58%1.16%
1 Month Performance8.21%-0.04%1.48%3.16%
1 Year Performance10.40%44.82%25.41%30.60%

Castle Biosciences Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
CSTL
Castle Biosciences
3.1908 of 5 stars
$20.70
flat
$42.83
+106.9%
+10.4%$627.83M$344.23MN/A540
HTFL
Heartflow
2.1412 of 5 stars
$28.61
+0.5%
$37.00
+29.3%
N/A$2.45B$191.42MN/A699
DFTX
Definium Therapeutics
2.994 of 5 stars
$21.93
-4.7%
$37.92
+72.9%
+245.2%$2.19BN/AN/A40
PGNY
Progyny
4.1753 of 5 stars
$25.98
+0.2%
$29.67
+14.2%
+26.6%$2.03B$1.29B33.71310
SGRY
Surgery Partners
4.0569 of 5 stars
$13.83
-0.1%
$22.18
+60.4%
-32.7%$1.81B$3.31BN/A16,000

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This page (NASDAQ:CSTL) was last updated on 6/15/2026 by MarketBeat.com Staff.
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