Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutic candidates for neurodegenerative diseases in the United States. The company offers leucine-rich repeat kinase 2 (LRRK2) inhibitor product candidates, including DNL201 and DNL151, which are in Phase 1 clinical trials for Parkinson's disease. It is also developing receptor interacting serine/threonine protein kinase 1 (RIPK1) product candidates, such as DNL747, a selective and brain-penetrant small molecule RIPK1 inhibitor product candidate that is in Phase 1 clinical trial for Alzheimer's disease and amyotrophic lateral sclerosis (ALS). In addition, the company develops enzyme transport vehicle: iduronate 2-sulfatase, an enzyme replacement therapy program for MPS II, a lysosomal storage disorder; antibody transport vehicle (ATV): alpha-synuclein (aSyn) program, a protein that has been identified as genetically linked to Parkinson's disease; ATV: triggering receptor expressed in myeloid cells 2, a therapeutic candidate designed to rescue microglial function in Alzheimer's disease; and ATV: beta-secretase 1/Tau, a bispecific program targeting the production of amyloid beta and the spreading of Tau. Further, it is developing LF1, a protein to treat neurodegeneration; and DNL788, a small molecule product candidate for the treatment of Alzheimer's disease and ALS. Additionally, the company has various seed programs under the research, discovery, and preclinical stages of development. Denali Therapeutics Inc. has collaboration agreement with Takeda Pharmaceutical Company and Genentech, Inc., Sanofi, F-star Gamma Limited, F-star Biotechnologische Forschungs-Und Entwicklungsges M.B.H, F-star Biotechnology Limited, SIRION Biotech GmbH, and AbCellera Biologics. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.
Industry, Sector and Symbol
Industry Biological products, except diagnostic
Sub-IndustryN/A
SectorMedical
Phone650-866-8548
Debt
Price-To-Earnings
Sales & Book Value
Annual SalesN/A
Profitability
Miscellaneous
Employees130
OptionableOptionable
Denali Therapeutics (NASDAQ:DNLI) Frequently Asked Questions
What is Denali Therapeutics' stock symbol?
Denali Therapeutics trades on the NASDAQ under the ticker symbol "DNLI."
How were Denali Therapeutics' earnings last quarter?
Denali Therapeutics Inc (NASDAQ:DNLI) issued its quarterly earnings results on Thursday, November, 8th. The company reported ($0.38) EPS for the quarter, missing the Thomson Reuters' consensus estimate of ($0.25) by $0.13. The business had revenue of $1.20 million for the quarter, compared to the consensus estimate of $3 million. View Denali Therapeutics' Earnings History.
When is Denali Therapeutics' next earnings date?
What price target have analysts set for DNLI?
2 brokers have issued 12-month price targets for Denali Therapeutics' shares. Their predictions range from $25.00 to $26.00. On average, they expect Denali Therapeutics' share price to reach $25.50 in the next year. This suggests a possible upside of 18.8% from the stock's current price. View Analyst Price Targets for Denali Therapeutics.
What is the consensus analysts' recommendation for Denali Therapeutics?
2 Wall Street analysts have issued "buy," "hold," and "sell" ratings for Denali Therapeutics in the last year. There are currently 1 hold rating and 1 buy rating for the stock, resulting in a consensus recommendation of "Buy." View Analyst Ratings for Denali Therapeutics.
What are Wall Street analysts saying about Denali Therapeutics stock?
Here are some recent quotes from research analysts about Denali Therapeutics stock:
- 1. According to Zacks Investment Research, "Denali Therapeutics Inc. is a biotechnology company. It focused on the discovery and development of therapies for patients with neurodegenerative disease, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and others. Denali Therapeutics Inc. is based in SOUTH SAN FRANCISCO, United States. " (1/3/2019)
- 2. Cantor Fitzgerald analysts commented, ". We reiterate our Overweight rating and 12-month PT of $25/share of DNLI after attending Denali’s R&D Day. We believe the company is approaching neurodegenerative diseases through rigorous therapeutic discovery and development, and we expect increasingly visible pipeline progress will enhance investor conviction over the next 12-18 months. The event provided a broad perspective on pipeline strategy that could address many of the historic challenges for neurodegenerative disease drug development. Our focus is currently on the small molecule programs for DNL201 in Parkinson’s disease (PD) and DNL747 in Alzheimer’s disease (AD), ALS, and MS, which are the most advanced programs." (12/7/2018)
Has Denali Therapeutics been receiving favorable news coverage?
News headlines about DNLI stock have been trending somewhat positive this week, according to InfoTrie Sentiment. The research firm identifies positive and negative news coverage by reviewing more than six thousand blog and news sources in real-time. The firm ranks coverage of public companies on a scale of negative five to five, with scores closest to five being the most favorable. Denali Therapeutics earned a media sentiment score of 0.9 on InfoTrie's scale. They also assigned news headlines about the company a news buzz of 4.0 out of 10, indicating that recent news coverage is somewhat unlikely to have an impact on the stock's share price in the immediate future.
Who are some of Denali Therapeutics' key competitors?
Some companies that are related to Denali Therapeutics include Neurocrine Biosciences (NBIX), bluebird bio (BLUE), BIO-TECHNE (TECH), argenx (ARGX), Ablynx (ABLYF), Allogene Therapeutics (ALLO), China Biologic Products (CBPO), Repligen (RGEN), Halozyme Therapeutics (HALO), Acceleron Pharma (XLRN), Spark Therapeutics (ONCE), Aerie Pharmaceuticals (AERI), Atara Biotherapeutics (ATRA), Regenxbio (RGNX) and Crispr Therapeutics (CRSP).
Who are Denali Therapeutics' key executives?
Denali Therapeutics' management team includes the folowing people:
- Dr. Ryan J. Watts Ph.D., Co-Founder, Pres, CEO, Chief Scientific Officer & Director (Age 43)
- Mr. Alexander O. Schuth M.D., Co-Founder, COO & Sec. (Age 46)
- Dr. Marc Tessier-Lavigne, Co-Founder, Chairman of Scientific Advisory Board & Director (Age 59)
- Mr. Steve E. Krognes, CFO, Principal Accounting Officer & Treasurer (Age 50)
- Dr. Carole Ho, Chief Medical Officer & Head of Devel. (Age 46)
When did Denali Therapeutics IPO?
(DNLI) raised $149 million in an initial public offering on Friday, December 8th 2017. The company issued 8,300,000 shares at a price of $17.00-$19.00 per share. Goldman Sachs, Morgan Stanley and J.P. Morgan served as the underwriters for the IPO and Evercore ISI was co-manager.
Who are Denali Therapeutics' major shareholders?
Denali Therapeutics' stock is owned by many different of retail and institutional investors. Top institutional shareholders include Crestline Management LP (20.50%), Baillie Gifford & Co. (6.56%), BlackRock Inc. (4.82%), Lord Abbett & CO. LLC (1.52%), Geode Capital Management LLC (0.75%) and Northern Trust Corp (0.65%). Company insiders that own Denali Therapeutics stock include Alexander O Schuth, Carole Ho, Douglas K Bratton and Ryan J Watts. View Institutional Ownership Trends for Denali Therapeutics.
Which major investors are selling Denali Therapeutics stock?
DNLI stock was sold by a variety of institutional investors in the last quarter, including Crestline Management LP, MetLife Investment Advisors LLC, Pier 88 Investment Partners LLC, Virtus ETF Advisers LLC, Raymond James Financial Services Advisors Inc. and Patriot Financial Group Insurance Agency LLC. Company insiders that have sold Denali Therapeutics company stock in the last year include Alexander O Schuth, Carole Ho and Ryan J Watts. View Insider Buying and Selling for Denali Therapeutics.
Which major investors are buying Denali Therapeutics stock?
DNLI stock was bought by a variety of institutional investors in the last quarter, including BlackRock Inc., Baillie Gifford & Co., Lord Abbett & CO. LLC, Casdin Capital LLC, Citigroup Inc., Caxton Associates LP, New York State Common Retirement Fund and Bank of New York Mellon Corp. View Insider Buying and Selling for Denali Therapeutics.
How do I buy shares of Denali Therapeutics?
Shares of DNLI can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Vanguard Brokerage Services, TD Ameritrade, E*TRADE, Scottrade, Fidelity and Charles Schwab.
What is Denali Therapeutics' stock price today?
One share of DNLI stock can currently be purchased for approximately $21.47.
How big of a company is Denali Therapeutics?
Denali Therapeutics has a market capitalization of $2.04 billion. The company earns $-88,180,000.00 in net income (profit) each year or ($5.89) on an earnings per share basis. Denali Therapeutics employs 130 workers across the globe.
What is Denali Therapeutics' official website?
How can I contact Denali Therapeutics?
Denali Therapeutics' mailing address is 151 OYSTER POINT BLVD. 2ND FLOOR, SOUTH SAN FRANCISCO CA, 94080. The company can be reached via phone at 650-866-8548.
MarketBeat Community Rating for Denali Therapeutics (NASDAQ DNLI)
MarketBeat's community ratings are surveys of what our community members think about Denali Therapeutics and other stocks. Vote "Outperform" if you believe DNLI will outperform the S&P 500 over the long term. Vote "Underperform" if you believe DNLI will underperform the S&P 500 over the long term. You may vote once every thirty days.
