NASDAQ:PTGX Protagonist Therapeutics (PTGX) Stock Price, News & Analysis $148.61 -2.89 (-1.91%) As of 10:23 AM Eastern This is a fair market value price provided by Massive. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsInsider TradesNews and TrendsOptions ChainOwnershipSEC FilingsShort Interest About Protagonist Therapeutics Stock (NASDAQ:PTGX) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get PTGX alerts:Sign Up Key Stats Today's Range$148.01▼$151.6850-Day Range$112.86▼$158.6252-Week Range$54.50▼$160.81Volume59,709 shsAverage Volume715,287 shsMarket Capitalization$9.62 billionP/E Ratio143.34Dividend YieldN/APrice Target$140.53Consensus RatingModerate Buy Company Overview Protagonist Therapeutics, Inc. (NASDAQ: PTGX) is a clinical-stage biopharmaceutical company focused on the development of novel, orally administered peptide-based therapies for immune-mediated and other serious diseases. The company leverages its proprietary Peptide 2.0 platform to design peptides that target G protein–coupled receptors and cytokine receptors, with the goal of combining the potency of biologics with the convenience of oral administration. Protagonist’s approach aims to address unmet medical needs in areas where injectable therapies have been the standard of care. Among its lead programs is PTG-100, an oral α4β7 integrin antagonist intended to block leukocyte migration to the gut in ulcerative colitis and Crohn’s disease. PTG-200, a selective interleukin-23 receptor antagonist, is in Phase 2 clinical trials for moderate to severe Crohn’s disease. The company’s PTG-300 program is a hepcidin mimetic being evaluated in hematologic disorders characterized by iron overload, including polycythemia vera and myelofibrosis. Founded in 2006 and headquartered in San Diego, California, Protagonist Therapeutics conducts global clinical trials across North America, Europe and Asia. The company is led by a team of seasoned biotechnology executives with deep expertise in peptide drug discovery and development. Protagonist maintains collaborations with academic institutions and industry partners to advance its pipeline and explore additional therapeutic areas where oral peptide therapeutics may deliver significant patient benefit.AI Generated. May Contain Errors. Read More Protagonist Therapeutics Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks32nd Percentile Overall ScorePTGX MarketRank™: Protagonist Therapeutics scored higher than 32% of companies evaluated by MarketBeat, and ranked 773rd out of 918 stocks in the healthcare sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion2.5 / 5Analyst RatingModerate Buy Consensus RatingProtagonist Therapeutics has received a consensus rating of Moderate Buy. The company's average rating score is 2.94, and is based on 1 strong buy rating, 15 buy ratings, 2 hold ratings, and no sell ratings.Downside RiskProtagonist Therapeutics has a consensus price target of $140.53, representing about 6.9% downside from its current price of $150.89.Amount of Analyst CoverageProtagonist Therapeutics has been the subject of 10 research reports in the past 90 days, demonstrating strong analyst interest in this stock.Read more about Protagonist Therapeutics' stock forecast and price target. Earnings and Valuation0.6 / 5Proj. Earnings GrowthDecreasing Earnings GrowthEarnings for Protagonist Therapeutics are expected to decrease in the coming year, from $4.22 to ($0.09) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Protagonist Therapeutics is 146.23, which means that it is trading at a more expensive P/E ratio than the market average P/E ratio of about 39.17.Price to Earnings Ratio vs. SectorThe P/E ratio of Protagonist Therapeutics is 146.23, which means that it is trading at a less expensive P/E ratio than the Healthcare sector average P/E ratio of about 272.19.Price to Book Value per Share RatioProtagonist Therapeutics has a P/B Ratio of 11.60. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.Read more about Protagonist Therapeutics' valuation and earnings. Short Interest0.0 / 5Short Interest LevelBearish Percentage of Shares Shorted12.70% of the float of Protagonist Therapeutics has been sold short.Short Interest Ratio / Days to CoverProtagonist Therapeutics has a short interest ratio ("days to cover") of 16.42, which indicates bearish sentiment.Change versus previous monthShort interest in Protagonist Therapeutics has recently increased by 3.30%, indicating that investor sentiment is decreasing. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldProtagonist Therapeutics does not currently pay a dividend.Dividend GrowthProtagonist Therapeutics does not have a long track record of dividend growth. News and Social Media4.0 / 5News Sentiment1.41 News SentimentProtagonist Therapeutics has a news sentiment score of 1.41. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a higher news sentiment than the 0.87 average news sentiment score of Healthcare companies.News Coverage This WeekMarketBeat has tracked 16 news articles for Protagonist Therapeutics this week, compared to 5 articles on an average week.Search InterestOnly 2 people have searched for PTGX on MarketBeat in the last 30 days. This is a decrease of -60% compared to the previous 30 days.MarketBeat Follows2 people have added Protagonist Therapeutics to their MarketBeat watchlist in the last 30 days. This is an increase of 100% compared to the previous 30 days. Company Ownership1.6 / 5Insider TradingSelling Shares Insider Buying vs. Insider SellingIn the past three months, Protagonist Therapeutics insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $17,818,139.00 in company stock.Percentage Held by Insiders5.19% of the stock of Protagonist Therapeutics is held by insiders.Percentage Held by Institutions98.63% of the stock of Protagonist Therapeutics is held by institutions. High institutional ownership can be a signal of strong market trust in this company.Read more about Protagonist Therapeutics' insider trading history. Receive PTGX Stock News and Ratings via Email Sign-up to receive the latest news and ratings for Protagonist Therapeutics and its competitors with MarketBeat's FREE daily newsletter. Submit View SMS TermsSMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. 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(PTGX)August 25 at 7:11 AM | finance.yahoo.comProtagonist Therapeutics (NASDAQ:PTGX) and NeuroSense Therapeutics (NASDAQ:NRSN) Head-To-Head SurveyAugust 24 at 2:44 AM | americanbankingnews.comTrump's New DollarPorter Stansberry says President Trump has signed an executive order initiating what he calls a full U.S. dollar reset - and most Americans don't know it's happening. The last time America underwent a monetary shift like this, under Nixon in the 1970s, it minted an average of 1,300 new millionaires a day for over half a century. Stansberry has released a new documentary naming the assets he believes are positioned to surge as a result.August 27 at 1:00 AM | Porter & Company (Ad)BMO Capital Markets Forecasts Strong Price Appreciation for Protagonist Therapeutics (NASDAQ:PTGX) StockAugust 19, 2026 | americanbankingnews.comProtagonist Therapeutics (NASDAQ:PTGX) CEO Dinesh Ph Patel Sells 34,239 Shares of StockAugust 13, 2026 | insidertrades.comProtagonist Therapeutics: "Strong Buy" ICOTYDE FDA Approval And PN-881 AdvancementAugust 12, 2026 | seekingalpha.comSilence Therapeutics' Divesiran Data Support Best-in-Class Potential, Morgan Stanley SaysAugust 11, 2026 | finance.yahoo.comProtagonist Therapeutics Inc.August 11, 2026 | marketwatch.comSee More Headlines PTGX Stock Analysis - Frequently Asked Questions How have PTGX shares performed this year? Protagonist Therapeutics' stock was trading at $87.34 on January 1st, 2026. Since then, PTGX shares have increased by 72.8% and is now trading at $150.8860. How were Protagonist Therapeutics' earnings last quarter? Protagonist Therapeutics, Inc. (NASDAQ:PTGX) issued its quarterly earnings results on Wednesday, August, 5th. The company reported $2.29 earnings per share (EPS) for the quarter, beating analysts' consensus estimates of $2.27 by $0.02. The business's revenue for the quarter was up 3746.8% compared to the same quarter last year. When did Protagonist Therapeutics IPO? Protagonist Therapeutics (PTGX) raised $90 million in an initial public offering on Wednesday, August 10th 2016. The company issued 7,500,000 shares at a price of $11.00-$13.00 per share. Leerink Partners, Barclays and BMO Capital Markets served as the underwriters for the IPO. Who are Protagonist Therapeutics' major shareholders? Protagonist Therapeutics' top institutional investors include BlackRock Inc. (16.03%), California State Teachers Retirement System (11.17%), Wellington Management Group LLP (5.28%) and Johnson & Johnson (3.81%). Insiders that own company stock include Dinesh V Ph D Patel, Suneel Gupta, Arturo Md Molina, Harold E Selick, Asif Ali, Bryan Giraudo, William D Waddill and Lewis T Williams. View institutional ownership trends. How do I buy shares of Protagonist Therapeutics? Shares of PTGX stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of Protagonist Therapeutics own? Based on aggregate information from My MarketBeat watchlists, some other companies that Protagonist Therapeutics investors own include Voyager Therapeutics (VYGR), American Water Works (AWK), The RMR Group (RMR), Waste Connections (WCN), DiamondRock Hospitality (DRH), iShares Micro-Cap ETF (IWC) and AUO (AUOTY). Company Calendar Last Earnings8/05/2026Today8/27/2026Next Earnings (Estimated)11/05/2026Fiscal Year End12/31/2026Get Stock Alerts Health Indicator TradeSmith's Health IndicatorA long-term volatility-based measure designed for securities held 12 months or longer.Green: Strong and healthy uptrend with normal pullbacks.Yellow: Significant pullback but still within expected volatility.Red: Dropped beyond expected volatility; considered unhealthy. Green Zone (15m+) 1-Year History Aug 25 Nov 25 Feb 26 May 26 Aug 26 PTGX's financial health is in the Green zone, according to TradeSmith. PTGX has been in this zone for over 15 months. Industry, Sector and Symbol Stock ExchangeNASDAQ SectorHealthcare Industry Biotechnology Sub-IndustryBiotechnology Current SymbolNASDAQ:PTGX CIK1377121 Webwww.protagonist-inc.com Phone(510) 474-0170FaxN/AEmployees120Year Founded2006Price Target and Rating Average Price Target for Protagonist Therapeutics$140.53 High Price Target$186.00 Low Price Target$82.00 Potential Upside/Downside-4.9%Consensus RatingModerate Buy Rating Score (0-4)2.94 Research Coverage18 Analysts Profitability EPS (Trailing Twelve Months)$1.03 Trailing P/E Ratio143.34 Forward P/E Ratio35.02 P/E GrowthN/ANet Income-$130.15 million Net Margins29.40% Pretax Margin29.91% Return on Equity12.03% Return on Assets11.23% Debt Debt-to-Equity RatioN/A Current Ratio21.71 Quick Ratio21.71 Sales & Book Value Annual Sales$281.99 million Price / Sales33.92 Cash FlowN/A Price / Cash FlowN/A Book Value$13.01 per share Price / Book11.36Miscellaneous Outstanding Shares64,708,000Free Float61,350,000Market Cap$9.56 billion OptionableOptionable Beta1.78 Social Links 7 Stocks That Could Lead the Next Market BoomTesla, Nvidia, and Google helped shape the last era of market growth, but the next wave could come from a new group of companies. 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