Trending NewsTrending NewsTop-Rated StocksTop-RatedNASDAQ:RYTM Rhythm Pharmaceuticals (RYTM) Stock Price, News & Analysis $89.00 +23.86 (+36.63%) Closing price 07/9/2025 04:00 PM EasternExtended Trading$87.52 -1.48 (-1.66%) As of 04:09 AM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Stock Analysis Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock About Rhythm Pharmaceuticals Stock (NASDAQ:RYTM) 30 days 90 days 365 days Advanced Chart View Price History Chart DataSkip Price History Chart Get Rhythm Pharmaceuticals alerts:Sign Up Key Stats Today's Range$75.01▼$89.0550-Day Range$56.79▼$89.0052-Week Range$40.61▼$89.05Volume4.79 million shsAverage Volume575,534 shsMarket Capitalization$5.66 billionP/E RatioN/ADividend YieldN/APrice Target$79.71Consensus RatingBuy Company Overview Rhythm Pharmaceuticals, Inc. (NASDAQ: RYTM) is a clinical-stage biopharmaceutical company focused on developing and commercializing therapies for rare genetic and endocrine-related disorders of obesity. The company’s lead product, setmelanotide (IMCIVREE), is an FDA-approved melanocortin-4 receptor (MC4R) agonist designed to address the underlying genetic causes of obesity in patients with specific genetic deficiencies, including POMC, PCSK1 and LEPR deficiencies. Beyond its approved indications, Rhythm is actively pursuing additional clinical trials to expand the use of setmelanotide to other rare genetic obesity disorders and exploring its potential in common obesity populations. Founded in 2013 and headquartered in Boston, Massachusetts, Rhythm Pharmaceuticals has established a robust pipeline aimed at transforming the treatment landscape for patients affected by rare obesity disorders. The company’s research and development efforts concentrate on the melanocortin pathway, which plays a central role in energy homeostasis and appetite regulation. Rhythm’s approach combines targeted molecular design with precision medicine, enabling tailored therapies that directly address specific genetic mutations. Its R&D infrastructure includes state-of-the-art laboratories and strategic collaborations with academic institutions and patient advocacy groups worldwide. Rhythm Pharmaceuticals serves a global patient community through a network of specialty pharmacies, healthcare providers and patient support programs. While its primary market is in the United States, the company is pursuing international regulatory approvals and partnerships to extend its reach into Europe and other key markets. Rhythm’s patient-centric initiatives include education, genetic testing support and financial assistance programs aimed at improving access to treatment for individuals with pathogenic genetic variants. Under the leadership of Chief Executive Officer David Meeker, Rhythm has grown its management team and board of directors with experienced professionals in biotechnology, regulatory affairs and commercial strategy. Meeker, previously a key executive at Amicus Therapeutics, brings extensive expertise in rare disease drug development and global commercialization. The company’s leadership team continues to expand as Rhythm advances its clinical programs and prepares for broader market launches.AI Generated. May Contain Errors. Read More Rhythm Pharmaceuticals Stock Analysis - MarketRank™See Top-Rated MarketRank™ Stocks70th Percentile Overall ScoreRYTM MarketRank™: Rhythm Pharmaceuticals scored higher than 70% of companies evaluated by MarketBeat, and ranked 285th out of 920 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation. Analyst's Opinion2.5 / 5Analyst RatingBuy Consensus RatingRhythm Pharmaceuticals has received a consensus rating of Buy. The company's average rating score is 3.07, and is based on 14 buy ratings, no hold ratings, and no sell ratings.Amount of Analyst CoverageRhythm Pharmaceuticals has been the subject of 5 research reports in the past 90 days, demonstrating strong analyst interest in this stock.Read more about Rhythm Pharmaceuticals' stock forecast and price target. Earnings and Valuation0.6 / 5Proj. Earnings GrowthGrowing Earnings GrowthEarnings for Rhythm Pharmaceuticals are expected to grow in the coming year, from ($4.32) to ($2.58) per share.Price to Earnings Ratio vs. the MarketThe P/E ratio of Rhythm Pharmaceuticals is -31.67, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Earnings Ratio vs. SectorThe P/E ratio of Rhythm Pharmaceuticals is -31.67, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.Price to Book Value per Share RatioRhythm Pharmaceuticals has a P/B Ratio of 254.29. P/B Ratios above 3 indicate that a company could be overvalued with respect to its assets and liabilities.Read more about Rhythm Pharmaceuticals' valuation and earnings. Short Interest2.0 / 5Short Interest LevelBearish Percentage of Shares Shorted7.97% of the float of Rhythm Pharmaceuticals has been sold short.Short Interest Ratio / Days to CoverRhythm Pharmaceuticals has a short interest ratio ("days to cover") of 6.7.Change versus previous monthShort interest in Rhythm Pharmaceuticals has recently decreased by 0.42%, indicating that investor sentiment is improving. Dividend0.0 / 5Dividend StrengthN/A Dividend YieldRhythm Pharmaceuticals does not currently pay a dividend.Dividend GrowthRhythm Pharmaceuticals does not have a long track record of dividend growth. Sustainability and ESG4.3 / 5Environmental Score-1.80 Percentage of Shares Shorted7.97% of the float of Rhythm Pharmaceuticals has been sold short.Short Interest Ratio / Days to CoverRhythm Pharmaceuticals has a short interest ratio ("days to cover") of 6.7.Change versus previous monthShort interest in Rhythm Pharmaceuticals has recently decreased by 0.42%, indicating that investor sentiment is improving. News and Social Media2.5 / 5News Sentiment0.53 News SentimentRhythm Pharmaceuticals has a news sentiment score of 0.53. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This news sentiment score is similar to the average news sentiment of Medical companies.News Coverage This WeekMarketBeat has tracked 24 news articles for Rhythm Pharmaceuticals this week, compared to 8 articles on an average week.Search Interest9 people have searched for RYTM on MarketBeat in the last 30 days. This is an increase of 125% compared to the previous 30 days. Company Ownership0.8 / 5Insider TradingSelling Shares Insider Buying vs. Insider SellingIn the past three months, Rhythm Pharmaceuticals insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $1,599,572.00 in company stock.Percentage Held by InsidersOnly 6.10% of the stock of Rhythm Pharmaceuticals is held by insiders.Read more about Rhythm Pharmaceuticals' insider trading history. Receive RYTM Stock News and Ratings via Email Sign-up to receive the latest news and ratings for Rhythm Pharmaceuticals and its competitors with MarketBeat's FREE daily newsletter. Email Address RYTM Stock News HeadlinesInsider Selling: Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) Insider Sells 1,319 Shares of StockJuly 4, 2025 | insidertrades.comBrokerages Set Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) PT at $77.312 hours ago | americanbankingnews.comTrump’s treachery Trump’s Final Reset Inside the shocking plot to re-engineer America’s financial system…and why you need to move your money now. | Porter & Company (Ad)Rhythm Pharma Shares Gain on Positive Results From Recent Trial of Obesity Treatment4 hours ago | marketwatch.comRhythm Pharmaceuticals To Announce Topline Results from Phase 2 Trial Evaluating Oral MC4R Agonist Bivamelagon in Acquired Hypothalamic Obesity - Morningstar4 hours ago | morningstar.comMRhythm's drug shows promise in study to treat brain damage-related obesity4 hours ago | reuters.comRhythm Pharmaceuticals Shares Jump Following Promising Phase 2 Data for Obesity Drug4 hours ago | msn.comRhythm Pharma Surges To Record High On 'Impressive' Results In Obesity4 hours ago | msn.comSee More Headlines RYTM Stock Analysis - Frequently Asked Questions How have RYTM shares performed this year? Rhythm Pharmaceuticals' stock was trading at $55.98 on January 1st, 2025. Since then, RYTM stock has increased by 59.0% and is now trading at $89.00. How were Rhythm Pharmaceuticals' earnings last quarter? Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) issued its quarterly earnings data on Wednesday, May, 7th. The company reported ($0.81) earnings per share (EPS) for the quarter, missing the consensus estimate of ($0.69) by $0.12. The firm's revenue for the quarter was up 25.9% on a year-over-year basis. Read the conference call transcript. When did Rhythm Pharmaceuticals IPO? Rhythm Pharmaceuticals (RYTM) raised $100 million in an initial public offering (IPO) on Thursday, October 5th 2017. The company issued 6,700,000 shares at $14.00-$16.00 per share. Morgan Stanley, BofA Merrill Lynch and Cowen served as the underwriters for the IPO and Needham was co-manager. Who are Rhythm Pharmaceuticals' major shareholders? Rhythm Pharmaceuticals' top institutional shareholders include Harbor Capital Advisors Inc. (0.14%) and E. Ohman J or Asset Management AB (0.01%). Insiders that own company stock include David P Meeker, Hunter C Smith, Yann Mazabraud, Pamela J Cramer, Joseph Shulman, William T Roberts, Jennifer Kayden Lee, Jennifer Chien, Alastair Garfield, Lynn A Tetrault, Jennifer L Good and Christopher Paul German. View institutional ownership trends. How do I buy shares of Rhythm Pharmaceuticals? Shares of RYTM stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of Rhythm Pharmaceuticals own? Based on aggregate information from My MarketBeat watchlists, some other companies that Rhythm Pharmaceuticals investors own include NVIDIA (NVDA), Meta Platforms (META), Advanced Micro Devices (AMD), JPMorgan Chase & Co. (JPM), Netflix (NFLX), Tesla (TSLA) and Palo Alto Networks (PANW). Company Calendar Last Earnings5/07/2025Today7/09/2025Next Earnings (Estimated)8/05/2025Fiscal Year End12/31/2025Get Stock AlertsIndustry, Sector and Symbol Stock ExchangeNASDAQ SectorMedical Industry MED - BIOMED/GENE Sub-IndustryPharmaceutical Products Current SymbolNASDAQ:RYTM CIK1649904 Webwww.rhythmtx.com Phone(857) 264-4280Fax857-264-4299Employees140Year FoundedN/APrice Target and Rating Average Price Target for Rhythm Pharmaceuticals$79.71 High Price Target$95.00 Low Price Target$63.00 Potential Upside/Downside-10.4%Consensus RatingBuy Rating Score (0-4)3.07 Research Coverage15 Analysts Profitability EPS (Trailing Twelve Months)($2.81) Trailing P/E RatioN/A Forward P/E RatioN/A P/E GrowthN/ANet Income-$260.60 million Net Margins-123.26% Pretax Margin-123.19% Return on Equity-739.62% Return on Assets-44.27% Debt Debt-to-Equity RatioN/A Current Ratio3.30 Quick Ratio3.13 Sales & Book Value Annual Sales$136.86 million Price / Sales41.37 Cash FlowN/A Price / Cash FlowN/A Book Value$0.35 per share Price / Book254.29Miscellaneous Outstanding Shares63,621,000Free Float59,740,000Market Cap$5.66 billion OptionableOptionable Beta2.26 10 Stocks Set to Soar in Summer 2025Enter your email address and we'll send you MarketBeat's list of ten stocks that are set to soar in Summer 2025, despite the threat of tariffs and other economic uncertainty. These ten stocks are incredibly resilient and are likely to thrive in any economic environment.Get This Free Report This page (NASDAQ:RYTM) was last updated on 7/10/2025 by MarketBeat.com Staff From Our PartnersA grave, grave error.I thought what happened 25 years ago was a once- in-a-lifetime event… but how wrong I was. Because here we...Porter & Company | SponsoredThis Signal Only Flashes Once Every 4 Years – And It Just TriggeredThis same signal has appeared twice before in the past 8 years — both times, it kicked off major moves in cryp...Crypto Swap Profits | Sponsored"Death Spiral" Threatening Your SavingsThe "Death Spiral" Threatening Your Savings But this time, it's not just Dalio ringing the alarm bells…GoldCo Precious Metals | SponsoredHow a Kansas farm boy gained 1,285% in two daysA former farm kid placed a simple trade… and cashed out a 1,285% gain two days later. 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