Sangamo Therapeutics (SGMO) Competitors $0.58 +0.04 (+7.41%) Closing price 08/15/2025 04:00 PM EasternExtended Trading$0.59 +0.01 (+1.55%) As of 08/15/2025 07:49 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock SGMO vs. LXRX, XOMA, CBIO, VNDA, CDXS, IRWD, AGEN, ACHV, DOMH, and FBIOShould you be buying Sangamo Therapeutics stock or one of its competitors? The main competitors of Sangamo Therapeutics include Lexicon Pharmaceuticals (LXRX), XOMA Royalty (XOMA), Crescent Biopharma (CBIO), Vanda Pharmaceuticals (VNDA), Codexis (CDXS), Ironwood Pharmaceuticals (IRWD), Agenus (AGEN), Achieve Life Sciences (ACHV), Dominari (DOMH), and Fortress Biotech (FBIO). These companies are all part of the "biotechnology" industry. Sangamo Therapeutics vs. Its Competitors Lexicon Pharmaceuticals XOMA Royalty Crescent Biopharma Vanda Pharmaceuticals Codexis Ironwood Pharmaceuticals Agenus Achieve Life Sciences Dominari Fortress Biotech Sangamo Therapeutics (NASDAQ:SGMO) and Lexicon Pharmaceuticals (NASDAQ:LXRX) are both small-cap medical companies, but which is the better business? We will compare the two businesses based on the strength of their analyst recommendations, profitability, valuation, institutional ownership, earnings, media sentiment, risk and dividends. Which has more volatility and risk, SGMO or LXRX? Sangamo Therapeutics has a beta of 1.18, indicating that its share price is 18% more volatile than the S&P 500. Comparatively, Lexicon Pharmaceuticals has a beta of 1.17, indicating that its share price is 17% more volatile than the S&P 500. Is SGMO or LXRX more profitable? Sangamo Therapeutics has a net margin of -77.48% compared to Lexicon Pharmaceuticals' net margin of -206.43%. Lexicon Pharmaceuticals' return on equity of -83.63% beat Sangamo Therapeutics' return on equity.Company Net Margins Return on Equity Return on Assets Sangamo Therapeutics-77.48% -293.05% -63.85% Lexicon Pharmaceuticals -206.43%-83.63%-42.22% Do insiders & institutionals hold more shares of SGMO or LXRX? 56.9% of Sangamo Therapeutics shares are owned by institutional investors. Comparatively, 74.7% of Lexicon Pharmaceuticals shares are owned by institutional investors. 4.1% of Sangamo Therapeutics shares are owned by insiders. Comparatively, 13.9% of Lexicon Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth. Does the media prefer SGMO or LXRX? In the previous week, Sangamo Therapeutics had 5 more articles in the media than Lexicon Pharmaceuticals. MarketBeat recorded 11 mentions for Sangamo Therapeutics and 6 mentions for Lexicon Pharmaceuticals. Lexicon Pharmaceuticals' average media sentiment score of 1.27 beat Sangamo Therapeutics' score of 0.94 indicating that Lexicon Pharmaceuticals is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Sangamo Therapeutics 2 Very Positive mention(s) 0 Positive mention(s) 2 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Lexicon Pharmaceuticals 2 Very Positive mention(s) 0 Positive mention(s) 0 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Do analysts rate SGMO or LXRX? Sangamo Therapeutics currently has a consensus price target of $4.50, suggesting a potential upside of 675.86%. Lexicon Pharmaceuticals has a consensus price target of $3.23, suggesting a potential upside of 160.08%. Given Sangamo Therapeutics' stronger consensus rating and higher possible upside, research analysts clearly believe Sangamo Therapeutics is more favorable than Lexicon Pharmaceuticals.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Sangamo Therapeutics 0 Sell rating(s) 2 Hold rating(s) 4 Buy rating(s) 0 Strong Buy rating(s) 2.67Lexicon Pharmaceuticals 0 Sell rating(s) 3 Hold rating(s) 3 Buy rating(s) 0 Strong Buy rating(s) 2.50 Which has stronger earnings and valuation, SGMO or LXRX? Sangamo Therapeutics has higher revenue and earnings than Lexicon Pharmaceuticals. Lexicon Pharmaceuticals is trading at a lower price-to-earnings ratio than Sangamo Therapeutics, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioSangamo Therapeutics$57.80M3.03-$97.94M-$0.29-2.00Lexicon Pharmaceuticals$31.08M14.50-$200.40M-$0.33-3.76 SummarySangamo Therapeutics beats Lexicon Pharmaceuticals on 10 of the 16 factors compared between the two stocks. Get Sangamo Therapeutics News Delivered to You Automatically Sign up to receive the latest news and ratings for SGMO and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding SGMO and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart SGMO vs. The Competition Export to ExcelMetricSangamo TherapeuticsMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$162.92M$3.10B$5.68B$9.81BDividend YieldN/A2.23%3.79%4.12%P/E Ratio-2.0020.8931.0825.11Price / Sales3.03366.96467.01193.48Price / CashN/A42.3037.4059.05Price / Book9.678.659.096.18Net Income-$97.94M-$54.65M$3.26B$265.11M7 Day Performance26.94%6.56%7.36%4.21%1 Month Performance20.51%7.53%5.47%2.01%1 Year Performance-34.09%13.69%30.61%23.75% Sangamo Therapeutics Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)SGMOSangamo Therapeutics3.0606 of 5 stars$0.58+7.4%$4.50+675.9%-34.8%$162.92M$57.80M-2.00480News CoverageAnalyst UpgradeShort Interest ↓Analyst RevisionGap UpLXRXLexicon Pharmaceuticals2.8927 of 5 stars$1.04-3.7%$3.23+210.1%-24.4%$375.95M$58.43M-3.15140Positive NewsXOMAXOMA Royalty4.417 of 5 stars$27.23+2.8%$69.50+155.2%+12.8%$325.86M$13.05M-23.6810News CoverageEarnings ReportAnalyst UpgradeAnalyst RevisionCBIOCrescent Biopharma3.8368 of 5 stars$12.90+0.4%$25.50+97.7%N/A$252.20M$10K-0.3750News CoverageAnalyst RevisionVNDAVanda Pharmaceuticals4.4612 of 5 stars$4.19-0.2%$16.50+293.8%-15.7%$247.58M$203.47M-3.71290News CoverageAnalyst RevisionCDXSCodexis3.6611 of 5 stars$2.80+1.1%$11.00+292.9%+7.1%$231.97M$49.82M-2.83250News CoverageEarnings ReportAnalyst UpgradeAnalyst RevisionIRWDIronwood Pharmaceuticals4.405 of 5 stars$0.84-6.8%$4.94+490.7%-76.9%$135.33M$351.41M-16.72220AGENAgenus4.0004 of 5 stars$4.27-11.0%$16.33+282.5%-10.4%$117.07M$99.52M-0.49440News CoverageEarnings ReportAnalyst UpgradeAnalyst RevisionACHVAchieve Life Sciences2.2043 of 5 stars$2.45-2.0%$14.33+485.0%-42.7%$84.98MN/A-1.6820DOMHDominari0.5563 of 5 stars$5.33-7.0%N/A+278.7%$78.05M$24.89M-1.184News CoverageEarnings ReportAnalyst UpgradeFBIOFortress Biotech2.3778 of 5 stars$1.92+5.5%$21.00+993.8%+11.6%$56.77M$57.67M-0.86170News CoverageEarnings ReportGap Up Related Companies and Tools Related Companies LXRX Alternatives XOMA Alternatives CBIO Alternatives VNDA Alternatives CDXS Alternatives IRWD Alternatives AGEN Alternatives ACHV Alternatives DOMH Alternatives FBIO Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:SGMO) was last updated on 8/16/2025 by MarketBeat.com Staff From Our PartnersWhen the levee breaksThe U.S. Treasury just confirmed it plans to borrow $1.01 trillion this quarter—nearly double what was project...Porter & Company | SponsoredBut this $20 American company could control the secretThe "Impossible" Chip That Runs on Pure Light Google's quantum computer shocked the world... but China DEMO...The Oxford Club | SponsoredIs Elon's empire crumbling?The Tesla Shock Nobody Sees Coming While headlines scream "Tesla is doomed"... Jeff Brown has uncovered ...Brownstone Research | SponsoredEveryone’s watching Nvidia right now. Here’s why I’m excited.So, unless you’ve been living under a rock, you probably saw the news… Nvidia just signed a $7 BILLION deal...Timothy Sykes | SponsoredREVEALED FREE: Our top 3 stocks to own in 2025 and beyondEvery time Weiss Ratings flashed green like this, the average gain on each and every stock has been 303% (incl...Weiss Ratings | SponsoredThe Trump Dump is starting; Get out of stocks now?The first 365 days of the Trump presidency… Will be the best time to get rich in American history.Paradigm Press | SponsoredCrypto Income (almost instantly)How would you like to collect a small percentage of the $4 billion changing hands daily in the crypto market? ...Awesomely, LLC | SponsoredThe Debt Crisis Is Coming—Will You Be Ready?A full-blown "economic heart attack" is coming—and the markets aren't ready. The problem? Exploding U.S. de...Investors Alley | Sponsored Adding Choose a watchlist: Watchlist Adding You have already added ten stocks to your watchlist. Upgrade to MarketBeat All Access to add more stocks to your watchlist. Adding Sangamo Therapeutics, Inc. Please log in to your account or sign up in order to add this asset to your watchlist. Share Sangamo Therapeutics With A Colleague Link copied to clipboard. Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. Real-time analyst ratings, insider transactions, earnings data, and more. Our daily ratings and market update email newsletter. Sign in to your free account to enjoy all that MarketBeat has to offer. Sign In Create Account Your Email Address: Email Address Required Your Password: Password Required Log In or Sign in with Facebook Sign in with Google Forgot your password? Your Email Address: Please enter your email address. Please enter a valid email address Choose a Password: Please enter your password. Your password must be at least 8 characters long and contain at least 1 number, 1 letter, and 1 special character. Create My Account (Free) or Sign in with Facebook Sign in with Google By creating a free account, you agree to our terms of service. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.