Upstream Bio (UPB) Competitors $11.13 +0.34 (+3.15%) Closing price 07/2/2025 04:00 PM EasternExtended Trading$11.22 +0.09 (+0.77%) As of 04:01 AM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOwnershipSEC FilingsTrendsBuy This Stock UPB vs. BHC, GMTX, APLS, ARWR, VCEL, TWST, KNSA, RXRX, DNLI, and NAMSShould you be buying Upstream Bio stock or one of its competitors? The main competitors of Upstream Bio include Bausch Health Cos (BHC), Gemini Therapeutics (GMTX), Apellis Pharmaceuticals (APLS), Arrowhead Pharmaceuticals (ARWR), Vericel (VCEL), Twist Bioscience (TWST), Kiniksa Pharmaceuticals International (KNSA), Recursion Pharmaceuticals (RXRX), Denali Therapeutics (DNLI), and NewAmsterdam Pharma (NAMS). These companies are all part of the "pharmaceutical products" industry. Upstream Bio vs. Its Competitors Bausch Health Cos Gemini Therapeutics Apellis Pharmaceuticals Arrowhead Pharmaceuticals Vericel Twist Bioscience Kiniksa Pharmaceuticals International Recursion Pharmaceuticals Denali Therapeutics NewAmsterdam Pharma Bausch Health Cos (NYSE:BHC) and Upstream Bio (NASDAQ:UPB) are both medical companies, but which is the better stock? We will contrast the two businesses based on the strength of their media sentiment, earnings, profitability, risk, analyst recommendations, valuation, institutional ownership and dividends. Is BHC or UPB more profitable? Upstream Bio has a net margin of 0.00% compared to Bausch Health Cos' net margin of -0.41%. Upstream Bio's return on equity of 0.00% beat Bausch Health Cos' return on equity.Company Net Margins Return on Equity Return on Assets Bausch Health Cos-0.41% -540.45% 5.26% Upstream Bio N/A N/A N/A Which has stronger valuation & earnings, BHC or UPB? Bausch Health Cos has higher revenue and earnings than Upstream Bio. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioBausch Health Cos$9.63B0.27-$46M-$0.11-64.64Upstream Bio$2.37M252.61-$62.81MN/AN/A Do institutionals & insiders believe in BHC or UPB? 78.7% of Bausch Health Cos shares are held by institutional investors. 8.1% of Bausch Health Cos shares are held by company insiders. Comparatively, 13.6% of Upstream Bio shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term. Do analysts prefer BHC or UPB? Bausch Health Cos currently has a consensus price target of $7.42, indicating a potential upside of 4.31%. Upstream Bio has a consensus price target of $56.50, indicating a potential upside of 407.64%. Given Upstream Bio's stronger consensus rating and higher possible upside, analysts plainly believe Upstream Bio is more favorable than Bausch Health Cos.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Bausch Health Cos 1 Sell rating(s) 6 Hold rating(s) 0 Buy rating(s) 0 Strong Buy rating(s) 1.86Upstream Bio 0 Sell rating(s) 0 Hold rating(s) 4 Buy rating(s) 0 Strong Buy rating(s) 3.00 Does the media refer more to BHC or UPB? In the previous week, Bausch Health Cos had 9 more articles in the media than Upstream Bio. MarketBeat recorded 10 mentions for Bausch Health Cos and 1 mentions for Upstream Bio. Upstream Bio's average media sentiment score of 0.93 beat Bausch Health Cos' score of 0.61 indicating that Upstream Bio is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Bausch Health Cos 1 Very Positive mention(s) 3 Positive mention(s) 3 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Upstream Bio 0 Very Positive mention(s) 0 Positive mention(s) 1 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive SummaryUpstream Bio beats Bausch Health Cos on 8 of the 13 factors compared between the two stocks. Get Upstream Bio News Delivered to You Automatically Sign up to receive the latest news and ratings for UPB and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding UPB and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart UPB vs. The Competition Export to ExcelMetricUpstream BioMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$580.43M$2.88B$5.54B$8.87BDividend YieldN/A2.64%5.39%4.10%P/E RatioN/A21.3126.1719.90Price / Sales252.61278.47413.55113.66Price / CashN/A41.4736.1356.90Price / Book1.277.518.025.38Net Income-$62.81M-$55.05M$3.15B$248.50M7 Day Performance1.74%2.07%1.48%2.06%1 Month Performance2.68%4.84%3.66%4.86%1 Year PerformanceN/A5.37%34.68%20.24% Upstream Bio Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)UPBUpstream Bio1.8585 of 5 stars$11.13+3.2%$56.50+407.6%N/A$580.43M$2.37M0.0038BHCBausch Health Cos3.2418 of 5 stars$6.11-1.1%$7.42+21.4%+0.0%$2.29B$9.63B-55.5520,700GMTXGemini TherapeuticsN/A$51.61+3.0%N/A+10.0%$2.24BN/A-51.6130High Trading VolumeAPLSApellis Pharmaceuticals4.5337 of 5 stars$17.62-0.4%$40.05+127.3%-49.1%$2.22B$781.37M-9.84770Trending NewsAnalyst ForecastAnalyst RevisionARWRArrowhead Pharmaceuticals3.9354 of 5 stars$15.51+1.2%$43.71+181.8%-33.0%$2.12B$3.55M-11.08400Positive NewsVCELVericel2.8722 of 5 stars$41.80-0.5%$61.14+46.3%-8.0%$2.12B$237.22M1,393.80300TWSTTwist Bioscience4.4187 of 5 stars$35.33+2.0%$50.40+42.7%-20.4%$2.08B$312.97M-10.87990News CoveragePositive NewsKNSAKiniksa Pharmaceuticals International3.7148 of 5 stars$28.72+1.0%$38.80+35.1%+48.7%$2.08B$481.17M-114.88220RXRXRecursion Pharmaceuticals1.8974 of 5 stars$4.83-4.0%$7.00+44.9%-27.2%$2.04B$58.84M-2.73400DNLIDenali Therapeutics4.5657 of 5 stars$13.62-1.9%$33.71+147.5%-31.5%$2.02B$330.53M-5.10430NAMSNewAmsterdam Pharma2.9978 of 5 stars$18.21+1.4%$42.89+135.5%-6.6%$2.02B$45.56M-9.694 Related Companies and Tools Related Companies BHC Alternatives GMTX Alternatives APLS Alternatives ARWR Alternatives VCEL Alternatives TWST Alternatives KNSA Alternatives RXRX Alternatives DNLI Alternatives NAMS Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:UPB) was last updated on 7/3/2025 by MarketBeat.com Staff From Our PartnersHere's the last trade you should make before heading out for the weekend tomorrow.Make this one trade at 2:59 PM on Friday afternoon, and you'll thank me on Monday morning.Timothy Sykes | SponsoredThis Signal Only Flashes Once Every 4 Years – And It Just TriggeredThis same signal has appeared twice before in the past 8 years — both times, it kicked off major moves in cryp...Crypto Swap Profits | SponsoredTrump’s New Order Could Boost Social Security Benefits by 400%If you collect—or plan to collect—Social Security, you need to see this. 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Oxford Economics says, "The Robotics Rev...Weiss Ratings | Sponsored Adding Choose a watchlist: Watchlist Adding You have already added ten stocks to your watchlist. Upgrade to MarketBeat All Access to add more stocks to your watchlist. Adding Upstream Bio, Inc. Please log in to your account or sign up in order to add this asset to your watchlist. Share Upstream Bio With A Colleague Link copied to clipboard. Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. 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