The following companies are subsidiares of Vertex Pharmaceuticals: Aurora Biosciences Corporation, Exonics Therapeutics, Semma Therapeutics, The Vertex Foundation Inc. a Delaware corporation, Torreyana Insurance Company Inc. a Vermont corporation, Vectrus, Vertex Farmaceutica do Brasil LTDA a Brazilian company, Vertex Holdings Inc. a Delaware corporation, Vertex Pharmaceuticals (Australia) Pty. Ltd. an Australian company, Vertex Pharmaceuticals (Belgium) BV, Vertex Pharmaceuticals (CH) GmbH a Swiss company, Vertex Pharmaceuticals (Canada) Incorporated a Canadian company, Vertex Pharmaceuticals (Cayman 509) Limited a Cayman Islands company, Vertex Pharmaceuticals (Cayman 765) Limited a Cayman Islands company, Vertex Pharmaceuticals (Cayman 787) Limited a Cayman Islands company, Vertex Pharmaceuticals (Cayman III) Limited a Cayman Islands company, Vertex Pharmaceuticals (Cayman) Limited a Cayman Islands company, Vertex Pharmaceuticals (Czech Republic) s.r.o, Vertex Pharmaceuticals (Delaware) LLC a Delaware limited liability company, Vertex Pharmaceuticals (Distribution) Incorporated a Delaware corporation, Vertex Pharmaceuticals (Europe) Limited a United Kingdom company, Vertex Pharmaceuticals (France) SAS a French company, Vertex Pharmaceuticals (Germany) GmbH a German company, Vertex Pharmaceuticals (Ireland) Limited an Irish company, Vertex Pharmaceuticals (Italy) S.r.L. an Italian company, Vertex Pharmaceuticals (Netherlands) B.V. a Dutch company, Vertex Pharmaceuticals (Poland) sp. z.o.o, Vertex Pharmaceuticals (Portugal) Unipessoal Lda. a Portuguese company, Vertex Pharmaceuticals (Puerto Rico) LLC a Delaware limited liability company, Vertex Pharmaceuticals (San Diego) LLC a Delaware limited liability company, Vertex Pharmaceuticals (Singapore) Pte. Ltd. a Singapore company, Vertex Pharmaceuticals (Spain) S.L. a Spanish company, Vertex Pharmaceuticals (Sweden) AB a Sweden company, Vertex Pharmaceuticals (U.K.) Limited a United Kingdom company, Vertex Pharmaceuticals GmbH an Austrian company, Vertex Pharmaceuticals Single Member Societe Anonyme a Greek company, and Vertex Securities Corporation a Massachusetts corporation.