Vertex Pharmaceuticals is a global biotechnology company dedicated to discovering, developing and commercializing innovative therapies for serious diseases. Since its founding in 1989 by Dr. Joshua Boger, the company has been at the forefront of translating cutting-edge science into medicines that address underlying causes rather than just symptoms. Headquartered in Boston, Vertex maintains research and development sites and commercial operations across North America, Europe, Australia and Asia.
Vertex’s core business revolves around cystic fibrosis (CF), where its portfolio of small-molecule therapies—including ivacaftor, lumacaftor, tezacaftor and elexacaftor—has transformed treatment paradigms for patients with specific genetic mutations. Beyond CF, the company has broadened its pipeline to include programs in sickle cell disease, beta-thalassemia, pain management and APOL1-mediated kidney disease, leveraging approaches such as gene editing, messenger RNA technology and novel ion channel modulators.
Research partnerships and collaborations are central to Vertex’s strategy. The company has teamed with academic institutions and industry leaders in gene therapy and CRISPR technology to accelerate development timelines and expand its reach into new therapeutic areas. Manufacturing facilities in North America and Europe support both clinical supply and commercial production, ensuring scalability as programs advance.
Under the leadership of President and Chief Executive Officer Reshma Kewalramani, Vertex continues to invest heavily in R&D, with a focus on precision medicine and genetic disease research. The company’s long-term vision emphasizes sustainable growth through innovation, strategic alliances and a patient-centric approach to drug development.
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