X4 Pharmaceuticals (XFOR) Competitors $2.85 -0.29 (-9.24%) Closing price 08/15/2025 04:00 PM EasternExtended Trading$2.82 -0.03 (-0.91%) As of 08/15/2025 07:59 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock XFOR vs. XLO, KPTI, ENLV, SCYX, RANI, SNYR, CLSD, AKTX, ITRM, and MRSNShould you be buying X4 Pharmaceuticals stock or one of its competitors? The main competitors of X4 Pharmaceuticals include Xilio Therapeutics (XLO), Karyopharm Therapeutics (KPTI), Enlivex Therapeutics (ENLV), SCYNEXIS (SCYX), Rani Therapeutics (RANI), Synergy CHC (SNYR), Clearside Biomedical (CLSD), Akari Therapeutics (AKTX), Iterum Therapeutics (ITRM), and Mersana Therapeutics (MRSN). These companies are all part of the "pharmaceutical products" industry. X4 Pharmaceuticals vs. Its Competitors Xilio Therapeutics Karyopharm Therapeutics Enlivex Therapeutics SCYNEXIS Rani Therapeutics Synergy CHC Clearside Biomedical Akari Therapeutics Iterum Therapeutics Mersana Therapeutics Xilio Therapeutics (NASDAQ:XLO) and X4 Pharmaceuticals (NASDAQ:XFOR) are both small-cap medical companies, but which is the superior business? We will contrast the two businesses based on the strength of their institutional ownership, analyst recommendations, earnings, valuation, profitability, risk, dividends and media sentiment. Does the media favor XLO or XFOR? In the previous week, X4 Pharmaceuticals had 7 more articles in the media than Xilio Therapeutics. MarketBeat recorded 15 mentions for X4 Pharmaceuticals and 8 mentions for Xilio Therapeutics. X4 Pharmaceuticals' average media sentiment score of 0.39 beat Xilio Therapeutics' score of 0.19 indicating that X4 Pharmaceuticals is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Xilio Therapeutics 0 Very Positive mention(s) 0 Positive mention(s) 4 Neutral mention(s) 1 Negative mention(s) 0 Very Negative mention(s) Neutral X4 Pharmaceuticals 1 Very Positive mention(s) 1 Positive mention(s) 7 Neutral mention(s) 2 Negative mention(s) 0 Very Negative mention(s) Neutral Which has higher earnings & valuation, XLO or XFOR? X4 Pharmaceuticals has lower revenue, but higher earnings than Xilio Therapeutics. Xilio Therapeutics is trading at a lower price-to-earnings ratio than X4 Pharmaceuticals, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioXilio Therapeutics$6.34M5.79-$58.24M-$0.84-0.84X4 Pharmaceuticals$2.56M6.45-$37.45M-$14.84-0.19 Do analysts prefer XLO or XFOR? Xilio Therapeutics currently has a consensus target price of $3.00, indicating a potential upside of 323.13%. X4 Pharmaceuticals has a consensus target price of $71.17, indicating a potential upside of 2,397.08%. Given X4 Pharmaceuticals' higher probable upside, analysts plainly believe X4 Pharmaceuticals is more favorable than Xilio Therapeutics.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Xilio Therapeutics 0 Sell rating(s) 0 Hold rating(s) 2 Buy rating(s) 1 Strong Buy rating(s) 3.33X4 Pharmaceuticals 0 Sell rating(s) 0 Hold rating(s) 3 Buy rating(s) 0 Strong Buy rating(s) 3.00 Which has more volatility & risk, XLO or XFOR? Xilio Therapeutics has a beta of -0.15, meaning that its stock price is 115% less volatile than the S&P 500. Comparatively, X4 Pharmaceuticals has a beta of 0.6, meaning that its stock price is 40% less volatile than the S&P 500. Is XLO or XFOR more profitable? X4 Pharmaceuticals has a net margin of -311.15% compared to Xilio Therapeutics' net margin of -374.79%. Xilio Therapeutics' return on equity of -342.32% beat X4 Pharmaceuticals' return on equity.Company Net Margins Return on Equity Return on Assets Xilio Therapeutics-374.79% -342.32% -67.61% X4 Pharmaceuticals -311.15%-375.31%-72.87% Do institutionals & insiders believe in XLO or XFOR? 54.3% of Xilio Therapeutics shares are held by institutional investors. Comparatively, 72.0% of X4 Pharmaceuticals shares are held by institutional investors. 5.2% of Xilio Therapeutics shares are held by insiders. Comparatively, 2.4% of X4 Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term. SummaryX4 Pharmaceuticals beats Xilio Therapeutics on 10 of the 17 factors compared between the two stocks. Get X4 Pharmaceuticals News Delivered to You Automatically Sign up to receive the latest news and ratings for XFOR and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding XFOR and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart XFOR vs. The Competition Export to ExcelMetricX4 PharmaceuticalsMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$18.18M$3.10B$5.67B$9.82BDividend YieldN/A2.23%3.79%4.08%P/E Ratio-0.1920.3830.5825.12Price / Sales6.45368.96464.24116.42Price / CashN/A42.3037.4059.05Price / Book4.138.659.096.18Net Income-$37.45M-$54.65M$3.25B$264.89M7 Day Performance91.28%6.58%7.42%4.22%1 Month Performance87.50%7.54%5.50%2.02%1 Year Performance-86.33%13.73%30.67%24.22% X4 Pharmaceuticals Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)XFORX4 Pharmaceuticals4.3603 of 5 stars$2.85-9.2%$71.17+2,397.1%-85.0%$18.18M$2.56M-0.1980News CoverageEarnings ReportAnalyst ForecastShort Interest ↑Analyst RevisionGap DownXLOXilio Therapeutics2.8005 of 5 stars$0.68+2.6%$3.00+341.0%-14.6%$34.33M$6.34M-0.8170News CoverageEarnings ReportAnalyst DowngradeHigh Trading VolumeKPTIKaryopharm Therapeutics3.8538 of 5 stars$3.77-4.3%$37.40+892.0%-52.7%$34.04M$145.24M-0.28380Earnings ReportAnalyst ForecastAnalyst RevisionENLVEnlivex Therapeutics3.3411 of 5 stars$1.47+2.8%$10.00+580.3%+49.2%$33.82MN/A-2.2370News CoverageShort Interest ↓Gap UpSCYXSCYNEXIS1.3671 of 5 stars$0.88+1.7%N/A-51.5%$33.75M$3.75M-1.5760News CoverageEarnings ReportRANIRani Therapeutics3.1814 of 5 stars$0.50-5.3%$7.33+1,366.7%-79.5%$33.37M$1.03M-0.55110Analyst UpgradeShort Interest ↓SNYRSynergy CHC4.5098 of 5 stars$3.84+8.5%$10.00+160.4%N/A$32.55M$34.83M0.0040News CoverageEarnings ReportCLSDClearside Biomedical2.7918 of 5 stars$0.40-1.1%$4.20+942.2%-59.9%$32M$1.66M-1.0930Earnings ReportShort Interest ↑AKTXAkari Therapeutics3.0991 of 5 stars$1.05+6.1%$5.00+376.2%-68.4%$31.85MN/A0.009Upcoming EarningsHigh Trading VolumeITRMIterum Therapeutics2.4173 of 5 stars$0.71+0.5%$9.00+1,160.2%-29.3%$31.75MN/A-0.8410MRSNMersana Therapeutics4.0895 of 5 stars$5.97-5.2%$130.00+2,077.6%-80.8%$31.41M$40.50M-0.40150News CoverageEarnings ReportAnalyst ForecastShort Interest ↓Analyst Revision Related Companies and Tools Related Companies XLO Competitors KPTI Competitors ENLV Competitors SCYX Competitors RANI Competitors SNYR Competitors CLSD Competitors AKTX Competitors ITRM Competitors MRSN Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:XFOR) was last updated on 8/16/2025 by MarketBeat.com Staff From Our PartnersGENIUS Act: Cancel Your Money?A new law called the GENIUS Act could quietly trigger the most radical shift in American finance in decades. 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