| 6/16/2019 | FMR LLC | 8,443,825 | $262.27M | 0.0% | +0.1% | 14.985% |  |
| 6/16/2019 | Redmile Group LLC | 3,036,603 | $94.32M | 2.8% | -1.6% | 5.389% | |
| 6/16/2019 | Marshall Wace LLP | 25,652 | $0.80M | 0.0% | +50.0% | 0.046% | |
| 5/14/2019 | Primecap Management Co. CA | 7,503,883 | $233.07M | 0.2% | -1.5% | 13.316% | |
| 5/10/2019 | Xact Kapitalforvaltning AB | 7,400 | $0.23M | 0.0% | -29.8% | 0.013% | |
| 5/10/2019 | DekaBank Deutsche Girozentrale | 18,200 | $0.77M | 0.0% | +15.3% | 0.032% | |
| 5/9/2019 | Shell Asset Management Co. | 4,666 | $0.15M | 0.0% | +50.0% | 0.008% | |
| 5/8/2019 | TD Asset Management Inc. | 121,703 | $3.78M | 0.0% | -12.2% | 0.216% | |
| 5/7/2019 | 361 Capital LLC | 78,791 | $2.45M | 0.4% | +8.1% | 0.140% | |
| 5/7/2019 | JPMorgan Chase & Co. | 236,899 | $7.36M | 0.0% | -4.1% | 0.420% | |
| 5/7/2019 | Spark Investment Management LLC | 10,069 | $0.31M | 0.0% | +50.0% | 0.018% | |
| 5/6/2019 | American International Group Inc. | 29,795 | $0.93M | 0.0% | -3.4% | 0.053% | |
| 5/3/2019 | State Board of Administration of Florida Retirement System | 19,139 | $0.59M | 0.0% | +2.4% | 0.034% | |
| 5/3/2019 | Victory Capital Management Inc. | 83,842 | $2.60M | 0.0% | -1.1% | 0.149% | |
| 5/1/2019 | Rhumbline Advisers | 82,098 | $2.55M | 0.0% | +10.8% | 0.146% | |
| 4/30/2019 | Tocqueville Asset Management L.P. | 8,100 | $0.25M | 0.0% | -11.0% | 0.014% | |
| 4/25/2019 | BNP Paribas Arbitrage SA | 10,629 | $0.33M | 0.0% | +47.8% | 0.019% | |
| 4/25/2019 | Los Angeles Capital Management & Equity Research Inc. | 16,289 | $0.51M | 0.0% | +36.8% | 0.029% | |
| 4/25/2019 | Virginia Retirement Systems ET AL | 26,400 | $0.82M | 0.0% | +6.0% | 0.047% | |
| 4/24/2019 | Bailard Inc. | 11,000 | $0.34M | 0.0% | -83.3% | 0.020% | |
| 4/11/2019 | Rhenman & Partners Asset Management AB | 325,965 | $10.12M | 1.2% | +24.8% | 0.579% | |
| 4/8/2019 | Equitec Specialists LLC | 10,417 | $0.32M | 0.1% | +5.4% | 0.019% | |
| 4/1/2019 | Deutsche Bank AG | 36,174 | $1.31M | 0.0% | +276.8% | 0.064% | |
| 3/6/2019 | Geode Capital Management LLC | 550,642 | $19.91M | 0.0% | +6.5% | 0.979% | |
| 3/4/2019 | Norges Bank | 781,835 | $28.27M | 0.0% | +50.0% | 1.390% | |
| 2/26/2019 | Dimensional Fund Advisors LP | 399,186 | $14.43M | 0.0% | +23.0% | 0.710% | |
| 2/26/2019 | FMR LLC | 8,435,149 | $305.02M | 0.0% | +0.7% | 15.001% | |
| 2/22/2019 | Sofinnova Investments Inc. | 199,682 | $7.22M | 0.9% | +50.0% | 0.355% | |
| 2/15/2019 | Amalgamated Bank | 6,853 | $0.25M | 0.0% | +50.0% | 0.012% | |
| 2/15/2019 | Legal & General Group Plc | 18,728 | $0.68M | 0.0% | +7.5% | 0.033% | |
| 2/14/2019 | Amundi Pioneer Asset Management Inc. | 5,400 | $0.20M | 0.0% | -74.2% | 0.010% | |
| 2/14/2019 | Gotham Asset Management LLC | 6,647 | $0.24M | 0.0% | +50.0% | 0.012% | |
| 2/14/2019 | Metropolitan Life Insurance Co. NY | 15,127 | $0.55M | 0.0% | +43.9% | 0.027% | |
| 2/14/2019 | MetLife Investment Advisors LLC | 21,420 | $0.78M | 0.0% | -123.0% | 0.038% | |
| 2/14/2019 | Squarepoint Ops LLC | 9,703 | $0.35M | 0.0% | +612.3% | 0.017% | |
| 2/14/2019 | Perceptive Advisors LLC | 196,810 | $6.83M | 0.3% | +145.3% | 0.350% | |
| 2/14/2019 | D. E. Shaw & Co. Inc. | 77,285 | $2.80M | 0.0% | +30.4% | 0.137% | |
| 2/14/2019 | Bank of America Corp DE | 32,333 | $1.17M | 0.0% | +13.1% | 0.057% | |
| 2/14/2019 | Two Sigma Advisers LP | 35,500 | $1.28M | 0.0% | -62.1% | 0.063% | |
| 2/14/2019 | Principal Financial Group Inc. | 14,141 | $0.51M | 0.0% | -16.1% | 0.025% | |
| 2/14/2019 | Mackay Shields LLC | 19,337 | $0.70M | 0.0% | -12.1% | 0.034% | |
| 2/14/2019 | Lord Abbett & CO. LLC | 194,082 | $7.02M | 0.0% | +1.7% | 0.345% | |
| 2/13/2019 | Geode Capital Management LLC | 550,642 | $19.91M | 0.0% | +6.5% | 0.979% | |
| 2/13/2019 | Tekla Capital Management LLC | 56,172 | $2.03M | 0.1% | +50.0% | 0.100% | |
| 2/13/2019 | Dimensional Fund Advisors LP | 399,186 | $14.43M | 0.0% | +23.0% | 0.710% | |
| 2/12/2019 | Northern Trust Corp | 603,917 | $21.84M | 0.0% | +0.3% | 1.074% | |
| 2/12/2019 | GSA Capital Partners LLP | 9,370 | $0.34M | 0.0% | +50.0% | 0.017% | |
| 2/12/2019 | Citigroup Inc. | 40,546 | $1.47M | 0.0% | +42.9% | 0.072% | |
| 2/11/2019 | Bank of New York Mellon Corp | 208,039 | $7.52M | 0.0% | -7.1% | 0.370% | |
| 2/8/2019 | BlackRock Inc. | 4,152,607 | $150.16M | 0.0% | +2.4% | 7.385% | |
| 2/8/2019 | New York State Common Retirement Fund | 45,400 | $1.64M | 0.0% | -15.2% | 0.081% | |
| 2/8/2019 | California Public Employees Retirement System | 51,814 | $1.87M | 0.0% | +8.2% | 0.092% | |
| 2/8/2019 | 361 Capital LLC | 71,802 | $2.60M | 0.5% | +50.0% | 0.128% | |
| 2/7/2019 | First Trust Advisors LP | 24,452 | $0.88M | 0.0% | +193.7% | 0.043% | |
| 2/7/2019 | Prudential Financial Inc. | 43,349 | $1.57M | 0.0% | +715.9% | 0.077% | |
| 2/7/2019 | Virginia Retirement Systems ET AL | 24,700 | $0.89M | 0.0% | +6.1% | 0.044% | |
| 2/5/2019 | Victory Capital Management Inc. | 84,772 | $3.07M | 0.0% | +37.4% | 0.151% | |
| 2/5/2019 | Virtus ETF Advisers LLC | 8,229 | $0.30M | 0.1% | -66.3% | 0.015% | |
| 2/5/2019 | Rhenman & Partners Asset Management AB | 218,537 | $7.90M | 0.9% | +3.8% | 0.389% | |
| 2/1/2019 | Chartwell Investment Partners LLC | 40,778 | $1.48M | 0.1% | +3.0% | 0.073% | |
| 2/1/2019 | TD Asset Management Inc. | 134,903 | $4.88M | 0.0% | -1.4% | 0.240% | |
| 2/1/2019 | State Board of Administration of Florida Retirement System | 18,659 | $0.68M | 0.0% | +9.8% | 0.033% | |
| 2/1/2019 | SG Americas Securities LLC | 16,581 | $0.60M | 0.0% | +50.0% | 0.029% | |
| 1/31/2019 | Rhumbline Advisers | 72,201 | $2.61M | 0.0% | +29.4% | 0.128% | |
| 1/30/2019 | Equitec Specialists LLC | 9,817 | $0.36M | 0.1% | +30.6% | 0.017% | |
| 1/22/2019 | Bank of Montreal Can | 790 | $29K | 0.0% | +116.9% | 0.001% | |
| 1/17/2019 | Meeder Asset Management Inc. | 2,910 | $0.11M | 0.0% | +24.2% | 0.005% | |
| 12/13/2018 | Vanguard Group Inc | 4,195,674 | $163.51M | 0.0% | +19.9% | 7.462% | |
| 12/13/2018 | Federated Investors Inc. PA | 61,489 | $2.40M | 0.0% | -16.6% | 0.109% | |
| 11/23/2018 | Vanguard Group Inc. | 4,195,674 | $163.51M | 0.0% | +19.9% | 7.462% | |
| 11/20/2018 | Morgan Stanley | 82,108 | $3.20M | 0.0% | -31.0% | 0.146% | |
| 11/20/2018 | Legal & General Group Plc | 17,211 | $0.67M | 0.0% | +36.6% | 0.031% | |
| 11/16/2018 | TIAA CREF Investment Management LLC | 145,811 | $5.68M | 0.0% | -5.5% | 0.259% | |
| 11/16/2018 | Teachers Advisors LLC | 91,034 | $3.55M | 0.0% | +3.2% | 0.162% | |
| 11/15/2018 | AQR Capital Management LLC | 63,061 | $2.46M | 0.0% | +33.9% | 0.112% | |
| 11/15/2018 | MetLife Investment Advisors LLC | 33,234 | $1.30M | 0.0% | +26.2% | 0.059% | |
| 11/15/2018 | Point72 Asset Management L.P. | 37,500 | $1.46M | 0.0% | +50.0% | 0.067% | |
| 11/15/2018 | Redmile Group LLC | 3,030,143 | $118.09M | 3.6% | -4.0% | 5.389% | |
| 11/15/2018 | First Light Asset Management LLC | 467,653 | $18.22M | 2.9% | -25.2% | 0.832% | |
| 11/15/2018 | Vident Investment Advisory LLC | 57,438 | $2.24M | 0.1% | -7.1% | 0.102% | |
| 11/14/2018 | BlueMountain Capital Management LLC | 3,306 | $0.13M | 0.0% | +128.6% | 0.006% | |
| 11/14/2018 | Perceptive Advisors LLC | 828,095 | $32.27M | 0.9% | -40.8% | 1.473% | |
| 11/14/2018 | Virtus ETF Advisers LLC | 11,509 | $0.45M | 0.0% | -254.6% | 0.020% | |
| 11/14/2018 | Baker BROS. Advisors LP | 602,495 | $23.48M | 0.2% | -81.0% | 1.071% | |
| 11/14/2018 | Dynamic Technology Lab Private Ltd | 10,526 | $0.41M | 0.1% | +50.0% | 0.019% | |
| 11/13/2018 | Loomis Sayles & Co. L P | 427,608 | $16.66M | 0.0% | +11.6% | 0.760% | |
| 11/13/2018 | JPMorgan Chase & Co. | 251,155 | $9.79M | 0.0% | +4.7% | 0.447% | |
| 11/13/2018 | Tower Research Capital LLC TRC | 3,641 | $0.14M | 0.0% | +50.0% | 0.006% | |
| 11/13/2018 | Primecap Management Co. CA | 7,621,743 | $297.02M | 0.2% | +0.7% | 13.555% | |
| 11/13/2018 | Franklin Resources Inc. | 497,074 | $19.37M | 0.0% | -19.0% | 0.884% | |
| 11/13/2018 | Dimensional Fund Advisors LP | 279,839 | $10.91M | 0.0% | +11.9% | 0.498% | |
| 11/13/2018 | Virtu Financial LLC | 21,956 | $0.86M | 0.0% | +50.0% | 0.039% | |
| 11/13/2018 | Credit Suisse AG | 50,529 | $1.97M | 0.0% | -18.6% | 0.090% | |
| 11/9/2018 | FMR LLC | 8,373,916 | $326.33M | 0.0% | +0.4% | 14.892% | |
| 11/9/2018 | Artal Group S.A. | 500,000 | $19.49M | 0.5% | +16.7% | 0.889% | |
| 11/9/2018 | BlackRock Inc. | 4,051,683 | $157.90M | 0.0% | +1.0% | 7.206% | |
| 11/9/2018 | Bank of New York Mellon Corp | 221,811 | $8.64M | 0.0% | -11.2% | 0.394% | |
| 11/8/2018 | Swiss National Bank | 87,300 | $3.40M | 0.0% | +2.2% | 0.155% | |
| 11/7/2018 | Rhumbline Advisers | 42,088 | $1.64M | 0.0% | -45.2% | 0.075% | |
| 11/7/2018 | Prudential Financial Inc. | 93,736 | $3.65M | 0.0% | +623.8% | 0.168% | |
