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Xencor (XNCR) Competitors

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$24.84 +0.07 (+0.28%)
Closing price 10/2/2026 04:00 PM Eastern
Extended Trading
$25.05 +0.21 (+0.85%)
As of 10/2/2026 07:41 PM Eastern
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XNCR vs. SYRE, ALKS, IMVT, RYTM, and IOVA

Should you buy Xencor stock or one of its competitors? Xencor's main competitors and comparable companies include Spyre Therapeutics (SYRE), Alkermes (ALKS), Immunovant (IMVT), Rhythm Pharmaceuticals (RYTM), and Iovance Biotherapeutics (IOVA). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Xencor compare to Spyre Therapeutics?

Xencor (NASDAQ:XNCR) and Spyre Therapeutics (NASDAQ:SYRE) are both healthcare companies, but which is the superior stock? We will contrast the two businesses based on the strength of their valuation, risk, institutional ownership, dividends, profitability, analyst recommendations, earnings and media sentiment.

Xencor currently has a consensus target price of $34.00, suggesting a potential upside of 36.88%. Spyre Therapeutics has a consensus target price of $109.71, suggesting a potential upside of 17.73%. Given Xencor's higher possible upside, equities research analysts clearly believe Xencor is more favorable than Spyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Xencor
1 Sell rating(s)
3 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.64
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.88

Xencor has a beta of 0.89, indicating that its share price is 11% less volatile than the broader market. Comparatively, Spyre Therapeutics has a beta of 3.1, indicating that its share price is 210% more volatile than the broader market.

In the previous week, Spyre Therapeutics had 5 more articles in the media than Xencor. MarketBeat recorded 15 mentions for Spyre Therapeutics and 10 mentions for Xencor. Xencor's average media sentiment score of 0.58 beat Spyre Therapeutics' score of 0.43 indicating that Xencor is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Xencor
2 Very Positive mention(s)
4 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Spyre Therapeutics
5 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
1 Negative mention(s)
0 Very Negative mention(s)
Neutral

Xencor has higher revenue and earnings than Spyre Therapeutics. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Xencor, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Xencor$104.97M17.59-$91.92M-$2.17N/A
Spyre Therapeutics$890K9,208.01-$155.20M-$1.95N/A

80.4% of Spyre Therapeutics shares are owned by institutional investors. 5.1% of Xencor shares are owned by company insiders. Comparatively, 15.7% of Spyre Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

Spyre Therapeutics has a net margin of 0.00% compared to Xencor's net margin of -155.59%. Xencor's return on equity of -28.66% beat Spyre Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Xencor-155.59% -28.66% -20.38%
Spyre Therapeutics N/A -30.74%-22.23%

Summary

Spyre Therapeutics beats Xencor on 9 of the 16 factors compared between the two stocks.

How does Xencor compare to Alkermes?

Xencor (NASDAQ:XNCR) and Alkermes (NASDAQ:ALKS) are both healthcare companies, but which is the better business? We will contrast the two businesses based on the strength of their profitability, analyst recommendations, institutional ownership, risk, earnings, media sentiment, dividends and valuation.

Alkermes has higher revenue and earnings than Xencor. Xencor is trading at a lower price-to-earnings ratio than Alkermes, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Xencor$104.97M17.59-$91.92M-$2.17N/A
Alkermes$1.48B4.75$241.66M$0.38109.87

Xencor currently has a consensus target price of $34.00, indicating a potential upside of 36.88%. Alkermes has a consensus target price of $54.47, indicating a potential upside of 30.47%. Given Xencor's higher probable upside, equities analysts plainly believe Xencor is more favorable than Alkermes.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Xencor
1 Sell rating(s)
3 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.64
Alkermes
1 Sell rating(s)
5 Hold rating(s)
11 Buy rating(s)
2 Strong Buy rating(s)
2.74

Alkermes has a net margin of 3.96% compared to Xencor's net margin of -155.59%. Alkermes' return on equity of 4.15% beat Xencor's return on equity.

Company Net Margins Return on Equity Return on Assets
Xencor-155.59% -28.66% -20.38%
Alkermes 3.96%4.15%2.19%

95.2% of Alkermes shares are held by institutional investors. 5.1% of Xencor shares are held by company insiders. Comparatively, 4.6% of Alkermes shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

In the previous week, Xencor had 4 more articles in the media than Alkermes. MarketBeat recorded 10 mentions for Xencor and 6 mentions for Alkermes. Alkermes' average media sentiment score of 0.82 beat Xencor's score of 0.58 indicating that Alkermes is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Xencor
2 Very Positive mention(s)
4 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Alkermes
2 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Xencor has a beta of 0.89, meaning that its share price is 11% less volatile than the broader market. Comparatively, Alkermes has a beta of 0.32, meaning that its share price is 68% less volatile than the broader market.

Summary

Alkermes beats Xencor on 12 of the 17 factors compared between the two stocks.

How does Xencor compare to Immunovant?

Immunovant (NASDAQ:IMVT) and Xencor (NASDAQ:XNCR) are both healthcare companies, but which is the superior investment? We will contrast the two companies based on the strength of their dividends, earnings, media sentiment, valuation, institutional ownership, profitability, risk and analyst recommendations.

Immunovant has a net margin of 0.00% compared to Xencor's net margin of -155.59%. Xencor's return on equity of -28.66% beat Immunovant's return on equity.

Company Net Margins Return on Equity Return on Assets
ImmunovantN/A -69.59% -62.49%
Xencor -155.59%-28.66%-20.38%

In the previous week, Xencor had 2 more articles in the media than Immunovant. MarketBeat recorded 10 mentions for Xencor and 8 mentions for Immunovant. Xencor's average media sentiment score of 0.58 beat Immunovant's score of 0.00 indicating that Xencor is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Immunovant
2 Very Positive mention(s)
0 Positive mention(s)
5 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral
Xencor
2 Very Positive mention(s)
4 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Xencor has higher revenue and earnings than Immunovant. Immunovant is trading at a lower price-to-earnings ratio than Xencor, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
ImmunovantN/AN/A-$505.61M-$2.82N/A
Xencor$104.97M17.59-$91.92M-$2.17N/A

Immunovant currently has a consensus price target of $44.00, indicating a potential upside of 30.87%. Xencor has a consensus price target of $34.00, indicating a potential upside of 36.88%. Given Xencor's stronger consensus rating and higher probable upside, analysts plainly believe Xencor is more favorable than Immunovant.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Immunovant
1 Sell rating(s)
3 Hold rating(s)
8 Buy rating(s)
0 Strong Buy rating(s)
2.58
Xencor
1 Sell rating(s)
3 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.64

Immunovant has a beta of 0.84, suggesting that its share price is 16% less volatile than the broader market. Comparatively, Xencor has a beta of 0.89, suggesting that its share price is 11% less volatile than the broader market.

47.1% of Immunovant shares are held by institutional investors. 1.9% of Immunovant shares are held by insiders. Comparatively, 5.1% of Xencor shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

Summary

Xencor beats Immunovant on 13 of the 16 factors compared between the two stocks.

How does Xencor compare to Rhythm Pharmaceuticals?

Rhythm Pharmaceuticals (NASDAQ:RYTM) and Xencor (NASDAQ:XNCR) are both healthcare companies, but which is the superior stock? We will contrast the two businesses based on the strength of their valuation, media sentiment, earnings, institutional ownership, profitability, risk, dividends and analyst recommendations.

Xencor has lower revenue, but higher earnings than Rhythm Pharmaceuticals. Rhythm Pharmaceuticals is trading at a lower price-to-earnings ratio than Xencor, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Rhythm Pharmaceuticals$239.92M26.52-$196.54M-$3.11N/A
Xencor$104.97M17.59-$91.92M-$2.17N/A

Rhythm Pharmaceuticals presently has a consensus target price of $140.67, indicating a potential upside of 51.53%. Xencor has a consensus target price of $34.00, indicating a potential upside of 36.88%. Given Rhythm Pharmaceuticals' stronger consensus rating and higher possible upside, equities analysts clearly believe Rhythm Pharmaceuticals is more favorable than Xencor.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Rhythm Pharmaceuticals
1 Sell rating(s)
3 Hold rating(s)
17 Buy rating(s)
0 Strong Buy rating(s)
2.76
Xencor
1 Sell rating(s)
3 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.64

Rhythm Pharmaceuticals has a beta of 2.01, indicating that its stock price is 101% more volatile than the broader market. Comparatively, Xencor has a beta of 0.89, indicating that its stock price is 11% less volatile than the broader market.

Rhythm Pharmaceuticals has a net margin of -85.59% compared to Xencor's net margin of -155.59%. Xencor's return on equity of -28.66% beat Rhythm Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Rhythm Pharmaceuticals-85.59% -159.87% -44.00%
Xencor -155.59%-28.66%-20.38%

In the previous week, Xencor had 6 more articles in the media than Rhythm Pharmaceuticals. MarketBeat recorded 10 mentions for Xencor and 4 mentions for Rhythm Pharmaceuticals. Xencor's average media sentiment score of 0.58 beat Rhythm Pharmaceuticals' score of 0.26 indicating that Xencor is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Rhythm Pharmaceuticals
1 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Xencor
2 Very Positive mention(s)
4 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Xencor beats Rhythm Pharmaceuticals on 8 of the 15 factors compared between the two stocks.

How does Xencor compare to Iovance Biotherapeutics?

Iovance Biotherapeutics (NASDAQ:IOVA) and Xencor (NASDAQ:XNCR) are both healthcare companies, but which is the better business? We will contrast the two companies based on the strength of their earnings, risk, analyst recommendations, dividends, institutional ownership, valuation, profitability and media sentiment.

Iovance Biotherapeutics has a net margin of -89.11% compared to Xencor's net margin of -155.59%. Xencor's return on equity of -28.66% beat Iovance Biotherapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Iovance Biotherapeutics-89.11% -40.51% -31.65%
Xencor -155.59%-28.66%-20.38%

In the previous week, Iovance Biotherapeutics had 39 more articles in the media than Xencor. MarketBeat recorded 49 mentions for Iovance Biotherapeutics and 10 mentions for Xencor. Iovance Biotherapeutics' average media sentiment score of 0.63 beat Xencor's score of 0.58 indicating that Iovance Biotherapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Iovance Biotherapeutics
11 Very Positive mention(s)
8 Positive mention(s)
12 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Xencor
2 Very Positive mention(s)
4 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Xencor has lower revenue, but higher earnings than Iovance Biotherapeutics. Iovance Biotherapeutics is trading at a lower price-to-earnings ratio than Xencor, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Iovance Biotherapeutics$324.97M19.82-$390.98M-$0.73N/A
Xencor$104.97M17.59-$91.92M-$2.17N/A

77.0% of Iovance Biotherapeutics shares are owned by institutional investors. 7.8% of Iovance Biotherapeutics shares are owned by insiders. Comparatively, 5.1% of Xencor shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

Iovance Biotherapeutics currently has a consensus price target of $12.40, indicating a potential downside of 12.80%. Xencor has a consensus price target of $34.00, indicating a potential upside of 36.88%. Given Xencor's higher possible upside, analysts clearly believe Xencor is more favorable than Iovance Biotherapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Iovance Biotherapeutics
1 Sell rating(s)
2 Hold rating(s)
9 Buy rating(s)
0 Strong Buy rating(s)
2.67
Xencor
1 Sell rating(s)
3 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.64

Iovance Biotherapeutics has a beta of 0.75, meaning that its share price is 25% less volatile than the broader market. Comparatively, Xencor has a beta of 0.89, meaning that its share price is 11% less volatile than the broader market.

Summary

Iovance Biotherapeutics beats Xencor on 10 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding XNCR and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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XNCR vs. The Competition

MetricXencorBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$1.84B$3.87B$7.14B$13.17B
Dividend YieldN/A3.64%2.53%16.77%
P/E Ratio-11.4513.06274.3326.04
Price / Sales17.591,290.02616.1185.50
Price / CashN/A122.6077.6051.75
Price / Book2.7916.6310.936.31
Net Income-$91.92M-$22.71M$3.51B$362.16M
7 Day Performance4.37%-2.98%-2.02%-1.67%
1 Month Performance-6.69%-10.59%-6.17%-4.51%
1 Year Performance111.05%19.46%7.45%2.03%

Xencor Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
XNCR
Xencor
2.0091 of 5 stars
$24.84
+0.3%
$34.00
+36.9%
+110.2%$1.84B$104.97MN/A260
SYRE
Spyre Therapeutics
2.0803 of 5 stars
$83.91
-2.2%
$109.69
+30.7%
+483.2%$7.37B$890KN/A112
ALKS
Alkermes
2.8189 of 5 stars
$40.64
+1.2%
$54.47
+34.0%
+33.6%$6.80B$1.48B106.672,050
IMVT
Immunovant
2.0669 of 5 stars
$32.58
-2.7%
$44.00
+35.0%
+101.0%$6.73BN/AN/A315
RYTM
Rhythm Pharmaceuticals
2.7009 of 5 stars
$96.45
-2.1%
$140.67
+45.9%
-4.5%$6.60B$189.76MN/A414

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This page (NASDAQ:XNCR) was last updated on 10/3/2026 by MarketBeat.com Staff.
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