Prime Medicine (PRME) Competitors $4.07 -0.01 (-0.25%) Closing price 09/12/2025 04:00 PM EasternExtended Trading$4.06 -0.02 (-0.37%) As of 09/12/2025 07:51 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock PRME vs. APGE, CDTX, BEAM, TWST, BHVN, IMCR, AUPH, TVTX, ARDX, and WVEShould you be buying Prime Medicine stock or one of its competitors? The main competitors of Prime Medicine include Apogee Therapeutics (APGE), Cidara Therapeutics (CDTX), Beam Therapeutics (BEAM), Twist Bioscience (TWST), Biohaven (BHVN), Immunocore (IMCR), Aurinia Pharmaceuticals (AUPH), Travere Therapeutics (TVTX), Ardelyx (ARDX), and WAVE Life Sciences (WVE). These companies are all part of the "pharmaceutical products" industry. Prime Medicine vs. Its Competitors Apogee Therapeutics Cidara Therapeutics Beam Therapeutics Twist Bioscience Biohaven Immunocore Aurinia Pharmaceuticals Travere Therapeutics Ardelyx WAVE Life Sciences Prime Medicine (NYSE:PRME) and Apogee Therapeutics (NASDAQ:APGE) are both small-cap medical companies, but which is the better stock? We will compare the two businesses based on the strength of their earnings, dividends, risk, profitability, institutional ownership, valuation, analyst recommendations and media sentiment. Does the media prefer PRME or APGE? In the previous week, Apogee Therapeutics had 9 more articles in the media than Prime Medicine. MarketBeat recorded 12 mentions for Apogee Therapeutics and 3 mentions for Prime Medicine. Apogee Therapeutics' average media sentiment score of 1.32 beat Prime Medicine's score of 0.26 indicating that Apogee Therapeutics is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Prime Medicine 0 Very Positive mention(s) 0 Positive mention(s) 3 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Neutral Apogee Therapeutics 8 Very Positive mention(s) 0 Positive mention(s) 3 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Which has higher valuation and earnings, PRME or APGE? Apogee Therapeutics has lower revenue, but higher earnings than Prime Medicine. Apogee Therapeutics is trading at a lower price-to-earnings ratio than Prime Medicine, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioPrime Medicine$4.96M110.40-$198.13M-$1.56-2.61Apogee TherapeuticsN/AN/A-$182.15M-$4.13-8.93 Do institutionals and insiders hold more shares of PRME or APGE? 70.4% of Prime Medicine shares are owned by institutional investors. Comparatively, 79.0% of Apogee Therapeutics shares are owned by institutional investors. 22.7% of Prime Medicine shares are owned by company insiders. Comparatively, 42.8% of Apogee Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term. Which has more volatility & risk, PRME or APGE? Prime Medicine has a beta of 2.38, suggesting that its share price is 138% more volatile than the S&P 500. Comparatively, Apogee Therapeutics has a beta of 1.42, suggesting that its share price is 42% more volatile than the S&P 500. Do analysts prefer PRME or APGE? Prime Medicine presently has a consensus target price of $8.92, suggesting a potential upside of 119.08%. Apogee Therapeutics has a consensus target price of $97.29, suggesting a potential upside of 163.79%. Given Apogee Therapeutics' stronger consensus rating and higher possible upside, analysts clearly believe Apogee Therapeutics is more favorable than Prime Medicine.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Prime Medicine 0 Sell rating(s) 3 Hold rating(s) 4 Buy rating(s) 1 Strong Buy rating(s) 2.75Apogee Therapeutics 0 Sell rating(s) 1 Hold rating(s) 7 Buy rating(s) 0 Strong Buy rating(s) 2.88 Is PRME or APGE more profitable? Apogee Therapeutics' return on equity of -34.65% beat Prime Medicine's return on equity.Company Net Margins Return on Equity Return on Assets Prime MedicineN/A -107.87% -74.97% Apogee Therapeutics N/A -34.65%-32.76% SummaryApogee Therapeutics beats Prime Medicine on 10 of the 15 factors compared between the two stocks. Get Prime Medicine News Delivered to You Automatically Sign up to receive the latest news and ratings for PRME and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding PRME and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NYSE and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart PRME vs. The Competition Export to ExcelMetricPrime MedicineBiological Products IndustryMedical SectorNYSE ExchangeMarket Cap$547.72M$287.04M$5.86B$21.59BDividend YieldN/AN/A5.68%3.48%P/E Ratio-1.99N/A75.2029.75Price / Sales110.40420.31514.9786.32Price / CashN/A22.4437.5625.00Price / Book2.9710.9112.154.58Net Income-$198.13M-$111.61M$3.29B$999.94M7 Day Performance9.41%-0.34%0.75%0.68%1 Month Performance6.82%3.23%4.82%3.10%1 Year Performance-0.49%-16.04%60.59%14.39% Prime Medicine Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)PRMEPrime Medicine3.2911 of 5 stars$4.07-0.2%$8.92+119.1%+0.5%$547.72M$4.96M-1.99234APGEApogee Therapeutics2.928 of 5 stars$36.37-0.7%$97.29+167.5%-25.0%$1.68BN/A-8.8191News CoveragePositive NewsCDTXCidara Therapeutics3.2774 of 5 stars$65.39+0.2%$64.14-1.9%+478.1%$1.66B$1.27M-5.8890Positive NewsBEAMBeam Therapeutics2.8753 of 5 stars$16.36-2.9%$48.45+196.2%-15.6%$1.66B$60.27M-3.64510TWSTTwist Bioscience3.9726 of 5 stars$26.97+1.4%$49.40+83.2%-43.2%$1.63B$362.27M-18.60990News CoverageBHVNBiohaven3.2792 of 5 stars$15.35-1.1%$54.23+253.2%-61.0%$1.62BN/A-2.00239Trending NewsGap DownIMCRImmunocore1.8645 of 5 stars$32.22-0.1%$56.89+76.6%+6.7%$1.62B$356.15M-80.55320AUPHAurinia Pharmaceuticals2.9246 of 5 stars$11.99-0.7%$12.00+0.1%+93.6%$1.58B$235.13M27.88300News CoveragePositive NewsTVTXTravere Therapeutics2.995 of 5 stars$17.50-1.1%$33.43+91.0%+86.3%$1.56B$333.87M-8.58460News CoverageAnalyst ForecastARDXArdelyx4.6288 of 5 stars$6.36-0.3%$11.50+80.8%+6.3%$1.53B$333.61M-27.6590News CoveragePositive NewsWVEWAVE Life Sciences4.555 of 5 stars$9.60-3.3%$20.27+111.1%+18.9%$1.53B$108.30M-10.67240Positive News Related Companies and Tools Related Companies Apogee Therapeutics Alternatives Cidara Therapeutics Alternatives Beam Therapeutics Alternatives Twist Bioscience Alternatives Biohaven Alternatives Immunocore Alternatives Aurinia Pharmaceuticals Alternatives Travere Therapeutics Alternatives Ardelyx Alternatives WAVE Life Sciences Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NYSE:PRME) was last updated on 9/13/2025 by MarketBeat.com Staff From Our PartnersWhy Trump’s “Smart Dollar” could rewrite the rulesMUST SEE: Donald Trump's Radical Overhaul of the U.S. Dollar Congress just approved President Trump's lates...Stansberry Research | SponsoredTrump's Law S.1582: $21T Dollar Revolution ComingDo you have money in any of these banks? 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