NYSEARCA:XBI SPDR S&P Biotech ETF (XBI) Price, Holdings, & News $163.38 -6.17 (-3.64%) As of 04:10 PM Eastern Add Compare Share Share Stock Analysis Stock AnalysisChartDividendHeadlinesHoldingsOwnershipRatingsShort InterestBuy This Stock About SPDR S&P Biotech ETF (NYSEARCA:XBI) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get SPDR S&P Biotech ETF alerts:Sign Up Key Stats Today's Range$162.53▼$167.5350-Day Range$132.74▼$169.5552-Week Range$88.23▼$169.68Volume15.02 million shsAverage Volume9.20 million shsMarket Capitalization$10.67 billionAssets Under Management$11.83 billionDividend Yield0.35%Net Expense Ratio0.35%Aggregate RatingModerate Buy ETF Overview SPDR S&P Biotech ETF (the Fund) seeks to closely match the returns and characteristics of the S&P Biotechnology Select Industry Index. The S&P Biotechnology Select Industry Index represents the biotechnology sub-industry portion of the S&P Total Markets Index. The S&P TMI tracks all the United States common stocks listed on the New York Stock Exchange, American Stock Exchange, National Association of Securities Dealers Automated Quotation (NASDAQ) National Market and NASDAQ Small Cap exchanges. The Biotech Index is a modified equal weight index. SSgA Funds Management, Inc. is the Fund's investment advisor. Read More SPDR S&P Biotech ETF ExpensesTypeXBIHealth Care ETFsEquity ETFsNYSEARCA ETFsAll ETFsManagement Fee0.35%0.55%0.57%0.51%0.53%Other Expenses0.00%0.52%0.53%0.60%0.54%Total Expense0.35%0.76%0.75%0.75%0.73%Fee Waiver0.00%-0.85%-0.67%-0.77%-0.68%Net Expense0.35%0.58%0.63%0.57%0.60% Receive XBI Stock News and Ratings via Email Sign-up to receive the latest news and ratings for SPDR S&P Biotech ETF and its competitors with MarketBeat's FREE daily newsletter. 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XBI ETF News HeadlinesXBI: Biotech's Breakthrough Moment Happend This Week (Upgrade)3 hours ago | seekingalpha.comXBI vs. FBT: Broad Biotech Exposure or Concentrated Bets?August 19 at 10:04 AM | finance.yahoo.comLook at this $5 stock’s addressA small public company trading under $5 a share operates inside the secure perimeter of Kennedy Space Center, right alongside SpaceX and Blue Origin. It holds a special agreement to use a multi-billion dollar federal launch facility for just $500, and its customer list already includes the Pentagon, Lockheed Martin, and GE Aerospace. Most Wall Street analysts have not caught on yet, but a major milestone could change that soon.August 20 at 1:00 AM | Freedom Financial (Ad)Which Healthcare ETF Is the Better Buy: VanEck's Pharma PPH or State Street's Biotech XBI?August 18 at 6:33 PM | finance.yahoo.comiShares Global Healthcare ETF vs State Street SPDR Biotech ETF. Which Healthcare-Focused Fund Will Bring You Profits in 2026 and Beyond?August 8, 2026 | fool.comThese New Drugs Could Fuel Fresh Highs for Biotech and Pharma StocksAugust 7, 2026 | barrons.comSee More Headlines XBI ETF - Frequently Asked Questions How have XBI shares performed this year? SPDR S&P Biotech ETF's stock was trading at $121.93 on January 1st, 2026. Since then, XBI stock has increased by 34.0% and is now trading at $163.39. Who are SPDR S&P Biotech ETF's major shareholders? Top institutional shareholders of SPDR S&P Biotech ETF include Northwestern Mutual Wealth Management Co. (0.48%), Annex Advisory Services LLC (0.37%), Wellington Management Group LLP (0.19%) and Polymer Capital Management HK LTD (0.16%). How do I buy shares of SPDR S&P Biotech ETF? Shares of XBI stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of SPDR S&P Biotech ETF own? Based on aggregate information from My MarketBeat watchlists, some other companies that SPDR S&P Biotech ETF investors own include American Water Works (AWK), Waste Connections (WCN), The RMR Group (RMR), iShares Micro-Cap ETF (IWC), Voyager Therapeutics (VYGR), DiamondRock Hospitality (DRH) and Humana (HUM). Fund Details IssuerSSgA Fund NameSPDR S&P Biotech ETF Tax ClassificationRegulated Investment Company Stock ExchangeNYSEARCACurrent SymbolNYSEARCA:XBI Inception Date1/31/2006 Fund ManagerMichael Feehily, Karl Schneider, Raymond Donofrio Webwww.spdrs.com Phone+1-866-7872257Fund Focus Asset ClassEquity BenchmarkS&P Biotechnology Select Industry Index CategorySector FocusHealth Care Development LevelDeveloped Markets RegionNorth America Number of Holdings167 Fund Statistics Assets Under Management$11.83 billion Average Daily Volume$7.79 million Discount/Premium0.07% Administrator, Advisor and Custodian AdministratorState Street Global Advisors Funds Management, Inc. AdvisorSSgA Funds Management, Inc. CustodianState Street Bank and Trust Company DistributorState Street Global Advisors Funds Distributors, LLC Transfer AgentState Street Bank and Trust Company TrusteeN/A Lead Market MakerVirtu Financial Options OptionableOptionable Options Volume60,509 Put Options23,519 Call Options36,990 Short Interest78,847,922 shs Miscellaneous Outstanding Shares65,300,000Beta0.83 Creation Unit50,000 Creation Fee$250.00 Don't Wait for the OpenAI IPOThe AI wave will soon hit public markets with Anthropic and OpenAI set to go public later this year. However, you don't have to wait to invest. This report shows seven AI stocks that you can buy today while the big model providers get ready to go public.Get This Free Report Top 10 XBI HoldingsTwist Bioscience (NASDAQ:TWST)Holding Weight: 1.76%Oruka Therapeutics (NASDAQ:ORKA)Holding Weight: 1.61%Apogee Therapeutics (NASDAQ:APGE)Holding Weight: 1.55%Praxis Precision Medicines (NASDAQ:PRAX)Holding Weight: 1.46%Kymera Therapeutics (NASDAQ:KYMR)Holding Weight: 1.39%Dianthus Therapeutics (NASDAQ:DNTH)Holding Weight: 1.37%Natera (NASDAQ:NTRA)Holding Weight: 1.37%Halozyme Therapeutics (NASDAQ:HALO)Holding Weight: 1.36%Protagonist Therapeutics (NASDAQ:PTGX)Holding Weight: 1.36%Revolution Medicines (NASDAQ:RVMD)Holding Weight: 1.33%Full Holdings DetailsXBI Sector ExposureXBI Industry Exposure This page (NYSEARCA:XBI) was last updated on 8/20/2026 by MarketBeat.com Staff. From Our PartnersThe retirement stock I'd buy before Nvidia todayIn 2014, Marc Chaikin pointed readers toward Nvidia. 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