Orbimed Advisors LLC Top Holdings and 13F Report (2025) About Orbimed Advisors LLCInvestment ActivityOrbimed Advisors LLC has $4.19 billion in total holdings as of March 31, 2025.Orbimed Advisors LLC owns shares of 108 different stocks, but just 30 companies or ETFs make up 80% of its holdings.Approximately 11.82% of the portfolio was purchased this quarter.About 16.32% of the portfolio was sold this quarter.This quarter, Orbimed Advisors LLC has purchased 113 new stocks and bought additional shares in 17 stocks.Orbimed Advisors LLC sold shares of 24 stocks and completely divested from 15 stocks this quarter.Largest Holdings Sinovac Biotech $333,996,595Edgewise Therapeutics $330,477,862Boston Scientific $283,795,616Eli Lilly and Company $278,827,216Enliven Therapeutics $156,643,708 Largest New Holdings this Quarter 05464T104 - Axsome Therapeutics $45,100,821 Holding829401108 - SIONNA THERAPEUTICS INC $38,753,871 Holding87650L103 - Tarsus Pharmaceuticals $33,582,778 Holding03753U106 - Apellis Pharmaceuticals $31,324,401 Holding031162100 - Amgen $13,770,510 Holding Largest Purchases this Quarter Pfizer 4,100,200 shares (about $103.90M)Axsome Therapeutics 386,700 shares (about $45.10M)SIONNA THERAPEUTICS INC 3,704,959 shares (about $38.75M)UnitedHealth Group 70,300 shares (about $36.82M)Tarsus Pharmaceuticals 653,743 shares (about $33.58M) Largest Sales this Quarter Intuitive Surgical 110,700 shares (about $54.83M)Tenet Healthcare 352,000 shares (about $47.34M)Boston Scientific 347,100 shares (about $35.02M)Gilead Sciences 248,100 shares (about $27.80M)SPDR S&P Biotech ETF 272,000 shares (about $22.06M) Sector Allocation Over TimeMap of 500 Largest Holdings ofOrbimed Advisors LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorSVASinovac Biotech$333,996,5950.0%2,718,7358.0%MedicalEWTXEdgewise Therapeutics$330,477,8620.0%15,021,7217.9%MedicalBSXBoston Scientific$283,795,616$35,015,448 ▼-11.0%2,813,2006.8%MedicalLLYEli Lilly and Company$278,827,2160.0%337,6006.6%MedicalELVNEnliven Therapeutics$156,643,7080.0%7,959,5383.7%MedicalISRGIntuitive Surgical$144,123,570$54,826,389 ▼-27.6%291,0003.4%MedicalSYKStryker$133,712,200$5,509,300 ▲4.3%359,2003.2%MedicalARGXargenx$122,338,496$10,061,705 ▲9.0%206,7002.9%MedicalEWEdwards Lifesciences$111,039,360$28,027,871 ▲33.8%1,532,0002.6%MedicalPFEPfizer$110,234,068$103,899,068 ▲1,640.1%4,350,2002.6%MedicalUNHUnitedHealth Group$105,378,500$36,819,625 ▲53.7%201,2002.5%MedicalSPRYARS Pharmaceuticals$104,269,4560.0%8,288,5102.5%MedicalNBIXNeurocrine Biosciences$103,371,184$384,888 ▼-0.4%934,6402.5%MedicalALNYAlnylam Pharmaceuticals$93,453,922$18,766,390 ▼-16.7%346,1002.2%MedicalITGRInteger$78,181,625$10,325,875 ▲15.2%662,5001.9%MedicalVRTXVertex Pharmaceuticals$77,522,718$4,314,898 ▲5.9%159,9001.8%MedicalNTRANatera$77,351,270$18,948,940 ▲32.4%547,0001.8%MedicalIONSIonis Pharmaceuticals$76,635,903$8,363,456 ▼-9.8%2,540,1361.8%MedicalIRONDisc Medicine$70,241,593$18,394,152 ▼-20.8%1,415,0201.7%MedicalTMOThermo Fisher Scientific$64,190,400$22,192,960 ▲52.8%129,0001.5%MedicalTHCTenet Healthcare$62,542,500$47,344,000 ▼-43.1%465,0001.5%MedicalCYTKCytokinetics$60,654,949$3,006,212 ▼-4.7%1,509,2051.4%MedicalCG ONCOLOGY INC$60,539,133$25,491,151 ▲72.7%2,471,9941.4%COMARRIVENT BIOPHARMA INC$55,975,2950.0%3,027,3281.3%COMRNAAvidity Biosciences$53,516,395$20,664,000 ▲62.9%1,812,8861.3%MedicalSWTXSpringWorks Therapeutics$49,549,164$5,835,354 ▼-10.5%1,122,8001.2%MedicalSIBNSI-BONE$48,303,228$3,507,500 ▼-6.8%3,442,8531.2%MedicalAXSMAxsome Therapeutics$45,100,821$45,100,821 ▲New Holding386,7001.1%MedicalCMPXCompass Therapeutics$42,489,4150.0%22,362,8501.0%MedicalNPCENeuroPace$41,863,8570.0%3,406,3351.0%MedicalSIONNA THERAPEUTICS INC$38,753,871$38,753,871 ▲New Holding3,704,9590.9%COMUPSTREAM BIO INC$34,844,7650.0%5,693,5890.8%COMXTNTXtant Medical$34,363,8580.0%73,114,5920.8%MedicalTARSTarsus Pharmaceuticals$33,582,778$33,582,778 ▲New Holding653,7430.8%MedicalCRNXCrinetics Pharmaceuticals$33,506,4600.0%999,0000.8%MedicalXENEXenon Pharmaceuticals$31,801,2730.0%947,8770.8%MedicalAPLSApellis Pharmaceuticals$31,324,401$31,324,401 ▲New Holding1,432,3000.7%MedicalMBX BIOSCIENCES INC$29,541,306$1,407,159 ▲5.0%4,002,8870.7%COMEXASExact Sciences$29,429,2350.0%679,8160.7%MedicalGILDGilead Sciences$22,129,875$27,799,605 ▼-55.7%197,5000.5%MedicalCRVSCorvus Pharmaceuticals$22,080,8200.0%6,943,6540.5%MedicalTERNTerns Pharmaceuticals$20,873,8000.0%7,562,9710.5%MedicalJANXJanux Therapeutics$20,481,2820.0%758,5660.5%MedicalRYTMRhythm Pharmaceuticals$20,128,600$1,059,400 ▼-5.0%380,0000.5%MedicalTHRDTF Financial$20,053,3760.0%5,779,0710.5%MedicalFOLDAmicus Therapeutics$18,648,8640.0%2,285,4000.4%MedicalVSTMVerastem$17,260,5610.0%2,862,4480.4%MedicalTYRATyra Biosciences$16,301,328$2,629,528 ▲19.2%1,752,8310.4%MedicalRAPTRAPT Therapeutics$16,025,0170.0%13,135,2600.4%MedicalSCPHscPharmaceuticals$15,936,5590.0%6,059,5280.4%MedicalVIRVir Biotechnology$14,568,654$6,287,985 ▼-30.1%2,248,2490.3%MedicalCGEMCullinan Therapeutics$14,563,582$141,559 ▼-1.0%1,923,8550.3%MedicalIMTXImmatics$13,924,4540.0%3,087,4620.3%MedicalGPCRStructure Therapeutics$13,883,1050.0%802,0280.3%MedicalAMGNAmgen$13,770,510$13,770,510 ▲New Holding44,2000.3%MedicalVERAVera Therapeutics$11,555,181$6,281,398 ▼-35.2%481,0650.3%MedicalCCCCC4 Therapeutics$10,928,480$3,683,840 ▲50.8%6,830,3000.3%MedicalDYNE THERAPEUTICS INC$10,612,831$2,222,426 ▼-17.3%1,014,6110.3%COMKROSKeros Therapeutics$10,380,8990.0%1,018,7340.2%MedicalSLRNAcelyrin$9,884,2260.0%4,001,7110.2%MedicalAGIOAgios Pharmaceuticals$9,537,150$8,754,840 ▲1,119.1%325,5000.2%MedicalABCLAbCellera Biologics$9,323,1130.0%4,180,7680.2%MedicalACETAdicet Bio$8,642,5910.0%11,447,1400.2%MedicalADCTADC Therapeutics$8,415,5160.0%5,968,4510.2%MedicalPRLDPrelude Therapeutics$8,378,3090.0%10,909,2560.2%MedicalIKENA ONCOLOGY INC$8,151,791$881,153 ▲12.1%6,368,5870.2%NONVOTINGXBISPDR S&P Biotech ETF$8,110,000$22,059,200 ▼-73.1%100,0000.2%ETFAVALO THERAPEUTICS INC$7,745,6700.0%967,0000.2%COM NEWAADIAadi Bioscience$7,415,480$7,415,480 ▲New Holding4,166,0000.2%MedicalAKROAkero Therapeutics$7,282,352$4,610,672 ▲172.6%179,9000.2%MedicalPMVPPMV Pharmaceuticals$7,058,0670.0%6,475,2910.2%MedicalTRVITrevi Therapeutics$7,044,800$7,044,800 ▲New Holding1,120,0000.2%MedicalKESTRA MED TECHNOLOGIES LTD$6,230,000$6,230,000 ▲New Holding250,0000.1%SHSCRBPCorbus Pharmaceuticals$6,224,8440.0%1,172,2870.1%MedicalNSPRInspireMD$5,738,8590.0%2,133,4050.1%MedicalSRRKScholar Rock$4,880,3700.0%151,8000.1%MedicalFORTE BIOSCIENCES INC$4,602,363$53,637 ▼-1.2%593,0880.1%COM NEWIKNAIkena Oncology$4,530,3780.0%3,539,3580.1%MedicalPRELUDE THERAPEUTICS INC$4,362,3830.0%5,680,1860.1%NONVOTINGKRYSKrystal Biotech$4,237,0500.0%23,5000.1%MedicalENGENE HOLDINGS INC$3,994,440$128,679 ▼-3.1%891,6160.1%COMORICORIC Pharmaceuticals$3,906,000$3,906,000 ▲New Holding700,0000.1%MedicalBICARA THERAPEUTICS INC$3,886,8620.0%298,3010.1%COMQ32 BIO INC$3,717,4290.0%2,252,9870.1%COMBIOAGE LABS INC$3,466,5660.0%921,9590.1%COMRPTXRepare Therapeutics$3,275,6410.0%3,322,4880.1%MedicalPASGPassage Bio$2,483,926$130,733 ▼-5.0%7,034,6260.1%MedicalINSMInsmed$2,186,395$5,027,511 ▼-69.7%28,6590.1%MedicalCERIBELL INC$2,161,1250.0%112,5000.1%COMINSTIL BIO INC$2,027,3880.0%116,7850.0%COM NEWCMMBChemomab Therapeutics$1,897,9880.0%1,741,2730.0%MedicalCRDFCardiff Oncology$1,801,996$3,028,775 ▼-62.7%573,8840.0%MedicalXFORX4 Pharmaceuticals$1,601,968$84,395 ▼-5.0%6,776,5150.0%MedicalNKTXNkarta$1,511,3760.0%821,4000.0%MedicalTRAWS PHARMA INC$1,392,7210.0%605,5310.0%COM NEWFATEFate Therapeutics$1,327,8260.0%1,680,5800.0%MedicalTURNSTONE BIOLOGICS CORP$1,270,6990.0%3,099,2650.0%COMAMLXAmylyx Pharmaceuticals$1,231,9200.0%348,0000.0%MedicalBIOMX INC$993,4620.0%1,787,7670.0%COM NEWKEZAR LIFE SCIENCES INC$940,3760.0%192,7000.0%COM NEWShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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