Orbimed Advisors LLC Top Holdings and 13F Report (2025) About Orbimed Advisors LLCInvestment ActivityOrbimed Advisors LLC has $4.00 billion in total holdings as of June 30, 2025.Orbimed Advisors LLC owns shares of 100 different stocks, but just 29 companies or ETFs make up 80% of its holdings.Approximately 9.58% of the portfolio was purchased this quarter.About 16.33% of the portfolio was sold this quarter.This quarter, Orbimed Advisors LLC has purchased 108 new stocks and bought additional shares in 20 stocks.Orbimed Advisors LLC sold shares of 23 stocks and completely divested from 24 stocks this quarter.Largest Holdings Sinovac Biotech $333,996,595Boston Scientific $302,165,812Eli Lilly and Company $263,169,328Edgewise Therapeutics $203,447,430Enliven Therapeutics $159,668,332 Largest New Holdings this Quarter 142152107 - CARIS LIFE SCIENCES INC $81,091,406 HoldingG76279101 - Roivant Sciences $31,324,142 Holding23284F105 - CytomX Therapeutics $19,207,605 Holding75382E208 - RAPT THERAPEUTICS INC $13,135,248 Holding603170101 - Mineralys Therapeutics $10,287,549 Holding Largest Purchases this Quarter CARIS LIFE SCIENCES INC 3,034,858 shares (about $81.09M)UnitedHealth Group 185,100 shares (about $57.75M)Roivant Sciences 2,779,427 shares (about $31.32M)Vertex Pharmaceuticals 50,387 shares (about $22.43M)CytomX Therapeutics 8,461,500 shares (about $19.21M) Largest Sales this Quarter Neurocrine Biosciences 496,100 shares (about $62.35M)Thermo Fisher Scientific 82,500 shares (about $33.45M)Integer 229,100 shares (about $28.17M)Compass Therapeutics 7,142,856 shares (about $18.57M)Tarsus Pharmaceuticals 455,843 shares (about $18.47M) Sector Allocation Over TimeMap of 500 Largest Holdings ofOrbimed Advisors LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorSVASinovac Biotech$333,996,5950.0%2,718,7358.3%MedicalBSXBoston Scientific$302,165,8120.0%2,813,2007.5%MedicalLLYEli Lilly and Company$263,169,3280.0%337,6006.6%MedicalEWTXEdgewise Therapeutics$203,447,430$6,512,668 ▲3.3%15,518,4925.1%MedicalELVNEnliven Therapeutics$159,668,3320.0%7,959,5384.0%MedicalISRGIntuitive Surgical$158,132,3100.0%291,0003.9%MedicalSPRYARS Pharmaceuticals$144,634,5000.0%8,288,5103.6%MedicalSYKStryker$142,110,2960.0%359,2003.5%MedicalEWEdwards Lifesciences$133,582,680$13,764,960 ▲11.5%1,708,0003.3%MedicalUNHUnitedHealth Group$120,514,011$57,745,647 ▲92.0%386,3003.0%MedicalARGXargenex$114,653,760$716,586 ▲0.6%208,0002.9%MedicalALNYAlnylam Pharmaceuticals$111,490,171$1,369,578 ▼-1.2%341,9002.8%MedicalNTRANatera$100,254,740$7,844,560 ▲8.5%593,4342.5%MedicalVRTXVertex Pharmaceuticals$93,619,772$22,432,292 ▲31.5%210,2872.3%MedicalTHCTenet Healthcare$81,840,0000.0%465,0002.0%MedicalCARIS LIFE SCIENCES INC$81,091,406$81,091,406 ▲New Holding3,034,8582.0%COMIRONDisc Medicine$74,939,4590.0%1,415,0201.9%MedicalARRIVENT BIOPHARMA INC$65,904,9310.0%3,027,3281.6%COMSIONNA THERAPEUTICS INC$64,281,0390.0%3,704,9591.6%COMUPSTREAM BIO INC$62,515,6070.0%5,693,5891.6%COMNBIXNeurocrine Biosciences$55,120,093$62,354,809 ▼-53.1%438,5401.4%MedicalITGRInteger$53,295,198$28,172,427 ▼-34.6%433,4001.3%MedicalCG ONCOLOGY INC$52,724,100$11,547,744 ▼-18.0%2,027,8501.3%COMRNAAvidity Biosciences$51,485,9620.0%1,812,8861.3%MedicalSIBNSiBone$48,536,385$16,258,109 ▼-25.1%2,578,9791.2%MedicalMBX BIOSCIENCES INC$45,672,9410.0%4,002,8871.1%COMAXSMAxsome Therapeutics$44,668,481$4,300,868 ▲10.7%427,9001.1%MedicalCMPXCompass Therapeutics$39,571,984$18,571,425 ▼-31.9%15,219,9941.0%MedicalCYTKCytokinetics$35,584,080$14,280,053 ▼-28.6%1,077,0000.9%MedicalCRNXCrinetics Pharmaceuticals$33,045,240$4,314,000 ▲15.0%1,149,0000.8%MedicalEXASExact Sciences$32,272,772$3,852,650 ▼-10.7%607,3160.8%MedicalTHRDThird Harmonic Bio$31,380,3560.0%5,779,0710.8%MedicalROIVRoivant Sciences$31,324,142$31,324,142 ▲New Holding2,779,4270.8%MedicalXENEXenon Pharmaceuticals$29,668,5500.0%947,8770.7%MedicalNPCENeuroPace$29,122,010$8,824,562 ▼-23.3%2,614,1840.7%MedicalCRVSCorvus Pharmaceuticals$28,660,024$885,408 ▲3.2%7,165,0060.7%MedicalTERNTerns Pharmaceuticals$28,209,8820.0%7,562,9710.7%MedicalJANXJanux Therapeutics$27,957,930$10,435,055 ▲59.6%1,210,3000.7%MedicalAPLSApellis Pharmaceuticals$26,524,113$1,731,000 ▲7.0%1,532,3000.7%MedicalGPCRStructure Therapeutics$24,873,482$8,239,421 ▲49.5%1,199,3000.6%MedicalSCPHscPharmaceuticals$23,086,8020.0%6,059,5280.6%MedicalCTMXCytomX Therapeutics$19,207,605$19,207,605 ▲New Holding8,461,5000.5%MedicalTMOThermo Fisher Scientific$18,853,890$33,450,450 ▼-64.0%46,5000.5%MedicalAGIOAgios Pharmaceuticals$18,555,754$7,729,624 ▲71.4%557,9000.5%MedicalTRVITrevi Therapeutics$18,096,948$11,970,548 ▲195.4%3,308,4000.5%MedicalADCTADC Therapeutics$15,831,701$163,748 ▼-1.0%5,907,3510.4%MedicalRYTMRhythm Pharmaceuticals$15,703,473$8,308,727 ▼-34.6%248,5120.4%MedicalFORTE BIOSCIENCES INC$15,476,628$7,808,000 ▲101.8%1,196,9550.4%COM NEWCGEMCullinan Therapeutics$14,486,6280.0%1,923,8550.4%MedicalKROSKeros Therapeutics$13,600,0990.0%1,018,7340.3%MedicalRAPT THERAPEUTICS INC$13,135,248$13,135,248 ▲New Holding1,641,9060.3%COM NEWFOLDAmicus Therapeutics$13,095,3420.0%2,285,4000.3%MedicalVIRVir Biotechnology$11,998,804$667,629 ▲5.9%2,380,7150.3%MedicalABCLAbCellera Biologics$11,471,868$2,868,166 ▼-20.0%3,344,5680.3%MedicalAKROAkero Therapeutics$11,274,968$1,675,504 ▲17.5%211,3000.3%MedicalMLYSMineralys Therapeutics$10,287,549$10,287,549 ▲New Holding760,3510.3%MedicalDYNE THERAPEUTICS INC$9,818,928$159,831 ▲1.7%1,031,4000.2%COMCCCCC4 Therapeutics$9,767,3290.0%6,830,3000.2%MedicalORICOric Pharmaceuticals$9,127,702$2,022,702 ▲28.5%899,2810.2%MedicalCPRXCatalyst Pharmaceuticals$9,046,730$9,046,730 ▲New Holding416,9000.2%MedicalPRLDPrelude Therapeutics$8,829,9520.0%10,909,2560.2%MedicalIKENA ONCOLOGY INC$8,533,907$922,457 ▲12.1%6,368,5870.2%NONVOTINGCRBPCorbus Pharmaceuticals$8,088,7800.0%1,172,2870.2%MedicalZLABZai Lab$8,078,070$8,078,070 ▲New Holding231,0000.2%MedicalTARSTarsus Pharmaceuticals$8,016,929$18,466,200 ▼-69.7%197,9000.2%MedicalAADIAadi Bioscience$7,790,4200.0%4,166,0000.2%MedicalTYRATyra Biosciences$7,700,051$9,074,542 ▼-54.1%804,6030.2%MedicalAZNAstraZeneca$6,988,000$6,988,000 ▲New Holding100,0000.2%MedicalACETAdicet Bio$6,982,7550.0%11,447,1400.2%MedicalITOSiTeos Therapeutics$6,979,000$6,979,000 ▲New Holding700,0000.2%MedicalPMVPPMV Pharmaceuticals$6,863,8080.0%6,475,2910.2%MedicalURGNUrogen Pharma$6,554,080$6,554,080 ▲New Holding478,4000.2%MedicalASNDAscendis Pharma A/S$5,937,440$5,937,440 ▲New Holding34,4000.1%MedicalALUMIS INC$5,779,269$5,779,269 ▲New Holding1,926,4230.1%COMJADE BIOSCIENCES INC$5,306,318$5,306,318 ▲New Holding531,1630.1%COM NEWNSPRInspireMD$4,842,8290.0%2,133,4050.1%MedicalAVALO THERAPEUTICS INC$4,825,3300.0%967,0000.1%COM NEWIKENA ONCOLOGY INC$4,742,7400.0%3,539,3580.1%COMRPTXRepare Therapeutics$4,618,2580.0%3,322,4880.1%MedicalPRELUDE THERAPEUTICS INC$4,597,5430.0%5,680,1860.1%NONVOTINGIMTXImmatics$3,873,067$12,737,477 ▼-76.7%719,9010.1%MedicalBIOAGE LABS INC$3,807,6910.0%921,9590.1%COMQ32 BIO INC$3,356,9510.0%2,252,9870.1%COMENGENE HOLDINGS INC$2,467,836$777,646 ▼-24.0%677,9770.1%COMPASGPassage Bio$2,423,937$392,024 ▼-13.9%6,055,3000.1%MedicalAMLXAmylyx Pharmaceuticals$2,007,612$223,068 ▼-10.0%313,2000.1%MedicalMURAL ONCOLOGY PUB LTD CO$1,454,336$1,454,336 ▲New Holding588,8000.0%ORD SHSINSMInsmed$1,354,514$1,529,728 ▼-53.0%13,4590.0%MedicalKRYSKrystal Biotech$1,264,632$1,965,678 ▼-60.9%9,2000.0%MedicalTURNSTONE BIOLOGICS CORP$1,112,6360.0%3,099,2650.0%COMCMMBChemomab Therapeutics$1,091,548$928,328 ▼-46.0%940,9900.0%MedicalTRAWS PHARMA INC$896,1860.0%605,5310.0%COM NEWKEZAR LIFE SCIENCES INC$882,5660.0%192,7000.0%COM NEWALTO NEUROSCIENCE INC$550,0000.0%250,0000.0%COM SHSDIH HLDG US INC$468,9840.0%1,915,0000.0%CL ALYELL IMMUNOPHARMA INC$457,267$457,267 ▲New Holding51,7270.0%COM NEWKORRO BIO INC$404,6760.0%32,4000.0%COMXERSXeris Biopharma$375,5610.0%80,4200.0%MedicalINMBINmune Bio$115,500$115,500 ▲New Holding50,0000.0%MedicalLAKESHORE BIOPHARMA CO LTD$55,895$87,342 ▼-61.0%54,7990.0%ORD SHS NEWShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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