Soleus Capital Management, L.P. Top Holdings and 13F Report (2025) About Soleus Capital Management, L.P.Investment ActivitySoleus Capital Management, L.P. has $1.39 billion in total holdings as of March 31, 2025.Soleus Capital Management, L.P. owns shares of 75 different stocks, but just 27 companies or ETFs make up 80% of its holdings.Approximately 28.03% of the portfolio was purchased this quarter.About 30.49% of the portfolio was sold this quarter.This quarter, Soleus Capital Management, L.P. has purchased 81 new stocks and bought additional shares in 22 stocks.Soleus Capital Management, L.P. sold shares of 21 stocks and completely divested from 23 stocks this quarter.Largest Holdings SPDR S&P Biotech ETF $113,540,000TG Therapeutics $112,245,499NovoCure $98,391,597Krystal Biotech $79,648,967BioMarin Pharmaceutical $76,296,000 Largest New Holdings this Quarter 852312305 - STAAR Surgical $45,183,804 Holding08659B102 - BETA BIONICS INC $41,558,974 Holding436440101 - Hologic $18,654,540 Holding04016X101 - argenx $17,128,573 Holding80105N105 - Sanofi $12,546,050 Holding Largest Purchases this Quarter NovoCure 2,781,710 shares (about $49.57M)STAAR Surgical 2,562,893 shares (about $45.18M)BETA BIONICS INC 3,395,341 shares (about $41.56M)PRAXIS PRECISION MEDICINES I 896,200 shares (about $33.94M)Madrigal Pharmaceuticals 56,600 shares (about $18.75M) Largest Sales this Quarter SPDR S&P Biotech ETF 1,600,000 shares (about $129.76M)AxoGen 1,509,826 shares (about $27.93M)Teva Pharmaceutical Industries 1,642,500 shares (about $25.25M)Adaptive Biotechnologies 2,973,142 shares (about $22.09M)Syndax Pharmaceuticals 1,675,390 shares (about $20.58M) Sector Allocation Over TimeMap of 500 Largest Holdings ofSoleus Capital Management, L.P. Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorXBISPDR S&P Biotech ETF$113,540,000$129,760,000 ▼-53.3%1,400,0008.2%ETFTGTXTG Therapeutics$112,245,499$6,524,127 ▲6.2%2,846,7038.1%MedicalNVCRNovoCure$98,391,597$49,570,072 ▲101.5%5,521,4147.1%MedicalKRYSKrystal Biotech$79,648,967$15,033,234 ▲23.3%441,7585.7%MedicalBMRNBioMarin Pharmaceutical$76,296,000$5,507,034 ▲7.8%1,079,3045.5%MedicalORGOOrganogenesis$53,906,476$28,188 ▼-0.1%12,478,3513.9%MedicalGRFSGrifols$50,408,634$3,444,063 ▲7.3%7,089,8223.6%MedicalUTHRUnited Therapeutics$47,903,308$14,180,420 ▲42.0%155,3943.4%MedicalSTAASTAAR Surgical$45,183,804$45,183,804 ▲New Holding2,562,8933.3%MedicalPRAXIS PRECISION MEDICINES I$43,161,954$33,939,094 ▲368.0%1,139,7403.1%COM NEWBETA BIONICS INC$41,558,974$41,558,974 ▲New Holding3,395,3413.0%COMNPCENeuroPace$32,054,385$2,150,750 ▲7.2%2,608,1682.3%MedicalNRIXNurix Therapeutics$28,783,256$3,801,600 ▲15.2%2,422,8332.1%MedicalAXGNAxoGen$26,753,165$27,931,782 ▼-51.1%1,446,1171.9%MedicalCELCCelcuity$26,024,373$91,344 ▲0.4%2,574,1221.9%MedicalIOVAIovance Biotherapeutics$25,924,050$4,079,250 ▲18.7%7,785,0001.9%MedicalSRDXSurmodics$24,090,002$12,059,350 ▲100.2%789,0601.7%MedicalIARTIntegra LifeSciences$23,577,766$4,481,474 ▼-16.0%1,072,2041.7%MedicalTERNTerns Pharmaceuticals$22,541,196$67,896 ▲0.3%8,167,1001.6%MedicalMDGLMadrigal Pharmaceuticals$22,358,025$18,747,618 ▲519.3%67,5001.6%MedicalINSMInsmed$20,924,211$3,509,340 ▼-14.4%274,2721.5%MedicalRIGEL PHARMACEUTICALS INC$20,340,9150.0%1,130,6791.5%COMHOLXHologic$18,654,540$18,654,540 ▲New Holding302,0001.3%MedicalARGXargenx$17,128,573$17,128,573 ▲New Holding28,9401.2%MedicalMRUSMerus$16,239,206$3,093,615 ▲23.5%385,8211.2%MedicalNUVLNuvalent$15,202,198$7,801,200 ▲105.4%214,3571.1%MedicalANIPANI Pharmaceuticals$15,042,594$1,298,161 ▲9.4%224,6841.1%MedicalEDAPEdap Tms$14,326,1380.0%7,309,2541.0%MedicalIKTInhibikase Therapeutics$13,851,7500.0%6,325,0001.0%MedicalEOLSEvolus$12,982,271$4,595,460 ▲54.8%1,079,1580.9%MedicalPHVSPharvaris$12,790,0360.0%814,6520.9%MedicalSNYSanofi$12,546,050$12,546,050 ▲New Holding226,2180.9%MedicalCCCCC4 Therapeutics$11,166,3070.0%6,978,9420.8%MedicalSLNOSoleno Therapeutics$10,717,500$10,717,500 ▲New Holding150,0000.8%MedicalKINIKSA PHARMACEUTICALS INTL$10,427,595$10,427,595 ▲New Holding469,5000.8%ORD SHS CL AACLXArcellx$10,038,834$2,099,200 ▲26.4%153,0310.7%MedicalSNDXSyndax Pharmaceuticals$10,032,054$20,582,166 ▼-67.2%816,6100.7%MedicalOFIXOrthofix Medical$9,817,397$1,377,363 ▼-12.3%601,9250.7%MedicalTNDMTandem Diabetes Care$9,504,107$9,504,107 ▲New Holding496,0390.7%MedicalSRRKScholar Rock$9,162,750$3,776,243 ▲70.1%285,0000.7%MedicalASNDAscendis Pharma A/S$8,774,918$13,668,922 ▼-60.9%56,3000.6%MedicalPTGXProtagonist Therapeutics$8,172,840$5,126,160 ▼-38.5%169,0000.6%MedicalIMUXImmunic$7,949,3780.0%7,293,0070.6%MedicalCG ONCOLOGY INC$7,434,797$612,250 ▼-7.6%303,5850.5%COMTEVATeva Pharmaceutical Industries$6,924,185$25,245,225 ▼-78.5%450,5000.5%MedicalTHERATECHNOLOGIES INC$6,721,9260.0%4,801,3760.5%COM NEWJASPER THERAPEUTICS INC$6,426,0060.0%1,494,4200.5%COM NEWINSPInspire Medical Systems$6,211,920$6,211,920 ▲New Holding39,0000.4%MedicalVSTMVerastem$5,643,531$7,526,145 ▼-57.1%935,9090.4%MedicalAKROAkero Therapeutics$4,736,160$4,736,160 ▲New Holding117,0000.3%MedicalLIVNLivaNova$4,597,331$4,597,331 ▲New Holding117,0400.3%MedicalSEPTERNA INC$4,350,334$439,716 ▲11.2%751,3530.3%COMGERNGeron$3,816,000$3,816,000 ▲New Holding2,400,0000.3%MedicalSRPTSarepta Therapeutics$3,701,560$3,701,560 ▲New Holding58,0000.3%MedicalEPIXESSA Pharma$3,574,0010.0%2,262,0260.3%MedicalMYOMyomo$3,387,563$941,437 ▼-21.7%704,2750.2%MedicalRVMDRevolution Medicines$2,997,962$4,112,368 ▼-57.8%84,7840.2%MedicalDCTHDelcath Systems$2,962,551$7,234,179 ▼-70.9%232,7220.2%MedicalERASErasca$2,962,1620.0%2,162,1620.2%MedicalNSPRInspireMD$2,543,061$1,164,103 ▼-31.4%945,3760.2%MedicalSIONNA THERAPEUTICS INC$2,510,400$2,510,400 ▲New Holding240,0000.2%COMAXSMAxsome Therapeutics$1,982,710$1,982,710 ▲New Holding17,0000.1%MedicalANABAnaptysBio$1,897,147$5,799,114 ▼-75.3%102,0520.1%MedicalDNLIDenali Therapeutics$1,835,325$1,835,325 ▲New Holding135,0000.1%MedicalEWTXEdgewise Therapeutics$1,590,600$2,442,000 ▼-60.6%72,3000.1%MedicalYMABY-mAbs Therapeutics$1,550,4200.0%349,9820.1%MedicalMREOMereo BioPharma Group$1,545,644$225,000 ▼-12.7%686,9530.1%MedicalCALCCalciMedica$1,497,2570.0%783,9040.1%MedicalTECTONIC THERAPEUTIC INC$1,360,854$796,950 ▲141.3%76,8410.1%COMADVERUM BIOTECHNOLOGIES INC$1,255,2650.0%287,2460.1%COM NEWKIDSOrthoPediatrics$1,108,350$1,108,350 ▲New Holding45,0000.1%MedicalABIVAX SA$781,2500.0%125,0000.1%SPONSORED ADSAPOGEE THERAPEUTICS INC$597,760$2,017,440 ▼-77.1%16,0000.0%COMIOBTIO Biotech$210,0100.0%192,6700.0%MedicalADPTAdaptive Biotechnologies$74,300$22,090,445 ▼-99.7%10,0000.0%MedicalAZNAstraZeneca$0$26,797,680 ▼-100.0%00.0%MedicalQDELQuidelOrtho$0$24,372,503 ▼-100.0%00.0%MedicalALNYAlnylam Pharmaceuticals$0$18,071,808 ▼-100.0%00.0%MedicalTAKTakeda Pharmaceutical$0$15,623,200 ▼-100.0%00.0%MedicalLLYEli Lilly and Company$0$8,999,976 ▼-100.0%00.0%MedicalPCVXVaxcyte$0$8,108,233 ▼-100.0%00.0%MedicalCSTLCastle Biosciences$0$6,740,238 ▼-100.0%00.0%MedicalVCELVericel$0$4,431,017 ▼-100.0%00.0%MedicalCRNXCrinetics Pharmaceuticals$0$4,346,050 ▼-100.0%00.0%MedicalRCKTRocket Pharmaceuticals$0$3,414,754 ▼-100.0%00.0%MedicalREPLReplimune Group$0$3,178,875 ▼-100.0%00.0%MedicalESTAEstablishment Labs$0$2,736,558 ▼-100.0%00.0%MedicalBLCOBausch + Lomb$0$2,176,230 ▼-100.0%00.0%MedicalMDXHEALTH SA$0$2,018,501 ▼-100.0%00.0%SHS NEWELVNEnliven Therapeutics$0$1,696,613 ▼-100.0%00.0%MedicalREGNRegeneron Pharmaceuticals$0$1,638,359 ▼-100.0%00.0%MedicalAADIAadi Bioscience$0$1,051,331 ▼-100.0%00.0%MedicalVRDNViridian Therapeutics$0$872,235 ▼-100.0%00.0%MedicalGSKGSK$0$341,920 ▼-100.0%00.0%MedicalWGSGeneDx$0$307,440 ▼-100.0%00.0%MedicalTHCTenet Healthcare$0$255,868 ▼-100.0%00.0%MedicalBGNEBeiGene$0$212,417 ▼-100.0%00.0%MedicalELVElevance Health$0$202,895 ▼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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