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Stocks to Compare Sections All Sections Selected Performance Chart Price & Volume MarketRank Analyst Ratings Sales & Book Value Profitability & Earnings Dividends Debt Ownership Miscellaneous Headlines About Compare NASDAQ:CRNX NASDAQ:MIST NASDAQ:NLTX NASDAQ:PRTA On This Page Performance ChartPrice & VolumeMarketRank™Analyst RatingsSales & Book ValueProfitability & EarningsDividendsDebtOwnershipMiscellaneousHeadlinesAbout Comparison Ideas Stock Ideas Comparative Price Performance Over Time1 day7 days30 days90 days365 daysCompare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeCRNXCrinetics Pharmaceuticals$35.12+1.9%$37.29$25.83▼$57.99$3.63B0.24913,841 shs931,248 shsMISTMilestone Pharmaceuticals$1.31+3.1%$1.65$1.00▼$3.06$158.11M0.961.11 million shs1.93 million shsNLTXNeoleukin Therapeutics$29.10+0.3%$26.73$2.03▼$14.36$273.48M1.1150,104 shs112,542 shsPRTAProthena$8.15-1.2%$9.96$5.29▼$11.80$431.91M-0.25499,267 shs622,612 shs10 Stocks Set to Soar in 2026Enter your email address and we’ll send you MarketBeat’s list of ten stocks set to soar in Summer 2026, despite the threat of tariffs and what's happening in Iran. These ten stocks are incredibly resilient and are likely to thrive in any economic environment. Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceCRNXCrinetics Pharmaceuticals0.00%+4.71%-6.26%-7.54%+8.50%MISTMilestone Pharmaceuticals0.00%+3.25%-15.61%-24.85%-23.03%NLTXNeoleukin Therapeutics0.00%+9.85%-6.94%+35.29%+47.27%PRTAProthena0.00%-6.14%-15.47%-10.03%+62.40%Compare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeCRNXCrinetics Pharmaceuticals$35.12+1.9%$37.29$25.83▼$57.99$3.63B0.24913,841 shs931,248 shsMISTMilestone Pharmaceuticals$1.31+3.1%$1.65$1.00▼$3.06$158.11M0.961.11 million shs1.93 million shsNLTXNeoleukin Therapeutics$29.10+0.3%$26.73$2.03▼$14.36$273.48M1.1150,104 shs112,542 shsPRTAProthena$8.15-1.2%$9.96$5.29▼$11.80$431.91M-0.25499,267 shs622,612 shs10 Stocks Set to Soar in 2026Enter your email address and we’ll send you MarketBeat’s list of ten stocks set to soar in Summer 2026, despite the threat of tariffs and what's happening in Iran. These ten stocks are incredibly resilient and are likely to thrive in any economic environment. Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceCRNXCrinetics Pharmaceuticals0.00%+4.71%-6.26%-7.54%+8.50%MISTMilestone Pharmaceuticals0.00%+3.25%-15.61%-24.85%-23.03%NLTXNeoleukin Therapeutics0.00%+9.85%-6.94%+35.29%+47.27%PRTAProthena0.00%-6.14%-15.47%-10.03%+62.40%Compare Analyst ForecastsCompanyConsensus Rating ScoreConsensus RatingConsensus Price Target% Upside from Current PriceCRNXCrinetics Pharmaceuticals 2.90Moderate Buy$76.13116.76% UpsideMISTMilestone Pharmaceuticals 2.50Moderate Buy$7.25453.44% UpsideNLTXNeoleukin Therapeutics 0.00N/AN/AN/APRTAProthena 2.63Moderate Buy$23.75191.41% UpsideCurrent Analyst Ratings BreakdownLatest CRNX, NLTX, MIST, and PRTA Analyst RatingsDateCompanyBrokerageActionRatingPrice TargetDetails6/15/2026CRNXCrinetics Pharmaceuticals HC WainwrightSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingBuy$81.006/11/2026CRNXCrinetics Pharmaceuticals Citizens JmpSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingMarket Outperform$95.006/2/2026PRTAProthena Weiss RatingsSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingDowngradeSell (D-) ➝ Sell (E+)5/15/2026MISTMilestone Pharmaceuticals Zacks ResearchSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingDowngradeHold ➝ Strong Sell5/14/2026PRTAProthena Weiss RatingsSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingUpgradeSell (E+) ➝ Sell (D-)5/14/2026MISTMilestone Pharmaceuticals Wells Fargo & CompanySubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingLower Price TargetOverweight$8.00 ➝ $7.005/11/2026CRNXCrinetics Pharmaceuticals OppenheimerSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingLower Price TargetOutperform$87.00 ➝ $84.005/8/2026PRTAProthena CitigroupSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingOutperform5/8/2026CRNXCrinetics Pharmaceuticals Citizens JmpSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingLower Price TargetMarket Outperform$97.00 ➝ $95.005/8/2026PRTAProthena Citizens JmpSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingBoost Price TargetMarket Outperform$19.00 ➝ $20.004/28/2026CRNXCrinetics Pharmaceuticals Citizens JmpSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingBoost Price TargetMarket Outperform$96.00 ➝ $97.00(Data available from 6/15/2023 forward. View 10+ years of historical ratings with our analyst ratings screener.)Compare Sales & Book ValueCompanyAnnual RevenuePrice/SalesCashflowPrice/CashBook ValuePrice/BookCRNXCrinetics Pharmaceuticals$7.70M480.92N/AN/A$9.71 per share3.62MISTMilestone Pharmaceuticals$1.55M105.22N/AN/A$0.39 per share3.36NLTXNeoleukin TherapeuticsN/AN/AN/AN/A$11.08 per shareN/APRTAProthena$9.68M44.08N/AN/A$5.21 per share1.56Compare Profitability & EarningsCompanyNet IncomeEPSTrailing P/E RatioForward P/E RatioP/E GrowthNet MarginsReturn on Equity (ROE)Return on Assets (ROA)Next Earnings DateCRNXCrinetics Pharmaceuticals-$465.32M-$5.13N/AN/AN/A-2,747.18%-43.96%-39.61%8/6/2026 (Estimated)MISTMilestone Pharmaceuticals-$63.06M-$0.68N/AN/AN/AN/A-339.33%-61.79%8/12/2026 (Estimated)NLTXNeoleukin Therapeutics-$57.56M-$3.11N/AN/AN/AN/A-37.22%-30.91%N/APRTAProthena-$244.09M-$2.82N/AN/A1.32-260.92%-43.44%-36.87%8/3/2026 (Estimated)Latest CRNX, NLTX, MIST, and PRTA EarningsDateQuarterCompanyConsensus EstimateReported EPSBeat/MissGap EPSRevenue EstimateActual RevenueDetails5/13/2026Q1 2026MISTMilestone Pharmaceuticals$0.06-$0.20-$0.26-$0.20$30.12 million$0.24 million5/7/2026Q1 2026CRNXCrinetics Pharmaceuticals-$1.22-$1.23-$0.01-$1.23$8.51 million$10.73 million5/7/2026Q1 2026PRTAProthena-$0.31$0.60+$0.91$0.60$0.81 million$51.08 million3/20/2026Q4 2025MISTMilestone Pharmaceuticals-$0.18-$0.16+$0.02-$0.15$37.52 million$1.55 millionCompare DividendsCompanyAnnual PayoutDividend Yield5-Year Annualized Dividend GrowthPayout RatioYears of Consecutive GrowthCRNXCrinetics PharmaceuticalsN/AN/AN/AN/AN/AMISTMilestone PharmaceuticalsN/AN/AN/AN/AN/ANLTXNeoleukin TherapeuticsN/AN/AN/AN/AN/APRTAProthenaN/AN/AN/AN/AN/ACompare DebtCompanyDebt-to-Equity RatioCurrent RatioQuick RatioCRNXCrinetics PharmaceuticalsN/A18.6018.56MISTMilestone Pharmaceuticals1.619.189.09NLTXNeoleukin TherapeuticsN/A15.3315.33PRTAProthenaN/A10.4310.43Compare OwnershipInstitutional OwnershipCompanyInstitutional OwnershipCRNXCrinetics Pharmaceuticals98.51%MISTMilestone Pharmaceuticals86.18%NLTXNeoleukin Therapeutics52.37%PRTAProthena97.08%Insider OwnershipCompanyInsider OwnershipCRNXCrinetics Pharmaceuticals3.80%MISTMilestone Pharmaceuticals5.03%NLTXNeoleukin Therapeutics1.58%PRTAProthena10.40%Compare Miscellaneous StatsCompanyEmployeesShares OutstandingFree FloatOptionableCRNXCrinetics Pharmaceuticals210105.44 million101.43 millionOptionableMISTMilestone Pharmaceuticals30124.50 million118.24 millionOptionableNLTXNeoleukin Therapeutics909.40 million9.25 millionNo DataPRTAProthena13052.35 million46.91 millionOptionableCRNX, NLTX, MIST, and PRTA HeadlinesRecent News About These CompaniesInsider Buying: Prothena (NASDAQ:PRTA) Major Shareholder Acquires 125,000 Shares of StockJune 13 at 7:02 AM | insidertrades.comInsider Buying: Prothena (NASDAQ:PRTA) Major Shareholder Acquires $465,500.00 in StockJune 8, 2026 | americanbankingnews.comProthena (NASDAQ:PRTA) Major Shareholder Acquires $465,500.00 in StockJune 6, 2026 | insidertrades.comProthena (NASDAQ:PRTA) Upgraded to Buy at Wall Street ZenJune 6, 2026 | americanbankingnews.comWilliam Scully Buys 50,000 Shares of Prothena (NASDAQ:PRTA) StockJune 4, 2026 | insidertrades.comWilliam Scully Purchases 100,000 Shares of Prothena (NASDAQ:PRTA) StockMay 27, 2026 | insidertrades.comProthena Corp. PlcMay 19, 2026 | edition.cnn.comPiper Sandler Sticks to Its Buy Rating for Prothena (PRTA)May 14, 2026 | theglobeandmail.comProthena (PRTA) Gets a Hold from RBC CapitalMay 14, 2026 | theglobeandmail.comEarnings Beat: Prothena Corporation plc Just Beat Analyst Forecasts, And Analysts Have Been Updating Their ModelsMay 12, 2026 | finance.yahoo.comProthena: Q1 Earnings SnapshotMay 8, 2026 | wtop.comWProthena Posts Q1 Earnings as Revenues Surge on Milestone PaymentMay 8, 2026 | zacks.comProthena Reports First Quarter 2026 Financial Results and Business HighlightsMay 7, 2026 | businesswire.comProthena to Report First Quarter 2026 Financial Results on May 7April 30, 2026 | businesswire.comProthena announces Novo Nordisk obtains fast track designation from the US FDA for Coramitug (PRX004) in ATTR amyloidosis with cardiomyopathyApril 27, 2026 | msn.comProthena Announces Novo Nordisk Obtains Fast Track Designation from the U.S. FDA for Coramitug (PRX004) in ATTR Amyloidosis with CardiomyopathyApril 27, 2026 | businesswire.comProthena Announces Leadership Team UpdatesApril 10, 2026 | businesswire.comWall Street Analysts Think Prothena (PRTA) Could Surge 120.19%: Read This Before Placing a BetMarch 26, 2026 | zacks.comProthena Partners Present Data Supporting Next Generation Treatments for Parkinson’s and Alzheimer’s Disease at AD/PD™ 2026March 21, 2026 | pharmiweb.comPProthena Partners Present Data Supporting Next Generation Treatments for Parkinson's and Alzheimer's Disease at AD/PD™ 2026March 21, 2026 | businesswire.comNew MarketBeat Followers Over TimeMedia Sentiment Over Time Top HeadlinesView All HeadlinesSpaceX Gets the Attention, But These 4 Stocks Could Get the ReturnsBy Bridget Bennett | May 25, 20265 Stocks Winning the AI Race While Everyone Watches NVIDIABy Bridget Bennett | May 26, 2026The Smart Glasses Gold Rush Is Leaving Old-School Eyewear BehindBy Jeffrey Neal Johnson | May 24, 20263 Space Infrastructure Stocks Gaining Momentum Ahead of the SpaceX IPOBy Ryan Hasson | May 20, 2026Zscaler Stock Drops 30%: Why the Dip Is a Buy OpportunityBy Thomas Hughes | May 27, 2026CRNX, NLTX, MIST, and PRTA Company DescriptionsCrinetics Pharmaceuticals NASDAQ:CRNX$35.12 +0.65 (+1.89%) Closing price 04:00 PM EasternExtended Trading$33.98 -1.14 (-3.24%) As of 07:37 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.Crinetics Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, focuses on the discovery, development, and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors. The company's lead product candidate is paltusotine, an oral selective nonpeptide somatostatin receptor type 2 agonist, which is in Phase 3 trial for the treatment of acromegaly; and Phase 2 trial for treating carcinoid syndrome associated with neuroendocrine tumors. It is also developing CRN04894, an investigational oral nonpeptide product candidate to antagonize the adrenocorticotrophic hormone (ACTH) receptor that has completed a Phase 1 study for the treatment of diseases caused by excess ACTH, including congenital adrenal hyperplasia and Cushing's disease. In addition, the company is developing antagonists of the parathyroid hormone (PTH) receptor for the treatment of primary hyperparathyroidism and humoral hypercalcemia of malignancy, and other diseases of excess PTH; identified investigational orally available somatostatin receptor type 3 targeted nonpeptide agonists for the treatment of autosomal dominant polycystic kidney disease; and developing thyroid-stimulating hormone receptor antagonists for the treatment of graves' disease and thyroid eye disease, as well as Oral GLP-1 and GIP nonpeptides for the treatment of diabetes and obesity. Crinetics Pharmaceuticals, Inc. was incorporated in 2008 and is headquartered in San Diego, California.Milestone Pharmaceuticals NASDAQ:MIST$1.31 +0.04 (+3.15%) Closing price 04:00 PM EasternExtended Trading$1.33 +0.02 (+1.37%) As of 07:49 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.Milestone Pharmaceuticals Inc., a biopharmaceutical company, focuses on the development and commercialization of cardiovascular medicines. The company's lead product candidate is etripamil, a novel and potent calcium channel blocker, which is in Phase III clinical trial for the treatment of paroxysmal supraventricular tachycardia in the United States and Canada; and Phase II clinical trial for the treatment of atrial fibrillation and rapid ventricular rate. It has a license and collaboration agreement with Ji Xing Pharmaceuticals to develop and commercialize etripamil prophylactic and therapeutic uses in humans, as well as with the Montreal Heart Institute, the WCN network, and other research centers. The company was incorporated in 2003 and is headquartered in Montréal, Canada.Neoleukin Therapeutics NASDAQ:NLTX$29.10 +0.10 (+0.34%) As of 06/12/2026Neoleukin Therapeutics, Inc., a biopharmaceutical company, develops immunotherapies for cancer, inflammation, and autoimmunity disorders using protein design technology. The company's lead product candidate is NL-201, a de novo protein designed to mimic the therapeutic activity of the cytokines interleukin (IL)-2/IL-15 for the treatment of various types of cancer, including renal cell carcinoma and melanoma. The company was formerly known as Aquinox Pharmaceuticals, Inc. and changed its name to Neoleukin Therapeutics, Inc. in August 2019. Neoleukin Therapeutics, Inc. was founded in 2003 and is headquartered in Seattle, Washington.Prothena NASDAQ:PRTA$8.15 -0.10 (-1.21%) Closing price 04:00 PM EasternExtended Trading$8.32 +0.16 (+2.02%) As of 07:59 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.Prothena Corporation plc, a late-stage clinical biotechnology company, focuses on discovery and development of novel therapies to treat diseases caused by protein dysregulation in the United States. The company is involved in developing birtamimab, an investigational humanized antibody that is in Phase III clinical trial for the treatment of AL amyloidosis; Prasinezumab, a humanized monoclonal antibody, for the treatment of Parkinson's disease and other related synucleinopathies which is in Phase IIb clinical trial; NNC6019 that is in Phase lI clinical trial for the treatment of ATTR amyloidosis; and BMS-986446 and PRX012, which is in Phase I clinical trial for the treatment of Alzheimer's disease. Its discovery and preclinical programs include PRX123, a dual Aß-Tau vaccine for the treatment and prevention of Alzheimer's disease; and PRX019 for the treatment of neurogenerative diseases, as well as TDP-43 for the treatment of amyotrophic lateral sclerosis. Prothena Corporation plc has a license, development, and commercialization agreement with F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. to develop and commercialize antibodies that target a-synuclein, including prasinezumab; and a collaboration agreement with Bristol-Myers Squibb to develop and commercialize antibodies targeting tau, TDP-43. The company was incorporated in 2012 and is based in Dublin, Ireland. 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