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Stocks to Compare Sections All Sections Selected Performance Chart Price & Volume MarketRank Analyst Ratings Sales & Book Value Profitability & Earnings Dividends Debt Ownership Miscellaneous Headlines About Compare NASDAQ:ACTU NASDAQ:MTVA NASDAQ:PLRZ NASDAQ:VYNE On This Page Performance ChartPrice & VolumeMarketRank™Analyst RatingsSales & Book ValueProfitability & EarningsDividendsDebtOwnershipMiscellaneousHeadlinesAbout Comparison Ideas Stock Ideas Comparative Price Performance Over Time1 day7 days30 days90 days365 daysCompare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeACTUActuate Therapeutics$1.18-6.3%$1.82$1.16▼$9.22$30.15M0.67465,919 shs93,394 shsMTVAMetaVia$1.48-2.0%$2.00$0.97▼$19.03$7.64M0.97575,819 shs69,642 shsPLRZPolyrizon$14.68-4.1%$13.54$2.88▼$18.20$31.91M-1.5938,981 shs117,798 shsVYNEVYNE Therapeutics$0.51-44.9%$0.68$0.28▼$1.60$30.83M21.84 million shs2.76 million shs7 Stocks to Buy And Hold ForeverClick the link to see MarketBeat's list of seven stocks and why their long-term outlooks are very promising. Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceACTUActuate Therapeutics-6.35%-18.06%-39.49%-60.27%-82.12%MTVAMetaVia-1.99%-13.45%-5.13%-5.13%-81.29%PLRZPolyrizon-4.11%+9.39%+22.95%-5.66%+30.14%VYNEVYNE Therapeutics-44.88%-33.11%-21.76%-21.10%-64.90%Compare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeACTUActuate Therapeutics$1.18-6.3%$1.82$1.16▼$9.22$30.15M0.67465,919 shs93,394 shsMTVAMetaVia$1.48-2.0%$2.00$0.97▼$19.03$7.64M0.97575,819 shs69,642 shsPLRZPolyrizon$14.68-4.1%$13.54$2.88▼$18.20$31.91M-1.5938,981 shs117,798 shsVYNEVYNE Therapeutics$0.51-44.9%$0.68$0.28▼$1.60$30.83M21.84 million shs2.76 million shs7 Stocks to Buy And Hold ForeverClick the link to see MarketBeat's list of seven stocks and why their long-term outlooks are very promising. Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceACTUActuate Therapeutics-6.35%-18.06%-39.49%-60.27%-82.12%MTVAMetaVia-1.99%-13.45%-5.13%-5.13%-81.29%PLRZPolyrizon-4.11%+9.39%+22.95%-5.66%+30.14%VYNEVYNE Therapeutics-44.88%-33.11%-21.76%-21.10%-64.90%Compare Analyst ForecastsCompanyConsensus Rating ScoreConsensus RatingConsensus Price Target% Upside from Current PriceACTUActuate Therapeutics 2.33Hold$17.501,383.05% UpsideMTVAMetaVia 2.00Hold$20.001,251.35% UpsidePLRZPolyrizon 1.00SellN/AN/AVYNEVYNE Therapeutics 1.75ReduceN/AN/ACurrent Analyst Ratings BreakdownLatest MTVA, VYNE, ACTU, and PLRZ Analyst RatingsDateCompanyBrokerageActionRatingPrice TargetDetails7/21/2026MTVAMetaVia Weiss RatingsSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingSell (E+)7/13/2026PLRZPolyrizon Weiss RatingsSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingUpgradeSell (E+) ➝ Sell (D-)7/10/2026MTVAMetaVia HC WainwrightSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingBuy6/26/2026PLRZPolyrizon Weiss RatingsSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingDowngradeSell (D-) ➝ Sell (E+)6/24/2026ACTUActuate Therapeutics Weiss RatingsSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingSell (E+)6/11/2026PLRZPolyrizon Weiss RatingsSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingUpgradeSell (E+) ➝ Sell (D-)6/10/2026ACTUActuate Therapeutics HC WainwrightSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingBuy5/21/2026PLRZPolyrizon Weiss RatingsSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingDowngradeSell (D-) ➝ Sell (E+)5/18/2026ACTUActuate Therapeutics HC WainwrightSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingBuy$15.005/18/2026MTVAMetaVia HC WainwrightSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingBuy$20.005/4/2026PLRZPolyrizon Weiss RatingsSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingSell (D-)(Data available from 7/25/2023 forward. View 10+ years of historical ratings with our analyst ratings screener.)Compare Sales & Book ValueCompanyAnnual RevenuePrice/SalesCashflowPrice/CashBook ValuePrice/BookACTUActuate TherapeuticsN/AN/AN/AN/A$0.34 per shareN/AMTVAMetaViaN/AN/AN/AN/A$2.31 per shareN/APLRZPolyrizonN/AN/AN/AN/A$13.05 per shareN/AVYNEVYNE Therapeutics$454K37.43N/AN/A$0.83 per share0.61Compare Profitability & EarningsCompanyNet IncomeEPSTrailing P/E RatioForward P/E RatioP/E GrowthNet MarginsReturn on Equity (ROE)Return on Assets (ROA)Next Earnings DateACTUActuate Therapeutics-$22.23M-$0.97N/AN/AN/AN/A-430.93%-180.86%N/AMTVAMetaVia-$12.97M-$5.19N/AN/AN/AN/A-172.92%-89.39%8/6/2026 (Estimated)PLRZPolyrizon-$3.34MN/AN/AN/AN/AN/AN/AN/AN/AVYNEVYNE Therapeutics-$26.48M-$0.38N/AN/AN/A-4,726.21%-70.42%-63.46%8/13/2026 (Estimated)Latest MTVA, VYNE, ACTU, and PLRZ EarningsDateQuarterCompanyConsensus EstimateReported EPSBeat/MissGap EPSRevenue EstimateActual RevenueDetails8/13/2026Q2 2026VYNEVYNE Therapeutics-$0.18N/AN/AN/A$0.20 millionN/A8/6/2026Q2 2026MTVAMetaVia-$0.85N/AN/AN/AN/AN/A5/15/2026Q1 2026VYNEVYNE Therapeutics-$0.18-$0.08+$0.10-$0.08$0.20 million$0.09 million5/14/2026Q1 2026ACTUActuate Therapeutics-$0.23-$0.24-$0.01-$0.24N/AN/A5/14/2026Q1 2026MTVAMetaVia-$0.76-$0.79-$0.03-$0.79N/AN/ACompare DividendsCompanyAnnual PayoutDividend Yield5-Year Annualized Dividend GrowthPayout RatioYears of Consecutive GrowthACTUActuate TherapeuticsN/AN/AN/AN/AN/AMTVAMetaViaN/AN/AN/AN/AN/APLRZPolyrizonN/AN/AN/AN/AN/AVYNEVYNE TherapeuticsN/AN/AN/AN/AN/ALatest MTVA, VYNE, ACTU, and PLRZ DividendsAnnouncementCompanyPeriodAmountYieldEx-Dividend DateRecord DatePayable Date7/10/2026VYNEVYNE Therapeuticsspecial$0.387/22/20267/23/2026(Data available from 1/1/2013 forward)Compare DebtCompanyDebt-to-Equity RatioCurrent RatioQuick RatioACTUActuate TherapeuticsN/A1.801.80MTVAMetaViaN/A2.732.73PLRZPolyrizonN/A29.0329.03VYNEVYNE TherapeuticsN/A20.8620.86Compare OwnershipInstitutional OwnershipCompanyInstitutional OwnershipACTUActuate TherapeuticsN/AMTVAMetaVia1.37%PLRZPolyrizonN/AVYNEVYNE Therapeutics83.78%Insider OwnershipCompanyInsider OwnershipACTUActuate Therapeutics57.98%MTVAMetaVia0.60%PLRZPolyrizonN/AVYNEVYNE Therapeutics3.03%Compare Miscellaneous StatsCompanyEmployeesShares OutstandingFree FloatOptionableACTUActuate Therapeutics1023.93 million10.05 millionN/AMTVAMetaVia85.16 million5.13 millionN/APLRZPolyrizonN/A2.08 millionN/AN/AVYNEVYNE Therapeutics3033.39 million32.37 millionNot OptionableMTVA, VYNE, ACTU, and PLRZ HeadlinesRecent News About These CompaniesVYNE Therapeutics Provides Update Regarding Cash Dividend, Reverse Stock Split and Anticipated Timing of Closing of the Proposed Merger with Yarrow BioscienceJuly 23 at 4:26 PM | globenewswire.comVYNE Therapeutics (NASDAQ:VYNE) Shares Scheduled to Reverse Split on Monday, July 27thJuly 23 at 1:20 AM | americanbankingnews.comVYNE Therapeutics Inc.: VYNE Therapeutics Announces 1-for-50 Reverse Stock Split and Provides Update Regarding Special Dividend in Connection with the Proposed Merger with ...July 22 at 5:11 PM | finanznachrichten.deVYNE Therapeutics (NASDAQ:VYNE) Draws Technical Attention After Reverse Split UpdateJuly 22 at 5:11 PM | kalkinemedia.comKVYNE Therapeutics Announces 1-for-50 Reverse Stock Split and Provides Update Regarding Special Dividend in Connection with the Proposed Merger with Yarrow BioscienceJuly 21, 2026 | globenewswire.comVyne Therapeutics (NASDAQ:VYNE): What’s Behind the Special Dividend?July 10, 2026 | kalkinemedia.comKVYNE Therapeutics Announces Special Cash Dividend in Connection with Pending Merger with Yarrow BioscienceJuly 10, 2026 | quiverquant.comQVYNE Therapeutics Declares Special Cash Dividend in Connection with the Proposed Merger with Yarrow BioscienceJuly 10, 2026 | globenewswire.comVYNE Therapeutics Insider Trading Activity | NASDAQ:VYNE | BenzingaJuly 1, 2026 | benzinga.comVYNE Therapeutics (VYNE) price target decreased by 38.46% to 2.04May 15, 2026 | msn.comShareholder Alert: The Ademi Firm investigates whether VYNE Therapeutics Inc. is obtaining a Fair Price for its Public ShareholdersDecember 18, 2025 | prnewswire.com3 penny stocks to watch now, 12/18/25December 18, 2025 | msn.comVYNE to merge with Yarrow in $200 million dealDecember 18, 2025 | thepharmaletter.comTRoundup: Harbor BioMed Announces Collaboration and License Agreement with Bristol Myers, Squibb, VYNE Therapeutics Enters Merger Agreement with Yarrow BioscienceDecember 17, 2025 | pharmexec.comP$HAREHOLDER ALERT: The M&A Class Action Firm Announces An Investigation of VYNE Therapeutics Inc. (NASDAQ: VYNE)December 17, 2025 | prnewswire.comVYNE Stock Alert: Halper Sadeh LLC is Investigating Whether the Merger of VYNE Therapeutics Inc. is Fair to ShareholdersDecember 17, 2025 | businesswire.comVYNE Therapeutics Inc. (VYNE) Yarrow Bioscience, Inc. - M&A Call Prepared Remarks TranscriptDecember 17, 2025 | seekingalpha.comVyne Therapeutics stock soars after merger with Yarrow BioscienceDecember 17, 2025 | za.investing.comVyne Therapeutics, Yarrow Bioscience to MergeDecember 17, 2025 | marketwatch.comVyne Therapeutics shares surge on merger deal with Yarrow BioscienceDecember 17, 2025 | msn.comNew MarketBeat Followers Over TimeMedia Sentiment Over Time Top HeadlinesView All HeadlinesThe AI Chip Sell-Off Looks Scary, But the Real Story May Be LiquidityBy Jeffrey Neal Johnson | July 7, 2026Micron's $250 Billion Bet Could Reshape the AI Memory RaceBy Jeffrey Neal Johnson | July 10, 2026A Market Panic Just Discounted the AI Highway's TollboothBy Jeffrey Neal Johnson | July 8, 2026Fabrinet Is Becoming a Quiet Winner in the AI Optics BuildoutBy Thomas Hughes | June 26, 2026Why the Comcast Spin-Off Won't Fix What's Actually BrokenBy Chris Markoch | July 3, 2026MTVA, VYNE, ACTU, and PLRZ Company DescriptionsActuate Therapeutics NASDAQ:ACTU$1.18 -0.08 (-6.35%) Closing price 07/24/2026 04:00 PM EasternExtended Trading$1.20 +0.02 (+1.27%) As of 07/24/2026 07:34 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.Actuate Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing therapies for the treatment of cancers. The company's lead product candidate is Elraglusib Injection, a novel glycogen synthase kinase-3 inhibitor to treat metastatic pancreatic ductal adenocarcinoma. It also develops Elraglusib for the treatment of Ewing sarcoma, metastatic melanoma, and colorectal cancer. The company was formerly known as Apotheca Therapeutics, Inc. and changed its name to Actuate Therapeutics, Inc. in October 2015. The company was incorporated in 2015 and is based in Fort Worth, Texas.MetaVia NASDAQ:MTVA$1.48 -0.03 (-1.99%) Closing price 07/24/2026 04:00 PM EasternExtended Trading$1.50 +0.02 (+1.01%) As of 07/24/2026 07:34 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.MetaVia Inc. is a clinical-stage biotechnology company focused on transforming cardiometabolic diseases. MetaVia Inc., formerly known as NeuroBo Pharmaceuticals Inc., is based in CAMBRIDGE, Mass.Polyrizon NASDAQ:PLRZ$14.68 -0.63 (-4.11%) Closing price 07/24/2026 04:00 PM EasternExtended Trading$14.86 +0.19 (+1.26%) As of 07/24/2026 07:34 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.Polyrizon Ltd. is a development stage biotech company specializing in the development of medical device hydrogels delivered in the form of nasal sprays. Polyrizon Ltd. is based in Raanana, Israel.VYNE Therapeutics NASDAQ:VYNE$0.51 -0.41 (-44.88%) Closing price 07/24/2026 04:00 PM EasternExtended Trading$0.48 -0.03 (-5.50%) As of 07/24/2026 07:34 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.VYNE Therapeutics Inc., a clinical-stage biopharmaceutical company, focuses on developing proprietary and therapeutics for the treatment of immuno-inflammatory conditions. The company's lead product is VYN201, a locally administered pan- bromodomain and extra-terminal (BET) inhibitor soft drug to address diseases involving multiple, diverse inflammatory cell signaling pathways with low systemic exposure. It also develops VYN202, a BD2-selective oral small molecule BET inhibitor for the treatment of immuno-inflammatory indications. The company was formerly known as Menlo Therapeutics Inc. and changed its name to VYNE Therapeutics Inc. in September 2020. VYNE Therapeutics Inc. was founded in 2003 and is based in Bridgewater, New Jersey. 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