Compare Stocks: PGEN, PRAX, NUVL, and KRYS

Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
KRYS Krystal Biotech	$333.56 +0.4%	$344.39	$136.73 ▼ $382.54	$9.87B	0.53	343,619 shs	48,778 shs
NUVL Nuvalent	$123.96	$123.05	$71.13 ▼ $123.99	$9.79B	1.14	1.93 million shs	N/A
PGEN Precigen	$6.68 +9.4%	$5.51	$2.62 ▼ $7.32	$2.39B	1.02	4.63 million shs	2.55 million shs
PRAX Praxis Precision Medicines	$390.51 +6.5%	$313.35	$37.19 ▼ $391.41	$10.90B	2.78	471,908 shs	200,325 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
KRYS Krystal Biotech	0.00%	+1.78%	-6.37%	+13.89%	+121.12%
NUVL Nuvalent	0.00%	0.00%	0.00%	+24.08%	+63.02%
PGEN Precigen	0.00%	-15.63%	+23.23%	+49.88%	+107.48%
PRAX Praxis Precision Medicines	0.00%	+1.68%	+16.67%	+14.44%	+679.12%

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
KRYS Krystal Biotech	$333.56 +0.4%	$344.39	$136.73 ▼ $382.54	$9.87B	0.53	343,619 shs	48,778 shs
NUVL Nuvalent	$123.96	$123.05	$71.13 ▼ $123.99	$9.79B	1.14	1.93 million shs	N/A
PGEN Precigen	$6.68 +9.4%	$5.51	$2.62 ▼ $7.32	$2.39B	1.02	4.63 million shs	2.55 million shs
PRAX Praxis Precision Medicines	$390.51 +6.5%	$313.35	$37.19 ▼ $391.41	$10.90B	2.78	471,908 shs	200,325 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
KRYS Krystal Biotech	0.00%	+1.78%	-6.37%	+13.89%	+121.12%
NUVL Nuvalent	0.00%	0.00%	0.00%	+24.08%	+63.02%
PGEN Precigen	0.00%	-15.63%	+23.23%	+49.88%	+107.48%
PRAX Praxis Precision Medicines	0.00%	+1.68%	+16.67%	+14.44%	+679.12%

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
KRYS Krystal Biotech	2.92	Moderate Buy	$365.40	9.55% Upside
NUVL Nuvalent	2.15	Hold	$127.73	3.04% Upside
PGEN Precigen	2.80	Moderate Buy	$14.50	117.23% Upside
PRAX Praxis Precision Medicines	3.00	Buy	$579.55	48.41% Upside

Current Analyst Ratings Breakdown

Latest PGEN, PRAX, NUVL, and KRYS Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
8/17/2026	PRAX Praxis Precision Medicines	Raymond James Financial Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Strong-Buy	$945.00
8/14/2026	KRYS Krystal Biotech	Royal Bank Of Canada Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Initiated Coverage	Outperform	$400.00
8/14/2026	KRYS Krystal Biotech	Royal Bank Of Canada Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Initiated Coverage	Outperform	$400.00
8/7/2026	PRAX Praxis Precision Medicines	Royal Bank Of Canada Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Outperform	$449.00 ➝ $462.00
8/7/2026	PRAX Praxis Precision Medicines	Robert W. Baird Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Set Price Target		$514.00
8/7/2026	PRAX Praxis Precision Medicines	Wells Fargo & Company Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Positive	$323.00 ➝ $362.00
8/6/2026	PRAX Praxis Precision Medicines	Needham & Company LLC Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Buy	$575.00 ➝ $582.00
8/5/2026	PGEN Precigen	HC Wainwright Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Buy	$14.00 ➝ $18.00
8/5/2026	PGEN Precigen	Zacks Research Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Upgrade	Hold ➝ Strong-Buy
8/4/2026	KRYS Krystal Biotech	Citigroup Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Buy	$378.00 ➝ $386.00
8/3/2026	KRYS Krystal Biotech	Weiss Ratings Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Upgrade	Buy (B-) ➝ Buy (B)

(Data available from 8/17/2023 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
KRYS Krystal Biotech	$389.13M	25.37	$7.32 per share	45.58	$42.06 per share	7.93
NUVL Nuvalent	N/A	N/A	N/A	N/A	$15.95 per share	N/A
PGEN Precigen	$9.68M	245.84	N/A	N/A	$0.06 per share	111.25
PRAX Praxis Precision Medicines	$8.55M	1,275.19	N/A	N/A	$34.85 per share	11.21

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
KRYS Krystal Biotech	$204.83M	$7.98	41.79	35.75	N/A	54.82%	19.34%	17.65%	11/2/2026 (Estimated)
NUVL Nuvalent	-$425.38M	-$6.06	N/A	N/A	N/A	N/A	-40.11%	-35.43%	N/A
PGEN Precigen	-$250.64M	-$1.04	N/A	7.76	N/A	-183.98%	423.75%	84.39%	N/A
PRAX Praxis Precision Medicines	-$303.27M	-$12.93	N/A	N/A	N/A	N/A	-34.15%	-32.42%	11/4/2026 (Estimated)

Latest PGEN, PRAX, NUVL, and KRYS Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
8/6/2026	Q2 2026	PRAX Praxis Precision Medicines	-$3.67	-$2.87	+$0.80	-$2.87	$1.25 million	N/A
8/4/2026	Q2 2026	PGEN Precigen	-$0.0121	$0.05	+$0.0621	$0.05	$27.98 million	$54.98 million
8/3/2026	Q2 2026	KRYS Krystal Biotech	$1.70	$1.79	+$0.09	$1.79	$120.93 million	$119.22 million

Compare Dividends

Company	Annual Payout	Dividend Yield	5-Year Annualized Dividend Growth	Payout Ratio	Years of Consecutive Growth
KRYS Krystal Biotech	N/A	N/A	N/A	N/A	N/A
NUVL Nuvalent	N/A	N/A	N/A	N/A	N/A
PGEN Precigen	N/A	N/A	N/A	N/A	N/A
PRAX Praxis Precision Medicines	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
KRYS Krystal Biotech	N/A	8.32	7.96
NUVL Nuvalent	N/A	16.14	16.14
PGEN Precigen	2.15	4.58	3.89
PRAX Praxis Precision Medicines	N/A	15.73	15.73

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
KRYS Krystal Biotech	86.29%
NUVL Nuvalent	97.26%
PGEN Precigen	33.51%
PRAX Praxis Precision Medicines	67.84%

Insider Ownership

Company	Insider Ownership
KRYS Krystal Biotech	13.10%
NUVL Nuvalent	5.02%
PGEN Precigen	41.40%
PRAX Praxis Precision Medicines	3.00%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
KRYS Krystal Biotech	210	29.60 million	25.72 million	Optionable
NUVL Nuvalent	40	79.00 million	75.03 million	Optionable
PGEN Precigen	190	356.51 million	208.92 million	Optionable
PRAX Praxis Precision Medicines	110	27.92 million	27.08 million	Optionable

PGEN, PRAX, NUVL, and KRYS Headlines

Recent News About These Companies

9,840 Shares in Praxis Precision Medicines, Inc. $PRAX Purchased by Handelsbanken Fonder AB

August 16 at 3:43 AM | marketbeat.com

HC Wainwright Has Bullish Forecast for PRAX Q3 Earnings

August 13, 2026 | americanbankingnews.com

Praxis Precision Medicines (NASDAQ:PRAX) Reaches New 12-Month High - Here's Why

August 12, 2026 | marketbeat.com

RBC Capital Reaffirms Their Buy Rating on Praxis Precision Medicines (PRAX)

August 11, 2026 | theglobeandmail.com

4 Biotech Stocks With Major Second-Half Pipeline Catalysts This Year

August 11, 2026 | zacks.com

Equities Analysts Offer Predictions for PRAX Q3 Earnings

August 11, 2026 | marketbeat.com

Dimensional Fund Advisors LP Has $10.04 Million Holdings in Praxis Precision Medicines, Inc. $PRAX

August 10, 2026 | marketbeat.com

Praxis Precision Medicines (NASDAQ:PRAX) Price Target Raised to $582.00

August 9, 2026 | americanbankingnews.com

Is Praxis (PRAX) Trading Bigger Losses for Long-Run CNS Ambition With Its Cash War Chest?

August 8, 2026 | finance.yahoo.com

Analysts Have Conflicting Sentiments on These Healthcare Companies: Praxis Precision Medicines (PRAX), Charles River Labs (CRL) and Senseonics Holdings (SENS)

August 8, 2026 | theglobeandmail.com

Analysts Offer Insights on Healthcare Companies: Praxis Precision Medicines (PRAX), BioCryst (BCRX) and GH Research (GHRS)

August 8, 2026 | theglobeandmail.com

Praxis Precision Medicines (NASDAQ:PRAX) Raised to Hold at Wall Street Zen

August 8, 2026 | americanbankingnews.com

Praxis Precision Medicines (NASDAQ:PRAX) Upgraded by Wall Street Zen to "Hold" Rating

August 8, 2026 | marketbeat.com

Praxis Precision Medicines (NASDAQ:PRAX) Reaches New 52-Week High After Strong Earnings

August 8, 2026 | americanbankingnews.com

Praxis signals two FDA decisions in ~six months, targets ~$10B ulixacaltamide peak sales while building a ~300-person field force

August 7, 2026 | seekingalpha.com

Praxis: Commercial Launch Could Smash Expectations (Video)

August 7, 2026 | seekingalpha.com

Praxis Precision Medicines, Inc. (PRAX) Q2 2026 Earnings Call Transcript

August 7, 2026 | seekingalpha.com

Glenmede Trust Co. NA Sells 2,878 Shares of Praxis Precision Medicines, Inc. $PRAX

August 7, 2026 | marketbeat.com

Praxis Precision Medicines Q2 Earnings Call Highlights

August 7, 2026 | marketbeat.com

Praxis Precision Medicines (NASDAQ:PRAX) Releases Quarterly Earnings Results, Beats Estimates By $0.80 EPS

August 6, 2026 | marketbeat.com

Needham & Company LLC Raises Praxis Precision Medicines (NASDAQ:PRAX) Price Target to $582.00

August 6, 2026 | marketbeat.com

New MarketBeat Followers Over Time

Media Sentiment Over Time

PGEN, PRAX, NUVL, and KRYS Company Descriptions

Krystal Biotech NASDAQ:KRYS

$333.56 +1.29 (+0.39%)

As of 01:01 PM Eastern

Krystal Biotech, Inc., a commercial-stage biotechnology company, discovers, develops, and commercializes genetic medicines for patients with rare diseases in the United States. It commercializes VYJUVEK (beremagene geperpavec-svdt, or B-VEC) for the treatment of dystrophic epidermolysis bullosa (DEB). The company also develops KB105, which is in Phase 1/2 clinical trials for treating patients with deficient autosomal recessive congenital ichthyosis; KB104 for treating netherton syndrome; KB407 that is in Phase 1 clinical trials for treating cystic fibrosis; KB707 that is in Phase 1 clinical trials for the treatment of anti-PD-1 relapsed/refractory; KB408, which is in Phase 1 clinical trials for treating Alpha-1 antitrypsin deficiency; and KB301 that is in Phase 2 clinical trials for treating aesthetic skin conditions, as well as in open label study with ophthalmic B-VEC for treating for ocular complications of deb. Krystal Biotech, Inc. was founded in 2016 and is headquartered in Pittsburgh, Pennsylvania.

Nuvalent NASDAQ:NUVL

$123.96 0.00 (0.00%)

As of 07/16/2026

Nuvalent, Inc., a clinical stage biopharmaceutical company, engages in the development of therapies for patients with cancer. Its lead product candidates are NVL-520, a novel ROS1-selective inhibitor to address the clinical challenges of emergent treatment resistance, central nervous system (CNS)-related adverse events, and brain metastases that may limit the use of ROS1 tyrosine kinase inhibitors (TKIs) for patients with ROS proto-oncogene 1 (ROS1)-positive non-small cell lung cancer (NSCLC) which is under the phase 2 portion of the ARROS-1 Phase 1/2 clinical trial; NVL-655, a brain-penetrant ALK-selective inhibitor, to address the clinical challenges of emergent treatment resistance, CNS-related adverse events, and brain metastases that might limit the use of first-, second-, and third-generation ALK inhibitors that is under the phase 2 portion of the ALKOVE-1 Phase 1/2 clinical trial; and NVL-330, a brain-penetrant human epidermal growth factor receptor 2 (HER2)-selective inhibitor designed to treat tumors driven by HER2ex20, brain metastases, and avoiding treatment-limiting adverse events including due to off-target inhibition of wild-type EGFR, which is expected to initiate phase 1 trial. The company was incorporated in 2017 and is headquartered in Cambridge, Massachusetts.

Precigen NASDAQ:PGEN

$6.68 +0.58 (+9.43%)

As of 01:01 PM Eastern

Precigen, Inc. operates as a discovery and clinical-stage biopharmaceutical company that develops gene and cell therapies using precision technology to target diseases in therapeutic areas of immuno-oncology, autoimmune disorders, and infectious diseases. It operates through two segments, Biopharmaceuticals and Exemplar. The company offers therapeutic platforms consisting of UltraCAR-T to provide chimeric antigen receptor T cell therapies for cancer patients; AdenoVerse immunotherapy, which utilizes a library of proprietary adenovectors for gene delivery of therapeutic effectors, immunomodulators, and vaccine antigen; and ActoBiotics for specific disease modification. It also develops programs based on the UltraCAR-T platform, including PRGN-3005 in Phase 1b clinical trial to treat advanced ovarian, fallopian tube, or primary peritoneal cancer; PRGN-3006 in Phase 1b trial for patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndromes; and PRGN-3007 in Phase 1/1b trial for the treatment of advanced receptor tyrosine kinase-like orphan receptor 1-positive, hematologic, and solid tumors. In addition, the company is developing programs based on the AdenoVerse immunotherapy platform comprising PRGN-2009 in Phase 2 trial for patients with HPV-associated cancer; and PRGN-2012 in Phase ½ trial to treat recurrent respiratory papillomatosis, as well as AG019, which is based on the ActoBiotics platform and in Phase 1b/2a trial, to treat type 1 diabetes mellitus. Further, it provides UltraPorator, a proprietary electroporation device; and develops research models and services for healthcare research applications. The company was formerly known as Intrexon Corporation and changed its name to Precigen, Inc. in February 2020. Precigen, Inc. was founded in 1998 and is headquartered in Germantown, Maryland.

Praxis Precision Medicines NASDAQ:PRAX

$390.50 +23.70 (+6.46%)

As of 01:01 PM Eastern

Praxis Precision Medicines, Inc., a clinical-stage biopharmaceutical company, engages in the development of therapies for central nervous system disorders characterized by neuronal excitation-inhibition imbalance. It is developing ulixacaltamide, a small molecule inhibitor of T-type calcium channels that is in Phase III clinical trial for the treatment of essential tremor; PRAX-562 for the treatment of pediatric patients with developmental and epileptic encephalopathies (DEE); and PRAX-628 to treat focal epilepsy. The company also develops PRAX-222 for the treatment of pediatric patients with early-onset SCN2A-DEE; PRAX-020 to treat KCNT1 related epilepsies; PRAX-080 for the treatment of PCDH19; and PRAX-090 and PRAX-100 for SYNGAP1 and SCN2A-LoF. It has a license agreement with RogCon Inc.; a research collaboration and license agreement with Ionis Pharmaceuticals, Inc.; a strategic collaboration and license agreement with UCB Biopharma SRL; and collaboration with The Florey Institute to develop three novel ASOs. The company was incorporated in 2015 and is based in Boston, Massachusetts.

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Compare Stocks

Comparative Price Performance Over Time

Compare Price & Volume

Compare Price Performance

Compare Price & Volume

Compare Price Performance

Compare Analyst Forecasts

Current Analyst Ratings Breakdown

Latest PGEN, PRAX, NUVL, and KRYS Analyst Ratings

Compare Sales & Book Value

Compare Profitability & Earnings

Latest PGEN, PRAX, NUVL, and KRYS Earnings

Compare Dividends

Compare Debt

Compare Ownership

Institutional Ownership

Insider Ownership

Compare Miscellaneous Stats

PGEN, PRAX, NUVL, and KRYS Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

PGEN, PRAX, NUVL, and KRYS Company Descriptions

Krystal Biotech NASDAQ:KRYS

Nuvalent NASDAQ:NUVL

Precigen NASDAQ:PGEN

Praxis Precision Medicines NASDAQ:PRAX

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Latest PGEN, PRAX, NUVL, and KRYS Analyst Ratings

Compare Sales & Book Value

Compare Profitability & Earnings

Latest PGEN, PRAX, NUVL, and KRYS Earnings

Compare Dividends

Compare Debt

Compare Ownership

Institutional Ownership

Insider Ownership

Compare Miscellaneous Stats

PGEN, PRAX, NUVL, and KRYS Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

PGEN, PRAX, NUVL, and KRYS Company Descriptions

Krystal Biotech NASDAQ:KRYS

Nuvalent NASDAQ:NUVL

Precigen NASDAQ:PGEN

Praxis Precision Medicines NASDAQ:PRAX

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