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Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
ACHN Achillion Pharmaceuticals	$6.76	$6.76	$2.06 ▼ $7.01	$946.72M	1.59	8.44 million shs	N/A
APRE Aprea Therapeutics	$1.75 +2.9%	$1.74	$1.41 ▼ $5.01	$9.68M	1.19	26,136 shs	9,119 shs
KNSA Kiniksa Pharmaceuticals International	$27.86 +1.5%	$27.49	$17.82 ▼ $30.69	$2.03B	0.05	551,956 shs	558,076 shs
RYTM Rhythm Pharmaceuticals	$65.78 -1.7%	$62.86	$40.61 ▼ $69.89	$4.18B	2.26	555,878 shs	628,374 shs
STOK Stoke Therapeutics	$11.49 -0.6%	$10.43	$5.35 ▼ $16.15	$627.08M	1.14	672,891 shs	185,804 shs

12 Stocks Corporate Insiders are Abandoning

If a company's CEO, COO, and CFO were all selling shares of their stock, would you want to know? MarketBeat just compiled its list of the twelve stocks that corporate insiders are abandoning. Complete the form below to see which companies made the list.

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
ACHN Achillion Pharmaceuticals	0.00%	0.00%	0.00%	+754.41%	+754.41%
APRE Aprea Therapeutics	0.00%	+4.48%	0.00%	+10.06%	-54.90%
KNSA Kiniksa Pharmaceuticals International	0.00%	-0.66%	-7.86%	+37.35%	+43.88%
RYTM Rhythm Pharmaceuticals	0.00%	+4.85%	-3.43%	+19.68%	+55.57%
STOK Stoke Therapeutics	0.00%	-1.25%	+3.10%	+91.10%	-12.46%

Compare MarketRank™

Company	Overall Score	Analyst's Opinion	Short Interest Score	Dividend Strength	ESG Score	News and Social Media Sentiment	Company Ownership	Earnings & Valuation
ACHN Achillion Pharmaceuticals	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
APRE Aprea Therapeutics	2.5158 of 5 stars	3.5	4.0	0.0	0.0	0.0	0.8	1.3
KNSA Kiniksa Pharmaceuticals International	3.2836 of 5 stars	3.5	4.0	0.0	0.0	1.4	3.3	0.6
RYTM Rhythm Pharmaceuticals	3.8115 of 5 stars	3.5	2.0	0.0	4.3	1.4	0.8	0.6
STOK Stoke Therapeutics	4.028 of 5 stars	3.6	0.0	0.0	4.8	2.4	0.8	1.3

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
ACHN Achillion Pharmaceuticals	0.00	N/A	N/A	N/A
APRE Aprea Therapeutics	3.00	Buy	$15.50	785.71% Upside
KNSA Kiniksa Pharmaceuticals International	3.00	Buy	$38.80	39.29% Upside
RYTM Rhythm Pharmaceuticals	3.00	Buy	$78.07	18.69% Upside
STOK Stoke Therapeutics	3.29	Buy	$23.20	102.00% Upside

Current Analyst Ratings Breakdown

Latest RYTM, APRE, KNSA, ACHN, and STOK Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
7/7/2025	RYTM Rhythm Pharmaceuticals	Leerink Partners Subscribe to MarketBeat All Access for the recommendation accuracy rating	Initiated Coverage	Outperform	$88.00
7/1/2025	STOK Stoke Therapeutics	Needham & Company LLC Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$22.00
6/26/2025	APRE Aprea Therapeutics	Wedbush Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Outperform	$11.00
6/26/2025	RYTM Rhythm Pharmaceuticals	JMP Securities Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Market Outperform ➝ Market Outperform	$84.00
5/29/2025	RYTM Rhythm Pharmaceuticals	Stifel Nicolaus Subscribe to MarketBeat All Access for the recommendation accuracy rating	Boost Price Target	Buy ➝ Buy	$78.00 ➝ $94.00
5/14/2025	STOK Stoke Therapeutics	Cantor Fitzgerald Subscribe to MarketBeat All Access for the recommendation accuracy rating	Upgrade	Strong-Buy
5/14/2025	STOK Stoke Therapeutics	HC Wainwright Subscribe to MarketBeat All Access for the recommendation accuracy rating	Lower Price Target	Buy ➝ Buy	$47.00 ➝ $35.00
5/7/2025	RYTM Rhythm Pharmaceuticals	Needham & Company LLC Subscribe to MarketBeat All Access for the recommendation accuracy rating	Boost Price Target	Buy ➝ Buy	$66.00 ➝ $72.00
4/29/2025	KNSA Kiniksa Pharmaceuticals International	Jefferies Financial Group Subscribe to MarketBeat All Access for the recommendation accuracy rating	Boost Price Target	Buy ➝ Buy	$40.00 ➝ $45.00
4/16/2025	KNSA Kiniksa Pharmaceuticals International	Wedbush Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Outperform ➝ Outperform	$34.00 ➝ $34.00
4/9/2025	STOK Stoke Therapeutics	Needham & Company LLC Subscribe to MarketBeat All Access for the recommendation accuracy rating	Reiterated Rating	Buy ➝ Buy	$22.00 ➝ $22.00

(Data available from 7/7/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
ACHN Achillion Pharmaceuticals	N/A	N/A	N/A	N/A	$1.92 per share	N/A
APRE Aprea Therapeutics	$1.50M	6.45	N/A	N/A	$3.55 per share	0.49
KNSA Kiniksa Pharmaceuticals International	$423.24M	4.80	N/A	N/A	$6.60 per share	4.22
RYTM Rhythm Pharmaceuticals	$130.13M	32.16	N/A	N/A	$0.35 per share	187.93
STOK Stoke Therapeutics	$36.56M	17.15	N/A	N/A	$4.32 per share	2.66

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
ACHN Achillion Pharmaceuticals	-$70.27M	-$0.51	N/A	N/A	N/A	N/A	-30.95%	-29.09%	N/A
APRE Aprea Therapeutics	-$12.96M	-$2.37	N/A	N/A	N/A	-1,095.02%	-68.39%	-55.74%	8/11/2025 (Estimated)
KNSA Kiniksa Pharmaceuticals International	-$43.19M	-$0.25	N/A	111.42	N/A	-3.52%	-3.83%	-2.98%	7/22/2025 (Estimated)
RYTM Rhythm Pharmaceuticals	-$260.60M	-$2.81	N/A	N/A	N/A	-123.26%	-739.62%	-44.27%	8/5/2025 (Estimated)
STOK Stoke Therapeutics	-$88.98M	$0.79	14.54	N/A	N/A	26.33%	19.08%	15.72%	8/5/2025 (Estimated)

Latest RYTM, APRE, KNSA, ACHN, and STOK Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
7/22/2025	Q2 2025	KNSA Kiniksa Pharmaceuticals International	$0.08	N/A	N/A	N/A	N/A	N/A
5/14/2025	Q1 2025	APRE Aprea Therapeutics	-$0.6543	-$0.66	-$0.0057	-$0.66	N/A	$0.16 million
5/7/2025	Q1 2025	RYTM Rhythm Pharmaceuticals	-$0.69	-$0.81	-$0.12	-$0.81	$40.43 million	$37.72 million
4/29/2025	Q1 2025	KNSA Kiniksa Pharmaceuticals International	$0.02	$0.11	+$0.09	$0.11	$128.35 million	$137.79 million

Compare Dividends

Company	Annual Payout	Dividend Yield	3-Year Dividend Growth	Payout Ratio	Years of Consecutive Growth
ACHN Achillion Pharmaceuticals	N/A	N/A	N/A	N/A	N/A
APRE Aprea Therapeutics	N/A	N/A	N/A	N/A	N/A
KNSA Kiniksa Pharmaceuticals International	N/A	N/A	N/A	N/A	N/A
RYTM Rhythm Pharmaceuticals	N/A	N/A	N/A	N/A	N/A
STOK Stoke Therapeutics	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
ACHN Achillion Pharmaceuticals	0.01	8.96	8.96
APRE Aprea Therapeutics	N/A	5.90	5.90
KNSA Kiniksa Pharmaceuticals International	N/A	3.66	3.43
RYTM Rhythm Pharmaceuticals	N/A	3.30	3.13
STOK Stoke Therapeutics	N/A	8.41	8.41

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
ACHN Achillion Pharmaceuticals	79.42%
APRE Aprea Therapeutics	34.19%
KNSA Kiniksa Pharmaceuticals International	53.95%
RYTM Rhythm Pharmaceuticals	N/A
STOK Stoke Therapeutics	N/A

Insider Ownership

Company	Insider Ownership
ACHN Achillion Pharmaceuticals	4.58%
APRE Aprea Therapeutics	13.63%
KNSA Kiniksa Pharmaceuticals International	53.48%
RYTM Rhythm Pharmaceuticals	6.10%
STOK Stoke Therapeutics	9.50%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
ACHN Achillion Pharmaceuticals	56	140.05 million	N/A	Optionable
APRE Aprea Therapeutics	7	5.53 million	4.78 million	No Data
KNSA Kiniksa Pharmaceuticals International	220	72.97 million	33.95 million	Optionable
RYTM Rhythm Pharmaceuticals	140	63.62 million	59.74 million	Optionable
STOK Stoke Therapeutics	100	54.60 million	49.41 million	Optionable

RYTM, APRE, KNSA, ACHN, and STOK Headlines

Recent News About These Companies

Stoke City move early for 'lethal' rising Manchester City star in second signing of the day

4 hours ago | msn.com

New Hanford waste incinerator could keep patients warm at Royal Stoke

4 hours ago | msn.com

Stoke sign Talovierov and Man City's Mubama

4 hours ago | msn.com

Zebra crossings to be installed outside TWO schools on same Stoke-on-Trent road

July 5 at 11:14 PM | msn.com

Stoke-on-Trent-based Prohire Limited falls into administration

July 5 at 11:14 PM | bbc.co.uk

Maksym Talovierov makes 'cold nights' promise with brilliant Stoke City statement

July 5 at 11:14 PM | msn.com

DONE DEAL: Stoke snap up Man City striker Mubama

July 5 at 11:14 PM | tribalfootball.comT

Five Guys to open first Stoke-on-Trent restaurant

July 5 at 11:14 PM | msn.com

Mubama set for Stoke loan switch

July 5 at 11:14 PM | sports.yahoo.com

Porch pirates target Stoke-on-Trent as parcels swiped from doorsteps

July 3, 2025 | uk.news.yahoo.com

Stoke Therapeutics, Inc. (NASDAQ:STOK) Receives $23.20 Average Target Price from Brokerages

July 3, 2025 | americanbankingnews.com

Stoke City on brink of agreement for Plymouth Argyle record signing

July 2, 2025 | msn.com

Stockley named Stoke's new academy manager

July 2, 2025 | msn.com

Stoke Therapeutics' (STOK) "Buy" Rating Reaffirmed at Needham & Company LLC

July 1, 2025 | marketbeat.com

Michelin’s Stoke-on-Trent plant set to lower CO2 emissions with tyre reprocessing site

July 1, 2025 | thebusinessdesk.comT

Stoke Therapeutics, Inc. (NASDAQ:STOK) Receives Average Rating of "Buy" from Analysts

June 30, 2025 | marketbeat.com

STOK Stoke Therapeutics, Inc. - Seeking Alpha

June 29, 2025 | seekingalpha.com

Analysts Are Bullish on These Healthcare Stocks: Apogee Therapeutics (APGE), Legend Biotech (LEGN)

June 28, 2025 | theglobeandmail.com

Stoke-on-Trent bungalow could be turned into children's home

June 28, 2025 | msn.com

Stoke City confirm new coach appointment as pre-season starts

June 27, 2025 | msn.com

Traditional Stoke-on-Trent pub reopens for the first time since Covid

June 27, 2025 | stokesentinel.co.ukS

New MarketBeat Followers Over Time

Media Sentiment Over Time

RYTM, APRE, KNSA, ACHN, and STOK Company Descriptions

Achillion Pharmaceuticals NASDAQ:ACHN

Achillion Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, discovers, develops, and commercializes small molecule drug therapies for immune system disorders. Its lead drug candidate is ACH-4471, an inhibitor of factor D that is Phase II clinical trials for patients with paroxysmal nocturnal hemoglobinuria (PNH) and C3 glomerulopathy/immune complex membranoproliferative glomerulonephritis. The company is also developing ACH-5228, a factor D inhibitor that is in Phase I clinical trials; and ACH-5548, a factor D inhibitor, which is in Phase I clinical trials for the treatment of PNH and other complement mediated diseases. It has license agreements with Ora, Inc. for the development and commercialization of ACH-702; and GCA Therapeutics, Ltd for elvucitabine, a nucleoside reverse transcriptase inhibitor for the treatment of hepatitis B infection and human immunodeficiency virus infection. The company was founded in 1998 and is based in New Haven, Connecticut.

Aprea Therapeutics NASDAQ:APRE

$1.75 +0.05 (+2.94%)

Closing price 07/3/2025 01:56 PM Eastern

Extended Trading

$1.75 0.00 (0.00%)

As of 08:08 AM Eastern

Aprea Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing novel synthetic lethality-based cancer therapeutics that targets DNA damage response pathways. Its lead product candidate is the ATRN-119 that is in Phase I clinical trials for treating advanced solid tumors. The company is also developing ATRN-1051 for the treatment of ovarian cancer; and APRE-DDRi for the treatment of advanced solid tumors. The company is headquartered in Doylestown, Pennsylvania.

Kiniksa Pharmaceuticals International NASDAQ:KNSA

$27.86 +0.42 (+1.51%)

Closing price 07/3/2025 02:30 PM Eastern

Extended Trading

$27.86 0.00 (0.00%)

As of 08:34 AM Eastern

Kiniksa Pharmaceuticals, Ltd., a biopharmaceutical company, focuses on discovering, acquiring, developing, and commercializing therapeutic medicines for patients suffering from debilitating diseases with significant unmet medical needs worldwide. Its product candidates include ARCALYST, an interleukin-1alpha and interleukin-1beta, for the treatment of recurrent pericarditis, which is an inflammatory cardiovascular disease; Mavrilimumab, a monoclonal antibody inhibitor that completed Phase II clinical trials for the treatment of giant cell arteritis; Vixarelimab, a monoclonal antibody, that is in Phase 2b clinical trial for the treatment of prurigo nodularis, a chronic inflammatory skin condition; and KPL-404, a monoclonal antibody inhibitor of the CD40- CD154 interaction, a T-cell co-stimulatory signal critical for B-cell maturation, immunoglobulin class switching, and type 1 immune response. The company was incorporated in 2015 and is based in Hamilton, Bermuda.

Rhythm Pharmaceuticals NASDAQ:RYTM

$65.78 -1.15 (-1.71%)

Closing price 07/3/2025 03:58 PM Eastern

Extended Trading

$65.74 -0.04 (-0.06%)

As of 06:08 AM Eastern

Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the rare neuroendocrine diseases. The company's lead product candidate is IMCIVREE (setmelanotide), a rare melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, and Bardet-Biedl and Alström syndrome. It is in Phase 3 clinical trials for treating POMC or LEPR heterozygous deficiency obesities, steroid receptor coactivator 1 deficiency obesity, SH2B1 deficiency obesity, MC4 receptor deficiency obesity, and other MC4R disorders. The company has licensing agreements with LG Chem, Ltd; Ipsen Pharma S.A.S; Camurus; RareStone Group Ltd.; and LG Chem, Ltd. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.

Stoke Therapeutics NASDAQ:STOK

$11.48 -0.07 (-0.56%)

Closing price 07/3/2025 03:52 PM Eastern

Extended Trading

$11.48 0.00 (0.00%)

As of 07/3/2025 04:20 PM Eastern

Stoke Therapeutics, Inc., an early-stage biopharmaceutical company, develops medicines to treat the underlying causes of severe genetic diseases in the United States. The company utilizes its proprietary targeted augmentation of nuclear gene output to develop antisense oligonucleotides to selectively restore protein levels. Its lead clinical candidate is STK-002, which is in preclinical stage for the treatment of autosomal dominant optic atrophy. The company also develops STK-001, which is in phase I/II clinical trial to treat Dravet syndrome; and programs focused on multiple targets, including haploinsufficiency diseases of the central nervous system and eye. The company has a license and collaboration agreement with Acadia Pharmaceuticals Inc. for the discovery, development, and commercialization of novel RNA-based medicines for the treatment of severe and rare genetic neurodevelopmental diseases of the central nervous system. The company was formerly known as ASOthera Pharmaceuticals, Inc. and changed its name to Stoke Therapeutics, Inc. in May 2016. Stoke Therapeutics, Inc. was incorporated in 2014 and is headquartered in Bedford, Massachusetts.

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Comparative Price Performance Over Time