Compare Stocks: ZLAB, SMMT, KRYS, and IONS

Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
IONS Ionis Pharmaceuticals	$58.13 -5.2%	$61.71	$50.01 ▼ $86.74	$10.19B	0.42	2.16 million shs	4.34 million shs
KRYS Krystal Biotech	$371.47 +0.6%	$350.09	$136.73 ▼ $382.54	$10.93B	0.54	203,785 shs	226,481 shs
SMMT Summit Therapeutics	$17.13 +17.3%	$14.17	$12.07 ▼ $29.23	$11.65B	-1.24	5.58 million shs	14.88 million shs
ZLAB Zai Lab	$27.00 +2.0%	$21.91	$15.96 ▼ $34.72	$3.01B	0.83	1.39 million shs	585,711 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
IONS Ionis Pharmaceuticals	-5.22%	-6.89%	+5.56%	-21.95%	-3.90%
KRYS Krystal Biotech	+0.61%	+3.92%	+14.38%	+23.41%	+147.32%
SMMT Summit Therapeutics	+17.33%	+19.54%	+24.49%	+15.98%	-27.17%
ZLAB Zai Lab	+1.96%	+0.67%	+46.02%	+62.45%	-13.74%

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
IONS Ionis Pharmaceuticals	$58.13 -5.2%	$61.71	$50.01 ▼ $86.74	$10.19B	0.42	2.16 million shs	4.34 million shs
KRYS Krystal Biotech	$371.47 +0.6%	$350.09	$136.73 ▼ $382.54	$10.93B	0.54	203,785 shs	226,481 shs
SMMT Summit Therapeutics	$17.13 +17.3%	$14.17	$12.07 ▼ $29.23	$11.65B	-1.24	5.58 million shs	14.88 million shs
ZLAB Zai Lab	$27.00 +2.0%	$21.91	$15.96 ▼ $34.72	$3.01B	0.83	1.39 million shs	585,711 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
IONS Ionis Pharmaceuticals	-5.22%	-6.89%	+5.56%	-21.95%	-3.90%
KRYS Krystal Biotech	+0.61%	+3.92%	+14.38%	+23.41%	+147.32%
SMMT Summit Therapeutics	+17.33%	+19.54%	+24.49%	+15.98%	-27.17%
ZLAB Zai Lab	+1.96%	+0.67%	+46.02%	+62.45%	-13.74%

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
IONS Ionis Pharmaceuticals	2.73	Moderate Buy	$94.15	61.96% Upside
KRYS Krystal Biotech	2.92	Moderate Buy	$365.40	-1.63% Downside
SMMT Summit Therapeutics	2.44	Hold	$24.07	40.53% Upside
ZLAB Zai Lab	2.71	Moderate Buy	$37.25	37.96% Upside

Current Analyst Ratings Breakdown

Latest ZLAB, SMMT, KRYS, and IONS Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
9/3/2026	SMMT Summit Therapeutics	HC Wainwright Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Neutral
9/1/2026	SMMT Summit Therapeutics	Cantor Fitzgerald Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Overweight
8/31/2026	IONS Ionis Pharmaceuticals	HC Wainwright Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy	$115.00
8/26/2026	SMMT Summit Therapeutics	Guggenheim Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy
8/26/2026	SMMT Summit Therapeutics	HC Wainwright Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Neutral
8/25/2026	SMMT Summit Therapeutics	Summit Redstone Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Set Price Target		$11.90
8/25/2026	SMMT Summit Therapeutics	Sanford C. Bernstein Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Upgrade	Underperform ➝ Market Perform	$9.80 ➝ $11.90
8/19/2026	IONS Ionis Pharmaceuticals	BMO Capital Markets Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Initiated Coverage	Outperform ➝ Market Perform	$60.00
8/18/2026	KRYS Krystal Biotech	Weiss Ratings Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Downgrade	Buy (B) ➝ Buy (B-)
8/18/2026	IONS Ionis Pharmaceuticals	BMO Capital Markets Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Upgrade	Hold
8/18/2026	SMMT Summit Therapeutics	HC Wainwright Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Neutral

(Data available from 9/4/2023 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
IONS Ionis Pharmaceuticals	$944M	10.23	N/A	N/A	$2.65 per share	21.94
KRYS Krystal Biotech	$389.13M	28.26	$7.33 per share	50.65	$45.92 per share	8.09
SMMT Summit Therapeutics	N/A	N/A	N/A	N/A	$0.79 per share	N/A
ZLAB Zai Lab	$460.16M	6.68	N/A	N/A	$5.34 per share	5.06

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
IONS Ionis Pharmaceuticals	-$381.39M	-$3.46	N/A	N/A	N/A	-64.76%	-111.08%	-17.41%	11/4/2026 (Estimated)
KRYS Krystal Biotech	$204.83M	$7.98	46.55	39.81	N/A	54.82%	19.34%	17.65%	11/2/2026 (Estimated)
SMMT Summit Therapeutics	-$1.08B	-$1.12	N/A	N/A	N/A	N/A	-168.94%	-141.92%	10/19/2026 (Estimated)
ZLAB Zai Lab	-$175.54M	-$1.71	N/A	N/A	N/A	-41.86%	-27.43%	-16.72%	11/5/2026 (Estimated)

Latest ZLAB, SMMT, KRYS, and IONS Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
8/6/2026	Q2 2026	ZLAB Zai Lab	-$0.6794	-$0.46	+$0.2194	-$0.50	$103.87 million	$106.31 million
8/3/2026	Q2 2026	KRYS Krystal Biotech	$1.70	$1.79	+$0.09	$1.79	$120.93 million	$119.22 million
7/29/2026	Q2 2026	IONS Ionis Pharmaceuticals	-$1.08	-$0.69	+$0.39	-$0.69	$189.10 million	$267.95 million
7/23/2026	Q2 2026	SMMT Summit Therapeutics	-$0.2744	-$0.28	-$0.0056	-$0.28	$0.11 million	N/A
6/30/2026	Q2 2026	ZLAB Zai Lab	N/A	-$0.50	N/A	-$0.50	N/A	$106.31 million

Compare Dividends

Company	Annual Payout	Dividend Yield	5-Year Annualized Dividend Growth	Payout Ratio	Years of Consecutive Growth
IONS Ionis Pharmaceuticals	N/A	N/A	N/A	N/A	N/A
KRYS Krystal Biotech	N/A	N/A	N/A	N/A	N/A
SMMT Summit Therapeutics	N/A	N/A	N/A	N/A	N/A
ZLAB Zai Lab	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
IONS Ionis Pharmaceuticals	3.07	7.89	7.73
KRYS Krystal Biotech	N/A	8.32	7.96
SMMT Summit Therapeutics	N/A	6.96	6.96
ZLAB Zai Lab	N/A	2.13	1.92

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
IONS Ionis Pharmaceuticals	93.86%
KRYS Krystal Biotech	86.29%
SMMT Summit Therapeutics	4.61%
ZLAB Zai Lab	41.65%

Insider Ownership

Company	Insider Ownership
IONS Ionis Pharmaceuticals	1.81%
KRYS Krystal Biotech	13.10%
SMMT Summit Therapeutics	83.50%
ZLAB Zai Lab	4.88%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
IONS Ionis Pharmaceuticals	1,402	166.18 million	163.18 million	Optionable
KRYS Krystal Biotech	210	29.60 million	25.72 million	Optionable
SMMT Summit Therapeutics	110	797.75 million	131.63 million	Optionable
ZLAB Zai Lab	1,784	113.78 million	108.23 million	Optionable

ZLAB, SMMT, KRYS, and IONS Headlines

Recent News About These Companies

Zai Lab (NASDAQ:ZLAB) Trading Up 6.9% - Still a Buy?

September 2 at 11:59 AM | marketbeat.com

Zai Lab Limited Unsponsored ADR $ZLAB Stock Position Boosted by Headlands Technologies LLC

September 1 at 4:23 AM | marketbeat.com

Zai Lab Limited Unsponsored ADR (NASDAQ:ZLAB) Given Consensus Rating of "Moderate Buy" by Analysts

August 29, 2026 | americanbankingnews.com

Zai Lab Limited Unsponsored ADR (NASDAQ:ZLAB) Given Average Recommendation of "Moderate Buy" by Brokerages

August 29, 2026 | marketbeat.com

Z.ai shares surge 8% after releasing new AI model running only on Chinese chips

August 26, 2026 | cnbc.com

Zai Lab: Revenue Growth And Zoci's Upside Optionality

August 19, 2026 | seekingalpha.com

Zai Lab and argenx Announce Positive Topline Results from Phase 3 ALKIVIA Trial of Efgartigimod in Autoimmune Myositis

August 17, 2026 | businesswire.com

Zai Lab (NASDAQ:ZLAB) CFO Sells 619 Shares

August 14, 2026 | insidertrades.com

Insider Selling: Zai Lab (NASDAQ:ZLAB) CFO Sells $15,475.00 in Stock

August 13, 2026 | marketbeat.com

William Lis Sells 8,506 Shares of Zai Lab (NASDAQ:ZLAB) Stock

August 13, 2026 | marketbeat.com

Zai Lab (ZLAB) Q2 2026 Earnings Call Transcript

August 13, 2026 | finance.yahoo.com

Zai Lab (NASDAQ:ZLAB) Shares Gap Down - What's Next?

August 12, 2026 | marketbeat.com

Is Zai Lab’s (ZLAB) Rising Loss on Softer Revenue Reframing Its Investment-Led Growth Story?

August 10, 2026 | finance.yahoo.com

Zai Lab Q2 Earnings Call Highlights

August 7, 2026 | marketbeat.com

Zai Lab (NASDAQ:ZLAB) Issues Earnings Results, Beats Estimates By $0.18 EPS

August 6, 2026 | marketbeat.com

Zai Lab Limited (ZLAB) Q2 2026 Earnings Call Transcript

August 6, 2026 | seekingalpha.com

Zai Lab Limited 2026 Q2 - Results - Earnings Call Presentation

August 6, 2026 | seekingalpha.com

Here's What Key Metrics Tell Us About Zai Lab Limited (ZLAB) Q2 Earnings

August 6, 2026 | zacks.com

Zai Lab (NASDAQ:ZLAB) Shares Up 14.5% on Strong Earnings

August 6, 2026 | marketbeat.com

Zai Lab Announces Second Quarter 2026 Financial Results and Recent Corporate Updates

August 6, 2026 | businesswire.com

Zai Lab Limited Unsponsored ADR (NASDAQ:ZLAB) Receives Average Rating of “Moderate Buy” from Analysts

August 4, 2026 | defenseworld.netD

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Media Sentiment Over Time

ZLAB, SMMT, KRYS, and IONS Company Descriptions

Ionis Pharmaceuticals NASDAQ:IONS

$58.13 -3.20 (-5.22%)

Closing price 09/3/2026 04:00 PM Eastern

Extended Trading

$58.64 +0.51 (+0.88%)

As of 04:27 AM Eastern

Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an antisense injection for the treatment of polyneuropathy caused by hereditary transthyretin amyloidosis in adults; and WAYLIVRA, an antisense medicine for treatment for familial chylomicronemia syndrome (FCS) and familial partial lipodystrophy. It also develops medicines for various indications that are in phase 3 study, including Eplontersen as a monthly self-administered subcutaneous injection to treat all types of ATTR; Olezarsen for patients with FCS and severe hypertriglyceridemia (SHTG); Donidalorsen for patients with hereditary angioedema; ION363 for patients with amyotrophic lateral sclerosis; Tofersen to inhibit the production of superoxide dismutase 1; Pelacarsen for patients with established cardiovascular disease and elevated lipoprotein(a); and Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus. In addition, the company develops IONIS-FB-LRx to inhibit the production of complement factor B and the alternative complement pathway; and ION224 to reduce the production of diacylglycerol acyltransferase 2. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with Metagenomi, Inc, AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis, Roche, Swedish Orphan Biovitrum AB, and PTC Therapeutics. The company was incorporated in 1989 and is based in Carlsbad, California.

Krystal Biotech NASDAQ:KRYS

$371.47 +2.24 (+0.61%)

As of 09/3/2026 04:00 PM Eastern

Krystal Biotech, Inc., a commercial-stage biotechnology company, discovers, develops, and commercializes genetic medicines for patients with rare diseases in the United States. It commercializes VYJUVEK (beremagene geperpavec-svdt, or B-VEC) for the treatment of dystrophic epidermolysis bullosa (DEB). The company also develops KB105, which is in Phase 1/2 clinical trials for treating patients with deficient autosomal recessive congenital ichthyosis; KB104 for treating netherton syndrome; KB407 that is in Phase 1 clinical trials for treating cystic fibrosis; KB707 that is in Phase 1 clinical trials for the treatment of anti-PD-1 relapsed/refractory; KB408, which is in Phase 1 clinical trials for treating Alpha-1 antitrypsin deficiency; and KB301 that is in Phase 2 clinical trials for treating aesthetic skin conditions, as well as in open label study with ophthalmic B-VEC for treating for ocular complications of deb. Krystal Biotech, Inc. was founded in 2016 and is headquartered in Pittsburgh, Pennsylvania.

Summit Therapeutics NASDAQ:SMMT

$17.13 +2.53 (+17.33%)

Closing price 09/3/2026 04:00 PM Eastern

Extended Trading

$16.94 -0.19 (-1.10%)

As of 04:26 AM Eastern

Summit Therapeutics Inc., a biopharmaceutical company, focuses on discovery, development, and commercialization of patient, physician, caregiver, and societal friendly medicinal therapies in the United States, and the United Kingdom. The company's lead development candidate is Ivonescimab, a bispecific antibody for immunotherapy through blockade of PD-1 with the anti-angiogenesis; and anti-infectives portfolio includes SMT-738, a novel class of precision antibiotics for the treatment of multidrug resistant infections, which primarily includes carbapenem-resistant Enterobacteriaceae infections. It has a collaboration and license agreement with Akeso, Inc. and its affiliates to develop and commercialize ivonescimab, as well as strategic collaboration with The University of Texas MD Anderson Cancer Center for the purpose of accelerating the development of ivonescimab. The company was founded in 2003 and is headquartered in Miami, Florida.

Zai Lab NASDAQ:ZLAB

$27.00 +0.52 (+1.96%)

Closing price 09/3/2026 04:00 PM Eastern

Extended Trading

$26.57 -0.43 (-1.60%)

As of 04:08 AM Eastern

Zai Lab Limited develops and commercializes therapies to treat oncology, autoimmune disorders, infectious diseases, and neuroscience. Its commercial products include Zejula, an orally administered poly polymerase 1/2 inhibitor; Optune, a cancer therapy that uses electric fields tuned to specific frequencies to kill tumor cells; NUZYRA for acute bacterial skin and skin structure infections, and community acquired bacterial pneumonia; Qinlock to treat gastrointestinal stromal tumors, and VYVGART, a human IgG1 antibody fragment for myesthenia gravis. The company also develops Tumor Treating Fields, a portable device for delivery of electric fields; Repotrectinib, a tyrosine kinase inhibitor (TKI) to target ROS1 and TRK A/B/C in TKI-naïve- or -pretreated cancer patients; Tisotumab vedotin, an antibody drug conjugate; Adagrasib for treating KRAS-G12C-mutated NSCLC, colorectal cancer, and pancreatic cancer; and Bemarituzumab to treat gastric and gastroesophageal junction cancer patients. In addition, it develops Sulbactam/durlobactam, a combination of a beta-lactam antibiotic and a beta-lactamase inhibitor for the treatment of serious infections caused by Acinetobacter; KarXT for the treatment of psychiatric and neurological conditions. It has license and collaboration agreement with Tesaro, Inc. to develop, manufacture, and commercialize niraparib; NovoCure to develop and commercialize Tumor Treating Fields; Deciphera to develop and commercialize ripretinib; Paratek Bermuda Ltd. to develop, manufacture, and commercialize omadacycline; argenx, to develop and commercialize efgartigimod; BMS to develop and commercialize tisotumab vedotin and repotrectinib; Mirati to research, develop, manufacture, and commercialize adagrasib; Amgen to develop and commercialize bemarituzumab; and Innoviva to develop and commercialize Sulbactam-Durlobactam; Karuna to develop and commercialize KarXT. The company was incorporated in 2013 and is headquartered in Shanghai, China.

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Compare Stocks

Comparative Price Performance Over Time

Compare Price & Volume

Compare Price Performance

Compare Price & Volume

Compare Price Performance

Compare Analyst Forecasts

Current Analyst Ratings Breakdown

Latest ZLAB, SMMT, KRYS, and IONS Analyst Ratings

Compare Sales & Book Value

Compare Profitability & Earnings

Latest ZLAB, SMMT, KRYS, and IONS Earnings

Compare Dividends

Compare Debt

Compare Ownership

Institutional Ownership

Insider Ownership

Compare Miscellaneous Stats

ZLAB, SMMT, KRYS, and IONS Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

ZLAB, SMMT, KRYS, and IONS Company Descriptions

Ionis Pharmaceuticals NASDAQ:IONS

Krystal Biotech NASDAQ:KRYS

Summit Therapeutics NASDAQ:SMMT

Zai Lab NASDAQ:ZLAB

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Latest ZLAB, SMMT, KRYS, and IONS Analyst Ratings

Compare Sales & Book Value

Compare Profitability & Earnings

Latest ZLAB, SMMT, KRYS, and IONS Earnings

Compare Dividends

Compare Debt

Compare Ownership

Institutional Ownership

Insider Ownership

Compare Miscellaneous Stats

ZLAB, SMMT, KRYS, and IONS Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

ZLAB, SMMT, KRYS, and IONS Company Descriptions

Ionis Pharmaceuticals NASDAQ:IONS

Krystal Biotech NASDAQ:KRYS

Summit Therapeutics NASDAQ:SMMT

Zai Lab NASDAQ:ZLAB

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