Geron Q1 2026 Earnings Report

Geron EPS Results

• Actual EPS: -$0.01
• Consensus EPS: -$0.03
• Beat/Miss: Beat by +$0.02
• One Year Ago EPS: N/A

Geron Revenue Results

• Actual Revenue: $51.84 million
• Expected Revenue: $50.59 million
• Beat/Miss: Beat by +$1.25 million
• YoY Revenue Growth: N/A

Geron Announcement Details

• Quarter: Q1 2026
• Date: 5/6/2026
• Time: Before Market Opens
• Conference Call Date: Wednesday, May 6, 2026
• Conference Call Time: 8:00AM ET

Geron (NASDAQ:GERN) (NASDAQ: GERN) is a clinical-stage biotechnology company dedicated to developing and commercializing novel treatments that target telomerase, an enzyme critical to cancer cell immortality. The company’s research is focused on hematologic malignancies and solid tumors, with a pipeline designed to address diseases that have historically had limited therapeutic options.

The lead product candidate, imetelstat, is a first-in-class telomerase inhibitor currently in Phase II and Phase III clinical trials for myelofibrosis and myelodysplastic syndromes. Imetelstat works by directly binding to the RNA template of telomerase, thereby blocking the enzyme’s activity and shortening telomeres in malignant cells. Preclinical studies have also explored potential applications of telomerase inhibition in various solid tumors.

Founded in 1990 by researchers Elizabeth Blackburn, Carol Greider and Jack Szostak—who later received the Nobel Prize in Physiology or Medicine for their work on telomeres—Geron is headquartered in Foster City, California. The company has established collaborations and licensing agreements with academic institutions, contract research organizations and pharmaceutical partners to advance its clinical programs and expand its research capabilities.

Under the leadership of CEO John A. Scarlett, Geron continues to build its infrastructure for late-stage clinical development. The company serves a global community of physicians, researchers and patients by conducting multi-center clinical trials across North America and Europe, with the goal of bringing telomerase-targeted therapies to market.

Geron Q1 2026 Earnings Call Transcript

Key Takeaways

• Positive Sentiment: Rytelo Q1 net revenue was $61.8M (up 31% YoY, 8% QoQ), demand grew ~6% QoQ, footprint expanded to ~1,450 prescribing accounts, and management says it is on track for 2026 revenue guidance of $220–$240M.
• Positive Sentiment: The phase III IMpactMF trial is fully enrolled with an interim overall‑survival event trigger expected in H2 2026, and management says a positive interim could materially strengthen imetelstat’s disease‑modifying profile and support broader MDS uptake.
• Neutral Sentiment: Geron is evaluating multiple go‑to‑market models for Europe (not pursuing a large internal build‑out), is conducting HTA/pricing work, and expects to announce its European commercial plan by year‑end.
• Negative Sentiment: Gross‑to‑net deductions rose to 21% (from 13% a year ago) due to increased 340B utilization and GPO contracting and are expected to remain in the low‑to‑mid 20s for 2026, which pressures realized net revenue.
• Neutral Sentiment: Total operating expenses declined ~9% YoY to $50.4M in Q1 and management reiterated Opex guidance of $230–$240M; cash was ~$341M at quarter end after planned bonus, severance and CMC investments.

Presentation

[Dawn Carter Bir, Board of Directors Member at Geron Corporation]

Good morning, everyone. Welcome to the Geron Corporation First Quarter 2026 Earnings Conference Call. Before we begin, please note that during the course of this presentation and question and answer session, we will be making forward-looking statements regarding future events, performance plans, expectations and other projections, including those relating to our 2026 financial guidance, our current RYTELO commercialization strategy and related opportunities in the U.S. and the E.U. The therapeutic potential of RYTELO, other anticipated clinical and commercial events and related timelines, the sufficiency of our financial resources and other statements that are not historical facts, which of course involve risks and uncertainties that could cause actual events, performance and results to differ materially from those contained in these forward-looking statements.

[Dawn Carter Bir, Board of Directors Member at Geron Corporation]

Therefore, I refer you to the risk and uncertainties described in today's earnings release and under the heading Risk Factors in Geron's most recent periodic report filed with the SEC, which identify important risk factors that could cause actual results to differ materially from those contained in these forward-looking statements and future updates to Geron's risk and uncertainty disclosures, including its upcoming quarterly report on Form 10-Q. Geron undertakes no duty or obligation to update its forward-looking statements. Joining me on today's call are several members of Geron's management team. Harout Semerjian, Chief Executive Officer, Ahmed ElNawawi, our Chief Commercial Officer, Dr. Joseph Eid, Executive Vice President of Research and Development and Chief Medical Officer, and Michelle Robertson, our Chief Financial Officer. With that, I'll turn the call over to Harout to review Geron's progress and strategy.

[Harout Semerjian, CEO at Geron Corporation]

Thank you, Dawn, and good morning, everyone. In the first quarter, we made progress on our 2026 strategic priorities. We grew RYTELO through focused commercial execution and advanced our European commercial and pricing strategy while maintaining our financial discipline. We also further strengthened our leadership team by welcoming Timothy Williams, our new Chief Legal Officer and Corporate Secretary for Geron, along with two new board members, Patricia Andrews and Constantine Chinoporos. Collectively, they bring decades of experience leading and advising biotech and cycle companies, and will be instrumental as we execute on our strategic priorities and drive commercial growth for RYTELO. RYTELO first quarter net revenue was $61.8 million, an increase of 31% year-over-year and 8% quarter-over-quarter, placing us on track to achieve our 2026 net revenue guidance of $220 million-$240 million.

[Harout Semerjian, CEO at Geron Corporation]

We continue to see strong tailwinds in the treatment landscape complementing our refocused commercial strategy and driving RYTELO demand. We are focused on three key initiatives fueling our RYTELO U.S. growth strategy. On the commercial side, we're continuing to increase awareness and education for RYTELO amongst U.S. healthcare professionals with a refined engagement plan to help identify appropriate second-line patients faster. Complementing our field force efforts by increasing our in-person and digital presence across hematology forums through accelerated investment in our surround sound approach. From a medical affairs perspective, we are expanding our research partnerships and Investigator-Sponsored Trial program with the U.S. hematology community to increase our knowledge and real-world experience with RYTELO.

[Harout Semerjian, CEO at Geron Corporation]

Growing RYTELO demand in U.S. markets remains our priority. We know from patients at eCTD there is an unmet need for lower-risk MDS treatment options in Europe and an interest in RYTELO to help address that need. This quarter, we engaged in conversations with European medical experts, made progress with health technology assessment, and conducted detailed research to better understand the European pricing environment. As a biotech company, we have an obligation to make our medicines available to patients. We also have a responsibility to maintain a value that reflects our innovation and supports our next wave of growth. We know the demand in Europe for RYTELO is real, and we are exploring engaged commercial strategy that could maximize RYTELO's value in Europe while maintaining its pricing integrity in U.S.

[Harout Semerjian, CEO at Geron Corporation]

We expect to communicate our commercial plans for Europe before the end of the year once we have clarity on pricing and market opportunities. Financial discipline remains another top priority for Geron. We reported total operating expenses for the first quarter of $50.4 million, down about 9% year-over-year, a testament to our financial discipline. A few first quarter dynamics, such as annual bonus, severance from last year's restructuring and CMC investments to strengthen our supply chain for RYTELO led to a decrease in cash, which was in line with our expectations. We are on track to achieve our 2026 total operating expenses of $230 million-$240 million. With that, I'll turn it over to Nawawi to provide more detail on RYTELO's commercial performance and execution.

[Ahmed ElNawawi, Chief Commercial Officer at Geron Corporation]

Thank you, Harout. RYTELO's first quarter performance was impressive. Our strategy is built to support sustainable growth and ensure RYTELO reaches more eligible patients at the right point in their treatment journey when they are most likely to benefit. In the first quarter, we were able to grow demand 6% quarter-over-quarter and approximately 12% in the prescribing accounts, expanding our footprint since launch to approximately 1,450 accounts. First- and second-line patient starts on a rolling 12-month basis was 33%. RYTELO has the potential to make the biggest impact for lower risk MDS patients in the second-line setting, which we currently estimate to be approximately 8,000 patients in the U.S. This patient segment is our primary commercial focus, and our strategy is supported by the current NCCN guidelines.

[Ahmed ElNawawi, Chief Commercial Officer at Geron Corporation]

The movement of luspatercept into the first-line setting, backed by RYTELO's growth data, a growing real-world experience, and last but not least, the IMerge data, including the data presented at ASH 2025, suggesting treatment-emergent cytopenias are consistent with on-target activity. Our commercial execution is focused on three core initiatives. First, targeted engagements with high-volume community accounts. We are prioritizing centers that treat earlier-line and second-line patients with our field engagements. Additionally, we continue to engage with lower volume accounts for those privately seeking salvage patients through digital tactics. Second, we are investing in the most effective marketing channels. This includes a strong emphasis on digital, non-personal promotion, and third-party educational platforms to create what we describe as a 3-D surround sound for RYTELO, ensuring consistent, high-quality messaging across multiple touchpoints.

[Ahmed ElNawawi, Chief Commercial Officer at Geron Corporation]

Third, we are executing cross-function through effective account management, leveraging data presented at ASH 2025 to proactively address the cytopenias and highlight the potential association with response while positioning RYTELO as the standard of care in appropriate second-line patients, regardless of their RS. We believe our commercial strategy and investments are well-aligned to bring RYTELO to eligible lower-risk MDS patients in the U.S. and position us to grow demand in 2026. I now turn it over to Joe to discuss our medical and scientific engagement.

[Joseph Eid, EVP of Research and Development and Chief Medical Officer at Geron Corporation]

Thanks, Nawawi. In the first quarter, we continued to engage closely with the hematology community to increase RYTELO's share of voice. Since the start of the year, we've had a presence at several medical meetings, including the Aplastic Anemia & MDS International Foundation, ASCO, and the 2026 Pan-Hematology Clinical Updates meeting. These are targeted peer-to-peer conferences that provide the opportunity for more detailed clinical dialogue and practical discussion among healthcare professionals. We are also looking forward to attending ASCO and EHA, where we will engage with hematologists to articulate the clear differentiation of imetelstat in low-risk MDS based on clinical efficacy, quality of life benefits, and mechanism of action, generate advocacy within the KOL community, and support investigator interest in research opportunities aligned with our medical strategy. These medical meetings enable us to further educate the hematology community on RYTELO's deep body of scientific evidence.

[Joseph Eid, EVP of Research and Development and Chief Medical Officer at Geron Corporation]

Our messaging continues to be focused on the ASH 2025 data suggesting treatment-emergent cytopenias are consistent with off-target activity. We are seeing increasing interest from community hematologists in understanding these data and learning how to incorporate these insights into their clinical practice. We were pleased to further reinforce the significance of these data with our recent publication in Blood Cancer Journal that examines the association between treatment-emergent cytopenia and clinical responses to RYTELO. We are also engaging with academic centers to support the high interest in imetelstat to advance ISTs and real-world evidence studies. Notably, we are seeing increased interest from centers in Europe wanting to contribute to preclinical, clinical, and real-world evidence data generation. We expect initial real-world evidence data to be available in the second half of 2026.

[Joseph Eid, EVP of Research and Development and Chief Medical Officer at Geron Corporation]

We are pleased to have achieved inclusion of imetelstat in the National Comprehensive Cancer Network, or NCCN, chemotherapy order template. Its inclusion positions imetelstat as an active therapeutic versus supportive care for lower-risk MDS. The order templates provide healthcare practitioners with clear guidance on administration, enabling imetelstat to be seamlessly incorporated into oncology practice workflows and supporting standardized and appropriate administration across treatment centers. This follows the NCCN guideline update in September 2025, recommending imetelstat as the preferred second-line treatment option in lower-risk MDS. Turning to our phase III IMpactMF trial in relapsed/refractory myelofibrosis. The fully enrolled trial is projected at this time to reach the interim analysis death event trigger in the second half of this year. Imetelstat works on the foundation of disease, which is why we believe it has the potential to be a first-in-class therapy in myelofibrosis.

[Joseph Eid, EVP of Research and Development and Chief Medical Officer at Geron Corporation]

In myelofibrosis, clinical trials conducted with imetelstat saw evidence of disease-modifying activity correlating with clinical benefit and overall survival through a reduction in mutation burden, specifically JAK2, CALR, and MPL driver mutation. An improvement in bone marrow fibrosis and reduced telomerase activity, which is important as telomerase is significantly upregulated in cancers.

[Joseph Eid, EVP of Research and Development and Chief Medical Officer at Geron Corporation]

For our IMpactMF trial, overall survival is the primary endpoint, and our confidence in this endpoint is supported by encouraging survival outcomes observed in the phase II IMbark trial, which informed the design of the IMpactMF trial. While our base case from a planning perspective remains progression to the final analysis in the second half of 2028, reaching the interim analysis represents an important milestone as we continue to advance the potential beyond lower-risk MDS. An earlier positive outcome would represent an upside scenario to our plan. I'll now hand it over to Michelle to walk through the financials.

[Michelle Robertson, CFO at Geron Corporation]

Thank you, Joe, and good morning, everyone. For more detailed results from the first quarter, please refer to the press release we issued this morning, which is available on our website. Our first quarter 2026 results reflect our dedication to commercial execution and financial discipline, which positions us well to achieve our 2026 financial guidance and advance our strategic priorities to create long-term value for patients and shareholders. In the first quarter, total net revenue for the three months ending March 31st, 2026 was $61.8 million compared to $39.6 million in Q1 2025. Gross-to-net reductions increased to 21% for the three months ending March 31st, 2026 compared to 13% for the same period last year. As volume increased, there was wider 340B utilization and expanded GPO contracting, which we foresee continuing as the business matures.

[Michelle Robertson, CFO at Geron Corporation]

For the remainder of 2026, we expect gross-to-net to be in the low to mid 20s. Research and development expenses for the three months ending March 31st, 2026 were $15 million, consistent with $15.1 million in expenses the same period in 2025. For 2026, we expect continued investment in CMC and our clinical development program and lower employee costs driven by the decrease in headcount as a result of the workforce reduction in December of 2025. Selling, general, and administrative expenses for the three months ending March 31st, 2026 were $35.4 million compared to $40 million for the same period in 2025. This change was primarily due to lower general and administrative personnel-related expenses and decreased headcount, partially offset by additional investment in marketing programs.

[Michelle Robertson, CFO at Geron Corporation]

For 2026, we expect continued investment in our RYTELO commercialization strategy and lower G&A personnel-related expenses driven by a decrease in headcount as a result of the workforce reduction in 2025. Total operating expenses, including cost of goods sold for the three months ending March 31st, 2026, were $50.4 million compared to $55.1 million for the same period in 2025. The reduction is primarily related to decreased headcount as a result of the workforce reduction in December 2025. As of March 31st, 2026, we had approximately $341 million in cash equivalents, restricted cash, and marketable securities compared to $401 million as of December 31st, 2025. As a reminder, in the first quarter, we typically see a larger cash outflow due to the timing of annual bonus payouts.

[Michelle Robertson, CFO at Geron Corporation]

In addition, severance related to the strategic restructuring we announced in December 2025 was paid out in cash in the first quarter. The decrease in our cash also reflects CMC investments to strengthen our supply chain for RYTELO. We are reiterating our 2026 financial guidance. We expect RYTELO net revenue $220 million-$240 million, with a greater portion of growth anticipated in the back half of the year. Our total operating expense guidance of $230 million-$240 million reflects strong financial discipline and investment to support our commercial strategy. We are in a strong financial position and are on track to achieve our 2026 financial guidance as we execute on our strategic priorities to grow RYTELO while maintaining financial discipline.

[Michelle Robertson, CFO at Geron Corporation]

With that, I'll turn the call back to Harout for closing remarks.

[Harout Semerjian, CEO at Geron Corporation]

Thanks, Michelle. We continue to build a patient-focused, performance-driven culture at Geron, marked by a high level of cross-functional collaboration. Last month, we hosted our first all-company national meeting, which was a great opportunity to bring this energized group together and rally around the mission, values, and goals that drive us. We have the right team in place to execute on our strategic priorities, bring RYTELO to eligible patients, and achieve our 2026 financial guidance. For the remainder of 2026, we are focused on growing RYTELO in the U.S., pursuing pathways to bring RYTELO to patients outside the U.S., advancing our IMpactMF trial, remaining financially disciplined, and evaluating opportunistic innovation as we build Geron into a leading hematology company. Thank you again for your time and interest in Geron. Operator, we're now ready to start the Q&A session.

[Operator]

Thank you. At this time, we'll conduct a question and answer session. As a reminder to ask a question, you will need to press star one one on your telephone and wait for your name to be announced. To withdraw your question, please press star one one again. Please stand by while we compile the Q&A roster. Our first question comes from the line of Tara Bancroft of TD Cowen. Your line is now open.

[Tara Bancroft, Analyst at TD Cowen]

Hi. Good morning. I have a question on MF. You know, I know we've been hearing this theme that physicians are very data sensitive in terms of awareness. I was wondering if you had any updated thoughts on how you'll communicate the MF interim analysis this year. Like, would you consider giving any numbers in that release at all? With that, I'm also wondering if you think that the interim outcome could have any read-through to potential uptake of RYTELO in MDS. Thank you so much.

[Harout Semerjian, CEO at Geron Corporation]

IMpactMF trial, as you know, is fully enrolled, and we do project that we will do our interim analysis in the back half of this year. That's still on track. Typically these things, Tara, you know, the DMC would meet and, you know, obviously we're blinded, and we continue to want to stay blinded, depending on the outcomes obviously. The highest likelihood, at least from a planning perspective we see, is that they tell us, you know, "Keep on going." If, if they tell us anything else, then all these material, obviously, that we would communicate to the market accordingly. Joe, do you wanna add anything more?

[Joseph Eid, EVP of Research and Development and Chief Medical Officer at Geron Corporation]

Yeah. Good morning, Tara. I think your question is how do physicians react to it? The second is disease or indication where you do have a proof of concept and an overall survival at that. It definitely will have an effect, a positive effect because our message at MDS is that this is a disease-modifying agent. Having this proof of concept at the phase III with overall survival from an MF would definitely enhance and augment that awareness and that value of the [audio distortion] on it.

[Tara Bancroft, Analyst at TD Cowen]

Great. Thank you.

[Operator]

Thank you. One moment for our next question. Our next question comes from the line of Gil Blum of Needham & Company. Your line is now open.

[Gil Blum, Analyst at Needham & Company]

Good morning, and congrats on the progress. Just a quick one from us. As it relates to European markets, you guys said you may have conducted some market research. Just, sounding, you know, listening to your messaging, it kinda sounds like you're considering, moving forward on your own. Is this fair, or is this still a question mark? Thank you.

[Harout Semerjian, CEO at Geron Corporation]

Yeah. Good morning, Gil. Yeah. In line with what we have said is we want to explore all options to bring RYTELO to patients in Europe. As you know, the European opportunity from a patient numbers perspective can be in line with U.S. opportunities, so it's quite significant from a patient numbers perspective. Of course, the second part of that is the pricing, which is a very key inflection point for us. That needs work, that's kind of the work that we're doing. If you think about options for a company like us, it's really three different areas. One is the classical built-up model. The second on the other end is a full partnership with another pharma. We are not doing, you know, the first, to be clear.

[Harout Semerjian, CEO at Geron Corporation]

That's not where we're pursuing a very big classical buildup. That's really not for us. You know, partnerships are always an option. But also what we are seeing in the marketplace, Gil, is an emergence of new models and new partners in Europe that can complement what we're doing because there are a lot of companies, U.S.-based biotechs, that are having to put their thinking cap on and see how they can, you know, serve European patients. Many of them are choosing not to do anything about it, which we think is unfortunate for patients and for the mission. But at the same time, we wanna make sure that we're doing a thoughtful work. We're pursuing all these different opportunities, Gil.

[Harout Semerjian, CEO at Geron Corporation]

Before the end of the year, we will update the market in terms of where we land and what we think is the optimal way to bring RYTELO commercially to ex-US markets.

[Gil Blum, Analyst at Needham & Company]

Thank you for that. As a follow-up, will there be real-world data from imetelstat and low-risk MDS patients presented sometime this year? Thank you.

[Harout Semerjian, CEO at Geron Corporation]

Yeah. Maybe I'll hand it over to Joe to address that. It's a good question.

[Joseph Eid, EVP of Research and Development and Chief Medical Officer at Geron Corporation]

Yeah. Gil, we have, you know, a slew of, you know, research, investigator-sponsored research, including real-world data that will be presented at the upcoming meetings in the second half of this year, as we have been saying. Some of it will include the real-world utilization in MDS and how it's playing out in the real world. The early, you know, indication, as we have mentioned in the past, is that the data reflects the IMerge data from a responses, as well as.

[Operator]

Thank you. One moment for our next question. Our next question comes from the line of Corinne Johnson of Goldman Sachs. Your line is now open.

[Corinne Johnson, Analyst at Goldman Sachs]

Good morning. I think you've talked about this one L2L share, and it's been pretty stable in the 30% range. Maybe you could talk to us about the tactics you're using to increase adoption in the earlier line population and when you think we could start to see those educational efforts flowing through to changes in actual prescribing patterns, in a more meaningful way. Thanks.

[Harout Semerjian, CEO at Geron Corporation]

Yes. Good morning, Corinne. I think if I heard you right, your question was about the first line, second line share-

[Corinne Johnson, Analyst at Goldman Sachs]

Yes.

[Harout Semerjian, CEO at Geron Corporation]

of patients versus later. Okay, good. Yeah. What we are communicating today, Corinne, is the share of our utilization in the first line, second line versus the later line is 33% this quarter with a 12-month look back. As you remember, last quarter, it was at 30% with a 12-month look back. We continue to make progress in getting more and more of our patients in the first line, second line, and that's how we see our, you know, performance going forward is continuous progress, continuous growth quarter-over-quarter. That's the part, you know, strategy we're pursuing, iterating our guidance for the top line, between $220 million and $240 million.

[Corinne Johnson, Analyst at Goldman Sachs]

Okay, thank you.

[Operator]

Thank you. One moment for our next question. Our next question comes from the line of Emily Bodnar of H.C. Wainwright. Your line is now open.

[Emily Bodnar, Analyst at H.C. Wainwright]

Hi, good morning. Thanks for taking the questions. In terms of the 6% increase of demand in this quarter, what's your confidence in the sustainability of that for future quarters in 2026? Were there any seasonality impacts or other factors that you could specifically point to that helped increase demand in the first quarter? Thanks.

[Harout Semerjian, CEO at Geron Corporation]

Yeah, thank you, Emily. Yeah, look, I mean, we're pleased with where we are in Q1. Where we have landed is in line with our expectations in terms of both top line growth, also on the investment side. Our plan is to continue to grow quarter, you know, over quarter. That's the strategy we're pursuing, regardless of seasonality, different things that will happen every year. We know that. At the same time, you know, we do expect a gradual, and, you know, continuous growth quarter-over-quarter. This is one way we have communicated that, we have a guidance for the year in terms of the top line.

[Harout Semerjian, CEO at Geron Corporation]

We have also communicated that we think that growth will be more accelerated in the second half of the year, purely by the fact that we have done, you know, significant surgeries in Q4 and Q1. A lot of these programs do need time to kick into action. We wanna continue to fuel this growth quarter-over-quarter. It's not that we don't see it as like a total transformation inflection point between one day to the other. This is a story for us of continuous growth quarter-over-quarter. We do believe that the potential is tremendous in this low-risk MDS area, and we look forward to serving more patients and continuing to grow the business.

[Emily Bodnar, Analyst at H.C. Wainwright]

Great. Thank you.

[Operator]

Thank you. One moment for our next question. Again, as a reminder, to ask a question, you will need to press star one one on your telephone. Our next question comes from the line of Stephen Willey of Stifel. Your line is now open.

[Stephen Willey, Analyst at Stifel]

Yeah, good morning. Thanks for taking the questions. Just curious about the data you're seeing on the treatment duration and persistency fronts. I know that you've been in the market now, I guess, messaging the correlation between cytopenias and clinical benefit. Has that driven any measurable improvement in patient persistency over the last four to five months? Then I just have a follow-up.

[Harout Semerjian, CEO at Geron Corporation]

Good morning, Steve. What we see in the real world is really, you know, quite close to what we've seen in IMerge data, Steve, in terms of average duration of patients staying on therapy on RYTELO. What we are, you know, pursuing is more patients in the first line, second line. That would, you know, obviously increase the persistency of patients on treatment, right? This quarter we're up to 33% versus last quarter with a full month look back was at 34%. We, you know, wanna see that number continuously and gradually grow. Within the line, at this point, what we see is really in line with what IMerge has shown us in terms of, you know, average duration of patients on therapy.

[Stephen Willey, Analyst at Stifel]

Okay. Then I just guess, you know, with the business approaching break even and presumably some level of confidence into achieving profitability at least on a non-GAAP basis before the end of this year, just curious how active some of the peripheral BD efforts might be right now. You know, just whether or not there's a specific stage of development that you're looking for in an asset, and whether you think there's both the appetite and bandwidth to potentially execute on a transaction before the end of this year.

[Harout Semerjian, CEO at Geron Corporation]

Thanks, Steve. I mean, ultimately our main focus is on growing RYTELO, especially in the U.S. for the time being. Exploring, you know, ways to bring RYTELO to ex-US patients as well. We continue to do that. We have a healthy cash position. We've, we think I'll be even more disciplined from a financial perspective to ensure that we're executing per plan by doing it in a financial disciplined manner. That provides us, Steve, with, you know, a lot of different optionality in terms of, you know, wanting to do deals, not having to do deals. You know, staying opportunistic, looking at where else can we build our company in terms of what our long-term aspiration of building a hematology, you know, company that's consistent and sustainable.

[Harout Semerjian, CEO at Geron Corporation]

That's ultimately where we wanna go. We do have optionality, Steve. It's too early for us to comment on will we do a deal or not. We're always, you know, in the market looking for opportunities, but our, you know, very focused efforts are now on execution and making sure that RYTELO grows in line with our expectations and really by focusing on those 8,000 patients in the U.S. in the second line, which we believe we can really help more and more of them as the quarters come.

[Stephen Willey, Analyst at Stifel]

All right. Thanks.

[Operator]

Thank you. I'm showing no further questions at this time. I'll now turn it back to Harout Semerjian for closing remarks.

[Harout Semerjian, CEO at Geron Corporation]

Thank you very much, everyone, for joining our call today. We look forward to updating on our progress over the next quarters to come. Thank you very much. This concludes our call.

[Operator]

Thank you for your participation in today's conference. This does conclude the program. You may now disconnect.

Participants

Executives

• Ahmed ElNawawi, Chief Commercial Officer
• Dawn Carter Bir, Board of Directors Member
• Harout Semerjian, CEO
• Joseph Eid, EVP of Research and Development and Chief Medical Officer
• Michelle Robertson, CFO

Analysts

• Corinne Johnson, Analyst at Goldman Sachs
• Emily Bodnar, Analyst at H.C. Wainwright
• Gil Blum, Analyst at Needham & Company
• Stephen Willey, Analyst at Stifel
• Tara Bancroft, Analyst at TD Cowen