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Biofrontera (BFRI) Competitors

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$1.32 +0.08 (+6.45%)
Closing price 09/18/2026 04:00 PM Eastern
Extended Trading
$1.31 -0.01 (-0.98%)
As of 09/18/2026 07:58 PM Eastern
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BFRI vs. TENX, LONA, SPRO, ZYBT, and ATHE

Should you buy Biofrontera stock or one of its competitors? Biofrontera's main competitors and comparable companies include Tenax Therapeutics (TENX), Athira Pharma (LONA), Spero Therapeutics (SPRO), Zhengye Biotechnology (ZYBT), and Alterity Therapeutics (ATHE). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "pharmaceuticals" industry.

How does Biofrontera compare to Tenax Therapeutics?

Biofrontera (NASDAQ:BFRI) and Tenax Therapeutics (NASDAQ:TENX) are both small-cap healthcare companies, but which is the superior investment? We will compare the two businesses based on the strength of their institutional ownership, dividends, earnings, risk, valuation, profitability, media sentiment and analyst recommendations.

10.1% of Biofrontera shares are owned by institutional investors. Comparatively, 1.7% of Tenax Therapeutics shares are owned by institutional investors. 8.1% of Biofrontera shares are owned by insiders. Comparatively, 10.8% of Tenax Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

Tenax Therapeutics has a net margin of 0.00% compared to Biofrontera's net margin of -13.78%. Tenax Therapeutics' return on equity of -61.54% beat Biofrontera's return on equity.

Company Net Margins Return on Equity Return on Assets
Biofrontera-13.78% -145.81% -31.30%
Tenax Therapeutics N/A -61.54%-57.42%

Tenax Therapeutics has a consensus price target of $14.00, indicating a potential upside of 636.84%. Given Tenax Therapeutics' stronger consensus rating and higher possible upside, analysts plainly believe Tenax Therapeutics is more favorable than Biofrontera.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Biofrontera
1 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00
Tenax Therapeutics
1 Sell rating(s)
5 Hold rating(s)
3 Buy rating(s)
1 Strong Buy rating(s)
2.40

In the previous week, Tenax Therapeutics had 4 more articles in the media than Biofrontera. MarketBeat recorded 9 mentions for Tenax Therapeutics and 5 mentions for Biofrontera. Tenax Therapeutics' average media sentiment score of 1.51 beat Biofrontera's score of 0.66 indicating that Tenax Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Biofrontera
2 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Tenax Therapeutics
5 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive

Biofrontera has a beta of 0.83, indicating that its stock price is 17% less volatile than the broader market. Comparatively, Tenax Therapeutics has a beta of 0.83, indicating that its stock price is 17% less volatile than the broader market.

Biofrontera has higher revenue and earnings than Tenax Therapeutics. Biofrontera is trading at a lower price-to-earnings ratio than Tenax Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Biofrontera$41.71M0.47-$10.54M-$0.45N/A
Tenax TherapeuticsN/AN/A-$52.60M-$1.48N/A

Summary

Tenax Therapeutics beats Biofrontera on 10 of the 15 factors compared between the two stocks.

How does Biofrontera compare to Athira Pharma?

Athira Pharma (NASDAQ:LONA) and Biofrontera (NASDAQ:BFRI) are both small-cap healthcare companies, but which is the better stock? We will compare the two companies based on the strength of their valuation, earnings, analyst recommendations, media sentiment, institutional ownership, dividends, risk and profitability.

57.1% of Athira Pharma shares are held by institutional investors. Comparatively, 10.1% of Biofrontera shares are held by institutional investors. 25.7% of Athira Pharma shares are held by company insiders. Comparatively, 8.1% of Biofrontera shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.

Biofrontera has higher revenue and earnings than Athira Pharma. Biofrontera is trading at a lower price-to-earnings ratio than Athira Pharma, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Athira PharmaN/AN/A-$105.61M-$4.21N/A
Biofrontera$41.71M0.47-$10.54M-$0.45N/A

Athira Pharma has a net margin of 0.00% compared to Biofrontera's net margin of -13.78%. Biofrontera's return on equity of -145.81% beat Athira Pharma's return on equity.

Company Net Margins Return on Equity Return on Assets
Athira PharmaN/A -411.58% -225.73%
Biofrontera -13.78%-145.81%-31.30%

Athira Pharma presently has a consensus target price of $17.33, suggesting a potential upside of 155.28%. Given Athira Pharma's stronger consensus rating and higher possible upside, equities research analysts plainly believe Athira Pharma is more favorable than Biofrontera.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Athira Pharma
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.50
Biofrontera
1 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00

Athira Pharma has a beta of 2.05, meaning that its stock price is 105% more volatile than the broader market. Comparatively, Biofrontera has a beta of 0.83, meaning that its stock price is 17% less volatile than the broader market.

In the previous week, Biofrontera had 5 more articles in the media than Athira Pharma. MarketBeat recorded 5 mentions for Biofrontera and 0 mentions for Athira Pharma. Biofrontera's average media sentiment score of 0.66 beat Athira Pharma's score of 0.00 indicating that Biofrontera is being referred to more favorably in the news media.

Company Overall Sentiment
Athira Pharma Neutral
Biofrontera Positive

Summary

Athira Pharma beats Biofrontera on 8 of the 15 factors compared between the two stocks.

How does Biofrontera compare to Spero Therapeutics?

Spero Therapeutics (NASDAQ:SPRO) and Biofrontera (NASDAQ:BFRI) are both small-cap healthcare companies, but which is the superior stock? We will contrast the two businesses based on the strength of their valuation, risk, profitability, institutional ownership, media sentiment, dividends, earnings and analyst recommendations.

Spero Therapeutics has higher revenue and earnings than Biofrontera. Biofrontera is trading at a lower price-to-earnings ratio than Spero Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Spero Therapeutics$66.80M0.99$8.57M$0.1110.27
Biofrontera$41.71M0.47-$10.54M-$0.45N/A

In the previous week, Spero Therapeutics had 5 more articles in the media than Biofrontera. MarketBeat recorded 10 mentions for Spero Therapeutics and 5 mentions for Biofrontera. Spero Therapeutics' average media sentiment score of 1.16 beat Biofrontera's score of 0.66 indicating that Spero Therapeutics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Spero Therapeutics
2 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Biofrontera
2 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

25.6% of Spero Therapeutics shares are owned by institutional investors. Comparatively, 10.1% of Biofrontera shares are owned by institutional investors. 2.9% of Spero Therapeutics shares are owned by insiders. Comparatively, 8.1% of Biofrontera shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

Spero Therapeutics has a beta of 1.49, meaning that its share price is 49% more volatile than the broader market. Comparatively, Biofrontera has a beta of 0.83, meaning that its share price is 17% less volatile than the broader market.

Spero Therapeutics presently has a consensus price target of $6.00, suggesting a potential upside of 430.97%. Given Spero Therapeutics' stronger consensus rating and higher possible upside, equities analysts plainly believe Spero Therapeutics is more favorable than Biofrontera.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Spero Therapeutics
0 Sell rating(s)
3 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.25
Biofrontera
1 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00

Spero Therapeutics has a net margin of 24.90% compared to Biofrontera's net margin of -13.78%. Spero Therapeutics' return on equity of 16.17% beat Biofrontera's return on equity.

Company Net Margins Return on Equity Return on Assets
Spero Therapeutics24.90% 16.17% 12.57%
Biofrontera -13.78%-145.81%-31.30%

Summary

Spero Therapeutics beats Biofrontera on 14 of the 15 factors compared between the two stocks.

How does Biofrontera compare to Zhengye Biotechnology?

Zhengye Biotechnology (NASDAQ:ZYBT) and Biofrontera (NASDAQ:BFRI) are both small-cap healthcare companies, but which is the better stock? We will compare the two companies based on the strength of their valuation, earnings, institutional ownership, media sentiment, profitability, dividends, risk and analyst recommendations.

Zhengye Biotechnology has a beta of -2.56, indicating that its stock price is 356% less volatile than the broader market. Comparatively, Biofrontera has a beta of 0.83, indicating that its stock price is 17% less volatile than the broader market.

Zhengye Biotechnology has higher earnings, but lower revenue than Biofrontera.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Zhengye Biotechnology$16.64M3.90-$9.98MN/AN/A
Biofrontera$41.71M0.47-$10.54M-$0.45N/A

Zhengye Biotechnology has a net margin of 0.00% compared to Biofrontera's net margin of -13.78%. Zhengye Biotechnology's return on equity of 0.00% beat Biofrontera's return on equity.

Company Net Margins Return on Equity Return on Assets
Zhengye BiotechnologyN/A N/A N/A
Biofrontera -13.78%-145.81%-31.30%

10.1% of Biofrontera shares are held by institutional investors. 8.1% of Biofrontera shares are held by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

In the previous week, Biofrontera had 5 more articles in the media than Zhengye Biotechnology. MarketBeat recorded 5 mentions for Biofrontera and 0 mentions for Zhengye Biotechnology. Biofrontera's average media sentiment score of 0.66 beat Zhengye Biotechnology's score of 0.00 indicating that Biofrontera is being referred to more favorably in the news media.

Company Overall Sentiment
Zhengye Biotechnology Neutral
Biofrontera Positive

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Zhengye Biotechnology
1 Sell rating(s)
0 Hold rating(s)
0 Buy rating(s)
0 Strong Buy rating(s)
1.00
Biofrontera
1 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00

Summary

Biofrontera beats Zhengye Biotechnology on 8 of the 13 factors compared between the two stocks.

How does Biofrontera compare to Alterity Therapeutics?

Biofrontera (NASDAQ:BFRI) and Alterity Therapeutics (NASDAQ:ATHE) are both small-cap healthcare companies, but which is the superior stock? We will contrast the two companies based on the strength of their earnings, risk, analyst recommendations, dividends, valuation, profitability, media sentiment and institutional ownership.

Alterity Therapeutics has a net margin of 0.00% compared to Biofrontera's net margin of -13.78%. Alterity Therapeutics' return on equity of 0.00% beat Biofrontera's return on equity.

Company Net Margins Return on Equity Return on Assets
Biofrontera-13.78% -145.81% -31.30%
Alterity Therapeutics N/A N/A N/A

10.1% of Biofrontera shares are held by institutional investors. Comparatively, 2.1% of Alterity Therapeutics shares are held by institutional investors. 8.1% of Biofrontera shares are held by company insiders. Comparatively, 38.8% of Alterity Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

Biofrontera has a beta of 0.83, suggesting that its share price is 17% less volatile than the broader market. Comparatively, Alterity Therapeutics has a beta of 0.27, suggesting that its share price is 73% less volatile than the broader market.

Biofrontera has higher revenue and earnings than Alterity Therapeutics.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Biofrontera$41.71M0.47-$10.54M-$0.45N/A
Alterity TherapeuticsN/AN/A-$15.88MN/AN/A

In the previous week, Biofrontera had 3 more articles in the media than Alterity Therapeutics. MarketBeat recorded 5 mentions for Biofrontera and 2 mentions for Alterity Therapeutics. Biofrontera's average media sentiment score of 0.66 beat Alterity Therapeutics' score of 0.33 indicating that Biofrontera is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Biofrontera
2 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Alterity Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Alterity Therapeutics has a consensus price target of $10.00, indicating a potential upside of 155.75%. Given Alterity Therapeutics' stronger consensus rating and higher probable upside, analysts clearly believe Alterity Therapeutics is more favorable than Biofrontera.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Biofrontera
1 Sell rating(s)
1 Hold rating(s)
1 Buy rating(s)
0 Strong Buy rating(s)
2.00
Alterity Therapeutics
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.57

Summary

Alterity Therapeutics beats Biofrontera on 7 of the 13 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding BFRI and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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BFRI vs. The Competition

MetricBiofronteraPharmaceuticals IndustryHealthcare SectorNASDAQ Exchange
Market Cap$19.60M$12.47B$7.24B$13.19B
Dividend YieldN/A2.64%2.57%12.81%
P/E Ratio-2.93797.25275.4925.40
Price / Sales0.47753.62646.0189.45
Price / CashN/A86.3676.2551.42
Price / Book1.4710.5310.466.33
Net Income-$10.54M$2.82B$3.49B$358.33M
7 Day Performance-14.84%1.69%0.59%1.12%
1 Month Performance-10.81%0.24%-1.74%-2.39%
1 Year Performance46.67%3.95%18.13%5.35%

Biofrontera Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
BFRI
Biofrontera
1.2234 of 5 stars
$1.32
+6.5%
N/A+46.7%$19.60M$41.71MN/A94
TENX
Tenax Therapeutics
4.0387 of 5 stars
$1.82
-0.5%
$14.00
+669.2%
-70.4%$68.49MN/AN/A16
LONA
Athira Pharma
2.3457 of 5 stars
$6.79
-6.2%
$17.33
+155.3%
N/A$68.01MN/AN/A19
SPRO
Spero Therapeutics
4.1015 of 5 stars
$1.11
-1.8%
$6.00
+440.5%
-43.5%$65.81M$66.80M10.09150
ZYBT
Zhengye Biotechnology
N/A$1.37
-0.7%
N/A-85.2%$65.40M$16.64MN/A269

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This page (NASDAQ:BFRI) was last updated on 9/20/2026 by MarketBeat.com Staff.
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