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Hyperion DeFi (HYPD) Competitors

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$3.11 0.00 (0.00%)
Closing price 07/2/2026 04:00 PM Eastern
Extended Trading
$3.07 -0.04 (-1.25%)
As of 07/2/2026 07:55 PM Eastern
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HYPD vs. VYGR, KROS, RNA, UNCY, and ALXO

Should you buy Hyperion DeFi stock or one of its competitors? MarketBeat compares Hyperion DeFi with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Hyperion DeFi include Voyager Therapeutics (VYGR), Keros Therapeutics (KROS), Avidity Biosciences (RNA), Unicycive Therapeutics (UNCY), and ALX Oncology (ALXO). These companies are all part of the "pharmaceutical products" industry.

How does Hyperion DeFi compare to Voyager Therapeutics?

Voyager Therapeutics (NASDAQ:VYGR) and Hyperion DeFi (NASDAQ:HYPD) are both small-cap medical companies, but which is the superior business? We will compare the two businesses based on the strength of their profitability, analyst recommendations, media sentiment, dividends, risk, earnings, valuation and institutional ownership.

Hyperion DeFi has a net margin of 0.00% compared to Voyager Therapeutics' net margin of -319.61%. Voyager Therapeutics' return on equity of -55.97% beat Hyperion DeFi's return on equity.

Company Net Margins Return on Equity Return on Assets
Voyager Therapeutics-319.61% -55.97% -43.12%
Hyperion DeFi N/A -91.59%-73.08%

In the previous week, Voyager Therapeutics had 2 more articles in the media than Hyperion DeFi. MarketBeat recorded 4 mentions for Voyager Therapeutics and 2 mentions for Hyperion DeFi. Hyperion DeFi's average media sentiment score of 0.88 beat Voyager Therapeutics' score of 0.45 indicating that Hyperion DeFi is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Voyager Therapeutics
2 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Hyperion DeFi
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Voyager Therapeutics has a beta of 1.27, suggesting that its stock price is 27% more volatile than the broader market. Comparatively, Hyperion DeFi has a beta of 2.49, suggesting that its stock price is 149% more volatile than the broader market.

Voyager Therapeutics presently has a consensus target price of $16.50, suggesting a potential upside of 336.51%. Hyperion DeFi has a consensus target price of $6.95, suggesting a potential upside of 123.47%. Given Voyager Therapeutics' stronger consensus rating and higher possible upside, research analysts plainly believe Voyager Therapeutics is more favorable than Hyperion DeFi.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Voyager Therapeutics
1 Sell rating(s)
0 Hold rating(s)
2 Buy rating(s)
1 Strong Buy rating(s)
2.75
Hyperion DeFi
2 Sell rating(s)
0 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.00

Hyperion DeFi has lower revenue, but higher earnings than Voyager Therapeutics. Voyager Therapeutics is trading at a lower price-to-earnings ratio than Hyperion DeFi, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Voyager Therapeutics$36.49M6.26-$119.72M-$1.97N/A
Hyperion DeFi$810K58.21-$45.31M-$9.95N/A

48.0% of Voyager Therapeutics shares are held by institutional investors. Comparatively, 25.8% of Hyperion DeFi shares are held by institutional investors. 12.7% of Voyager Therapeutics shares are held by insiders. Comparatively, 7.5% of Hyperion DeFi shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

Summary

Voyager Therapeutics beats Hyperion DeFi on 10 of the 16 factors compared between the two stocks.

How does Hyperion DeFi compare to Keros Therapeutics?

Hyperion DeFi (NASDAQ:HYPD) and Keros Therapeutics (NASDAQ:KROS) are both small-cap medical companies, but which is the better business? We will contrast the two companies based on the strength of their profitability, valuation, analyst recommendations, risk, media sentiment, earnings, dividends and institutional ownership.

In the previous week, Hyperion DeFi had 1 more articles in the media than Keros Therapeutics. MarketBeat recorded 2 mentions for Hyperion DeFi and 1 mentions for Keros Therapeutics. Hyperion DeFi's average media sentiment score of 0.88 beat Keros Therapeutics' score of 0.00 indicating that Hyperion DeFi is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Hyperion DeFi
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Keros Therapeutics
0 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Hyperion DeFi has a net margin of 0.00% compared to Keros Therapeutics' net margin of -256.60%. Keros Therapeutics' return on equity of -17.04% beat Hyperion DeFi's return on equity.

Company Net Margins Return on Equity Return on Assets
Hyperion DeFiN/A -91.59% -73.08%
Keros Therapeutics -256.60%-17.04%-15.84%

25.8% of Hyperion DeFi shares are held by institutional investors. Comparatively, 71.6% of Keros Therapeutics shares are held by institutional investors. 7.5% of Hyperion DeFi shares are held by company insiders. Comparatively, 20.6% of Keros Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

Hyperion DeFi presently has a consensus target price of $6.95, suggesting a potential upside of 123.47%. Keros Therapeutics has a consensus target price of $20.40, suggesting a potential upside of 81.17%. Given Hyperion DeFi's higher probable upside, equities analysts plainly believe Hyperion DeFi is more favorable than Keros Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Hyperion DeFi
2 Sell rating(s)
0 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.00
Keros Therapeutics
1 Sell rating(s)
4 Hold rating(s)
3 Buy rating(s)
0 Strong Buy rating(s)
2.25

Keros Therapeutics has higher revenue and earnings than Hyperion DeFi. Keros Therapeutics is trading at a lower price-to-earnings ratio than Hyperion DeFi, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Hyperion DeFi$810K58.21-$45.31M-$9.95N/A
Keros Therapeutics$244.06M0.91$87.01M-$3.01N/A

Hyperion DeFi has a beta of 2.49, suggesting that its share price is 149% more volatile than the broader market. Comparatively, Keros Therapeutics has a beta of 0.97, suggesting that its share price is 3% less volatile than the broader market.

Summary

Keros Therapeutics beats Hyperion DeFi on 9 of the 16 factors compared between the two stocks.

How does Hyperion DeFi compare to Avidity Biosciences?

Hyperion DeFi (NASDAQ:HYPD) and Avidity Biosciences (NASDAQ:RNA) are both small-cap medical companies, but which is the superior business? We will contrast the two companies based on the strength of their risk, analyst recommendations, media sentiment, earnings, valuation, institutional ownership, dividends and profitability.

25.8% of Hyperion DeFi shares are held by institutional investors. 7.5% of Hyperion DeFi shares are held by company insiders. Comparatively, 3.8% of Avidity Biosciences shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

Hyperion DeFi has higher earnings, but lower revenue than Avidity Biosciences. Avidity Biosciences is trading at a lower price-to-earnings ratio than Hyperion DeFi, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Hyperion DeFi$810K58.21-$45.31M-$9.95N/A
Avidity Biosciences$36.68M6.37-$322.30M-$0.97N/A

Hyperion DeFi presently has a consensus target price of $6.95, suggesting a potential upside of 123.47%. Avidity Biosciences has a consensus target price of $66.81, suggesting a potential upside of 389.47%. Given Avidity Biosciences' stronger consensus rating and higher possible upside, analysts clearly believe Avidity Biosciences is more favorable than Hyperion DeFi.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Hyperion DeFi
2 Sell rating(s)
0 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.00
Avidity Biosciences
1 Sell rating(s)
12 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.32

In the previous week, Hyperion DeFi had 2 more articles in the media than Avidity Biosciences. MarketBeat recorded 2 mentions for Hyperion DeFi and 0 mentions for Avidity Biosciences. Hyperion DeFi's average media sentiment score of 0.88 beat Avidity Biosciences' score of 0.00 indicating that Hyperion DeFi is being referred to more favorably in the media.

Company Overall Sentiment
Hyperion DeFi Positive
Avidity Biosciences Neutral

Hyperion DeFi has a net margin of 0.00% compared to Avidity Biosciences' net margin of -3,650.39%. Avidity Biosciences' return on equity of -44.92% beat Hyperion DeFi's return on equity.

Company Net Margins Return on Equity Return on Assets
Hyperion DeFiN/A -91.59% -73.08%
Avidity Biosciences -3,650.39%-44.92%-39.57%

Hyperion DeFi has a beta of 2.49, meaning that its stock price is 149% more volatile than the broader market. Comparatively, Avidity Biosciences has a beta of 0.93, meaning that its stock price is 7% less volatile than the broader market.

Summary

Hyperion DeFi beats Avidity Biosciences on 9 of the 17 factors compared between the two stocks.

How does Hyperion DeFi compare to Unicycive Therapeutics?

Hyperion DeFi (NASDAQ:HYPD) and Unicycive Therapeutics (NASDAQ:UNCY) are both small-cap medical companies, but which is the superior investment? We will compare the two businesses based on the strength of their media sentiment, valuation, risk, analyst recommendations, dividends, earnings, profitability and institutional ownership.

Hyperion DeFi has a beta of 2.49, meaning that its share price is 149% more volatile than the broader market. Comparatively, Unicycive Therapeutics has a beta of 1.79, meaning that its share price is 79% more volatile than the broader market.

25.8% of Hyperion DeFi shares are held by institutional investors. Comparatively, 40.4% of Unicycive Therapeutics shares are held by institutional investors. 7.5% of Hyperion DeFi shares are held by insiders. Comparatively, 6.0% of Unicycive Therapeutics shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

In the previous week, Unicycive Therapeutics had 41 more articles in the media than Hyperion DeFi. MarketBeat recorded 43 mentions for Unicycive Therapeutics and 2 mentions for Hyperion DeFi. Hyperion DeFi's average media sentiment score of 0.88 beat Unicycive Therapeutics' score of -0.20 indicating that Hyperion DeFi is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Hyperion DeFi
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Unicycive Therapeutics
1 Very Positive mention(s)
2 Positive mention(s)
7 Neutral mention(s)
1 Negative mention(s)
2 Very Negative mention(s)
Neutral

Hyperion DeFi's return on equity of -91.59% beat Unicycive Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Hyperion DeFiN/A -91.59% -73.08%
Unicycive Therapeutics N/A -134.69%-84.51%

Unicycive Therapeutics has lower revenue, but higher earnings than Hyperion DeFi. Unicycive Therapeutics is trading at a lower price-to-earnings ratio than Hyperion DeFi, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Hyperion DeFi$810K58.21-$45.31M-$9.95N/A
Unicycive Therapeutics$680K230.80-$26.56M-$2.21N/A

Hyperion DeFi currently has a consensus price target of $6.95, suggesting a potential upside of 123.47%. Unicycive Therapeutics has a consensus price target of $27.40, suggesting a potential upside of 378.18%. Given Unicycive Therapeutics' stronger consensus rating and higher probable upside, analysts plainly believe Unicycive Therapeutics is more favorable than Hyperion DeFi.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Hyperion DeFi
2 Sell rating(s)
0 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.00
Unicycive Therapeutics
1 Sell rating(s)
0 Hold rating(s)
6 Buy rating(s)
0 Strong Buy rating(s)
2.71

Summary

Unicycive Therapeutics beats Hyperion DeFi on 8 of the 15 factors compared between the two stocks.

How does Hyperion DeFi compare to ALX Oncology?

ALX Oncology (NASDAQ:ALXO) and Hyperion DeFi (NASDAQ:HYPD) are both small-cap medical companies, but which is the superior business? We will compare the two companies based on the strength of their profitability, media sentiment, dividends, risk, analyst recommendations, institutional ownership, valuation and earnings.

In the previous week, ALX Oncology and ALX Oncology both had 2 articles in the media. Hyperion DeFi's average media sentiment score of 0.88 beat ALX Oncology's score of 0.00 indicating that Hyperion DeFi is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
ALX Oncology
0 Very Positive mention(s)
0 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Hyperion DeFi
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

98.0% of ALX Oncology shares are held by institutional investors. Comparatively, 25.8% of Hyperion DeFi shares are held by institutional investors. 21.0% of ALX Oncology shares are held by insiders. Comparatively, 7.5% of Hyperion DeFi shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

ALX Oncology currently has a consensus target price of $4.60, suggesting a potential upside of 122.22%. Hyperion DeFi has a consensus target price of $6.95, suggesting a potential upside of 123.47%. Given Hyperion DeFi's higher possible upside, analysts plainly believe Hyperion DeFi is more favorable than ALX Oncology.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
ALX Oncology
1 Sell rating(s)
0 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.67
Hyperion DeFi
2 Sell rating(s)
0 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.00

ALX Oncology has a beta of 0.42, suggesting that its stock price is 58% less volatile than the broader market. Comparatively, Hyperion DeFi has a beta of 2.49, suggesting that its stock price is 149% more volatile than the broader market.

Hyperion DeFi has higher revenue and earnings than ALX Oncology. ALX Oncology is trading at a lower price-to-earnings ratio than Hyperion DeFi, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
ALX OncologyN/AN/A-$101.69M-$1.49N/A
Hyperion DeFi$810K58.21-$45.31M-$9.95N/A

Hyperion DeFi's return on equity of -91.59% beat ALX Oncology's return on equity.

Company Net Margins Return on Equity Return on Assets
ALX OncologyN/A -124.06% -85.57%
Hyperion DeFi N/A -91.59%-73.08%

Summary

Hyperion DeFi beats ALX Oncology on 8 of the 13 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding HYPD and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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HYPD vs. The Competition

MetricHyperion DeFiBiotechnology IndustryMedical SectorNASDAQ Exchange
Market Cap$47.14M$431.50M$7.16B$12.48B
Dividend YieldN/A3.88%2.66%6.52%
P/E Ratio-0.313.0928.0224.70
Price / Sales58.216,669.11540.3799.46
Price / CashN/A13.1349.2657.09
Price / Book0.6688.6710.966.46
Net Income-$45.31M-$96.07M$3.57B$337.01M
7 Day Performance2.81%0.17%2.12%1.69%
1 Month Performance4.01%2.10%5.25%3.81%
1 Year Performance-80.51%68.02%33.29%23.90%

Hyperion DeFi Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
HYPD
Hyperion DeFi
3.4239 of 5 stars
$3.11
flat
$6.95
+123.5%
-80.5%$47.14M$810KN/A40
VYGR
Voyager Therapeutics
2.9489 of 5 stars
$3.70
-0.7%
$16.50
+346.5%
+15.2%$223.44M$36.49MN/A100
KROS
Keros Therapeutics
2.7087 of 5 stars
$11.27
+2.6%
$20.40
+81.1%
-15.5%$222.95M$244.06MN/A100
RNA
Avidity Biosciences
1.9465 of 5 stars
$13.00
+0.5%
$66.81
+413.9%
-53.1%$222.38M$36.68MN/A190
UNCY
Unicycive Therapeutics
3.2652 of 5 stars
$8.11
+3.0%
$24.75
+205.2%
+23.6%$222.33M$680KN/A9

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This page (NASDAQ:HYPD) was last updated on 7/5/2026 by MarketBeat.com Staff.
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