Clearside Biomedical (CLSD) Competitors $0.35 +0.01 (+3.00%) Closing price 09/4/2025 04:00 PM EasternExtended Trading$0.34 -0.01 (-1.51%) As of 04:16 AM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock CLSD vs. PLX, TARA, CRBP, OTLK, COYA, IOBT, EQ, ADAG, BMEA, and ANEBShould you be buying Clearside Biomedical stock or one of its competitors? The main competitors of Clearside Biomedical include Protalix BioTherapeutics (PLX), Protara Therapeutics (TARA), Corbus Pharmaceuticals (CRBP), Oncobiologics (OTLK), Coya Therapeutics (COYA), IO Biotech (IOBT), Equillium (EQ), Adagene (ADAG), Biomea Fusion (BMEA), and Anebulo Pharmaceuticals (ANEB). These companies are all part of the "pharmaceutical products" industry. Clearside Biomedical vs. Its Competitors Protalix BioTherapeutics Protara Therapeutics Corbus Pharmaceuticals Oncobiologics Coya Therapeutics IO Biotech Equillium Adagene Biomea Fusion Anebulo Pharmaceuticals Protalix BioTherapeutics (NYSE:PLX) and Clearside Biomedical (NASDAQ:CLSD) are both small-cap medical companies, but which is the better stock? We will compare the two companies based on the strength of their earnings, risk, analyst recommendations, profitability, institutional ownership, dividends, media sentiment and valuation. Do insiders and institutionals hold more shares of PLX or CLSD? 16.5% of Protalix BioTherapeutics shares are owned by institutional investors. Comparatively, 18.8% of Clearside Biomedical shares are owned by institutional investors. 6.5% of Protalix BioTherapeutics shares are owned by company insiders. Comparatively, 6.7% of Clearside Biomedical shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock will outperform the market over the long term. Which has more risk and volatility, PLX or CLSD? Protalix BioTherapeutics has a beta of -0.23, suggesting that its share price is 123% less volatile than the S&P 500. Comparatively, Clearside Biomedical has a beta of 2.11, suggesting that its share price is 111% more volatile than the S&P 500. Does the media favor PLX or CLSD? In the previous week, Protalix BioTherapeutics had 1 more articles in the media than Clearside Biomedical. MarketBeat recorded 1 mentions for Protalix BioTherapeutics and 0 mentions for Clearside Biomedical. Protalix BioTherapeutics' average media sentiment score of 1.73 beat Clearside Biomedical's score of 0.00 indicating that Protalix BioTherapeutics is being referred to more favorably in the media. Company Overall Sentiment Protalix BioTherapeutics Very Positive Clearside Biomedical Neutral Which has preferable earnings and valuation, PLX or CLSD? Protalix BioTherapeutics has higher revenue and earnings than Clearside Biomedical. Clearside Biomedical is trading at a lower price-to-earnings ratio than Protalix BioTherapeutics, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioProtalix BioTherapeutics$61.95M2.05$8.31M$0.0722.71Clearside Biomedical$1.66M16.57-$34.35M-$0.37-0.95 Is PLX or CLSD more profitable? Protalix BioTherapeutics has a net margin of -21.03% compared to Clearside Biomedical's net margin of -665.19%. Clearside Biomedical's return on equity of 0.00% beat Protalix BioTherapeutics' return on equity.Company Net Margins Return on Equity Return on Assets Protalix BioTherapeutics-21.03% -30.89% -11.74% Clearside Biomedical -665.19%N/A -124.15% Do analysts prefer PLX or CLSD? Protalix BioTherapeutics presently has a consensus price target of $15.00, suggesting a potential upside of 843.40%. Clearside Biomedical has a consensus price target of $4.20, suggesting a potential upside of 1,098.97%. Given Clearside Biomedical's higher probable upside, analysts plainly believe Clearside Biomedical is more favorable than Protalix BioTherapeutics.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Protalix BioTherapeutics 0 Sell rating(s) 0 Hold rating(s) 1 Buy rating(s) 0 Strong Buy rating(s) 3.00Clearside Biomedical 0 Sell rating(s) 5 Hold rating(s) 1 Buy rating(s) 0 Strong Buy rating(s) 2.17 SummaryProtalix BioTherapeutics beats Clearside Biomedical on 8 of the 15 factors compared between the two stocks. Get Clearside Biomedical News Delivered to You Automatically Sign up to receive the latest news and ratings for CLSD and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding CLSD and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart CLSD vs. The Competition Export to ExcelMetricClearside BiomedicalMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$26.70M$3.13B$5.76B$9.85BDividend YieldN/A2.28%6.67%4.51%P/E Ratio-0.9520.8975.7526.43Price / Sales16.57458.96547.78119.09Price / CashN/A44.5237.0558.92Price / Book-0.699.9311.156.06Net Income-$34.35M-$53.38M$3.29B$266.28M7 Day Performance-4.68%0.63%0.20%-0.32%1 Month Performance-17.90%6.31%6.30%3.44%1 Year Performance-62.23%11.63%54.81%23.11% Clearside Biomedical Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)CLSDClearside Biomedical2.5268 of 5 stars$0.35+3.0%$4.20+1,099.0%-63.5%$26.70M$1.66M-0.9530Gap DownPLXProtalix BioTherapeutics3.3838 of 5 stars$1.60-3.6%$15.00+837.5%+57.4%$127.57M$61.95M-12.31200Positive NewsTARAProtara Therapeutics2.5456 of 5 stars$3.05-1.9%$19.60+542.6%+64.2%$119.99MN/A-1.8830CRBPCorbus Pharmaceuticals4.0236 of 5 stars$9.89+1.0%$49.00+395.4%-81.9%$119.98MN/A-2.0840OTLKOncobiologics1.6122 of 5 stars$2.97+10.8%$9.60+223.2%-87.9%$119.05M$1.51M-5.2120Options VolumeGap UpHigh Trading VolumeCOYACoya Therapeutics2.6411 of 5 stars$6.50-5.2%$16.50+153.8%+9.6%$114.73M$3.55M-5.246Analyst ForecastGap UpHigh Trading VolumeIOBTIO Biotech2.3258 of 5 stars$1.71-1.7%$8.67+406.8%+84.3%$114.63MN/A-1.0830Short Interest ↑EQEquillium0.5072 of 5 stars$1.90flat$1.00-47.4%+76.6%$113.06M$41.10M-3.3940News CoverageShort Interest ↑ADAGAdagene3.0546 of 5 stars$2.35-1.7%$7.00+197.9%-25.2%$112.59M$100K0.00260Short Interest ↓Gap DownBMEABiomea Fusion3.5771 of 5 stars$1.81-1.1%$16.80+828.2%-76.1%$108.90MN/A-0.6050News CoverageANEBAnebulo Pharmaceuticals1.9658 of 5 stars$2.70+3.8%$5.50+103.7%+27.1%$106.82MN/A-10.384 Related Companies and Tools Related Companies Protalix BioTherapeutics Competitors Protara Therapeutics Competitors Corbus Pharmaceuticals Competitors Oncobiologics Competitors Coya Therapeutics Competitors IO Biotech Competitors Equillium Competitors Adagene Competitors Biomea Fusion Competitors Anebulo Pharmaceuticals Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:CLSD) was last updated on 9/5/2025 by MarketBeat.com Staff From Our Partners“Sell Nvidia before earnings”Eric Fry just went live with one of his most controversial calls yet: “Sell Nvidia.” While Wall Street has bee...InvestorPlace | SponsoredHow “Trump’s New Dollar” Could Impact Your WealthPresident Trump just signed a game-changing law… That could soon upgrade the U.S. dollar in your checking a...Brownstone Research | SponsoredForget Tesla — This Tiny AI Stock Is Musk’s Real PlayWhile Wall Street focused on Tesla’s earnings, Elon Musk was quietly building a supercomputer so powerful it c...Behind the Markets | SponsoredRetire Comfortably with These New Monthly Income ETFs?Too many retirees lie awake at night, worried their savings won’t last. 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