OPKO Health (OPK) Competitors $1.40 -0.03 (-2.10%) Closing price 09/12/2025 04:00 PM EasternExtended Trading$1.41 +0.01 (+0.71%) As of 09/12/2025 07:27 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock OPK vs. LGND, FOLD, BCRX, MNKD, CLDX, INVA, NVAX, DVAX, ZBIO, and GERNShould you be buying OPKO Health stock or one of its competitors? The main competitors of OPKO Health include Ligand Pharmaceuticals (LGND), Amicus Therapeutics (FOLD), BioCryst Pharmaceuticals (BCRX), MannKind (MNKD), Celldex Therapeutics (CLDX), Innoviva (INVA), Novavax (NVAX), Dynavax Technologies (DVAX), Zenas BioPharma (ZBIO), and Geron (GERN). These companies are all part of the "biotechnology" industry. OPKO Health vs. Its Competitors Ligand Pharmaceuticals Amicus Therapeutics BioCryst Pharmaceuticals MannKind Celldex Therapeutics Innoviva Novavax Dynavax Technologies Zenas BioPharma Geron Ligand Pharmaceuticals (NASDAQ:LGND) and OPKO Health (NASDAQ:OPK) are both medical companies, but which is the better stock? We will contrast the two companies based on the strength of their dividends, profitability, earnings, media sentiment, valuation, analyst recommendations, risk and institutional ownership. Do institutionals and insiders have more ownership in LGND or OPK? 91.3% of Ligand Pharmaceuticals shares are held by institutional investors. Comparatively, 64.6% of OPKO Health shares are held by institutional investors. 7.0% of Ligand Pharmaceuticals shares are held by insiders. Comparatively, 49.7% of OPKO Health shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company will outperform the market over the long term. Which has more risk and volatility, LGND or OPK? Ligand Pharmaceuticals has a beta of 0.96, meaning that its stock price is 4% less volatile than the S&P 500. Comparatively, OPKO Health has a beta of 1.4, meaning that its stock price is 40% more volatile than the S&P 500. Do analysts prefer LGND or OPK? Ligand Pharmaceuticals presently has a consensus target price of $176.50, suggesting a potential upside of 6.49%. OPKO Health has a consensus target price of $2.75, suggesting a potential upside of 96.43%. Given OPKO Health's higher possible upside, analysts clearly believe OPKO Health is more favorable than Ligand Pharmaceuticals.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Ligand Pharmaceuticals 0 Sell rating(s) 0 Hold rating(s) 6 Buy rating(s) 0 Strong Buy rating(s) 3.00OPKO Health 0 Sell rating(s) 2 Hold rating(s) 3 Buy rating(s) 1 Strong Buy rating(s) 2.83 Does the media refer more to LGND or OPK? In the previous week, Ligand Pharmaceuticals had 3 more articles in the media than OPKO Health. MarketBeat recorded 5 mentions for Ligand Pharmaceuticals and 2 mentions for OPKO Health. Ligand Pharmaceuticals' average media sentiment score of 1.73 beat OPKO Health's score of 0.97 indicating that Ligand Pharmaceuticals is being referred to more favorably in the media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Ligand Pharmaceuticals 4 Very Positive mention(s) 0 Positive mention(s) 0 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Very Positive OPKO Health 0 Very Positive mention(s) 0 Positive mention(s) 1 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Is LGND or OPK more profitable? OPKO Health has a net margin of -26.68% compared to Ligand Pharmaceuticals' net margin of -40.44%. Ligand Pharmaceuticals' return on equity of -9.21% beat OPKO Health's return on equity.Company Net Margins Return on Equity Return on Assets Ligand Pharmaceuticals-40.44% -9.21% -8.09% OPKO Health -26.68%-13.17%-8.28% Which has stronger earnings and valuation, LGND or OPK? Ligand Pharmaceuticals has higher earnings, but lower revenue than OPKO Health. Ligand Pharmaceuticals is trading at a lower price-to-earnings ratio than OPKO Health, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioLigand Pharmaceuticals$167.13M19.44-$4.03M-$4.00-41.44OPKO Health$713.10M1.56-$53.22M-$0.25-5.60 SummaryLigand Pharmaceuticals beats OPKO Health on 9 of the 17 factors compared between the two stocks. Get OPKO Health News Delivered to You Automatically Sign up to receive the latest news and ratings for OPK and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding OPK and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart OPK vs. The Competition Export to ExcelMetricOPKO HealthMED INSTRUMENTS IndustryMedical SectorNASDAQ ExchangeMarket Cap$1.14B$6.88B$5.84B$10.14BDividend YieldN/A1.21%5.68%4.60%P/E Ratio-5.6026.0175.4125.98Price / Sales1.56191.22515.81181.13Price / Cash20.7922.1337.5660.44Price / Book0.705.0012.156.29Net Income-$53.22M$176.38M$3.29B$271.07M7 Day Performance3.70%1.00%0.74%3.87%1 Month Performance3.70%2.09%5.00%5.49%1 Year Performance-10.83%10.96%62.55%25.86% OPKO Health Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)OPKOPKO Health4.398 of 5 stars$1.40-2.1%$2.75+96.4%-10.8%$1.14B$713.10M-5.602,997LGNDLigand Pharmaceuticals4.2733 of 5 stars$165.86-0.5%$176.50+6.4%+58.2%$3.25B$167.13M-41.4780Positive NewsShort Interest ↑FOLDAmicus Therapeutics3.9591 of 5 stars$7.98-0.1%$16.00+100.5%-29.3%$2.46B$528.29M-66.49480Positive NewsBCRXBioCryst Pharmaceuticals4.2487 of 5 stars$8.19-1.0%$16.70+103.9%-0.1%$1.72B$450.71M-45.50530Positive NewsMNKDMannKind4.4177 of 5 stars$5.57+0.5%$10.71+92.4%-11.2%$1.71B$285.50M50.64400Positive NewsShort Interest ↓CLDXCelldex Therapeutics2.403 of 5 stars$23.40+2.3%$46.67+99.4%-44.6%$1.55B$7.02M-7.77150Positive NewsHigh Trading VolumeINVAInnoviva4.8494 of 5 stars$20.46-0.1%$42.75+108.9%-2.2%$1.29B$358.71M66.00100Positive NewsAnalyst DowngradeShort Interest ↓NVAXNovavax4.4823 of 5 stars$7.73-2.2%$14.29+84.8%-41.4%$1.26B$682.16M3.391,990Positive NewsDVAXDynavax Technologies4.458 of 5 stars$9.70-3.6%$24.33+150.9%-15.8%$1.14B$277.25M-21.09350Positive NewsZBIOZenas BioPharma1.1926 of 5 stars$21.51+4.9%$36.67+70.5%N/A$905.79M$5M-6.06N/AHigh Trading VolumeGERNGeron3.1322 of 5 stars$1.37-2.1%$4.19+205.7%-71.8%$874.09M$76.99M-10.5470Positive News Related Companies and Tools Related Companies LGND Competitors FOLD Competitors BCRX Competitors MNKD Competitors CLDX Competitors INVA Competitors NVAX Competitors DVAX Competitors ZBIO Competitors GERN Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:OPK) was last updated on 9/14/2025 by MarketBeat.com Staff From Our PartnersStunning new initiative unfolding in the White House?what I just learned about what’s unfolding in the White House is truly stunning… And you need to see it for...Paradigm Press | SponsoredTrump set to Boost Social Security Checks by 400%?If you're collecting or planning to collect social security... 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