OPKO Health (OPK) Competitors $1.35 -0.03 (-2.17%) Closing price 04:00 PM EasternExtended Trading$1.32 -0.03 (-2.22%) As of 04:25 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock OPK vs. FOLD, LGND, BCRX, MNKD, DVAX, CLDX, INVA, NVAX, GERN, and MYGNShould you be buying OPKO Health stock or one of its competitors? The main competitors of OPKO Health include Amicus Therapeutics (FOLD), Ligand Pharmaceuticals (LGND), BioCryst Pharmaceuticals (BCRX), MannKind (MNKD), Dynavax Technologies (DVAX), Celldex Therapeutics (CLDX), Innoviva (INVA), Novavax (NVAX), Geron (GERN), and Myriad Genetics (MYGN). These companies are all part of the "biotechnology" industry. OPKO Health vs. Amicus Therapeutics Ligand Pharmaceuticals BioCryst Pharmaceuticals MannKind Dynavax Technologies Celldex Therapeutics Innoviva Novavax Geron Myriad Genetics OPKO Health (NASDAQ:OPK) and Amicus Therapeutics (NASDAQ:FOLD) are both medical companies, but which is the better business? We will compare the two companies based on the strength of their profitability, risk, community ranking, institutional ownership, media sentiment, earnings, valuation, dividends and analyst recommendations. Does the MarketBeat Community prefer OPK or FOLD? Amicus Therapeutics received 19 more outperform votes than OPKO Health when rated by MarketBeat users. Likewise, 72.98% of users gave Amicus Therapeutics an outperform vote while only 65.69% of users gave OPKO Health an outperform vote. CompanyUnderperformOutperformOPKO HealthOutperform Votes51365.69% Underperform Votes26834.31% Amicus TherapeuticsOutperform Votes53272.98% Underperform Votes19727.02% Is OPK or FOLD more profitable? Amicus Therapeutics has a net margin of -10.62% compared to OPKO Health's net margin of -18.65%. Amicus Therapeutics' return on equity of 12.44% beat OPKO Health's return on equity.Company Net Margins Return on Equity Return on Assets OPKO Health-18.65% -9.76% -6.46% Amicus Therapeutics -10.62%12.44%2.60% Which has stronger valuation & earnings, OPK or FOLD? Amicus Therapeutics has lower revenue, but higher earnings than OPKO Health. Amicus Therapeutics is trading at a lower price-to-earnings ratio than OPKO Health, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioOPKO Health$713.14M1.26-$188.86M-$0.09-14.83Amicus Therapeutics$528.30M3.93-$151.58M-$0.18-37.54 Do institutionals & insiders have more ownership in OPK or FOLD? 64.6% of OPKO Health shares are owned by institutional investors. 49.7% of OPKO Health shares are owned by company insiders. Comparatively, 2.2% of Amicus Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term. Does the media prefer OPK or FOLD? In the previous week, OPKO Health had 5 more articles in the media than Amicus Therapeutics. MarketBeat recorded 20 mentions for OPKO Health and 15 mentions for Amicus Therapeutics. Amicus Therapeutics' average media sentiment score of 1.07 beat OPKO Health's score of 0.39 indicating that Amicus Therapeutics is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment OPKO Health 4 Very Positive mention(s) 2 Positive mention(s) 9 Neutral mention(s) 1 Negative mention(s) 0 Very Negative mention(s) Neutral Amicus Therapeutics 6 Very Positive mention(s) 0 Positive mention(s) 5 Neutral mention(s) 1 Negative mention(s) 0 Very Negative mention(s) Positive Do analysts recommend OPK or FOLD? OPKO Health currently has a consensus target price of $2.75, suggesting a potential upside of 105.99%. Amicus Therapeutics has a consensus target price of $16.75, suggesting a potential upside of 147.85%. Given Amicus Therapeutics' stronger consensus rating and higher probable upside, analysts plainly believe Amicus Therapeutics is more favorable than OPKO Health.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score OPKO Health 0 Sell rating(s) 1 Hold rating(s) 3 Buy rating(s) 0 Strong Buy rating(s) 2.75Amicus Therapeutics 0 Sell rating(s) 2 Hold rating(s) 7 Buy rating(s) 0 Strong Buy rating(s) 2.78 Which has more volatility and risk, OPK or FOLD? OPKO Health has a beta of 1.78, suggesting that its stock price is 78% more volatile than the S&P 500. Comparatively, Amicus Therapeutics has a beta of 0.79, suggesting that its stock price is 21% less volatile than the S&P 500. SummaryAmicus Therapeutics beats OPKO Health on 11 of the 18 factors compared between the two stocks. Get OPKO Health News Delivered to You Automatically Sign up to receive the latest news and ratings for OPK and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding {thisCompany.Symbol} and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart OPK vs. The Competition Export to ExcelMetricOPKO HealthPharmaceutical IndustryMedical SectorNASDAQ ExchangeMarket Cap$896.52M$6.74B$5.50B$7.96BDividend YieldN/A3.05%5.11%4.23%P/E Ratio-7.037.3822.6318.55Price / Sales1.26241.88397.30103.38Price / CashN/A65.8538.1834.62Price / Book0.746.476.704.25Net Income-$188.86M$143.68M$3.23B$248.27M7 Day Performance-8.56%1.85%1.36%1.28%1 Month Performance-19.58%6.73%3.85%3.75%1 Year Performance5.12%-2.72%15.87%5.31% OPKO Health Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)OPKOPKO Health4.4752 of 5 stars$1.35-2.2%$2.75+103.7%+13.1%$906.59M$713.14M-7.114,200Earnings ReportNews CoverageGap DownFOLDAmicus Therapeutics4.3781 of 5 stars$6.71-1.8%$16.75+149.6%-23.1%$2.06B$528.30M-37.28480News CoveragePositive NewsGap DownLGNDLigand Pharmaceuticals4.394 of 5 stars$105.04+0.1%$146.43+39.4%+57.2%$2.02B$167.13M41.8580Upcoming EarningsNews CoverageBCRXBioCryst Pharmaceuticals4.4718 of 5 stars$7.55+2.0%$15.57+106.2%+114.3%$1.58B$450.71M-12.38530Upcoming EarningsAnalyst ForecastAnalyst RevisionNews CoverageMNKDMannKind3.1248 of 5 stars$4.45-2.0%$9.56+114.9%+22.6%$1.35B$285.50M63.57400Upcoming EarningsDVAXDynavax Technologies4.3666 of 5 stars$10.41+1.0%$20.50+96.9%+3.3%$1.29B$277.25M57.83350Upcoming EarningsCLDXCelldex Therapeutics1.9858 of 5 stars$19.00+3.8%$54.33+186.0%-44.3%$1.26B$7.02M-7.39150Upcoming EarningsAnalyst ForecastNews CoveragePositive NewsGap UpINVAInnoviva4.2281 of 5 stars$18.31+0.2%$55.00+200.4%+23.7%$1.15B$358.71M26.54100Upcoming EarningsAnalyst UpgradeNews CoveragePositive NewsNVAXNovavax3.6179 of 5 stars$6.09+1.5%$18.00+195.6%+54.0%$979.54M$682.16M-2.691,990GERNGeron4.0034 of 5 stars$1.36+6.7%$5.75+324.4%-64.1%$863.02M$76.99M-4.2370Upcoming EarningsMYGNMyriad Genetics4.1143 of 5 stars$7.45-2.5%$20.61+176.6%-62.1%$686.67M$837.60M-5.732,600Upcoming Earnings Related Companies and Tools Related Companies FOLD Competitors LGND Competitors BCRX Competitors MNKD Competitors DVAX Competitors CLDX Competitors INVA Competitors NVAX Competitors GERN Competitors MYGN Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:OPK) was last updated on 5/1/2025 by MarketBeat.com Staff From Our PartnersHow to invest in Elon Musk’s Optimus before its launchElon Musk is set to completely take over the AI industry with Optimus… A breakthrough AI-powered robot that El...InvestorPlace | SponsoredBlackrock’s Sending THIS Crypto Higher on PurposeWhile everyone's distracted by Bitcoin's moves, a stealth revolution is underway. 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