Phio Pharmaceuticals (PHIO) Competitors $2.18 -0.14 (-6.03%) Closing price 09/12/2025 04:00 PM EasternExtended Trading$2.22 +0.03 (+1.61%) As of 09/12/2025 07:27 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsHeadlinesInsider TradesOwnershipSEC FilingsShort InterestTrendsBuy This Stock PHIO vs. ANVS, AADI, LTRN, TPST, ATHE, XFOR, TELO, KLTO, IPSC, and ACRVShould you be buying Phio Pharmaceuticals stock or one of its competitors? The main competitors of Phio Pharmaceuticals include Annovis Bio (ANVS), Aadi Bioscience (AADI), Lantern Pharma (LTRN), Tempest Therapeutics (TPST), Alterity Therapeutics (ATHE), X4 Pharmaceuticals (XFOR), Telomir Pharmaceuticals (TELO), Klotho Neurosciences (KLTO), Century Therapeutics (IPSC), and Acrivon Therapeutics (ACRV). These companies are all part of the "pharmaceutical products" industry. Phio Pharmaceuticals vs. Its Competitors Annovis Bio Aadi Bioscience Lantern Pharma Tempest Therapeutics Alterity Therapeutics X4 Pharmaceuticals Telomir Pharmaceuticals Klotho Neurosciences Century Therapeutics Acrivon Therapeutics Annovis Bio (NYSE:ANVS) and Phio Pharmaceuticals (NASDAQ:PHIO) are both small-cap medical companies, but which is the better business? We will contrast the two companies based on the strength of their dividends, risk, valuation, earnings, institutional ownership, analyst recommendations, profitability and media sentiment. Do analysts recommend ANVS or PHIO? Annovis Bio currently has a consensus target price of $17.33, suggesting a potential upside of 596.12%. Phio Pharmaceuticals has a consensus target price of $14.00, suggesting a potential upside of 542.20%. Given Annovis Bio's higher possible upside, analysts clearly believe Annovis Bio is more favorable than Phio Pharmaceuticals.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Annovis Bio 0 Sell rating(s) 2 Hold rating(s) 3 Buy rating(s) 0 Strong Buy rating(s) 2.60Phio Pharmaceuticals 0 Sell rating(s) 0 Hold rating(s) 1 Buy rating(s) 0 Strong Buy rating(s) 3.00 Which has more volatility and risk, ANVS or PHIO? Annovis Bio has a beta of 1.65, meaning that its stock price is 65% more volatile than the S&P 500. Comparatively, Phio Pharmaceuticals has a beta of 0.89, meaning that its stock price is 11% less volatile than the S&P 500. Does the media prefer ANVS or PHIO? In the previous week, Annovis Bio and Annovis Bio both had 2 articles in the media. Phio Pharmaceuticals' average media sentiment score of 1.45 beat Annovis Bio's score of 0.77 indicating that Phio Pharmaceuticals is being referred to more favorably in the news media. Company Overall Sentiment Annovis Bio Positive Phio Pharmaceuticals Positive Is ANVS or PHIO more profitable? Phio Pharmaceuticals' return on equity of -88.75% beat Annovis Bio's return on equity.Company Net Margins Return on Equity Return on Assets Annovis BioN/A -206.01% -158.26% Phio Pharmaceuticals N/A -88.75%-77.98% Which has better earnings and valuation, ANVS or PHIO? Annovis Bio is trading at a lower price-to-earnings ratio than Phio Pharmaceuticals, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioAnnovis BioN/AN/A-$24.59M-$2.04-1.22Phio PharmaceuticalsN/AN/A-$7.15M-$3.25-0.67 Do insiders & institutionals hold more shares of ANVS or PHIO? 15.8% of Annovis Bio shares are held by institutional investors. Comparatively, 57.3% of Phio Pharmaceuticals shares are held by institutional investors. 20.8% of Annovis Bio shares are held by company insiders. Comparatively, 0.9% of Phio Pharmaceuticals shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term. SummaryPhio Pharmaceuticals beats Annovis Bio on 7 of the 12 factors compared between the two stocks. Get Phio Pharmaceuticals News Delivered to You Automatically Sign up to receive the latest news and ratings for PHIO and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding PHIO and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart PHIO vs. The Competition Export to ExcelMetricPhio PharmaceuticalsMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$13.29M$2.59B$5.86B$10.14BDividend YieldN/A56.51%5.68%4.59%P/E Ratio-0.6723.5374.5225.93Price / SalesN/A699.46547.62126.81Price / CashN/A171.1637.5660.44Price / Book3.165.3712.166.29Net Income-$7.15M$32.95M$3.28B$270.77M7 Day Performance6.86%1.28%0.87%3.88%1 Month Performance-0.46%6.09%4.96%4.88%1 Year Performance-33.94%-2.15%60.75%26.01% Phio Pharmaceuticals Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)PHIOPhio Pharmaceuticals3.0209 of 5 stars$2.18-6.0%$14.00+542.2%-24.8%$13.29MN/A-0.6710Short Interest ↓ANVSAnnovis Bio2.5303 of 5 stars$2.32flat$18.00+675.9%-70.6%$45.01MN/A-1.143AADIAadi BioscienceN/A$1.81+2.0%N/A+13.6%$44.58M$25.07M-0.7940LTRNLantern Pharma2.5962 of 5 stars$4.08+0.5%$25.00+512.7%+1.1%$44.06MN/A-2.2920Positive NewsTPSTTempest Therapeutics2.4474 of 5 stars$9.92+0.7%$30.00+202.4%-40.7%$44.05MN/A-0.6820ATHEAlterity Therapeutics2.4686 of 5 stars$4.94-1.6%$12.00+142.9%+287.3%$43.80MN/A0.0010XFORX4 Pharmaceuticals4.6982 of 5 stars$3.76-8.7%$34.17+808.7%-84.0%$42.84M$2.56M-0.2580Short Interest ↓Gap DownTELOTelomir Pharmaceuticals1.987 of 5 stars$1.32-10.8%$15.00+1,036.4%-77.1%$42.61MN/A-2.441Short Interest ↑KLTOKlotho Neurosciences0.4444 of 5 stars$0.69-4.3%N/AN/A$42.58MN/A-1.54N/AGap UpIPSCCentury Therapeutics2.3813 of 5 stars$0.49-2.0%$3.75+665.3%-67.5%$42.48M$6.59M-1.69170Positive NewsACRVAcrivon Therapeutics3.5733 of 5 stars$1.34+0.8%$17.57+1,211.3%-83.5%$42.15MN/A-0.6058Short Interest ↓Gap Up Related Companies and Tools Related Companies ANVS Competitors AADI Competitors LTRN Competitors TPST Competitors ATHE Competitors XFOR Competitors TELO Competitors KLTO Competitors IPSC Competitors ACRV Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:PHIO) was last updated on 9/13/2025 by MarketBeat.com Staff From Our PartnersWhy Trump’s “Smart Dollar” could rewrite the rulesMUST SEE: Donald Trump's Radical Overhaul of the U.S. Dollar Congress just approved President Trump's lates...Stansberry Research | SponsoredTrump's Law S.1582: $21T Dollar Revolution ComingDo you have money in any of these banks? 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