Spero Therapeutics (SPRO) Competitors $0.66 +0.00 (+0.30%) Closing price 04:00 PM EasternExtended Trading$0.66 +0.00 (+0.30%) As of 04:08 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock SPRO vs. IPHA, CYBN, LFVN, AARD, NBTX, MOLN, DMAC, TNGX, ACIU, and DERMShould you be buying Spero Therapeutics stock or one of its competitors? The main competitors of Spero Therapeutics include Innate Pharma (IPHA), Cybin (CYBN), LifeVantage (LFVN), Aardvark Therapeutics (AARD), Nanobiotix (NBTX), Molecular Partners (MOLN), DiaMedica Therapeutics (DMAC), Tango Therapeutics (TNGX), AC Immune (ACIU), and Journey Medical (DERM). These companies are all part of the "pharmaceutical products" industry. Spero Therapeutics vs. Innate Pharma Cybin LifeVantage Aardvark Therapeutics Nanobiotix Molecular Partners DiaMedica Therapeutics Tango Therapeutics AC Immune Journey Medical Innate Pharma (NASDAQ:IPHA) and Spero Therapeutics (NASDAQ:SPRO) are both small-cap medical companies, but which is the better stock? We will compare the two companies based on the strength of their profitability, media sentiment, dividends, valuation, risk, institutional ownership, community ranking, analyst recommendations and earnings. Which has more risk & volatility, IPHA or SPRO? Innate Pharma has a beta of 0.31, indicating that its share price is 69% less volatile than the S&P 500. Comparatively, Spero Therapeutics has a beta of 0.64, indicating that its share price is 36% less volatile than the S&P 500. Do institutionals and insiders believe in IPHA or SPRO? 0.2% of Innate Pharma shares are held by institutional investors. Comparatively, 25.6% of Spero Therapeutics shares are held by institutional investors. 31.9% of Innate Pharma shares are held by company insiders. Comparatively, 4.5% of Spero Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock will outperform the market over the long term. Does the media prefer IPHA or SPRO? In the previous week, Innate Pharma had 11 more articles in the media than Spero Therapeutics. MarketBeat recorded 15 mentions for Innate Pharma and 4 mentions for Spero Therapeutics. Spero Therapeutics' average media sentiment score of 0.22 beat Innate Pharma's score of -0.05 indicating that Spero Therapeutics is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Innate Pharma 2 Very Positive mention(s) 1 Positive mention(s) 3 Neutral mention(s) 2 Negative mention(s) 0 Very Negative mention(s) Neutral Spero Therapeutics 0 Very Positive mention(s) 0 Positive mention(s) 2 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Neutral Does the MarketBeat Community favor IPHA or SPRO? Spero Therapeutics received 161 more outperform votes than Innate Pharma when rated by MarketBeat users. Likewise, 69.67% of users gave Spero Therapeutics an outperform vote while only 60.00% of users gave Innate Pharma an outperform vote. CompanyUnderperformOutperformInnate PharmaOutperform Votes4860.00% Underperform Votes3240.00% Spero TherapeuticsOutperform Votes20969.67% Underperform Votes9130.33% Which has better earnings & valuation, IPHA or SPRO? Spero Therapeutics has higher revenue and earnings than Innate Pharma. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioInnate Pharma$12.63M14.89-$8.19MN/AN/ASpero Therapeutics$27.40M1.35$22.81M-$1.27-0.52 Do analysts prefer IPHA or SPRO? Innate Pharma presently has a consensus target price of $11.00, suggesting a potential upside of 390.20%. Spero Therapeutics has a consensus target price of $5.00, suggesting a potential upside of 657.58%. Given Spero Therapeutics' higher probable upside, analysts plainly believe Spero Therapeutics is more favorable than Innate Pharma.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Innate Pharma 0 Sell rating(s) 0 Hold rating(s) 1 Buy rating(s) 1 Strong Buy rating(s) 3.50Spero Therapeutics 0 Sell rating(s) 2 Hold rating(s) 2 Buy rating(s) 0 Strong Buy rating(s) 2.50 Is IPHA or SPRO more profitable? Spero Therapeutics has a net margin of 3.30% compared to Innate Pharma's net margin of 0.00%. Spero Therapeutics' return on equity of 4.03% beat Innate Pharma's return on equity.Company Net Margins Return on Equity Return on Assets Innate PharmaN/A N/A N/A Spero Therapeutics 3.30%4.03%2.21% SummarySpero Therapeutics beats Innate Pharma on 12 of the 17 factors compared between the two stocks. Get Spero Therapeutics News Delivered to You Automatically Sign up to receive the latest news and ratings for SPRO and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding {thisCompany.Symbol} and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart SPRO vs. The Competition Export to ExcelMetricSpero TherapeuticsPharmaceutical IndustryMedical SectorNASDAQ ExchangeMarket Cap$36.90M$6.84B$5.53B$7.93BDividend YieldN/A3.05%5.11%4.22%P/E Ratio9.437.3222.5118.54Price / Sales1.35241.49397.62103.34Price / Cash1.6265.8538.1834.62Price / Book0.336.486.734.25Net Income$22.81M$143.41M$3.22B$248.18M7 Day Performance-8.97%2.30%1.58%1.25%1 Month Performance-4.90%7.14%4.05%3.76%1 Year Performance-57.28%-2.61%15.75%5.28% Spero Therapeutics Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)SPROSpero Therapeutics4.3282 of 5 stars$0.66+0.3%$5.00+657.6%-53.7%$36.90M$27.40M9.43150Short Interest ↑IPHAInnate Pharma2.5698 of 5 stars$1.93-2.0%$11.50+495.9%-3.5%$161.79M$12.63M0.00220Analyst RevisionCYBNCybin1.5963 of 5 stars$7.29-0.8%$86.00+1,079.7%+1,820.0%$156.57MN/A-1.6650LFVNLifeVantage4.2047 of 5 stars$12.38-7.8%$30.50+146.4%+102.8%$155.38M$212.15M22.11260Positive NewsGap DownAARDAardvark TherapeuticsN/A$7.12+1.7%$31.50+342.4%N/A$154.48MN/A0.0018NBTXNanobiotix1.9488 of 5 stars$3.23-1.8%$8.00+147.7%-43.0%$152.24M$-11,609,000.000.00100Gap DownMOLNMolecular Partners2.4054 of 5 stars$3.77-5.0%$12.00+218.3%+3.1%$152.21M$4.97M-1.75180Gap UpDMACDiaMedica Therapeutics1.7026 of 5 stars$3.53-0.3%$8.00+126.6%+60.9%$151.28MN/A-6.3020Upcoming EarningsTNGXTango Therapeutics2.3695 of 5 stars$1.38+7.0%$12.33+793.7%-81.7%$149.19M$42.07M-1.1790Upcoming EarningsNews CoverageACIUAC Immune2.4787 of 5 stars$1.48flat$12.00+710.8%-30.2%$148.61M$27.31M-3.22140Earnings ReportAnalyst ForecastNews CoveragePositive NewsDERMJourney Medical2.6531 of 5 stars$6.33+1.3%$9.88+56.0%+101.1%$146.25M$56.13M-6.7390Short Interest ↑News Coverage Related Companies and Tools Related Companies Innate Pharma Alternatives Cybin Alternatives LifeVantage Alternatives Aardvark Therapeutics Alternatives Nanobiotix Alternatives Molecular Partners Alternatives DiaMedica Therapeutics Alternatives Tango Therapeutics Alternatives AC Immune Alternatives Journey Medical Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:SPRO) was last updated on 5/1/2025 by MarketBeat.com Staff From Our PartnersHow to invest in Elon Musk’s Optimus before its launchElon Musk is set to completely take over the AI industry with Optimus… A breakthrough AI-powered robot that El...InvestorPlace | SponsoredElon’s Terrifying Warning Forces Trump To Take ActionElon Musk has avoided two major financial crises before. 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