Spyre Therapeutics (SYRE) Stock Price, News & Analysis

Company Overview

Spyre Therapeutics, Inc. is a clinical-stage biotechnology company focused on the discovery and development of novel immunotherapies for cancer. The company leverages proprietary protein engineering and biologics design platforms to create targeted molecules intended to enhance anti-tumor immune responses and inhibit tumor growth. Its preclinical pipeline comprises multiple candidate therapies for solid tumor and hematologic oncology indications.

Established by a team with deep expertise in protein design, immunology and translational research, Spyre Therapeutics collaborates with leading academic institutions and research organizations to accelerate its discovery efforts. The company utilizes advanced screening technologies and a modular engineering approach to optimize therapeutic candidates, streamline preclinical development and position its programs for clinical readiness.

Based in the United States, Spyre Therapeutics operates a modern research and development facility that supports both in-house projects and external partnerships. Led by a management team experienced in biopharmaceutical innovation and development, the company is working to advance its lead programs into human trials and aims to bring new treatment options to patients with high-need cancers.

Key Stats

• Today's Range: $15.09 to $15.46
• 50-Day Range: $14.82 to $17.81
• 52-Week Range: $10.91 to $40.26
• Volume: 82,799 shs
• Average Volume: 597,520 shs
• Market Capitalization: $916.28 million
• P/E Ratio: N/A
• Dividend Yield: N/A
• Price Target: $56.17
• Consensus Rating: Buy

Spyre Therapeutics Stock Analysis - MarketRank™

Spyre Therapeutics scored higher than 53% of companies evaluated by MarketBeat, and ranked 543rd out of 950 stocks in the medical sector. Scores are calculated by averaging available category scores, with extra weight given to analysis and valuation.

Analyst's Opinion

• Score: 4.0 / 5
• Analyst Rating: Buy

Consensus Rating

Spyre Therapeutics has received a consensus rating of Buy. The company's average rating score is 3.25, and is based on 6 buy ratings, no hold ratings, and no sell ratings.

Upside Potential

Spyre Therapeutics has a consensus price target of $56.17, representing about 266.6% upside from its current price of $15.32.

Amount of Analyst Coverage

Spyre Therapeutics has only been the subject of 2 research reports in the past 90 days.

Earnings and Valuation

• Score: 0.6 / 5
• Proj. Earnings Growth: Growing

Earnings Growth

Earnings for Spyre Therapeutics are expected to grow in the coming year, from ($4.46) to ($3.99) per share.

Price to Earnings Ratio vs. the Market

The P/E ratio of Spyre Therapeutics is -4.51, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Earnings Ratio vs. Sector

The P/E ratio of Spyre Therapeutics is -4.51, which means that its earnings are negative and its P/E ratio cannot be compared to companies with positive earnings.

Price to Book Value per Share Ratio

Spyre Therapeutics has a P/B Ratio of 2.18. P/B Ratios below 3 indicates that a company is reasonably valued with respect to its assets and liabilities.

Short Interest

• Score: 0.0 / 5
• Short Interest Level: Bearish

Percentage of Shares Shorted

27.61% of the float of Spyre Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Spyre Therapeutics has a short interest ratio ("days to cover") of 25.8, which indicates bearish sentiment.

Change versus previous month

Short interest in Spyre Therapeutics has recently increased by 6.82%, indicating that investor sentiment is decreasing significantly.

Dividend

• Score: 0.0 / 5
• Dividend Strength: N/A

Dividend Yield

Spyre Therapeutics does not currently pay a dividend.

Dividend Growth

Spyre Therapeutics does not have a long track record of dividend growth.

Sustainability and ESG

• Score: N/A
• Environmental Score: N/A

Percentage of Shares Shorted

27.61% of the float of Spyre Therapeutics has been sold short.

Short Interest Ratio / Days to Cover

Spyre Therapeutics has a short interest ratio ("days to cover") of 25.8, which indicates bearish sentiment.

Change versus previous month

Short interest in Spyre Therapeutics has recently increased by 6.82%, indicating that investor sentiment is decreasing significantly.

News and Social Media

• Score: 2.4 / 5
• News Sentiment: 0.35

News Sentiment

Spyre Therapeutics has a news sentiment score of 0.35. This score is calculated as an average of sentiment of articles about the company over the last seven days and ranges from 2 (good news) to -2 (bad news). This is a lower news sentiment than the 0.63 average news sentiment score of Medical companies.

News Coverage This Week

MarketBeat has tracked 9 news articles for Spyre Therapeutics this week, compared to 4 articles on an average week.

Search Interest

6 people have searched for SYRE on MarketBeat in the last 30 days. This is an increase of 200% compared to the previous 30 days.

Company Ownership

• Score: 3.3 / 5
• Insider Trading: Selling Shares

Insider Buying vs. Insider Selling

In the past three months, Spyre Therapeutics insiders have sold more of their company's stock than they have bought. Specifically, they have bought $0.00 in company stock and sold $299,639.00 in company stock.

Percentage Held by Insiders

15.43% of the stock of Spyre Therapeutics is held by insiders. A high percentage of insider ownership can be a sign of company health.

Percentage Held by Institutions

80.39% of the stock of Spyre Therapeutics is held by institutions. High institutional ownership can be a signal of strong market trust in this company.

SYRE Stock Analysis - Frequently Asked Questions

How have SYRE shares performed this year?

Spyre Therapeutics' stock was trading at $23.28 at the beginning of the year. Since then, SYRE shares have decreased by 34.2% and is now trading at $15.32.

How were Spyre Therapeutics' earnings last quarter?

Spyre Therapeutics, Inc. (NASDAQ:SYRE) announced its earnings results on Tuesday, August, 5th. The company reported ($0.49) earnings per share (EPS) for the quarter, topping analysts' consensus estimates of ($0.73) by $0.24.

Who are Spyre Therapeutics' major shareholders?

Spyre Therapeutics' top institutional shareholders include Perceptive Advisors LLC (2.53%), Jefferies Financial Group Inc. (2.30%), Geode Capital Management LLC (2.04%) and Franklin Resources Inc. (1.32%).
View institutional ownership trends.

How do I buy shares of Spyre Therapeutics?

Shares of SYRE stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services.

What other stocks do shareholders of Spyre Therapeutics own?

Based on aggregate information from My MarketBeat watchlists, some other companies that Spyre Therapeutics investors own include NVIDIA (NVDA), Meta Platforms (META), Broadcom (AVGO), Advanced Micro Devices (AMD), Adobe (ADBE), ServiceNow (NOW) and Arista Networks (ANET).

Company Calendar

• Last Earnings: 8/05/2025
• Today: 9/19/2025
• Next Earnings (Estimated): 11/06/2025
• Fiscal Year End: 12/31/2025

Industry, Sector and Symbol

• Stock Exchange: NASDAQ
• Sector: Medical
• Industry: MED - BIOMED/GENE
• Sub-Industry: Pharmaceutical Products
• Current Symbol: NASDAQ:SYRE
• Previous Symbol: NASDAQ:SYRE
• CIK: 1636282
• Web: www.aeglea.com
• Phone: 512-942-2935
• Fax: 512-872-5121
• Employees: 73
• Year Founded: N/A

Price Target and Rating

• Average Price Target for Spyre Therapeutics: $56.17
• High Price Target: $70.00
• Low Price Target: $27.00
• Potential Upside/Downside: +266.6%
• Consensus Rating: Buy
• Rating Score (0-4): 3.25
• Research Coverage: 8 Analysts

Profitability

• EPS (Trailing Twelve Months): ($3.40)
• Trailing P/E Ratio: N/A
• Forward P/E Ratio: N/A
• P/E Growth: N/A
• Net Income: -$208.02 million
• Net Margins: N/A
• Pretax Margin: N/A
• Return on Equity: -71.30%
• Return on Assets: -38.69%

Debt

• Debt-to-Equity Ratio: N/A
• Current Ratio: 6.49
• Quick Ratio: 6.49

Sales & Book Value

• Annual Sales: N/A
• Price / Sales: N/A
• Cash Flow: N/A
• Price / Cash Flow: N/A
• Book Value: $7.04 per share
• Price / Book: 2.18

Miscellaneous

• Outstanding Shares: 60,401,000
• Free Float: 51,081,000
• Market Cap: $925.34 million
• Optionable: Optionable
• Beta: 2.87