Spyre Therapeutics (SYRE) Competitors $17.06 +0.48 (+2.90%) Closing price 08/26/2025 04:00 PM EasternExtended Trading$17.05 -0.01 (-0.06%) As of 04:00 AM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestTrendsBuy This Stock SYRE vs. ADMA, ZLAB, AKRO, TLX, PTCT, LNTH, APLS, MLTX, PTGX, and MIRMShould you be buying Spyre Therapeutics stock or one of its competitors? The main competitors of Spyre Therapeutics include ADMA Biologics (ADMA), Zai Lab (ZLAB), Akero Therapeutics (AKRO), Telix Pharmaceuticals (TLX), PTC Therapeutics (PTCT), Lantheus (LNTH), Apellis Pharmaceuticals (APLS), MoonLake Immunotherapeutics (MLTX), Protagonist Therapeutics (PTGX), and Mirum Pharmaceuticals (MIRM). These companies are all part of the "pharmaceutical products" industry. Spyre Therapeutics vs. Its Competitors ADMA Biologics Zai Lab Akero Therapeutics Telix Pharmaceuticals PTC Therapeutics Lantheus Apellis Pharmaceuticals MoonLake Immunotherapeutics Protagonist Therapeutics Mirum Pharmaceuticals Spyre Therapeutics (NASDAQ:SYRE) and ADMA Biologics (NASDAQ:ADMA) are both medical companies, but which is the better business? We will contrast the two companies based on the strength of their institutional ownership, analyst recommendations, media sentiment, profitability, valuation, earnings, risk and dividends. Do analysts rate SYRE or ADMA? Spyre Therapeutics currently has a consensus price target of $53.40, suggesting a potential upside of 213.01%. ADMA Biologics has a consensus price target of $27.67, suggesting a potential upside of 61.79%. Given Spyre Therapeutics' higher possible upside, equities analysts clearly believe Spyre Therapeutics is more favorable than ADMA Biologics.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Spyre Therapeutics 0 Sell rating(s) 0 Hold rating(s) 5 Buy rating(s) 2 Strong Buy rating(s) 3.29ADMA Biologics 0 Sell rating(s) 0 Hold rating(s) 2 Buy rating(s) 1 Strong Buy rating(s) 3.33 Which has more risk and volatility, SYRE or ADMA? Spyre Therapeutics has a beta of 2.82, meaning that its share price is 182% more volatile than the S&P 500. Comparatively, ADMA Biologics has a beta of 0.38, meaning that its share price is 62% less volatile than the S&P 500. Which has preferable earnings & valuation, SYRE or ADMA? ADMA Biologics has higher revenue and earnings than Spyre Therapeutics. Spyre Therapeutics is trading at a lower price-to-earnings ratio than ADMA Biologics, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioSpyre Therapeutics$890K1,157.78-$208.02M-$3.40-5.02ADMA Biologics$426.45M9.57$197.67M$0.8619.88 Is SYRE or ADMA more profitable? ADMA Biologics has a net margin of 44.06% compared to Spyre Therapeutics' net margin of 0.00%. ADMA Biologics' return on equity of 41.01% beat Spyre Therapeutics' return on equity.Company Net Margins Return on Equity Return on Assets Spyre TherapeuticsN/A -71.30% -38.69% ADMA Biologics 44.06%41.01%28.47% Do insiders & institutionals hold more shares of SYRE or ADMA? 80.4% of Spyre Therapeutics shares are held by institutional investors. Comparatively, 75.7% of ADMA Biologics shares are held by institutional investors. 6.2% of Spyre Therapeutics shares are held by insiders. Comparatively, 3.7% of ADMA Biologics shares are held by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term. Does the media prefer SYRE or ADMA? In the previous week, ADMA Biologics had 7 more articles in the media than Spyre Therapeutics. MarketBeat recorded 9 mentions for ADMA Biologics and 2 mentions for Spyre Therapeutics. ADMA Biologics' average media sentiment score of 1.70 beat Spyre Therapeutics' score of 1.33 indicating that ADMA Biologics is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Spyre Therapeutics 0 Very Positive mention(s) 0 Positive mention(s) 1 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive ADMA Biologics 8 Very Positive mention(s) 0 Positive mention(s) 0 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Very Positive SummaryADMA Biologics beats Spyre Therapeutics on 10 of the 17 factors compared between the two stocks. Get Spyre Therapeutics News Delivered to You Automatically Sign up to receive the latest news and ratings for SYRE and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding SYRE and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart SYRE vs. The Competition Export to ExcelMetricSpyre TherapeuticsMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$1.00B$3.07B$5.73B$9.74BDividend YieldN/A2.26%3.95%4.07%P/E Ratio-5.0220.5230.3026.09Price / Sales1,157.78354.12423.66106.24Price / CashN/A44.2437.7259.08Price / Book3.438.139.816.67Net Income-$208.02M-$54.08M$3.27B$265.43M7 Day Performance4.34%4.48%3.64%3.36%1 Month Performance-4.10%3.64%3.82%0.39%1 Year Performance-38.66%7.34%32.55%19.43% Spyre Therapeutics Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)SYRESpyre Therapeutics2.8654 of 5 stars$17.06+2.9%$53.40+213.0%-36.8%$1.00B$890K-5.0273News CoveragePositive NewsADMAADMA Biologics4.2713 of 5 stars$17.63+3.8%$27.67+56.9%-2.1%$4.05B$474.17M20.50530Positive NewsZLABZai Lab2.3996 of 5 stars$35.69-0.1%$57.22+60.3%+80.1%$3.97B$398.99M-17.501,869Analyst ForecastAKROAkero Therapeutics3.9862 of 5 stars$48.59-1.6%$81.57+67.9%+76.0%$3.95BN/A-24.3030Positive NewsTLXTelix PharmaceuticalsN/A$11.90+3.1%$22.33+87.7%N/A$3.91B$516.72M0.00N/AAnalyst RevisionHigh Trading VolumePTCTPTC Therapeutics4.3331 of 5 stars$49.80+2.0%$70.15+40.9%+41.7%$3.88B$1.76B7.141,410LNTHLantheus4.7626 of 5 stars$55.97+3.3%$105.50+88.5%-48.1%$3.68B$1.52B14.89700Analyst RevisionAPLSApellis Pharmaceuticals4.1324 of 5 stars$27.35-1.4%$34.12+24.7%-29.9%$3.50B$781.37M-15.03770MLTXMoonLake Immunotherapeutics2.0184 of 5 stars$53.73-1.2%$74.43+38.5%+13.2%$3.49BN/A-19.332PTGXProtagonist Therapeutics1.898 of 5 stars$56.21+0.2%$67.20+19.6%+37.0%$3.49B$434.43M80.30120News CoveragePositive NewsMIRMMirum Pharmaceuticals3.6124 of 5 stars$66.68-1.8%$74.13+11.2%+72.2%$3.41B$336.89M-55.11140Positive NewsAnalyst Downgrade Related Companies and Tools Related Companies ADMA Competitors ZLAB Competitors AKRO Competitors TLX Competitors PTCT Competitors LNTH Competitors APLS Competitors MLTX Competitors PTGX Competitors MIRM Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:SYRE) was last updated on 8/27/2025 by MarketBeat.com Staff From Our PartnersBONUS GUIDE - Ben Stein Prepares For the Next Financial CrisisWith inflation high, debt soaring, and global tensions rising, a financial storm may be brewing. 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