NYSEARCA:SBIO ALPS Medical Breakthroughs ETF (SBIO) Price, Holdings, & News $55.21 -1.17 (-2.08%) As of 04:10 PM Eastern Add Compare Share Share Stock Analysis Stock AnalysisChartHoldingsOwnershipRatingsShort InterestBuy This Stock About ALPS Medical Breakthroughs ETF (NYSEARCA:SBIO) View Price History Chart DataSkip Price History Chart 1 Day 5 Days 30 Days 90 Days 1 Year Advanced 1 Day 1 Day 5 Days 30 Days 90 Days 1 Year Advanced Show volume Show extended hours Get SBIO alerts:Sign Up Key Stats Today's Range$54.16▼$56.3850-Day Range$48.06▼$57.6052-Week Range$26.86▼$57.77Volume27,175 shsAverage Volume38,314 shsMarket Capitalization$160.11 millionAssets Under Management$163.30 millionDividend YieldN/ANet Expense Ratio0.50%Aggregate RatingModerate Buy ETF Overview The ALPS Medical Breakthroughs ETF (SBIO) is an exchange-traded fund that is based on the S-Network Medical Breakthroughs index. The fund tracks, a market-cap weighted index comprising US-listed biotech companies with one or more drugs currently in either Phase II or Phase III FDA clinical trials. SBIO was launched on Dec 31, 2014 and is managed by ALPS. Read More ALPS Medical Breakthroughs ETF ExpensesTypeSBIOHealth Care ETFsEquity ETFsNYSEARCA ETFsAll ETFsManagement Fee0.50%0.56%0.57%0.51%0.53%Other Expenses0.00%0.47%0.55%0.58%0.55%Total Expense0.50%0.74%0.76%0.74%0.73%Fee Waiver0.00%-0.71%-0.64%-0.70%-0.61%Net Expense0.50%0.59%0.63%0.58%0.60% Receive SBIO Stock News and Ratings via Email Sign-up to receive the latest news and ratings for ALPS Medical Breakthroughs ETF and its competitors with MarketBeat's FREE daily newsletter. Submit View SMS TermsSMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. 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SBIO ETF News HeadlinesSBIO: Leaning Into Drug Discovery And Medical BreakthroughsApril 28, 2026 | seekingalpha.comCreator TV® Announces 2026 Sports Programming under Studio Label, Creator TV SportsApril 2, 2026 | prnewswire.comIran's New Leader Just Said Something That Should Terrify Every AmericanIran's Supreme Leader has declared the Strait of Hormuz closed as leverage against the U.S. - and with 40% of the world's oil passing through that corridor, crude has already crossed $100 per barrel. History shows gold surged 571% during the 1973 oil crisis and 425% in 1979. Today, the U.S. holds 8,133 tonnes of gold valued on the books at $42.22 per ounce - while gold trades above $5,000. American Alternative Assets has released The Great Gold Reset report detailing what this gap could mean for investors.May 7 at 1:00 AM | American Alternative (Ad)Creator TV® and Convergence Announce Partnership to Bring Creator-Led Programming to TelevisionMarch 25, 2026 | prnewswire.comALPS Medical Breakthroughs ETF declares annual distribution of $0.0000December 19, 2025 | msn.comSBIO: A Shock Biotech Winner In 2025November 28, 2025 | seekingalpha.comSee More Headlines SBIO ETF - Frequently Asked Questions How have SBIO shares performed this year? ALPS Medical Breakthroughs ETF's stock was trading at $51.22 on January 1st, 2026. Since then, SBIO stock has increased by 7.8% and is now trading at $55.21. Who are ALPS Medical Breakthroughs ETF's major shareholders? ALPS Medical Breakthroughs ETF's top institutional investors include Moran Wealth Management LLC (1.17%), Sterling Investment Advisors Ltd. (0.76%), Silver Oak Securities Incorporated (0.66%) and Kestra Advisory Services LLC (0.29%). How do I buy shares of ALPS Medical Breakthroughs ETF? Shares of SBIO stock can be purchased through any online brokerage account. Popular online brokerages with access to the U.S. stock market include Charles Schwab, E*TRADE, Fidelity, and Vanguard Brokerage Services. What other stocks do shareholders of ALPS Medical Breakthroughs ETF own? Based on aggregate information from My MarketBeat watchlists, some other companies that ALPS Medical Breakthroughs ETF investors own include Waste Connections (WCN), American Water Works (AWK), iShares Micro-Cap ETF (IWC), The RMR Group (RMR), AUO (AUOTY), DiamondRock Hospitality (DRH) and Triple Flag Precious Metals (TFPM). Fund Details IssuerALPS Fund NameALPS Medical Breakthroughs ETF Tax ClassificationRegulated Investment Company Stock ExchangeNYSEARCACurrent SymbolNYSEARCA:SBIO Inception Date12/30/2014 Fund ManagerRyan Mischker, Andrew Hicks WebN/A PhoneN/AFund Focus Asset ClassEquity BenchmarkS-Network Medical Breakthroughs Index CategorySector FocusHealth Care Development LevelDeveloped Markets RegionNorth America Number of Holdings89 Fund Statistics Assets Under Management$163.30 million Average Daily Volume$41.66 thousand Discount/Premium0.07% Administrator, Advisor and Custodian AdministratorALPS Fund Services, Inc. AdvisorALPS Advisors, Inc. CustodianState Street Bank and Trust Company DistributorALPS Distributors, Inc. Transfer AgentState Street Bank and Trust Company TrusteeN/A Lead Market MakerGTS Options OptionableOptionable Options Volume3 Put Options2 Call Options3 Short Interest20,700 shs Miscellaneous Outstanding Shares2,900,000Beta0.77 Creation Unit50,000 Creation Fee$500.00 7 Stocks That Could Be Bigger Than Tesla, Nvidia, and GoogleLooking for the next FAANG stock before everyone has heard about it? Click the link to see which stocks MarketBeat analysts think might become the next trillion dollar tech company.Get This Free Report Top 10 SBIO HoldingsKymera Therapeutics (NASDAQ:KYMR)Holding Weight: 4.30%Alkermes (NASDAQ:ALKS)Holding Weight: 3.57%Mirum Pharmaceuticals (NASDAQ:MIRM)Holding Weight: 3.56%Celcuity (NASDAQ:CELC)Holding Weight: 3.49%CG Oncology (NASDAQ:CGON)Holding Weight: 3.48%Spyre Therapeutics (NASDAQ:SYRE)Holding Weight: 3.38%Apellis Pharmaceuticals (NASDAQ:APLS)Holding Weight: 3.29%Apogee Therapeutics (NASDAQ:APGE)Holding Weight: 3.00%Xenon Pharmaceuticals (NASDAQ:XENE)Holding Weight: 2.85%Crinetics Pharmaceuticals (NASDAQ:CRNX)Holding Weight: 2.51%Full Holdings DetailsSBIO Sector ExposureSBIO Industry Exposure This page (NYSEARCA:SBIO) was last updated on 5/7/2026 by MarketBeat.com Staff. 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