Affinity Asset Advisors, LLC Top Holdings and 13F Report (2025) About Affinity Asset Advisors, LLCInvestment ActivityAffinity Asset Advisors, LLC has $1.05 billion in total holdings as of March 31, 2025.Affinity Asset Advisors, LLC owns shares of 91 different stocks, but just 25 companies or ETFs make up 80% of its holdings.Approximately 50.32% of the portfolio was purchased this quarter.About 13.23% of the portfolio was sold this quarter.This quarter, Affinity Asset Advisors, LLC has purchased 83 new stocks and bought additional shares in 32 stocks.Affinity Asset Advisors, LLC sold shares of 17 stocks and completely divested from 18 stocks this quarter.Largest Holdings SPDR S&P 500 ETF Trust $240,537,700iShares Russell 2000 ETF $59,847,000Xenon Pharmaceuticals $44,560,271APOGEE THERAPEUTICS INC $43,008,795SPDR S&P Biotech ETF $40,550,000 Largest New Holdings this Quarter 78462F103 - SPDR S&P 500 ETF Trust $240,537,700 Holding464287655 - iShares Russell 2000 ETF $59,847,000 Holding02043Q107 - Alnylam Pharmaceuticals $14,851,100 Holding218352102 - Corcept Therapeutics $7,995,400 Holding89532M101 - Trevi Therapeutics $7,862,500 Holding Largest Purchases this Quarter SPDR S&P 500 ETF Trust 430,000 shares (about $240.54M)iShares Russell 2000 ETF 300,000 shares (about $59.85M)Protagonist Therapeutics 442,500 shares (about $21.40M)Travere Therapeutics 870,000 shares (about $15.59M)Mineralys Therapeutics 950,000 shares (about $15.09M) Largest Sales this Quarter SPDR S&P Biotech ETF 250,000 shares (about $20.28M)Crinetics Pharmaceuticals 307,748 shares (about $10.32M)Soleno Therapeutics 80,200 shares (about $5.73M)SPYRE THERAPEUTICS INC 342,650 shares (about $5.53M)Alkermes 100,000 shares (about $3.30M) Sector Allocation Over TimeMap of 500 Largest Holdings ofAffinity Asset Advisors, LLC Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorSPYSPDR S&P 500 ETF Trust$240,537,700$240,537,700 ▲New Holding430,00023.0%FinanceIWMiShares Russell 2000 ETF$59,847,000$59,847,000 ▲New Holding300,0005.7%FinanceXENEXenon Pharmaceuticals$44,560,271$5,600,770 ▲14.4%1,328,1754.3%MedicalAPOGEE THERAPEUTICS INC$43,008,795$8,199,437 ▲23.6%1,151,1994.1%COMXBISPDR S&P Biotech ETF$40,550,000$20,275,000 ▼-33.3%500,0003.9%ETFVRNAVerona Pharma$39,046,350$2,857,050 ▼-6.8%615,0003.7%MedicalACLXArcellx$34,768,000$6,888,000 ▲24.7%530,0003.3%MedicalALKSAlkermes$33,020,000$3,302,000 ▼-9.1%1,000,0003.2%MedicalNUVLNuvalent$32,623,200$12,411,000 ▲61.4%460,0003.1%MedicalPTGXProtagonist Therapeutics$27,686,100$21,399,300 ▲340.4%572,5002.6%MedicalMDGLMadrigal Pharmaceuticals$26,498,400$828,075 ▼-3.0%80,0002.5%MedicalCNTACentessa Pharmaceuticals$22,241,000$6,481,613 ▲41.1%1,546,6622.1%MedicalAMGNAmgen$21,808,500$12,462,000 ▲133.3%70,0002.1%MedicalTEVATeva Pharmaceutical Industries$21,518,0000.0%1,400,0002.1%MedicalMLYSMineralys Therapeutics$20,644,000$15,086,000 ▲271.4%1,300,0002.0%MedicalTVTXTravere Therapeutics$19,174,400$15,590,400 ▲435.0%1,070,0001.8%MedicalVERAVera Therapeutics$14,895,835$4,687,335 ▲45.9%620,1431.4%MedicalALNYAlnylam Pharmaceuticals$14,851,100$14,851,100 ▲New Holding55,0001.4%MedicalWVEWave Life Sciences$14,746,000$2,626,000 ▲21.7%1,825,0001.4%MedicalOMEROS CORP$14,275,2380.0%15,525,0001.4%NOTE 5.250% 2/1MRUSMerus$13,551,381$2,831,773 ▼-17.3%321,9621.3%MedicalAXSMAxsome Therapeutics$11,663,000$2,915,750 ▲33.3%100,0001.1%MedicalKARYOPHARM THERAPEUTICS INC$11,611,2320.0%15,250,0001.1%NOTE 3.000%10/1ESTAEstablishment Labs$11,425,400$22,647 ▲0.2%280,0001.1%MedicalINSMInsmed$10,680,600$6,866,100 ▲180.0%140,0001.0%MedicalBBIOBridgeBio Pharma$10,371,000$3,457,000 ▲50.0%300,0001.0%MedicalNAMSNewAmsterdam Pharma$10,230,906$1,531,156 ▲17.6%499,8001.0%MedicalNRIXNurix Therapeutics$9,630,748$1,537,438 ▼-13.8%810,6690.9%MedicalCORTCorcept Therapeutics$7,995,400$7,995,400 ▲New Holding70,0000.8%MedicalTRVITrevi Therapeutics$7,862,500$7,862,500 ▲New Holding1,250,0000.8%MedicalSPYRE THERAPEUTICS INC$7,771,875$5,528,658 ▼-41.6%481,6780.7%COM NEWIMVTImmunovant$7,348,700$5,639,700 ▲330.0%430,0000.7%MedicalTRAVERE THERAPEUTICS INC$6,993,000$999,000 ▲16.7%7,000,0000.7%NOTE 2.250% 3/0ORUKA THERAPEUTICS INC$5,595,414$1,812,573 ▲47.9%545,3620.5%COMNBIXNeurocrine Biosciences$5,530,000$5,530,000 ▲New Holding50,0000.5%MedicalAVALO THERAPEUTICS INC$5,263,804$852,176 ▲19.3%657,1540.5%COM NEWVRDNViridian Therapeutics$5,257,200$3,105,603 ▲144.3%390,0000.5%MedicalLEXEO THERAPEUTICS INC$5,138,657$5,138,657 ▲New Holding1,480,8810.5%COMCRNXCrinetics Pharmaceuticals$5,106,532$10,321,868 ▼-66.9%152,2520.5%MedicalEXELExelixis$4,984,200$4,984,200 ▲New Holding135,0000.5%MedicalRZLTRezolute$4,930,000$362,500 ▲7.9%1,700,0000.5%MedicalPERSPECTIVE THERAPEUTICS INC$4,737,537$1,968,537 ▲71.1%2,224,1960.5%COM NEWAUTLAutolus Therapeutics$4,719,750$2,255,250 ▼-32.3%3,045,0000.5%MedicalERASErasca$4,577,881$1,153,661 ▲33.7%3,341,5190.4%MedicalEWTXEdgewise Therapeutics$4,400,000$4,400,000 ▲New Holding200,0000.4%MedicalPRQRProQR Therapeutics$4,368,401$611,151 ▲16.3%3,284,5120.4%MedicalQUREuniQure$4,240,000$4,240,000 ▲New Holding400,0000.4%MedicalPERCEPTIVE CAP SOLUTIONS COR$3,619,0000.0%350,0000.3%CL A ORD SHSSLNOSoleno Therapeutics$3,572,500$5,730,290 ▼-61.6%50,0000.3%MedicalINZYInozyme Pharma$3,519,616$95,193 ▼-2.6%3,867,7100.3%MedicalIBRXImmunityBio$3,085,250$2,332,750 ▲310.0%1,025,0000.3%MedicalAKBAAkebia Therapeutics$2,880,000$2,880,000 ▲New Holding1,500,0000.3%MedicalCMPXCompass Therapeutics$2,776,863$2,776,863 ▲New Holding1,461,5070.3%MedicalMAZE THERAPEUTICS INC$2,752,500$2,752,500 ▲New Holding250,0000.3%COMNAMSWNewAmsterdam Pharma$2,746,212$45,650 ▲1.7%241,9570.3%MedicalKYMRKymera Therapeutics$2,737,000$1,642,200 ▲150.0%100,0000.3%MedicalOAKTREE ACQUISITION CORP III$2,595,0000.0%250,0000.2%UNIT 10/04/2029GERNGeron$2,385,000$1,192,500 ▼-33.3%1,500,0000.2%MedicalMONOPAR THERAPEUTICS INC$2,257,420$2,257,420 ▲New Holding62,0000.2%COM NEWGALTGalectin Therapeutics$2,240,164$800,076 ▼-26.3%1,836,2000.2%MedicalMIRMMirum Pharmaceuticals$2,238,625$948,303 ▼-29.8%49,6920.2%MedicalAVTEAerovate Therapeutics$2,008,0000.0%800,0000.2%MedicalCGEMCullinan Therapeutics$1,997,0950.0%263,8170.2%MedicalELYMEliem Therapeutics$1,830,000$1,220,000 ▲200.0%1,500,0000.2%MedicalONKURE THERAPEUTICS INC$1,694,884$1,075,000 ▲173.4%394,1590.2%COM CL ATOURMALINE BIO INC$1,521,000$1,521,000 ▲New Holding100,0000.1%COMROIVRoivant Sciences$1,513,500$1,513,500 ▲New Holding150,0000.1%MedicalNKTXNkarta$1,472,0000.0%800,0000.1%MedicalANTERIS TECHNOLOGIES GLOBAL$1,419,600$327,600 ▲30.0%390,0000.1%COMMBX BIOSCIENCES INC$1,291,500$1,291,500 ▲New Holding175,0000.1%COMTHRDTF Financial$1,283,900$1,283,900 ▲New Holding370,0000.1%MedicalETNB89bio$1,272,250$1,272,250 ▲New Holding175,0000.1%MedicalABIVAX SA$1,250,000$1,250,000 ▲New Holding200,0000.1%SPONSORED ADSOLMAOlema Pharmaceuticals$1,222,000$1,222,000 ▲New Holding325,0000.1%MedicalNXTCNextCure$1,105,9380.0%2,302,5980.1%MedicalMGTXMeiraGTx$1,017,000$1,017,000 ▲New Holding150,0000.1%MedicalPCVXVaxcyte$944,0000.0%25,0000.1%MedicalVKTXViking Therapeutics$603,750$603,750 ▲New Holding25,0000.1%MedicalSTROSutro Biopharma$489,721$489,721 ▲New Holding752,7220.0%MedicalCNTXContext Therapeutics$404,280$217,107 ▼-34.9%660,5890.0%MedicalBDTXBlack Diamond Therapeutics$387,500$479,203 ▼-55.3%250,0000.0%MedicalRADIOPHARM THERANOSTICS LTD$310,726$440,457 ▼-58.6%64,6000.0%SPONSORED ADSZURAZura Bio$288,1020.0%223,3350.0%MedicalOVIDOvid Therapeutics$208,198$208,198 ▲New Holding667,5160.0%MedicalRPTXRepare Therapeutics$197,180$98,590 ▲100.0%200,0000.0%MedicalADAGIO MED HLDGS INC$169,5430.0%213,2350.0%COMOMEROmeros$81,8550.0%9,9580.0%MedicalALLKAllakos$56,900$56,900 ▲New Holding250,0000.0%MedicalQ32 BIO INC$45,8320.0%27,7770.0%COMRCKTWRocket Pharmaceuticals$3,5250.0%75,0000.0%MedicalIMTXWImmatics$2,9580.0%187,2040.0%MedicalMESOBLAST LTD$0$16,604,280 ▼-100.0%00.0%SPONS ADRCOHERUS BIOSCIENCES INC$0$16,189,425 ▼-100.0%00.0%NOTE 1.500% 4/1ARVNArvinas$0$12,077,100 ▼-100.0%00.0%MedicalARWRArrowhead Pharmaceuticals$0$5,640,000 ▼-100.0%00.0%MedicalNEUMORA THERAPEUTICS INC.$0$5,035,000 ▼-100.0%00.0%COMSAVACassava Sciences$0$4,104,984 ▼-100.0%00.0%MedicalCMPSCOMPASS Pathways$0$3,214,935 ▼-100.0%00.0%MedicalCG ONCOLOGY INC$0$2,868,000 ▼-100.0%00.0%COMTECTONIC THERAPEUTIC INC$0$2,693,142 ▼-100.0%00.0%COMShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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