Baker Bros. Advisors Lp Top Holdings and 13F Report (2025) About Baker Bros. Advisors LpInvestment ActivityBaker Bros. Advisors Lp has $9.04 billion in total holdings as of March 31, 2025.Baker Bros. Advisors Lp owns shares of 89 different stocks, but just 9 companies or ETFs make up 80% of its holdings.Approximately 2.28% of the portfolio was purchased this quarter.About 4.58% of the portfolio was sold this quarter.This quarter, Baker Bros. Advisors Lp has purchased 95 new stocks and bought additional shares in 11 stocks.Baker Bros. Advisors Lp sold shares of 15 stocks and completely divested from 11 stocks this quarter.Largest Holdings BeiGene $2,394,838,255Incyte $1,861,304,154ACADIA Pharmaceuticals $712,202,185Madrigal Pharmaceuticals $654,043,446Summit Therapeutics $471,155,646 Largest New Holdings this Quarter 925050106 - Verona Pharma $14,211,792 Holding75915K309 - Regulus Therapeutics $4,714,577 Holding829401108 - Sionna Therapeutics, Inc. $4,184,000 Holding878972108 - Tectonic Therapeutic, Inc. $1,771,000 Holding Largest Purchases this Quarter Immunovant 3,750,000 shares (about $64.09M)Insmed 373,763 shares (about $28.51M)Immunocore 807,338 shares (about $23.95M)Vaxcyte 592,000 shares (about $22.35M)Celcuity 1,579,182 shares (about $15.97M) Largest Sales this Quarter BeiGene 732,827 shares (about $199.45M)Rhythm Pharmaceuticals 479,766 shares (about $25.41M)CRISPR Therapeutics 653,912 shares (about $22.25M)Akero Therapeutics 548,369 shares (about $22.20M)Xenon Pharmaceuticals 646,271 shares (about $21.68M) Sector Allocation Over TimeMap of 500 Largest Holdings ofBaker Bros. Advisors Lp Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorBGNEBeiGene$2,394,838,255$199,453,525 ▼-7.7%8,799,05326.5%MedicalINCYIncyte$1,861,304,154$29,488 ▲0.0%30,739,95320.6%MedicalACADACADIA Pharmaceuticals$712,202,1850.0%42,877,9167.9%MedicalMDGLMadrigal Pharmaceuticals$654,043,4460.0%1,974,5907.2%MedicalSMMTSummit Therapeutics$471,155,6460.0%24,424,8655.2%MedicalINSMInsmed$410,487,958$28,514,379 ▲7.5%5,380,6264.5%MedicalRYTMRhythm Pharmaceuticals$296,869,465$25,413,205 ▼-7.9%5,604,4833.3%MedicalRVMDRevolution Medicines$280,651,3300.0%7,936,9723.1%MedicalKYMRKymera Therapeutics$164,108,5770.0%5,995,9291.8%MedicalALKSAlkermes$148,038,071$9,956,653 ▲7.2%4,483,2851.6%MedicalEWTXEdgewise Therapeutics$135,430,6800.0%6,155,9401.5%MedicalREPLReplimune Group$107,692,0260.0%11,045,3361.2%MedicalInsmed Incorporated$101,588,4370.0%42,850,0001.1%Note 0.75% 6/1/2028IMVTImmunovant$93,275,186$64,087,500 ▲219.6%5,457,8811.0%MedicalBCYCBicycle Therapeutics$92,416,6810.0%10,885,3571.0%MedicalIMCRImmunocore$68,913,204$23,953,719 ▲53.3%2,322,6560.8%MedicalKiniksa Pharmaceuticals International, plc$62,594,9540.0%2,818,3230.7%ORD SHS CL AABCLAbCellera Biologics$61,382,1770.0%27,525,6400.7%MedicalRAREUltragenyx Pharmaceutical$57,071,0880.0%1,576,1140.6%MedicalDNLIDenali Therapeutics$50,732,3940.0%3,731,6950.6%MedicalKODKodiak Sciences$48,555,9240.0%17,310,4900.5%MedicalNRIXNurix Therapeutics$46,119,6450.0%3,882,1250.5%MedicalARGXargenx$46,023,422$20,208,638 ▼-30.5%77,7600.5%MedicalTRDAEntrada Therapeutics$43,987,0040.0%4,865,8190.5%MedicalCELCCelcuity$43,045,701$15,965,530 ▲59.0%4,257,7350.5%MedicalGRAIL, Inc.$41,633,3930.0%1,630,1250.5%COMROIVRoivant Sciences$38,016,8300.0%3,767,7730.4%MedicalIMTXImmatics$32,813,9930.0%7,275,8300.4%MedicalSTOKStoke Therapeutics$30,815,0230.0%4,633,8380.3%MedicalCERSCerus$26,898,011$175,490 ▼-0.6%19,351,0870.3%MedicalPCVXVaxcyte$24,199,818$22,353,920 ▲1,211.0%640,8850.3%MedicalGLUEMonte Rosa Therapeutics$22,810,6810.0%4,916,0950.3%MedicalCRSPCRISPR Therapeutics$22,258,989$22,252,625 ▼-50.0%654,0990.2%MedicalAKROAkero Therapeutics$22,211,902$22,197,977 ▼-50.0%548,7130.2%MedicalSERASera Prognostics$20,233,266$234,677 ▲1.2%5,498,1700.2%MedicalCNTACentessa Pharmaceuticals$17,646,8200.0%1,227,1780.2%MedicalNeurogene Inc.$17,403,402$9,505,593 ▲120.4%1,486,2000.2%COMIDYAIDEAYA Biosciences$17,397,5750.0%1,062,1230.2%MedicalVRNAVerona Pharma$14,211,792$14,211,792 ▲New Holding223,8430.2%MedicalCADLCandel Therapeutics$13,770,118$3,078,086 ▼-18.3%2,437,1890.2%MedicalPraxis Precision Medicines, Inc.$12,555,1550.0%331,5330.1%COMTSVT2seventy bio$12,337,7780.0%2,497,5260.1%MedicalXENEXenon Pharmaceuticals$11,655,538$21,682,391 ▼-65.0%347,4080.1%MedicalBicara Therapeutics Inc.$10,858,3290.0%833,3330.1%COMIONSIonis Pharmaceuticals$10,798,2960.0%357,9150.1%MedicalDBV Technologies S.A.$9,966,9190.0%1,461,4250.1%SPONSORED ADSAlumis Inc.$9,593,7500.0%1,562,5000.1%COMMRUSMerus$9,407,115$9,533,385 ▼-50.3%223,5000.1%MedicalPRLDPrelude Therapeutics$7,775,0970.0%10,123,8240.1%MedicalVERVVerve Therapeutics$7,730,2920.0%1,691,5300.1%MedicalRCKTRocket Pharmaceuticals$7,317,517$6,670,000 ▲1,030.1%1,097,0790.1%MedicalXNCRXencor$7,133,3860.0%670,4310.1%MedicalDyne Therapeutics, Inc.$7,030,1240.0%672,0960.1%COMKALAKALA BIO$6,886,8530.0%1,201,8940.1%MedicalDSGNDesign Therapeutics$6,730,7790.0%1,743,7250.1%MedicalGPCRStructure Therapeutics$6,258,6900.0%361,5650.1%MedicalTSHATaysha Gene Therapies$5,566,6110.0%4,004,7560.1%MedicalRGLSRegulus Therapeutics$4,714,577$4,714,577 ▲New Holding2,694,0440.1%MedicalIGMSIGM Biosciences$4,709,546$1,096 ▲0.0%4,095,2570.1%MedicalNTLAIntellia Therapeutics$4,579,6650.0%644,1160.1%MedicalCLDXCelldex Therapeutics$4,494,7390.0%247,6440.0%MedicalSionna Therapeutics, Inc.$4,184,000$4,184,000 ▲New Holding400,0000.0%COMBNTXBioNTech$4,100,5230.0%45,0310.0%MedicalTCRXTScan Therapeutics$3,843,0130.0%2,784,7920.0%MedicalIRONDisc Medicine$3,824,7620.0%77,0500.0%MedicalVIRVir Biotechnology$3,515,653$3,512,160 ▼-50.0%542,5390.0%MedicalSANASana Biotechnology$3,411,994$588,000 ▼-14.7%2,030,9490.0%MedicalSagimet Biosciences Inc.$3,106,7670.0%952,9960.0%COM SER ARLAYRelay Therapeutics$3,039,5070.0%1,160,1170.0%MedicalWVEWave Life Sciences$2,780,0290.0%344,0630.0%MedicalFATEFate Therapeutics$2,574,4630.0%3,258,4020.0%MedicalSkye Bioscience, Inc.$2,306,5140.0%1,450,6380.0%COMTARAProtara Therapeutics$2,286,9040.0%536,8320.0%MedicalELVNEnliven Therapeutics$2,259,9130.0%114,8330.0%MedicalContineum Therapeutics, Inc.$2,181,2500.0%312,5000.0%CL APRMEPrime Medicine$2,046,6470.0%1,028,4660.0%MedicalTectonic Therapeutic, Inc.$1,771,000$1,771,000 ▲New Holding100,0000.0%COMvTv Therapeutics, Inc.$1,685,4780.0%97,3140.0%CL ACMPXCompass Therapeutics$1,040,246$1,919,250 ▼-64.9%547,4980.0%MedicalNeumora Therapeutics, Inc.$1,034,6000.0%1,034,6000.0%COMHOOKIPA Pharma Inc.$877,8390.0%812,8140.0%COMGBIOGeneration Bio$787,7030.0%1,944,9450.0%MedicalAligos Therapeutics, Inc.$685,2040.0%83,0550.0%COMLPTXLeap Therapeutics$123,487$234,142 ▼-65.5%404,7440.0%MedicalIPSCCentury Therapeutics$115,042$264,550 ▼-69.7%241,6840.0%MedicalTYRATyra Biosciences$98,6450.0%10,6070.0%MedicalACRVAcrivon Therapeutics$46,302$61,054 ▼-56.9%22,8090.0%MedicalSRZNWSurrozen$25,0000.0%833,3330.0%MedicalOPTOpthea$0-4.0%2,087,3200.0%MedicalIonis Pharmaceuticals, Inc.$0$29,543,640 ▼-100.0%00.0%Note 1.75% 6/15/2028KRYSKrystal Biotech$0$26,621,860 ▼-100.0%00.0%MedicalMIRMMirum Pharmaceuticals$0$7,876,183 ▼-100.0%00.0%MedicalARVNArvinas$0$7,774,892 ▼-100.0%00.0%MedicalBMEABiomea Fusion$0$5,633,721 ▼-100.0%00.0%MedicalARCTArcturus Therapeutics$0$2,568,053 ▼-100.0%00.0%MedicalMRSNMersana Therapeutics$0$1,553,144 ▼-100.0%00.0%MedicalPTCTPTC Therapeutics$0$920,856 ▼-100.0%00.0%MedicalPMVPPMV Pharmaceuticals$0$486,256 ▼-100.0%00.0%MedicalFHTXFoghorn Therapeutics$0$212,527 ▼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. 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