Baker Bros. Advisors Lp Top Holdings and 13F Report (2025) About Baker Bros. Advisors LpInvestment ActivityBaker Bros. Advisors Lp has $10.31 billion in total holdings as of June 30, 2025.Baker Bros. Advisors Lp owns shares of 89 different stocks, but just 10 companies or ETFs make up 80% of its holdings.Approximately 9.49% of the portfolio was purchased this quarter.About 2.46% of the portfolio was sold this quarter.This quarter, Baker Bros. Advisors Lp has purchased 89 new stocks and bought additional shares in 23 stocks.Baker Bros. Advisors Lp sold shares of 8 stocks and completely divested from 13 stocks this quarter.Largest Holdings BeiGene $2,129,986,760Incyte $2,093,617,028ACADIA Pharmaceuticals $925,281,603Insmed $776,226,256Summit Therapeutics $717,624,887 Largest New Holdings this Quarter 92790C104 - Viridian Therapeutics $24,386,796 Holding09627Y109 - Blueprint Medicines $16,091,461 Holding04280A100 - Arrowhead Pharmaceuticals $14,838,949 Holding252828108 - Dianthus Therapeutics, Inc. $14,713,210 Holding171757206 - Cidara Therapeutics, Inc. $11,070,419 Holding Largest Purchases this Quarter Insmed 2,332,274 shares (about $234.72M)Summit Therapeutics 9,298,109 shares (about $197.86M)Alkermes 1,927,318 shares (about $55.14M)Revolution Medicines 1,428,000 shares (about $52.54M)Structure Therapeutics 2,147,202 shares (about $44.53M) Largest Sales this Quarter argenex 40,000 shares (about $22.05M)Akero Therapeutics 224,083 shares (about $11.96M)Candel Therapeutics 2,082,077 shares (about $10.54M)Cerus 6,467,243 shares (about $9.12M)Neurogene Inc. 494,509 shares (about $7.39M) Sector Allocation Over TimeMap of 500 Largest Holdings ofBaker Bros. Advisors Lp Selling Neutral Buying Latest 13F Holdings and Changes Since Previous Quarterly FilingIssuer NameHoldings ValueApproximate Purchase/SaleChange in SharesShares Held% of PortfolioSectorBGNEBeiGene$2,129,986,7600.0%8,799,05320.7%MedicalINCYIncyte$2,093,617,028$226,228 ▲0.0%30,743,27520.3%MedicalACADACADIA Pharmaceuticals$925,281,603$404,955 ▲0.0%42,896,6909.0%MedicalINSMInsmed$776,226,256$234,720,055 ▲43.3%7,712,9007.5%MedicalSMMTSummit Therapeutics$717,624,887$197,863,760 ▲38.1%33,722,9747.0%MedicalMDGLMadrigal Pharmaceuticals$598,022,088$432,170 ▲0.1%1,976,0185.8%MedicalRYTMRhythm Pharmaceuticals$354,147,2810.0%5,604,4833.4%MedicalRVMDRevolution Medicines$344,537,320$52,536,120 ▲18.0%9,364,9723.3%MedicalKYMRKymera Therapeutics$290,268,362$28,606,020 ▲10.9%6,651,4292.8%MedicalALKSAlkermes$183,407,352$55,140,568 ▲43.0%6,410,6031.8%MedicalREPLReplimune Group$102,611,1710.0%11,045,3361.0%MedicalRAREUltragenyx Pharmaceutical$100,815,081$43,507,576 ▲75.9%2,772,6921.0%MedicalEWTXEdgewise Therapeutics$95,780,873$15,076,500 ▲18.7%7,305,9400.9%MedicalABCLAbCellera Biologics$94,412,9450.0%27,525,6400.9%MedicalIMVTImmunovant$87,326,0960.0%5,457,8810.8%MedicalGRAIL, Inc.$83,821,0280.0%1,630,1250.8%COMKiniksa Pharmaceuticals International, plc$78,158,591$175,594 ▲0.2%2,824,6690.8%ORD SHS CL ABCYCBicycle Therapeutics$75,653,2310.0%10,885,3570.7%MedicalIMCRImmunocore$72,884,9450.0%2,322,6560.7%MedicalCELCCelcuity$72,763,441$15,922,679 ▲28.0%5,450,4450.7%MedicalKODKodiak Sciences$64,568,1280.0%17,310,4900.6%MedicalIMTXImmatics$54,708,687$15,564,722 ▲39.8%10,168,9010.5%MedicalSTOKStoke Therapeutics$52,594,0610.0%4,633,8380.5%MedicalDNLIDenali Therapeutics$52,206,4130.0%3,731,6950.5%MedicalGPCRStructure Therapeutics$52,031,828$44,532,970 ▲593.9%2,508,7670.5%MedicalIDYAIDEAYA Biosciences$44,535,663$22,209,837 ▲99.5%2,118,7280.4%MedicalNRIXNurix Therapeutics$44,217,4040.0%3,882,1250.4%MedicalROIVRoivant Sciences$42,462,8020.0%3,767,7730.4%MedicalBNTXBioNTech$39,279,232$34,484,781 ▲719.3%368,9230.4%MedicalTRDAEntrada Therapeutics$32,698,3040.0%4,865,8190.3%MedicalMRUSMerus$30,212,230$18,456,130 ▲157.0%574,3770.3%MedicalPraxis Precision Medicines, Inc.$28,992,970$15,052,008 ▲108.0%689,4880.3%COMNTLAIntellia Therapeutics$25,097,822$19,056,014 ▲315.4%2,675,6740.2%MedicalVRDNViridian Therapeutics$24,386,796$24,386,796 ▲New Holding1,744,4060.2%MedicalGLUEMonte Rosa Therapeutics$22,171,5880.0%4,916,0950.2%MedicalVRNAVerona Pharma PLC American Depositary Share$21,171,0710.0%223,8430.2%MedicalPCVXVaxcyte$20,835,1710.0%640,8850.2%MedicalARGXargenex$20,814,067$22,048,800 ▼-51.4%37,7600.2%MedicalVERVVerve Therapeutics$18,995,8820.0%1,691,5300.2%MedicalCERSCerus$18,166,220$9,118,813 ▼-33.4%12,883,8440.2%MedicalIRONDisc Medicine$17,850,168$13,769,600 ▲337.4%337,0500.2%MedicalAKROAkero Therapeutics$17,322,257$11,957,069 ▼-40.8%324,6300.2%MedicalBPMCBlueprint Medicines$16,091,461$16,091,461 ▲New Holding125,5380.2%MedicalSERASera Prognostics$15,229,9310.0%5,498,1700.1%MedicalARWRArrowhead Pharmaceuticals$14,838,949$14,838,949 ▲New Holding939,1740.1%MedicalNeurogene Inc.$14,825,780$7,392,909 ▼-33.3%991,6910.1%COMDianthus Therapeutics, Inc.$14,713,210$14,713,210 ▲New Holding789,7590.1%COMCLDXCelldex Therapeutics$13,540,280$8,500,724 ▲168.7%665,3700.1%MedicalDBV Technologies S.A.$13,386,5070.0%1,461,4250.1%SPONSORED ADSXENEXenon Pharmaceuticals$11,587,510$713,640 ▲6.6%370,2080.1%MedicalCidara Therapeutics, Inc.$11,070,419$11,070,419 ▲New Holding227,2720.1%COMACLXArcellx$10,985,426$10,985,426 ▲New Holding166,8250.1%MedicalNUVLNuvalent$10,982,393$10,982,393 ▲New Holding143,9370.1%MedicalSpyre Therapeutics, Inc.$9,381,744$9,381,744 ▲New Holding626,7030.1%COMTSHATaysha Gene Therapies$9,250,9860.0%4,004,7560.1%MedicalPRLDPrelude Therapeutics$8,194,2230.0%10,123,8240.1%MedicalCRNXCrinetics Pharmaceuticals$8,052,800$8,052,800 ▲New Holding280,0000.1%MedicalCTMXCytomX Therapeutics$7,909,193$7,909,193 ▲New Holding3,484,2260.1%MedicalSagimet Biosciences Inc.$7,261,8300.0%952,9960.1%COM SER ASionna Therapeutics, Inc.$6,940,0000.0%400,0000.1%COMAGIOAgios Pharmaceuticals$6,314,943$6,314,943 ▲New Holding189,8660.1%MedicalRapport Therapeutics, Inc.$6,254,523$6,254,523 ▲New Holding550,0900.1%COMSkye Bioscience, Inc.$6,063,6670.0%1,450,6380.1%COMDSGNDesign Therapeutics$5,772,412$103,941 ▼-1.8%1,712,8820.1%MedicalKALAKALA BIO$5,721,0150.0%1,201,8940.1%MedicalSANASana Biotechnology$5,544,4910.0%2,030,9490.1%MedicalXNCRXencor$5,269,5880.0%670,4310.1%MedicalAlumis Inc.$4,687,5000.0%1,562,5000.0%COMIGMSIGM Biosciences$4,587,755$1,067 ▲0.0%4,096,2100.0%MedicalTCRXTScan Therapeutics$4,037,9480.0%2,784,7920.0%MedicalRLAYRelay Therapeutics$4,014,0050.0%1,160,1170.0%MedicalFATEFate Therapeutics$2,783,220$866,190 ▼-23.7%2,485,0180.0%MedicalVIRVir Biotechnology$2,734,3970.0%542,5390.0%MedicalELVNEnliven Therapeutics$2,303,5500.0%114,8330.0%MedicalWVEWAVE Life Sciences$2,236,4100.0%344,0630.0%MedicalTectonic Therapeutic, Inc.$1,987,0000.0%100,0000.0%COMCADLCandel Therapeutics$1,796,867$10,535,311 ▼-85.4%355,1120.0%MedicalTARAProtara Therapeutics$1,626,6010.0%536,8320.0%MedicalvTv Therapeutics, Inc.$1,459,7100.0%97,3140.0%CL ARCKTRocket Pharmaceuticals$1,352,594$1,335,250 ▼-49.7%552,0790.0%MedicalContineum Therapeutics, Inc.$1,240,6250.0%312,5000.0%CL AHOOKIPA Pharma Inc.$1,020,0820.0%812,8140.0%COMNeumora Therapeutics, Inc.$758,6720.0%1,034,6000.0%COMGBIOGeneration Bio$622,5770.0%1,944,9450.0%MedicalAligos Therapeutics, Inc.$598,8270.0%83,0550.0%COMTYRATyra Biosciences$101,5090.0%10,6070.0%MedicalACRVAcrivon Therapeutics$27,1430.0%22,8090.0%MedicalSRZNWSurrozen$15,0830.0%833,3330.0%MedicalOPTOpthea$00.0%2,087,3200.0%MedicalInsmed Incorporated$0$101,588,437 ▼-100.0%00.0%Note 0.75% 6/1/2028CRSPCRISPR Therapeutics$0$22,258,989 ▼-100.0%00.0%MedicalCNTACentessa Pharmaceuticals$0$17,646,820 ▼-100.0%00.0%MedicalTSVT2seventy bio$0$12,337,778 ▼-100.0%00.0%MedicalBicara Therapeutics Inc.$0$10,858,329 ▼-100.0%00.0%COMIONSIonis Pharmaceuticals$0$10,798,296 ▼-100.0%00.0%MedicalDyne Therapeutics, Inc.$0$7,030,124 ▼-100.0%00.0%COMRGLSRegulus Therapeutics$0$4,714,577 ▼-100.0%00.0%MedicalPRMEPrime Medicine$0$2,046,647 ▼-100.0%00.0%MedicalCMPXCompass Therapeutics$0$1,040,246 ▼-100.0%00.0%MedicalLPTXLeap Therapeutics$0$123,487 ▼-100.0%00.0%MedicalShowing largest 100 holdings. View all holdings. More Institutional Buying and Selling Information SEC Filings and Trading Data SEC Filings 13F Filings Top 13F Buys Top 13F Sells Get 30 Days of MarketBeat All Access for Free Sign up for MarketBeat All Access to gain access to MarketBeat's full suite of research tools. Start Your 30-Day Trial MarketBeat All Access Features Best-in-Class Portfolio Monitoring Get personalized stock ideas. Compare portfolio to indices. Check stock news, ratings, SEC filings, and more. Stock Ideas and Recommendations See daily stock ideas from top analysts. Receive short-term trading ideas from MarketBeat. Identify trending stocks on social media. Advanced Stock Screeners and Research Tools Use our seven stock screeners to find suitable stocks. Stay informed with MarketBeat's real-time news. Export data to Excel for personal analysis. Sign in to your free account to enjoy these benefits In-depth profiles and analysis for 20,000 public companies. Real-time analyst ratings, insider transactions, earnings data, and more. Our daily ratings and market update email newsletter. Sign in to your free account to enjoy all that MarketBeat has to offer. Sign In Create Account Your Email Address: Email Address Required Your Password: Password Required Log In or Sign in with Facebook Sign in with Google Forgot your password? Your Email Address: Please enter your email address. Please enter a valid email address Choose a Password: Please enter your password. Your password must be at least 8 characters long and contain at least 1 number, 1 letter, and 1 special character. Create My Account (Free) or Sign in with Facebook Sign in with Google By creating a free account, you agree to our terms of service. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
MarketBeat All Access