Compare Stocks: CDNA, CYTK, SYRE, and PCVX

Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
CDNA CareDx	$48.61 +3.4%	$35.85	$12.28 ▼ $49.76	$2.51B	2.39	1.17 million shs	1.16 million shs
CYTK Cytokinetics	$76.84 -0.4%	$80.09	$35.22 ▼ $88.31	$9.56B	0.38	1.92 million shs	1.52 million shs
PCVX Vaxcyte	$62.62 +2.1%	$56.43	$29.87 ▼ $65.00	$9.32B	1.23	965,036 shs	1.14 million shs
SYRE Spyre Therapeutics	$106.49 -1.2%	$97.22	$14.51 ▼ $110.18	$9.36B	3.03	844,575 shs	1.01 million shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
CDNA CareDx	0.00%	+7.26%	+29.25%	+124.73%	+299.42%
CYTK Cytokinetics	0.00%	+3.66%	-6.20%	-0.13%	+105.89%
PCVX Vaxcyte	0.00%	+7.84%	+12.54%	+32.39%	+100.32%
SYRE Spyre Therapeutics	0.00%	+2.76%	+6.50%	+43.81%	+551.31%

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
CDNA CareDx	$48.61 +3.4%	$35.85	$12.28 ▼ $49.76	$2.51B	2.39	1.17 million shs	1.16 million shs
CYTK Cytokinetics	$76.84 -0.4%	$80.09	$35.22 ▼ $88.31	$9.56B	0.38	1.92 million shs	1.52 million shs
PCVX Vaxcyte	$62.62 +2.1%	$56.43	$29.87 ▼ $65.00	$9.32B	1.23	965,036 shs	1.14 million shs
SYRE Spyre Therapeutics	$106.49 -1.2%	$97.22	$14.51 ▼ $110.18	$9.36B	3.03	844,575 shs	1.01 million shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
CDNA CareDx	0.00%	+7.26%	+29.25%	+124.73%	+299.42%
CYTK Cytokinetics	0.00%	+3.66%	-6.20%	-0.13%	+105.89%
PCVX Vaxcyte	0.00%	+7.84%	+12.54%	+32.39%	+100.32%
SYRE Spyre Therapeutics	0.00%	+2.76%	+6.50%	+43.81%	+551.31%

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
CDNA CareDx	2.57	Moderate Buy	$47.75	-1.77% Downside
CYTK Cytokinetics	2.86	Moderate Buy	$102.20	33.00% Upside
PCVX Vaxcyte	2.50	Moderate Buy	$86.00	37.34% Upside
SYRE Spyre Therapeutics	2.87	Moderate Buy	$111.69	4.89% Upside

Current Analyst Ratings Breakdown

Latest CDNA, CYTK, SYRE, and PCVX Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
8/14/2026	CYTK Cytokinetics	HC Wainwright Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy
8/13/2026	CDNA CareDx	Weiss Ratings Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Upgrade	Sell (D+) ➝ Hold (C)
8/13/2026	CYTK Cytokinetics	Barclays Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Overweight	$95.00 ➝ $110.00
8/13/2026	CYTK Cytokinetics	JPMorgan Chase & Co. Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Overweight	$97.00 ➝ $103.00
8/12/2026	PCVX Vaxcyte	Zacks Research Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Upgrade	Strong Sell ➝ Hold
8/11/2026	SYRE Spyre Therapeutics	BTIG Research Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Buy	$112.00 ➝ $132.00
8/10/2026	CYTK Cytokinetics	Truist Financial Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Buy	$106.00 ➝ $112.00
8/7/2026	CYTK Cytokinetics	Royal Bank Of Canada Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Lower Price Target	Outperform	$117.00 ➝ $112.00
8/7/2026	CYTK Cytokinetics	Citigroup Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Market Outperform
8/7/2026	CYTK Cytokinetics	Citizens Jmp Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Market Outperform	$105.00 ➝ $110.00
8/7/2026	CYTK Cytokinetics	Needham & Company LLC Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Buy	$102.00 ➝ $112.00

(Data available from 8/23/2023 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
CDNA CareDx	$458.09M	5.49	$0.01 per share	7,463.08	$8.23 per share	5.91
CYTK Cytokinetics	$88.04M	108.60	N/A	N/A	($1.39) per share	-55.28
PCVX Vaxcyte	N/A	N/A	N/A	N/A	$18.53 per share	N/A
SYRE Spyre Therapeutics	$890K	10,522.17	N/A	N/A	$10.86 per share	9.81

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
CDNA CareDx	-$21.35M	$2.07	23.48	77.16	N/A	24.23%	2.87%	2.17%	11/3/2026 (Estimated)
CYTK Cytokinetics	-$784.96M	-$7.22	N/A	N/A	N/A	-1,321.12%	N/A	-51.01%	11/4/2026 (Estimated)
PCVX Vaxcyte	-$766.63M	-$7.63	N/A	N/A	N/A	N/A	-37.56%	-33.62%	11/3/2026 (Estimated)
SYRE Spyre Therapeutics	-$155.20M	-$1.95	N/A	N/A	N/A	N/A	-30.74%	-22.23%	11/3/2026 (Estimated)

Latest CDNA, CYTK, SYRE, and PCVX Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
8/6/2026	Q2 2026	CYTK Cytokinetics	-$1.63	-$1.50	+$0.13	-$1.50	$17.59 million	$28.62 million
8/5/2026	Q2 2026	PCVX Vaxcyte	-$2.06	-$1.97	+$0.09	-$1.97	$12.50 million	N/A
8/4/2026	Q2 2026	SYRE Spyre Therapeutics	-$0.7589	-$0.36	+$0.3989	-$0.36	N/A	N/A
7/30/2026	Q2 2026	CDNA CareDx	$0.2321	$0.37	+$0.1379	$2.07	$114.05 million	$131.95 million

Compare Dividends

Company	Annual Payout	Dividend Yield	5-Year Annualized Dividend Growth	Payout Ratio	Years of Consecutive Growth
CDNA CareDx	N/A	N/A	N/A	N/A	N/A
CYTK Cytokinetics	N/A	N/A	N/A	N/A	N/A
PCVX Vaxcyte	N/A	N/A	N/A	N/A	N/A
SYRE Spyre Therapeutics	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
CDNA CareDx	N/A	4.58	4.51
CYTK Cytokinetics	N/A	6.66	6.66
PCVX Vaxcyte	N/A	5.72	5.72
SYRE Spyre Therapeutics	N/A	18.53	18.53

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
CDNA CareDx	N/A
CYTK Cytokinetics	N/A
PCVX Vaxcyte	96.78%
SYRE Spyre Therapeutics	80.39%

Insider Ownership

Company	Insider Ownership
CDNA CareDx	2.40%
CYTK Cytokinetics	2.60%
PCVX Vaxcyte	3.30%
SYRE Spyre Therapeutics	15.69%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
CDNA CareDx	740	51.73 million	50.49 million	Optionable
CYTK Cytokinetics	250	124.43 million	121.20 million	Optionable
PCVX Vaxcyte	160	148.80 million	143.89 million	Optionable
SYRE Spyre Therapeutics	73	87.94 million	74.14 million	Optionable

CDNA, CYTK, SYRE, and PCVX Headlines

Recent News About These Companies

Spyre Therapeutics, Inc. (NASDAQ:SYRE) Receives Consensus Recommendation of "Moderate Buy" from Brokerages

August 21 at 4:28 AM | marketbeat.com

This stock’s already up nearly 600% over the past year

August 19, 2026 | msn.com

Spyre Therapeutics (NASDAQ:SYRE) Hits New 52-Week High - Here's What Happened

August 18, 2026 | marketbeat.com

LifeSci Capital Reaffirms Their Buy Rating on Spyre Therapeutics (SYRE)

August 17, 2026 | theglobeandmail.com

Handelsbanken Fonder AB Makes New $2.31 Million Investment in Spyre Therapeutics, Inc. $SYRE

August 17, 2026 | marketbeat.com

Spyre Therapeutics (NASDAQ:SYRE) Downgraded to Sell Rating by Wall Street Zen

August 16, 2026 | americanbankingnews.com

Wall Street Zen Downgrades Spyre Therapeutics (NASDAQ:SYRE) to Sell

August 16, 2026 | marketbeat.com

Wedbush Keeps Their Buy Rating on Spyre Therapeutics (SYRE)

August 14, 2026 | theglobeandmail.com

Dimensional Fund Advisors LP Sells 29,593 Shares of Spyre Therapeutics, Inc. $SYRE

August 14, 2026 | marketbeat.com

BTIG Research Increases Spyre Therapeutics (NASDAQ:SYRE) Price Target to $132.00

August 13, 2026 | americanbankingnews.com

Spyre Therapeutics Launches Program, Mid-Stage Trial for Drug Combination to Treat Hidradenitis Suppurativa

August 11, 2026 | finance.yahoo.com

Spyre Therapeutics (NASDAQ:SYRE) Stock Price Expected to Rise, BTIG Research Analyst Says

August 11, 2026 | marketbeat.com

Spyre Therapeutics, Inc. $SYRE Shares Bought by Bank of America Corp DE

August 11, 2026 | marketbeat.com

Spyre Therapeutics (NASDAQ:SYRE) Director Sells 18,000 Shares

August 10, 2026 | marketbeat.com

Spyre Therapeutics Announces Launch of SPY772 Program and Initiation of Phase 2 SKYLIGHT Trial in Hidradenitis Suppurativa

August 10, 2026 | markets.businessinsider.com

California State Teachers Retirement System Purchases 11,204 Shares of Spyre Therapeutics, Inc. $SYRE

August 10, 2026 | marketbeat.com

Can Spyre Therapeutics (SYRE) Justify Its Premium After Positive Phase 2 Data?

August 9, 2026 | finance.yahoo.com

Spyre Therapeutics (NASDAQ:SYRE) Stock Rating Upgraded by Wall Street Zen

August 8, 2026 | marketbeat.com

Spyre Therapeutics Announces Grants of Inducement Awards

August 7, 2026 | globenewswire.com

Analysts Have Conflicting Sentiments on These Healthcare Companies: Spyre Therapeutics (SYRE), Ultragenyx Pharmaceutical (RARE) and Bruker (BRKR)

August 7, 2026 | theglobeandmail.com

Scott Burrows Sells 7,500 Shares of Spyre Therapeutics (NASDAQ:SYRE) Stock

August 6, 2026 | insidertrades.com

New MarketBeat Followers Over Time

Media Sentiment Over Time

CDNA, CYTK, SYRE, and PCVX Company Descriptions

CareDx NASDAQ:CDNA

$48.61 +1.62 (+3.45%)

As of 08/21/2026 04:00 PM Eastern

CareDx, Inc. engages in the discovery, development, and commercialization of diagnostic solutions for transplant patients and caregivers in the United States and internationally. It also provides AlloSure Kidney, a donor-derived cell-free DNA (dd-cfDNA) solution for kidney transplant patients; AlloMap Heart, a gene expression solution for heart transplant patients; AlloSure Heart, a dd-cfDNA solution for heart transplant patients; and AlloSure Lung, a dd-cfDNA solution for lung transplant patients. The company offers Olerup SSP, which is used to type human leukocyte antigen (HLA) alleles based on sequence specific primer technology; QTYPE that enables precision in HLA typing; and Ottr, a transplant patient management software. In addition, it provides AlloSeq Tx, a high-resolution HLA typing solution; AlloSeq cfDNA, a surveillance solution to measure dd-cfDNA in blood; AlloSeq HCT, a solution for chimerism testing for stem cell transplant recipients; Allocell, a surveillance solution that monitors the level of engraftment and persistence of allogeneic cells for patients who have received cell therapy transplants; and XynQAPI cloud-based transplant quality management software, as well as AlloCare, a mobile app that offers a patient-centric resource for transplant recipients. The company offers its products directly to customers, as well as through third-party distributors and sub-distributors. It has a license agreement with Illumina, Inc. for the distribution, development, and commercialization of NGS products and technologies; and Cibiltech SAS to commercialize iBox, a software for the predictive analysis of post-transplantation kidney allograft loss. The company was formerly known as XDx, Inc. and changed its name to CareDx, Inc. in March 2014. The company was incorporated in 1998 and is headquartered in South San Francisco, California.

Cytokinetics NASDAQ:CYTK

$76.84 -0.34 (-0.44%)

As of 08/21/2026 04:00 PM Eastern

Cytokinetics, Incorporated, a late-stage biopharmaceutical company, focuses on discovering, developing, and commercializing muscle activators and inhibitors as potential treatments for debilitating diseases. The company develops small molecule drug candidates primarily engineered to impact muscle function and contractility. Its drug candidates include omecamtiv mecarbil, a novel cardiac myosin activator that is in Phase III clinical trial in patients with heart failure. The company also develops CK-136, a novel cardiac troponin activator that is in Phase I clinical trial; CK-586, a small molecule cardiac myosin inhibitor, that is in Phase I clinical trial; and aficamten, a novel cardiac myosin inhibitor, which is in Phase III clinical trial for the treatment of patients with symptomatic obstructive hypertrophic cardiomyopathy. Cytokinetics, Incorporated has a strategic alliance with Ji Xing Pharmaceuticals Limited. The company was incorporated in 1997 and is headquartered in South San Francisco, California.

Vaxcyte NASDAQ:PCVX

$62.62 +1.28 (+2.09%)

As of 08/21/2026 04:00 PM Eastern

Vaxcyte, Inc., a clinical-stage biotechnology vaccine company, develops novel protein vaccines to prevent or treat bacterial infectious diseases. Its lead vaccine candidate is VAX-24, a 24-valent investigational pneumococcal conjugate vaccine for the prevention of invasive pneumococcal disease. The company also develops VAX-31 to protect against emerging strains and to help address antibiotic resistance; VAX-A1, a novel conjugate vaccine candidate to prevent disease caused by Group A Streptococcus; VAX-PG, a novel protein vaccine candidate targeting keystone pathogen responsible for periodontitis; and VAX-GI to prevent Shigella, a bacterial illness. The company was formerly known as SutroVax, Inc. and changed its name to Vaxcyte, Inc. in May 2020. Vaxcyte, Inc. was incorporated in 2013 and is headquartered in San Carlos, California.

Spyre Therapeutics NASDAQ:SYRE

$106.49 -1.30 (-1.21%)

As of 08/21/2026 04:00 PM Eastern

Spyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts.

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Compare Stocks

Comparative Price Performance Over Time

Compare Price & Volume

Compare Price Performance

Compare Price & Volume

Compare Price Performance

Compare Analyst Forecasts

Current Analyst Ratings Breakdown

Latest CDNA, CYTK, SYRE, and PCVX Analyst Ratings

Compare Sales & Book Value

Compare Profitability & Earnings

Latest CDNA, CYTK, SYRE, and PCVX Earnings

Compare Dividends

Compare Debt

Compare Ownership

Institutional Ownership

Insider Ownership

Compare Miscellaneous Stats

CDNA, CYTK, SYRE, and PCVX Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

CDNA, CYTK, SYRE, and PCVX Company Descriptions

CareDx NASDAQ:CDNA

Cytokinetics NASDAQ:CYTK

Vaxcyte NASDAQ:PCVX

Spyre Therapeutics NASDAQ:SYRE

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Current Analyst Ratings Breakdown

Latest CDNA, CYTK, SYRE, and PCVX Analyst Ratings

Compare Sales & Book Value

Compare Profitability & Earnings

Latest CDNA, CYTK, SYRE, and PCVX Earnings

Compare Dividends

Compare Debt

Compare Ownership

Institutional Ownership

Insider Ownership

Compare Miscellaneous Stats

CDNA, CYTK, SYRE, and PCVX Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

CDNA, CYTK, SYRE, and PCVX Company Descriptions

CareDx NASDAQ:CDNA

Cytokinetics NASDAQ:CYTK

Vaxcyte NASDAQ:PCVX

Spyre Therapeutics NASDAQ:SYRE

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