Compare Stocks: PTGX, BIIB, ALNY, and INSM

Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
ALNY Alnylam Pharmaceuticals	$216.98 -1.0%	$278.55	$197.81 ▼ $495.55	$29.33B	0.3	2.27 million shs	1.40 million shs
BIIB Biogen	$207.13 -0.4%	$202.63	$127.71 ▼ $219.72	$30.72B	0.17	1.35 million shs	706,405 shs
INSM Insmed	$134.75 +2.8%	$105.71	$90.39 ▼ $212.75	$28.63B	0.81	3.17 million shs	3.63 million shs
PTGX Protagonist Therapeutics	$150.00 +2.8%	$125.41	$50.58 ▼ $151.60	$9.38B	1.78	553,066 shs	545,760 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
ALNY Alnylam Pharmaceuticals	0.00%	+6.66%	-26.63%	-23.04%	-50.06%
BIIB Biogen	0.00%	+2.46%	+4.41%	+5.05%	+59.13%
INSM Insmed	0.00%	+32.96%	+13.40%	+26.19%	+19.67%
PTGX Protagonist Therapeutics	0.00%	+6.75%	+11.00%	+40.94%	+185.63%

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
ALNY Alnylam Pharmaceuticals	$216.98 -1.0%	$278.55	$197.81 ▼ $495.55	$29.33B	0.3	2.27 million shs	1.40 million shs
BIIB Biogen	$207.13 -0.4%	$202.63	$127.71 ▼ $219.72	$30.72B	0.17	1.35 million shs	706,405 shs
INSM Insmed	$134.75 +2.8%	$105.71	$90.39 ▼ $212.75	$28.63B	0.81	3.17 million shs	3.63 million shs
PTGX Protagonist Therapeutics	$150.00 +2.8%	$125.41	$50.58 ▼ $151.60	$9.38B	1.78	553,066 shs	545,760 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
ALNY Alnylam Pharmaceuticals	0.00%	+6.66%	-26.63%	-23.04%	-50.06%
BIIB Biogen	0.00%	+2.46%	+4.41%	+5.05%	+59.13%
INSM Insmed	0.00%	+32.96%	+13.40%	+26.19%	+19.67%
PTGX Protagonist Therapeutics	0.00%	+6.75%	+11.00%	+40.94%	+185.63%

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
ALNY Alnylam Pharmaceuticals	2.92	Moderate Buy	$396.72	82.84% Upside
BIIB Biogen	2.56	Moderate Buy	$224.61	8.44% Upside
INSM Insmed	3.00	Buy	$205.52	52.52% Upside
PTGX Protagonist Therapeutics	3.00	Buy	$137.86	-8.10% Downside

Current Analyst Ratings Breakdown

Latest PTGX, BIIB, ALNY, and INSM Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
8/10/2026	INSM Insmed	Truist Financial Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy	$185.00 ➝ $195.00
8/10/2026	PTGX Protagonist Therapeutics	Truist Financial Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Buy	$145.00 ➝ $170.00
8/10/2026	PTGX Protagonist Therapeutics	Wedbush Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Outperform	$118.00 ➝ $173.00
8/10/2026	INSM Insmed	HC Wainwright Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy
8/10/2026	PTGX Protagonist Therapeutics	UBS Group Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Upgrade	Buy
8/10/2026	PTGX Protagonist Therapeutics	The Goldman Sachs Group Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Upgrade	Neutral ➝ Buy	$110.00 ➝ $186.00
8/10/2026	INSM Insmed	JPMorgan Chase & Co. Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Lower Price Target	Overweight	$179.00 ➝ $175.00
8/7/2026	INSM Insmed	Morgan Stanley Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Overweight	$218.00
8/7/2026	INSM Insmed	Evercore Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Outperform	$170.00
8/7/2026	INSM Insmed	Guggenheim Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Lower Price Target	Buy	$207.00 ➝ $205.00
8/7/2026	INSM Insmed	UBS Group Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy	$172.00

(Data available from 8/10/2023 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
ALNY Alnylam Pharmaceuticals	$3.71B	7.82	$2.77 per share	78.39	$5.97 per share	36.35
BIIB Biogen	$9.89B	3.09	$22.54 per share	9.19	$124.45 per share	1.66
INSM Insmed	$606.42M	48.53	N/A	N/A	$3.46 per share	38.95
PTGX Protagonist Therapeutics	$46.02M	209.62	N/A	N/A	$9.83 per share	15.26

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
ALNY Alnylam Pharmaceuticals	$313.75M	$5.38	40.33	22.48	N/A	15.26%	84.93%	14.30%	10/29/2026 (Estimated)
BIIB Biogen	$1.29B	$5.65	36.66	12.64	6.42	8.32%	11.18%	6.88%	10/29/2026 (Estimated)
INSM Insmed	-$1.28B	-$4.11	N/A	228.39	N/A	-76.94%	-123.94%	-44.30%	10/29/2026 (Estimated)
PTGX Protagonist Therapeutics	-$130.15M	$1.03	145.63	N/A	N/A	29.40%	12.03%	11.23%	N/A

Latest PTGX, BIIB, ALNY, and INSM Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
8/6/2026	Q2 2026	INSM Insmed	-$0.6724	-$0.06	+$0.6124	-$0.06	$395.50 million	$425.49 million
8/5/2026	Q2 2026	PTGX Protagonist Therapeutics	$2.27	$2.29	+$0.02	$2.29	$212.03 million	$213.48 million
7/29/2026	Q2 2026	BIIB Biogen	$2.94	$3.60	+$0.66	$0.66	$2.46 billion	$2.74 billion

Compare Dividends

Company	Annual Payout	Dividend Yield	5-Year Annualized Dividend Growth	Payout Ratio	Years of Consecutive Growth
ALNY Alnylam Pharmaceuticals	N/A	N/A	N/A	N/A	N/A
BIIB Biogen	N/A	N/A	N/A	N/A	N/A
INSM Insmed	N/A	N/A	N/A	N/A	N/A
PTGX Protagonist Therapeutics	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
ALNY Alnylam Pharmaceuticals	0.75	3.05	2.99
BIIB Biogen	0.39	1.87	1.26
INSM Insmed	0.74	3.72	3.40
PTGX Protagonist Therapeutics	N/A	21.71	21.71

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
ALNY Alnylam Pharmaceuticals	92.97%
BIIB Biogen	87.93%
INSM Insmed	N/A
PTGX Protagonist Therapeutics	98.63%

Insider Ownership

Company	Insider Ownership
ALNY Alnylam Pharmaceuticals	0.86%
BIIB Biogen	0.25%
INSM Insmed	2.10%
PTGX Protagonist Therapeutics	5.19%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
ALNY Alnylam Pharmaceuticals	2,770	133.81 million	132.66 million	Optionable
BIIB Biogen	7,500	147.75 million	147.39 million	Optionable
INSM Insmed	1,664	218.38 million	213.80 million	Optionable
PTGX Protagonist Therapeutics	120	64.31 million	60.97 million	Optionable

PTGX, BIIB, ALNY, and INSM Headlines

Recent News About These Companies

Wedbush Adjusts PT on Protagonist Therapeutics to $173 From $118, Keeps Outperform Rating

August 10 at 12:14 PM | finance.yahoo.com

What is HC Wainwright's Estimate for PTGX FY2026 Earnings?

August 10 at 1:28 AM | americanbankingnews.com

HC Wainwright Has Negative Forecast for PTGX FY2026 Earnings

August 10 at 1:26 AM | marketbeat.com

HC Wainwright Analysts Decrease Earnings Estimates for PTGX

August 9 at 1:14 AM | americanbankingnews.com

Citigroup Raises Protagonist Therapeutics (NASDAQ:PTGX) Price Target to $175.00

August 8 at 3:19 AM | americanbankingnews.com

Protagonist Therapeutics (NASDAQ:PTGX) Reaches New 1-Year High on Earnings Beat

August 8 at 2:24 AM | americanbankingnews.com

Protagonist Therapeutics (NASDAQ:PTGX) Downgraded by Wall Street Zen to Buy

August 8 at 1:48 AM | americanbankingnews.com

Protagonist Therapeutics (NASDAQ:PTGX) Rating Lowered to Buy at Wall Street Zen

August 8 at 1:47 AM | marketbeat.com

Surging Earnings Estimates Signal Upside for Protagonist Therapeutics (PTGX) Stock

August 7 at 1:21 PM | zacks.com

HC Wainwright Has Negative Forecast for PTGX Q3 Earnings

August 7 at 6:11 AM | marketbeat.com

Bank of America Corp DE Has $136.54 Million Stock Position in Protagonist Therapeutics, Inc. $PTGX

August 7 at 3:19 AM | marketbeat.com

Citigroup Forecasts Strong Price Appreciation for Protagonist Therapeutics (NASDAQ:PTGX) Stock

August 6, 2026 | marketbeat.com

Protagonist Therapeutics (NASDAQ:PTGX) Hits New 12-Month High Following Strong Earnings

August 6, 2026 | marketbeat.com

Protagonist Therapeutics, Inc. $PTGX Shares Acquired by California State Teachers Retirement System

August 6, 2026 | marketbeat.com

Protagonist Therapeutics (NASDAQ:PTGX) Releases Quarterly Earnings Results, Beats Estimates By $0.06 EPS

August 5, 2026 | marketbeat.com

Protagonist Therapeutics: Q2 Earnings Snapshot

August 5, 2026 | sfgate.com

Protagonist Therapeutics (PTGX) Beats Q2 Earnings Estimates

August 5, 2026 | zacks.com

Protagonist Reports Second Quarter 2026 Financial Results and Provides Corporate Update

August 5, 2026 | accessnewswire.comA

PTGX’s PN-881 Phase 1 Completion: A Quiet Milestone With Big Pipeline Implications

August 5, 2026 | tipranks.com

Protagonist Therapeutics Reports Granting of Inducement Awards

August 4, 2026 | accessnewswire.comA

The Manufacturers Life Insurance Company Purchases 14,478 Shares of Protagonist Therapeutics, Inc. $PTGX

August 3, 2026 | marketbeat.com

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PTGX, BIIB, ALNY, and INSM Company Descriptions

Alnylam Pharmaceuticals NASDAQ:ALNY

$216.98 -2.22 (-1.01%)

As of 04:00 PM Eastern

Alnylam Pharmaceuticals, Inc., a biopharmaceutical company, focuses on discovering, developing, and commercializing novel therapeutics based on ribonucleic acid interference. Its marketed products include ONPATTRO (patisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; AMVUTTRA for the treatment of hATTR amyloidosis with polyneuropathy in adults; GIVLAARI for the treatment of adults with acute hepatic porphyria; and OXLUMO for the treatment of primary hyperoxaluria type 1. In addition, the company develops patisiran for the treatment of transthyretin amyloidosis, or ATTR amyloidosis, with cardiomyopathy; cemdisiran to treat complement-mediated diseases; Belcesiran for the treatment of alpha-1 liver disease; Elebsiran to treat chronic HBV infection; Zilebesiran to treat hypertension; ALN-APP to treat Alzheimer's disease and cerebral amyloid angiopathy; and ALN-HSD to treat NASH. Further, it offers Fitusiran for the treatment of hemophilia, Inclisiran to treat hypercholesterolemia, lumasiran for the treatment of advanced PH1, and vutrisiran for the treatment of ATTR amyloidosis, which is in phase 3 clinical trial. Alnylam Pharmaceuticals, Inc. has strategic collaborations with Regeneron Pharmaceuticals, Inc. to discover, develop, and commercialize RNAi therapeutics for a range of diseases by addressing therapeutic targets expressed in the eye and CNS; and Roche to develop pharmaceutical products containing zilebesiran. It also has license and collaboration agreements with Novartis AG; Vir Biotechnology, Inc.; Dicerna Pharmaceuticals, Inc.; Ionis Pharmaceuticals, Inc.; and PeptiDream, Inc. The company was founded in 2002 and is headquartered in Cambridge, Massachusetts.

Biogen NASDAQ:BIIB

$207.13 -0.81 (-0.39%)

As of 04:00 PM Eastern

Biogen Inc. discovers, develops, manufactures, and delivers therapies for treating neurological and neurodegenerative diseases in the United States, Europe, Germany, Asia, and internationally. The company provides TECFIDERA, VUMERITY, AVONEX, PLEGRIDY, TYSABRI, and FAMPYRA for multiple sclerosis (MS); SPINRAZA for spinal muscular atrophy; ADUHELM to treat Alzheimer's disease; FUMADERM to treat plaque psoriasis; BENEPALI, an etanercept biosimilar referencing ENBREL; IMRALDI, an adalimumab biosimilar referencing HUMIRA; FLIXABI, an infliximab biosimilar referencing REMICADE; and BYOOVIZ, a ranibizumab biosimilar referencing LUCENTIS. It offers RITUXAN for treating non-Hodgkin's lymphoma, chronic lymphocytic leukemia (CLL), rheumatoid arthritis, two forms of ANCA-associated vasculitis, and pemphigus vulgaris; RITUXAN HYCELA for non-Hodgkin's lymphoma and CLL; GAZYVA to treat CLL and follicular lymphoma; OCREVUS for relapsing MS and primary progressive MS; LUNSUMIO to treat relapsed or refractory follicular lymphoma; glofitamab for non-Hodgkin's lymphoma; and other anti-CD20 therapies. In addition, the company is developing various products for the treatment of MS, Alzheimer's disease and dementia, neuromuscular disorders, Parkinson's disease and movement disorders, neuropsychiatry, genetic neurodevelopmental disorders, and biosimilars, which are under various stages of development. It has collaboration and license agreements with Acorda Therapeutics, Inc.; Alkermes Pharma Ireland Limited; Denali Therapeutics Inc.; Eisai Co., Ltd.; Genentech, Inc.; Neurimmune SubOne AG; Ionis Pharmaceuticals, Inc.; Samsung Bioepis Co., Ltd.; Sangamo Therapeutics, Inc.; and Sage Therapeutics, Inc., as well as collaboration with Fujirebio to potentially identify and develop blood-based biomarkers for tau pathology in the brain. The company was founded in 1978 and is headquartered in Cambridge, Massachusetts.

Insmed NASDAQ:INSM

$134.75 +3.65 (+2.78%)

As of 04:00 PM Eastern

Insmed Incorporated is a global biopharmaceutical company on a mission to transform the lives of patients with serious and rare diseases. Insmed's first commercial product is ARIKAYCE® (amikacin liposome inhalation suspension), which is approved in the United States for the treatment of Mycobacterium avium complex (MAC) lung disease as part of a combination antibacterial drug regimen for adult patients with limited or no alternative treatment options. MAC lung disease is a rare and often chronic infection that can cause irreversible lung damage and can be fatal. Insmed's earlier-stage clinical pipeline includes INS1007, a novel oral reversible inhibitor of dipeptidyl peptidase 1 with therapeutic potential in non-cystic fibrosis bronchiectasis and other inflammatory diseases, and INS1009, an inhaled formulation of a treprostinil prodrug that may offer a differentiated product profile for rare pulmonary disorders, including pulmonary arterial hypertension.

Protagonist Therapeutics NASDAQ:PTGX

$150.00 +4.13 (+2.83%)

As of 04:00 PM Eastern

Protagonist Therapeutics, Inc., a biopharmaceutical company, develops peptide-based drugs for hematology and blood disorders, and inflammatory and immunomodulatory diseases. It is developing Rusfertide (PTG-300), an injectable hepcidin mimetic that completed phase 2 clinical trials for the treatment of polycythemia vera and other blood disorders; and JNJ-2113, an orally delivered investigational drug to block biological pathways that completed phase 2b clinical trials for the treatment of moderate-to-severe plaque psoriasis; and PN-943, an orally delivered, gut-restricted alpha 4 beta 7 specific integrin antagonist completed a phase 2 clinical trials in patients with moderate to severe ulcerative colitis. The company has a license and collaboration agreement with Takeda to commercialize rusfertide; and JNJ Innovative Medicines to co-develop Interleukin-23 receptor antagonist compound JNJ-2113. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

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Compare Stocks

Comparative Price Performance Over Time

Compare Price & Volume

Compare Price Performance

Compare Price & Volume

Compare Price Performance

Compare Analyst Forecasts

Current Analyst Ratings Breakdown

Latest PTGX, BIIB, ALNY, and INSM Analyst Ratings

Compare Sales & Book Value

Compare Profitability & Earnings

Latest PTGX, BIIB, ALNY, and INSM Earnings

Compare Dividends

Compare Debt

Compare Ownership

Institutional Ownership

Insider Ownership

Compare Miscellaneous Stats

PTGX, BIIB, ALNY, and INSM Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

Top Headlines

PTGX, BIIB, ALNY, and INSM Company Descriptions

Alnylam Pharmaceuticals NASDAQ:ALNY

Biogen NASDAQ:BIIB

Insmed NASDAQ:INSM

Protagonist Therapeutics NASDAQ:PTGX

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Comparative Price Performance Over Time

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Latest PTGX, BIIB, ALNY, and INSM Analyst Ratings

Compare Sales & Book Value

Compare Profitability & Earnings

Latest PTGX, BIIB, ALNY, and INSM Earnings

Compare Dividends

Compare Debt

Compare Ownership

Institutional Ownership

Insider Ownership

Compare Miscellaneous Stats

PTGX, BIIB, ALNY, and INSM Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

Top Headlines

PTGX, BIIB, ALNY, and INSM Company Descriptions

Alnylam Pharmaceuticals NASDAQ:ALNY

Biogen NASDAQ:BIIB

Insmed NASDAQ:INSM

Protagonist Therapeutics NASDAQ:PTGX

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