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Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
ARCT Arcturus Therapeutics	$11.22 -6.5%	$18.88	$8.04 ▼ $24.17	$304.68M	2.39	644,358 shs	3.86 million shs
CNST Constellation Pharmaceuticals	$33.99	$33.89	$17.00 ▼ $39.30	$1.63B	2.59	940,325 shs	N/A
MNKD MannKind	$5.31 -3.3%	$5.12	$3.38 ▼ $7.63	$1.63B	1.08	2.99 million shs	2.97 million shs
RYTM Rhythm Pharmaceuticals	$110.47 +1.2%	$101.29	$45.90 ▼ $113.91	$7.34B	2.12	649,703 shs	356,081 shs
TRIL Defiance Trillion Dollar Club Index ETF	$20.10 +1.0%	$18.12	$5.80 ▼ $20.96	$2.11B	2.08	1.87 million shs	3,032 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
ARCT Arcturus Therapeutics	+3.99%	-44.78%	-40.77%	-19.68%	-40.00%
CNST Constellation Pharmaceuticals	0.00%	0.00%	0.00%	0.00%	0.00%
MNKD MannKind	-0.72%	+2.62%	+2.62%	+35.22%	-15.41%
RYTM Rhythm Pharmaceuticals	-0.05%	-1.85%	+10.56%	+26.22%	+122.60%
TRIL Defiance Trillion Dollar Club Index ETF	-0.92%	+0.23%	+7.93%	+7.93%	+7.93%

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
ARCT Arcturus Therapeutics	$11.22 -6.5%	$18.88	$8.04 ▼ $24.17	$304.68M	2.39	644,358 shs	3.86 million shs
CNST Constellation Pharmaceuticals	$33.99	$33.89	$17.00 ▼ $39.30	$1.63B	2.59	940,325 shs	N/A
MNKD MannKind	$5.31 -3.3%	$5.12	$3.38 ▼ $7.63	$1.63B	1.08	2.99 million shs	2.97 million shs
RYTM Rhythm Pharmaceuticals	$110.47 +1.2%	$101.29	$45.90 ▼ $113.91	$7.34B	2.12	649,703 shs	356,081 shs
TRIL Defiance Trillion Dollar Club Index ETF	$20.10 +1.0%	$18.12	$5.80 ▼ $20.96	$2.11B	2.08	1.87 million shs	3,032 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
ARCT Arcturus Therapeutics	+3.99%	-44.78%	-40.77%	-19.68%	-40.00%
CNST Constellation Pharmaceuticals	0.00%	0.00%	0.00%	0.00%	0.00%
MNKD MannKind	-0.72%	+2.62%	+2.62%	+35.22%	-15.41%
RYTM Rhythm Pharmaceuticals	-0.05%	-1.85%	+10.56%	+26.22%	+122.60%
TRIL Defiance Trillion Dollar Club Index ETF	-0.92%	+0.23%	+7.93%	+7.93%	+7.93%

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
ARCT Arcturus Therapeutics	2.64	Moderate Buy	$31.71	182.66% Upside
CNST Constellation Pharmaceuticals	0.00	N/A	N/A	N/A
MNKD MannKind	2.89	Moderate Buy	$10.86	104.47% Upside
RYTM Rhythm Pharmaceuticals	2.94	Moderate Buy	$107.21	-2.95% Downside
TRIL Defiance Trillion Dollar Club Index ETF	0.00	N/A	N/A	N/A

Current Analyst Ratings Breakdown

Latest RYTM, ARCT, TRIL, CNST, and MNKD Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
10/24/2025	ARCT Arcturus Therapeutics	Weiss Ratings Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Sell (D-)
10/24/2025	ARCT Arcturus Therapeutics	HC Wainwright Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy ➝ Neutral	$60.00 ➝ $12.00
10/23/2025	ARCT Arcturus Therapeutics	Wells Fargo & Company Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Lower Price Target	Overweight	$42.00 ➝ $20.00
10/23/2025	ARCT Arcturus Therapeutics	Citigroup Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Downgrade	Buy ➝ Neutral	$49.00 ➝ $12.00
10/22/2025	ARCT Arcturus Therapeutics	BTIG Research Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Lower Price Target	Buy	$48.00 ➝ $23.00
10/22/2025	ARCT Arcturus Therapeutics	Guggenheim Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Downgrade	Buy ➝ Neutral
10/20/2025	MNKD MannKind	Wells Fargo & Company Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Initiated Coverage	Overweight	$10.00
10/17/2025	RYTM Rhythm Pharmaceuticals	The Goldman Sachs Group Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Lower Price Target	Buy	$157.00 ➝ $139.00
10/16/2025	RYTM Rhythm Pharmaceuticals	Morgan Stanley Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Overweight	$122.00 ➝ $129.00
10/13/2025	ARCT Arcturus Therapeutics	Zacks Research Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Upgrade	Hold ➝ Strong-Buy
10/13/2025	MNKD MannKind	HC Wainwright Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy	$11.00

(Data available from 10/24/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
ARCT Arcturus Therapeutics	$109.80M	2.77	N/A	N/A	$8.90 per share	1.26
CNST Constellation Pharmaceuticals	N/A	N/A	N/A	N/A	$8.63 per share	N/A
MNKD MannKind	$285.50M	5.71	$0.13 per share	39.85	($0.29) per share	-18.31
RYTM Rhythm Pharmaceuticals	$130.13M	56.39	N/A	N/A	$0.35 per share	315.63
TRIL Defiance Trillion Dollar Club Index ETF	$150K	14,065.83	N/A	N/A	$2.56 per share	7.85

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
ARCT Arcturus Therapeutics	-$80.94M	-$2.23	N/A	N/A	N/A	-49.26%	-24.87%	-17.75%	11/6/2025 (Estimated)
CNST Constellation Pharmaceuticals	-$126.36M	-$2.81	N/A	N/A	N/A	N/A	-33.12%	-29.92%	N/A
MNKD MannKind	$27.59M	$0.11	48.28	23.09	N/A	10.87%	-32.60%	7.81%	11/6/2025 (Estimated)
RYTM Rhythm Pharmaceuticals	-$260.60M	-$3.01	N/A	N/A	N/A	-117.13%	-1,831.43%	-48.33%	11/4/2025 (Estimated)
TRIL Defiance Trillion Dollar Club Index ETF	-$59.35M	$0.62	32.41	N/A	N/A	N/A	-23.31%	-18.66%	N/A

Latest RYTM, ARCT, TRIL, CNST, and MNKD Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
11/6/2025	Q3 2025	ARCT Arcturus Therapeutics	-$1.09	N/A	N/A	N/A	$17.47 million	N/A
11/6/2025	Q3 2025	MNKD MannKind	$0.01	N/A	N/A	N/A	$80.47 million	N/A
11/4/2025	Q3 2025	RYTM Rhythm Pharmaceuticals	-$0.72	N/A	N/A	N/A	$50.71 million	N/A
8/11/2025	Q2 2025	ARCT Arcturus Therapeutics	-$1.11	-$0.34	+$0.77	-$0.34	$17.64 million	$28.30 million
8/6/2025	Q2 2025	MNKD MannKind	$0.04	$0.05	+$0.01	N/A	$77.82 million	$76.53 million
8/5/2025	Q2 2025	RYTM Rhythm Pharmaceuticals	-$0.66	-$0.75	-$0.09	-$0.75	$43.72 million	$48.50 million

Compare Dividends

Company	Annual Payout	Dividend Yield	3-Year Dividend Growth	Payout Ratio	Years of Consecutive Growth
ARCT Arcturus Therapeutics	$0.71	6.37%	N/A	N/A	N/A
CNST Constellation Pharmaceuticals	N/A	N/A	N/A	N/A	N/A
MNKD MannKind	N/A	N/A	N/A	N/A	N/A
RYTM Rhythm Pharmaceuticals	N/A	N/A	N/A	N/A	N/A
TRIL Defiance Trillion Dollar Club Index ETF	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
ARCT Arcturus Therapeutics	N/A	5.90	5.90
CNST Constellation Pharmaceuticals	N/A	15.39	15.39
MNKD MannKind	N/A	2.50	2.24
RYTM Rhythm Pharmaceuticals	N/A	2.79	2.64
TRIL Defiance Trillion Dollar Club Index ETF	N/A	19.82	19.82

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
ARCT Arcturus Therapeutics	94.54%
CNST Constellation Pharmaceuticals	N/A
MNKD MannKind	49.55%
RYTM Rhythm Pharmaceuticals	N/A
TRIL Defiance Trillion Dollar Club Index ETF	87.15%

Insider Ownership

Company	Insider Ownership
ARCT Arcturus Therapeutics	16.60%
CNST Constellation Pharmaceuticals	43.70%
MNKD MannKind	2.70%
RYTM Rhythm Pharmaceuticals	6.10%
TRIL Defiance Trillion Dollar Club Index ETF	9.10%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
ARCT Arcturus Therapeutics	180	27.16 million	22.65 million	Optionable
CNST Constellation Pharmaceuticals	154	47.92 million	N/A	Not Optionable
MNKD MannKind	400	306.83 million	298.54 million	Optionable
RYTM Rhythm Pharmaceuticals	140	66.42 million	62.37 million	Optionable
TRIL Defiance Trillion Dollar Club Index ETF	33	105.00 million	95.44 million	No Data

RYTM, ARCT, TRIL, CNST, and MNKD Headlines

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BridgeBio raises $1.25bn, and other biotech financings

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The Global T-Cell therapy Market size is expected to reach $9.2 billion by 2030, rising at a market growth of 17.5% CAGR during the forecast period

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New MarketBeat Followers Over Time

Media Sentiment Over Time

Top Headlines

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RYTM, ARCT, TRIL, CNST, and MNKD Company Descriptions

Arcturus Therapeutics NASDAQ:ARCT

$11.22 -0.78 (-6.50%)

Closing price 04:00 PM Eastern

Extended Trading

$11.23 +0.01 (+0.09%)

As of 07:01 PM Eastern

Arcturus Therapeutics Holdings Inc., a late-stage clinical messenger RNA medicines and vaccine company, focuses on the development of infectious disease vaccines and other products within liver and respiratory rare diseases. Its technology platforms include LUNAR lipid-mediated delivery and STARR mRNA. The company is developing ARCT-810 (LUNAR-OTC), a mRNA-based therapeutic candidate, which is in Phase 2 clinical trial for treating ornithine transcarbamylase deficiency; and ARCT-154 (LUNAR-COV19), a mRNA vaccine candidate that is in Phase 3 arm of a Phase 1/2/3 study in Vietnam for the treatment of COVID-19, as well as ARCT-032 (LUNAR-CF), a mRNA therapeutic candidate for cystic fibrosis. Its product pipeline includes, ARCT-2301 for bivalent: ancestral/omicron which is in Phase 3; ARCT-2303 for monovalent that is in Phase 3; ARCT-2138 for quadrivalent which is in Phase 1; and LUNAR-FLU which is in pre-clinical trial. Arcturus Therapeutics Holdings Inc. was founded in 2013 and is headquartered in San Diego, California.

Constellation Pharmaceuticals NASDAQ:CNST

Constellation Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, discovers and develops therapeutics to address serious unmet medical needs in patients with cancers associated with abnormal gene expression or drug resistance. The company's lead product candidates include Pelabresib that is in Phase 3 clinical trials for the treatment of patients with myelofibrosis in combination with ruxolitinib. It is also developing CPI-0209 that is in Phase 1 dose escalation portion of a Phase 1/2 clinical trial to treat solid tumors; and CPI-482, which is in preclinical stage for cancer patients. The company was formerly known as Epigenetix, Inc. and changed its name to Constellation Pharmaceuticals, Inc. in March 2008. Constellation Pharmaceuticals, Inc. was incorporated in 2008 and is headquartered in Cambridge, Massachusetts.

MannKind NASDAQ:MNKD

$5.31 -0.18 (-3.28%)

Closing price 04:00 PM Eastern

Extended Trading

$5.34 +0.04 (+0.66%)

As of 06:56 PM Eastern

MannKind Corporation, a biopharmaceutical company, focuses on the development and commercialization of inhaled therapeutic products for endocrine and orphan lung diseases in the United States. It offers Afrezza, an inhaled insulin used to improve glycemic control in adults with diabetes, and the V-Go wearable insulin delivery device, which provides continuous subcutaneous infusion of insulin in adults. The company's product pipeline also includes Tyvaso DPI (Treprostinil), an inhalation powder for the treatment of pulmonary arterial hypertension and pulmonary hypertension associated with interstitial lung disease; MNKD-101, a nebulized formulation of clofazimine, for the treatment of severe chronic and recurrent pulmonary infections, including nontuberculous mycobacterial lung disease; MNKD-201, a dry-powder formulation of nintedanib, for the treatment of idiopathic pulmonary fibrosis (IPF). In addition, it has collaboration and license agreement with United Therapeutics Corporation for development, regulatory, and commercial activities of Tyvaso DPI; co-promotion agreement with Vertice Pharma to promote Thyquidity; and collaboration agreement with Thirona to evaluate the therapeutic for the treatment of pulmonary fibrosis. Further, the company has supply and distribution agreement with Biomm S.A. for the commercialization of Afrezza in Brazil; and license and distribution agreement with Cipla Ltd. for the marketing and distribution of Afrezza in India. MannKind Corporation was incorporated in 1991 and is headquartered in Danbury, Connecticut.

Rhythm Pharmaceuticals NASDAQ:RYTM

$110.47 +1.35 (+1.24%)

Closing price 04:00 PM Eastern

Extended Trading

$110.44 -0.03 (-0.03%)

As of 04:47 PM Eastern

Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the rare neuroendocrine diseases. The company's lead product candidate is IMCIVREE (setmelanotide), a rare melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, and Bardet-Biedl and Alström syndrome. It is in Phase 3 clinical trials for treating POMC or LEPR heterozygous deficiency obesities, steroid receptor coactivator 1 deficiency obesity, SH2B1 deficiency obesity, MC4 receptor deficiency obesity, and other MC4R disorders. The company has licensing agreements with LG Chem, Ltd; Ipsen Pharma S.A.S; Camurus; RareStone Group Ltd.; and LG Chem, Ltd. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.

Defiance Trillion Dollar Club Index ETF NASDAQ:TRIL

Trillium Therapeutics, Inc. is a clinical stage immuno-oncology company, which engages in the research and development of therapies for the treatment of cancer. It offers clinical programs, TTI-621 and TTI-622, target CD47, a signal that cancer cells frequently use to evade the immune system. The company was founded on March 31, 2004 and is headquartered in Mississauga, Canada.

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Compare Stocks

Comparative Price Performance Over Time

Compare Price & Volume

Compare Price Performance

Compare Price & Volume

Compare Price Performance

Compare Analyst Forecasts

Current Analyst Ratings Breakdown

Latest RYTM, ARCT, TRIL, CNST, and MNKD Analyst Ratings

Compare Sales & Book Value

Compare Profitability & Earnings

Latest RYTM, ARCT, TRIL, CNST, and MNKD Earnings

Compare Dividends

Compare Debt

Compare Ownership

Institutional Ownership

Insider Ownership

Compare Miscellaneous Stats

RYTM, ARCT, TRIL, CNST, and MNKD Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

Top Headlines

RYTM, ARCT, TRIL, CNST, and MNKD Company Descriptions

Arcturus Therapeutics NASDAQ:ARCT

Constellation Pharmaceuticals NASDAQ:CNST

MannKind NASDAQ:MNKD

Rhythm Pharmaceuticals NASDAQ:RYTM

Defiance Trillion Dollar Club Index ETF NASDAQ:TRIL

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