Compare Stocks: SPRB, AVDL, and SIGA

Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
AVDL Avadel Pharmaceuticals	$21.39 -1.1%	$21.48	$8.19 ▼ $23.57	$2.09B	1.31	2.03 million shs	35.02 million shs
SIGA Siga Technologies	$3.31 +3.4%	$3.18	$2.83 ▼ $8.46	$237.82M	1.04	606,914 shs	759,408 shs
SPRB Spruce Biosciences	$46.99 +2.9%	$50.25	$38.06 ▼ $129.00	$134.86M	3.25	65,784 shs	58,842 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
AVDL Avadel Pharmaceuticals	0.00%	0.00%	0.00%	0.00%	+15.06%
SIGA Siga Technologies	+3.44%	+6.09%	-4.34%	+1.85%	-60.78%
SPRB Spruce Biosciences	+2.94%	+9.97%	-1.09%	+8.35%	-62.26%

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
AVDL Avadel Pharmaceuticals	$21.39 -1.1%	$21.48	$8.19 ▼ $23.57	$2.09B	1.31	2.03 million shs	35.02 million shs
SIGA Siga Technologies	$3.31 +3.4%	$3.18	$2.83 ▼ $8.46	$237.82M	1.04	606,914 shs	759,408 shs
SPRB Spruce Biosciences	$46.99 +2.9%	$50.25	$38.06 ▼ $129.00	$134.86M	3.25	65,784 shs	58,842 shs

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MarketBeat just released its list of the 7 hottest IPOs expected to hit Wall Street in 2026. See which companies are preparing to go public and why investors are watching closely.

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
AVDL Avadel Pharmaceuticals	0.00%	0.00%	0.00%	0.00%	+15.06%
SIGA Siga Technologies	+3.44%	+6.09%	-4.34%	+1.85%	-60.78%
SPRB Spruce Biosciences	+2.94%	+9.97%	-1.09%	+8.35%	-62.26%

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
AVDL Avadel Pharmaceuticals	1.67	Reduce	$22.50	5.19% Upside
SIGA Siga Technologies	1.00	Sell	N/A	N/A
SPRB Spruce Biosciences	2.83	Moderate Buy	$158.33	236.95% Upside

Current Analyst Ratings Breakdown

Latest SPRB, AVDL, and SIGA Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
10/6/2026	SPRB Spruce Biosciences	Weiss Ratings Subscribe to MarketBeat All Access to unlock brokerage rankings	Upgrade	Sell (E+) ➝ Sell (D-)
9/24/2026	SPRB Spruce Biosciences	Citizens Jmp Subscribe to MarketBeat All Access to unlock brokerage rankings	Reiterated Rating	Market Outperform	$144.00
9/18/2026	SPRB Spruce Biosciences	Citigroup Subscribe to MarketBeat All Access to unlock brokerage rankings	Reiterated Rating	Market Outperform
9/17/2026	SPRB Spruce Biosciences	Lake Street Capital Subscribe to MarketBeat All Access to unlock brokerage rankings	Initiated Coverage	Buy	$149.00
9/16/2026	SPRB Spruce Biosciences	Weiss Ratings Subscribe to MarketBeat All Access to unlock brokerage rankings	Downgrade	Sell (D-) ➝ Sell (E+)
8/27/2026	SPRB Spruce Biosciences	Weiss Ratings Subscribe to MarketBeat All Access to unlock brokerage rankings	Upgrade	Sell (E+) ➝ Sell (D-)
8/26/2026	SPRB Spruce Biosciences	HC Wainwright Subscribe to MarketBeat All Access to unlock brokerage rankings	Reiterated Rating	Buy
8/17/2026	SPRB Spruce Biosciences	Guggenheim Subscribe to MarketBeat All Access to unlock brokerage rankings	Reiterated Rating	Buy	$123.00 ➝ $104.00
8/13/2026	SPRB Spruce Biosciences	The Goldman Sachs Group Subscribe to MarketBeat All Access to unlock brokerage rankings	Upgrade	Overweight
8/13/2026	SPRB Spruce Biosciences	Citigroup Subscribe to MarketBeat All Access to unlock brokerage rankings	Reiterated Rating	Market Outperform
8/11/2026	SIGA Siga Technologies	Weiss Ratings Subscribe to MarketBeat All Access to unlock brokerage rankings	Downgrade	Sell (D+) ➝ Sell (D)

(Data available from 10/29/2023 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
AVDL Avadel Pharmaceuticals	$248.52M	8.41	N/A	N/A	$0.77 per share	27.78
SIGA Siga Technologies	$53.66M	4.43	$0.35 per share	9.37	$2.78 per share	1.19
SPRB Spruce Biosciences	$4.91M	27.47	N/A	N/A	$39.72 per share	1.18

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
AVDL Avadel Pharmaceuticals	-$48.83M	N/A	N/A	356.50	N/A	-0.11%	-0.33%	-0.15%	N/A
SIGA Siga Technologies	$23.28M	-$0.05	N/A	N/A	N/A	-5.19%	-1.55%	-1.32%	11/5/2026 (Estimated)
SPRB Spruce Biosciences	-$38.97M	-$39.78	N/A	N/A	N/A	N/A	-123.53%	-90.35%	11/9/2026 (Estimated)

Latest SPRB, AVDL, and SIGA Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
11/9/2026	Q3 2026	SPRB Spruce Biosciences	-$5.6756	N/A	N/A	N/A	$50.00 million	N/A
8/12/2026	Q2 2026	SPRB Spruce Biosciences	-$5.79	-$6.68	-$0.89	-$6.68	N/A	N/A
8/6/2026	Q2 2026	SIGA Siga Technologies	N/A	$0.17	N/A	$0.17	N/A	$41.00 million

Compare Dividends

Company	Annual Payout	Dividend Yield	5-Year Annualized Dividend Growth	Payout Ratio	Years of Consecutive Growth
AVDL Avadel Pharmaceuticals	N/A	N/A	N/A	N/A	N/A
SIGA Siga Technologies	N/A	N/A	N/A	N/A	N/A
SPRB Spruce Biosciences	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
AVDL Avadel Pharmaceuticals	N/A	2.76	2.37
SIGA Siga Technologies	N/A	21.72	16.48
SPRB Spruce Biosciences	0.05	9.23	9.23

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
AVDL Avadel Pharmaceuticals	69.19%
SIGA Siga Technologies	55.40%
SPRB Spruce Biosciences	91.71%

Insider Ownership

Company	Insider Ownership
AVDL Avadel Pharmaceuticals	5.20%
SIGA Siga Technologies	2.73%
SPRB Spruce Biosciences	4.30%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
AVDL Avadel Pharmaceuticals	70	97.66 million	92.58 million	Optionable
SIGA Siga Technologies	49	71.85 million	69.89 million	Optionable
SPRB Spruce Biosciences	8	2.87 million	2.75 million	Optionable

SPRB, AVDL, and SIGA Headlines

Recent News About These Companies

Spruce Biosciences, Inc. (SPRB) - What Are Investment Firms Thinking About This Stock?

October 18, 2026 | americanbankingnews.com

Spruce Biosciences to Participate in the Craig-Hallum Biotech Catalyst Conference

October 15, 2026 | finance.yahoo.com

Spruce Biosciences, Inc. (NASDAQ:SPRB) Stock Rated "Moderate Buy" by Wall Street Analysts

October 13, 2026 | marketbeat.com

Spruce Biosciences Announces Presentation of MPS IIIB Natural History Data at the 55th Child Neurology Society Annual Meeting

October 8, 2026 | financialpost.comF

Analysts Are Bullish on These Healthcare Stocks: Spruce Biosciences (SPRB), Arcus Biosciences (RCUS)

October 3, 2026 | theglobeandmail.com

Spruce Biosciences (SPRB) Reiterated at Market Outperform by Citizens on TA-ERT Therapy Lead

September 24, 2026 | streetinsider.com

Lake Street initiates coverage of Spruce Biosciences at buy

September 18, 2026 | msn.com

Spruce Biosciences to Participate in the H.C. Wainwright 28th Annual Global Investment Conference

September 8, 2026 | businesswire.com

Oppenheimer Sticks to Its Buy Rating for Spruce Biosciences (SPRB)

August 28, 2026 | theglobeandmail.com

Spruce Biosciences stock gains after analyst backs regulatory progress

August 27, 2026 | finance.yahoo.com

Spruce Biosciences Announces Launch of MPS3BStudy.com

August 26, 2026 | finance.yahoo.com

Spruce Biosciences Announces Positive Pre-BLA Meetings with FDA and Confirms BLA Submission for TA-ERT on Track for Q4 2026

August 24, 2026 | finance.yahoo.com

Spruce Biosciences Inc.

August 16, 2026 | marketwatch.com

Spruce Biosciences Reports Second Quarter 2026 Financial Results and Provides Corporate Updates

August 12, 2026 | aol.comA

Cure Sanfilippo Foundation and National MPS Society Make $5.5 Million Strategic Investment in Spruce Biosciences

August 12, 2026 | finance.yahoo.com

Spruce Biosciences Appoints Jessica Cohen Pfeffer, M.D., as Vice President, Clinical Development

August 3, 2026 | finance.yahoo.com

Spruce Biosciences Appoints Adrian Quartel, M.D., FFPM, as Chief Medical Officer

July 27, 2026 | finance.yahoo.com

Spruce Biosciences Names Adrian Quartel Chief Medical Officer

July 27, 2026 | tipranks.com

Spruce Biosciences to Participate in the B. Riley Securities 2026 Mind, Muscle & Vision Healthcare Summit

July 8, 2026 | finance.yahoo.com

Spruce Biosciences Possibly First In-MPS IIIB Class Enzyme Replacement Therapy

July 8, 2026 | seekingalpha.com

Spruce Biosciences Joins the Russell 3000® Index

June 29, 2026 | finance.yahoo.com

New MarketBeat Followers Over Time

Media Sentiment Over Time

SPRB, AVDL, and SIGA Company Descriptions

Avadel Pharmaceuticals NASDAQ:AVDL

Avadel Pharmaceuticals plc operates as a biopharmaceutical company in the United States. Its lead product candidate is LUMRYZ, a formulation of sodium oxybate, which is in a Phase 3 clinical trial for the treatment of excessive daytime sleepiness or cataplexy in adults with narcolepsy. The company was formerly known as Flamel Technologies SA and changed its name to Avadel Pharmaceuticals plc in January 2017. Avadel Pharmaceuticals plc was incorporated in 2015 and is headquartered in Dublin, Ireland.

Siga Technologies NASDAQ:SIGA

$3.31 +0.11 (+3.44%)

Closing price 10/28/2026 04:00 PM Eastern

Extended Trading

$3.30 -0.01 (-0.30%)

As of 07:11 AM Eastern

SIGA Technologies, Inc., a commercial-stage pharmaceutical company, focuses on the health security related markets in the United States. Its lead product is TPOXX, an oral formulation antiviral drug for the treatment of human smallpox disease caused by variola virus. The company was incorporated in 1995 and is headquartered in New York, New York.

Spruce Biosciences NASDAQ:SPRB

$46.99 +1.34 (+2.94%)

Closing price 10/28/2026 04:00 PM Eastern

Extended Trading

$46.96 -0.03 (-0.06%)

As of 07:00 AM Eastern

Spruce Biosciences, Inc., a biopharmaceutical company, focuses on developing and commercializing novel therapies for rare endocrine disorders. The company engages in developing tildacerfont, a non-steroidal therapy to enhance disease control and reduce steroid burden for patients suffering from congenital adrenal hyperplasia (CAH), which is in Phase 2b clinical trial; and to evaluate glucocorticoid reduction in adult patients with classic CAH that is Phase 2b clinical trial. It is also developing tildacerfont for the treatment of pediatric classic congenital adrenal hyperplasia in children that is in Phase 2 clinical trial; and for females with polycystic ovary syndrome, which is in Phase 2 clinical trial. Spruce Biosciences, Inc. has a license agreement with Eli Lilly and Company to research, develop, and commercialize compounds for various pharmaceutical uses; and collaboration and license agreement with Kaken Pharmaceutical Co. Ltd. to develop, manufacture, and commercialize tildacerfont for the treatment of CAH in Japan. The company was incorporated in 2014 and is headquartered in South San Francisco, California.

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Compare Stocks

Comparative Price Performance Over Time

Compare Price & Volume

Compare Price Performance

Compare Price & Volume

Compare Price Performance

Compare Analyst Forecasts

Current Analyst Ratings Breakdown

Latest SPRB, AVDL, and SIGA Analyst Ratings

Compare Sales & Book Value

Compare Profitability & Earnings

Latest SPRB, AVDL, and SIGA Earnings

Compare Dividends

Compare Debt

Compare Ownership

Institutional Ownership

Insider Ownership

Compare Miscellaneous Stats

SPRB, AVDL, and SIGA Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

SPRB, AVDL, and SIGA Company Descriptions

Avadel Pharmaceuticals NASDAQ:AVDL

Siga Technologies NASDAQ:SIGA

Spruce Biosciences NASDAQ:SPRB

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Compare Stocks

Comparative Price Performance Over Time

Compare Price & Volume

Compare Price Performance

Compare Price & Volume

Compare Price Performance

Compare Analyst Forecasts

Current Analyst Ratings Breakdown

Latest SPRB, AVDL, and SIGA Analyst Ratings

Compare Sales & Book Value

Compare Profitability & Earnings

Latest SPRB, AVDL, and SIGA Earnings

Compare Dividends

Compare Debt

Compare Ownership

Institutional Ownership

Insider Ownership

Compare Miscellaneous Stats

SPRB, AVDL, and SIGA Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

SPRB, AVDL, and SIGA Company Descriptions

Avadel Pharmaceuticals NASDAQ:AVDL

Siga Technologies NASDAQ:SIGA

Spruce Biosciences NASDAQ:SPRB

More Stock Comparisions from MarketBeat

Stock Comparison Ideas (A-K)

Stock Comparison Ideas (L-Z)

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