Cyclerion Therapeutics (CYCN) Competitors $3.64 +0.09 (+2.54%) Closing price 07/11/2025 03:50 PM EasternExtended Trading$3.59 -0.05 (-1.37%) As of 07/11/2025 06:59 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisChartCompetitorsEarningsInsider TradesOwnershipSEC FilingsShort InterestTrendsBuy This Stock CYCN vs. KPTI, EGRX, ACRV, PEPG, AKTX, XCUR, BRNS, MRSN, ARTV, and ELYMShould you be buying Cyclerion Therapeutics stock or one of its competitors? The main competitors of Cyclerion Therapeutics include Karyopharm Therapeutics (KPTI), Eagle Pharmaceuticals (EGRX), Acrivon Therapeutics (ACRV), PepGen (PEPG), Akari Therapeutics (AKTX), Exicure (XCUR), Barinthus Biotherapeutics (BRNS), Mersana Therapeutics (MRSN), Artiva Biotherapeutics (ARTV), and Eliem Therapeutics (ELYM). These companies are all part of the "pharmaceutical products" industry. Cyclerion Therapeutics vs. Its Competitors Karyopharm Therapeutics Eagle Pharmaceuticals Acrivon Therapeutics PepGen Akari Therapeutics Exicure Barinthus Biotherapeutics Mersana Therapeutics Artiva Biotherapeutics Eliem Therapeutics Cyclerion Therapeutics (NASDAQ:CYCN) and Karyopharm Therapeutics (NASDAQ:KPTI) are both small-cap medical companies, but which is the superior investment? We will compare the two businesses based on the strength of their earnings, media sentiment, risk, dividends, profitability, analyst recommendations, institutional ownership and valuation. Do analysts rate CYCN or KPTI? Karyopharm Therapeutics has a consensus target price of $37.40, indicating a potential upside of 721.98%. Given Karyopharm Therapeutics' stronger consensus rating and higher probable upside, analysts clearly believe Karyopharm Therapeutics is more favorable than Cyclerion Therapeutics.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Cyclerion Therapeutics 0 Sell rating(s) 0 Hold rating(s) 0 Buy rating(s) 0 Strong Buy rating(s) 0.00Karyopharm Therapeutics 0 Sell rating(s) 0 Hold rating(s) 5 Buy rating(s) 0 Strong Buy rating(s) 3.00 Do insiders & institutionals hold more shares of CYCN or KPTI? 75.6% of Cyclerion Therapeutics shares are owned by institutional investors. Comparatively, 66.4% of Karyopharm Therapeutics shares are owned by institutional investors. 34.3% of Cyclerion Therapeutics shares are owned by company insiders. Comparatively, 3.0% of Karyopharm Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term. Does the media refer more to CYCN or KPTI? In the previous week, Karyopharm Therapeutics had 4 more articles in the media than Cyclerion Therapeutics. MarketBeat recorded 5 mentions for Karyopharm Therapeutics and 1 mentions for Cyclerion Therapeutics. Cyclerion Therapeutics' average media sentiment score of 1.87 beat Karyopharm Therapeutics' score of 0.25 indicating that Cyclerion Therapeutics is being referred to more favorably in the media. Company Overall Sentiment Cyclerion Therapeutics Very Positive Karyopharm Therapeutics Neutral Which has more volatility & risk, CYCN or KPTI? Cyclerion Therapeutics has a beta of 1.55, indicating that its share price is 55% more volatile than the S&P 500. Comparatively, Karyopharm Therapeutics has a beta of 0.24, indicating that its share price is 76% less volatile than the S&P 500. Which has higher earnings & valuation, CYCN or KPTI? Cyclerion Therapeutics has higher earnings, but lower revenue than Karyopharm Therapeutics. Cyclerion Therapeutics is trading at a lower price-to-earnings ratio than Karyopharm Therapeutics, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioCyclerion Therapeutics$2M5.84-$3.06M-$1.16-3.14Karyopharm Therapeutics$142.13M0.28-$76.42M-$13.26-0.34 Is CYCN or KPTI more profitable? Cyclerion Therapeutics has a net margin of 0.00% compared to Karyopharm Therapeutics' net margin of -43.99%. Karyopharm Therapeutics' return on equity of 0.00% beat Cyclerion Therapeutics' return on equity.Company Net Margins Return on Equity Return on Assets Cyclerion TherapeuticsN/A -34.02% -30.68% Karyopharm Therapeutics -43.99%N/A -35.95% SummaryCyclerion Therapeutics beats Karyopharm Therapeutics on 9 of the 16 factors compared between the two stocks. Get Cyclerion Therapeutics News Delivered to You Automatically Sign up to receive the latest news and ratings for CYCN and its competitors with MarketBeat's FREE daily newsletter. Email Address New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding CYCN and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart CYCN vs. The Competition Export to ExcelMetricCyclerion TherapeuticsMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$11.40M$2.97B$5.62B$9.10BDividend YieldN/A2.39%5.24%4.00%P/E Ratio-3.1420.7128.1320.27Price / Sales5.84288.38428.2998.73Price / CashN/A42.8637.4658.16Price / Book1.117.638.045.49Net Income-$3.06M-$55.05M$3.18B$250.45M7 Day Performance10.14%8.43%3.62%4.78%1 Month Performance17.42%5.42%4.06%7.67%1 Year Performance8.66%2.03%30.01%16.43% Cyclerion Therapeutics Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)CYCNCyclerion Therapeutics2.0247 of 5 stars$3.64+2.5%N/A+7.7%$11.40M$2M-3.1430Positive NewsGap UpKPTIKaryopharm Therapeutics3.943 of 5 stars$4.31-1.8%$43.20+902.3%-68.5%$37.93M$145.24M-0.32380News CoverageAnalyst ForecastGap DownEGRXEagle Pharmaceuticals2.4585 of 5 stars$2.90+7.4%N/A-41.1%$37.66M$257.55M0.00100News CoverageGap DownACRVAcrivon Therapeutics3.9657 of 5 stars$1.19-0.8%$17.71+1,388.6%-83.3%$37.63MN/A-0.5458PEPGPepGen3.1177 of 5 stars$1.11-3.5%$7.67+590.7%-92.7%$37.63MN/A-0.3530AKTXAkari Therapeutics0.8741 of 5 stars$1.17+0.9%N/A-68.0%$37.30MN/A0.009XCURExicure1.5061 of 5 stars$7.04+19.5%N/A+2,115.8%$37.21M$500K-1.8450High Trading VolumeBRNSBarinthus Biotherapeutics3.4602 of 5 stars$0.93+1.5%$6.25+572.0%-30.3%$36.95M$14.97M-0.57107Gap DownMRSNMersana Therapeutics4.0398 of 5 stars$0.30+1.7%$5.20+1,656.8%-83.1%$36.27M$40.50M-0.50150Gap UpARTVArtiva Biotherapeutics3.0347 of 5 stars$1.51+2.7%$17.80+1,078.8%N/A$35.81M$250K0.0081Positive NewsELYMEliem TherapeuticsN/A$1.18-6.3%N/A-80.9%$35.11MN/A-2.239High Trading Volume Related Companies and Tools Related Companies KPTI Competitors EGRX Competitors ACRV Competitors PEPG Competitors AKTX Competitors XCUR Competitors BRNS Competitors MRSN Competitors ARTV Competitors ELYM Competitors Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:CYCN) was last updated on 7/12/2025 by MarketBeat.com Staff From Our PartnersThis Signal Only Flashes Once Every 4 Years – And It Just TriggeredThis same signal has appeared twice before in the past 8 years — both times, it kicked off major moves in cryp...Crypto Swap Profits | SponsoredTrump wipes out trillions overnight…Is there anybody more powerful than Donald Trump right now? 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