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Prothena (PRTA) Competitors

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$10.02 +0.75 (+8.09%)
Closing price 06/26/2026 04:00 PM Eastern
Extended Trading
$9.82 -0.21 (-2.05%)
As of 06/26/2026 07:34 PM Eastern
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PRTA vs. MESO, ADMA, TSHA, HRMY, and NRIX

Should you buy Prothena stock or one of its competitors? MarketBeat compares Prothena with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Prothena include Mesoblast (MESO), ADMA Biologics (ADMA), Taysha Gene Therapies (TSHA), Harmony Biosciences (HRMY), and Nurix Therapeutics (NRIX). These companies are all part of the "pharmaceutical products" industry.

How does Prothena compare to Mesoblast?

Prothena (NASDAQ:PRTA) and Mesoblast (NASDAQ:MESO) are both small-cap medical companies, but which is the better investment? We will compare the two companies based on the strength of their institutional ownership, valuation, risk, profitability, dividends, earnings, analyst recommendations and media sentiment.

97.1% of Prothena shares are owned by institutional investors. Comparatively, 1.4% of Mesoblast shares are owned by institutional investors. 10.4% of Prothena shares are owned by insiders. Comparatively, 18.8% of Mesoblast shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock is poised for long-term growth.

Prothena currently has a consensus target price of $23.75, indicating a potential upside of 137.03%. Given Prothena's stronger consensus rating and higher probable upside, research analysts clearly believe Prothena is more favorable than Mesoblast.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Prothena
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
1 Strong Buy rating(s)
2.71
Mesoblast
1 Sell rating(s)
1 Hold rating(s)
0 Buy rating(s)
1 Strong Buy rating(s)
2.33

Prothena has a beta of -0.25, meaning that its stock price is 125% less volatile than the broader market. Comparatively, Mesoblast has a beta of 2.05, meaning that its stock price is 105% more volatile than the broader market.

Mesoblast has higher revenue and earnings than Prothena. Mesoblast is trading at a lower price-to-earnings ratio than Prothena, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Prothena$9.68M54.19-$244.09M-$2.82N/A
Mesoblast$17.20M99.28-$102.14M-$0.54N/A

In the previous week, Mesoblast had 1 more articles in the media than Prothena. MarketBeat recorded 3 mentions for Mesoblast and 2 mentions for Prothena. Prothena's average media sentiment score of 0.88 beat Mesoblast's score of 0.81 indicating that Prothena is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Prothena
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Mesoblast
0 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Mesoblast has a net margin of 0.00% compared to Prothena's net margin of -260.92%. Mesoblast's return on equity of 0.00% beat Prothena's return on equity.

Company Net Margins Return on Equity Return on Assets
Prothena-260.92% -43.44% -36.87%
Mesoblast N/A N/A N/A

Summary

Mesoblast beats Prothena on 10 of the 16 factors compared between the two stocks.

How does Prothena compare to ADMA Biologics?

ADMA Biologics (NASDAQ:ADMA) and Prothena (NASDAQ:PRTA) are both medical companies, but which is the superior business? We will contrast the two companies based on the strength of their earnings, dividends, analyst recommendations, media sentiment, profitability, risk, institutional ownership and valuation.

ADMA Biologics presently has a consensus price target of $19.67, suggesting a potential upside of 124.89%. Prothena has a consensus price target of $23.75, suggesting a potential upside of 137.03%. Given Prothena's stronger consensus rating and higher probable upside, analysts plainly believe Prothena is more favorable than ADMA Biologics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
ADMA Biologics
1 Sell rating(s)
2 Hold rating(s)
3 Buy rating(s)
0 Strong Buy rating(s)
2.33
Prothena
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
1 Strong Buy rating(s)
2.71

ADMA Biologics has a beta of 0.72, suggesting that its share price is 28% less volatile than the broader market. Comparatively, Prothena has a beta of -0.25, suggesting that its share price is 125% less volatile than the broader market.

In the previous week, ADMA Biologics had 37 more articles in the media than Prothena. MarketBeat recorded 39 mentions for ADMA Biologics and 2 mentions for Prothena. Prothena's average media sentiment score of 0.88 beat ADMA Biologics' score of 0.04 indicating that Prothena is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
ADMA Biologics
1 Very Positive mention(s)
4 Positive mention(s)
32 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral
Prothena
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

ADMA Biologics has higher revenue and earnings than Prothena. Prothena is trading at a lower price-to-earnings ratio than ADMA Biologics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
ADMA Biologics$510.17M3.97$146.93M$0.6812.86
Prothena$9.68M54.19-$244.09M-$2.82N/A

ADMA Biologics has a net margin of 32.43% compared to Prothena's net margin of -260.92%. ADMA Biologics' return on equity of 39.98% beat Prothena's return on equity.

Company Net Margins Return on Equity Return on Assets
ADMA Biologics32.43% 39.98% 28.08%
Prothena -260.92%-43.44%-36.87%

75.7% of ADMA Biologics shares are owned by institutional investors. Comparatively, 97.1% of Prothena shares are owned by institutional investors. 3.9% of ADMA Biologics shares are owned by insiders. Comparatively, 10.4% of Prothena shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

Summary

ADMA Biologics beats Prothena on 9 of the 17 factors compared between the two stocks.

How does Prothena compare to Taysha Gene Therapies?

Taysha Gene Therapies (NASDAQ:TSHA) and Prothena (NASDAQ:PRTA) are both small-cap medical companies, but which is the superior stock? We will contrast the two businesses based on the strength of their risk, institutional ownership, dividends, profitability, media sentiment, analyst recommendations, earnings and valuation.

Taysha Gene Therapies has a beta of 1.19, meaning that its stock price is 19% more volatile than the broader market. Comparatively, Prothena has a beta of -0.25, meaning that its stock price is 125% less volatile than the broader market.

In the previous week, Taysha Gene Therapies had 13 more articles in the media than Prothena. MarketBeat recorded 15 mentions for Taysha Gene Therapies and 2 mentions for Prothena. Prothena's average media sentiment score of 0.88 beat Taysha Gene Therapies' score of 0.44 indicating that Prothena is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Taysha Gene Therapies
3 Very Positive mention(s)
0 Positive mention(s)
9 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Prothena
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Taysha Gene Therapies has a net margin of 0.00% compared to Prothena's net margin of -260.92%. Prothena's return on equity of -43.44% beat Taysha Gene Therapies' return on equity.

Company Net Margins Return on Equity Return on Assets
Taysha Gene TherapiesN/A -56.07% -40.16%
Prothena -260.92%-43.44%-36.87%

77.7% of Taysha Gene Therapies shares are owned by institutional investors. Comparatively, 97.1% of Prothena shares are owned by institutional investors. 3.8% of Taysha Gene Therapies shares are owned by insiders. Comparatively, 10.4% of Prothena shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a stock will outperform the market over the long term.

Taysha Gene Therapies presently has a consensus price target of $12.38, indicating a potential upside of 95.34%. Prothena has a consensus price target of $23.75, indicating a potential upside of 137.03%. Given Prothena's higher probable upside, analysts plainly believe Prothena is more favorable than Taysha Gene Therapies.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Taysha Gene Therapies
1 Sell rating(s)
0 Hold rating(s)
11 Buy rating(s)
2 Strong Buy rating(s)
3.00
Prothena
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
1 Strong Buy rating(s)
2.71

Taysha Gene Therapies has higher revenue and earnings than Prothena. Taysha Gene Therapies is trading at a lower price-to-earnings ratio than Prothena, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Taysha Gene Therapies$9.77M186.48-$109M-$0.38N/A
Prothena$9.68M54.19-$244.09M-$2.82N/A

Summary

Taysha Gene Therapies beats Prothena on 10 of the 17 factors compared between the two stocks.

How does Prothena compare to Harmony Biosciences?

Harmony Biosciences (NASDAQ:HRMY) and Prothena (NASDAQ:PRTA) are both medical companies, but which is the better investment? We will compare the two businesses based on the strength of their risk, dividends, profitability, earnings, analyst recommendations, institutional ownership, valuation and media sentiment.

86.2% of Harmony Biosciences shares are owned by institutional investors. Comparatively, 97.1% of Prothena shares are owned by institutional investors. 11.0% of Harmony Biosciences shares are owned by insiders. Comparatively, 10.4% of Prothena shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.

In the previous week, Prothena had 1 more articles in the media than Harmony Biosciences. MarketBeat recorded 2 mentions for Prothena and 1 mentions for Harmony Biosciences. Harmony Biosciences' average media sentiment score of 1.91 beat Prothena's score of 0.88 indicating that Harmony Biosciences is being referred to more favorably in the media.

Company Overall Sentiment
Harmony Biosciences Very Positive
Prothena Positive

Harmony Biosciences has higher revenue and earnings than Prothena. Prothena is trading at a lower price-to-earnings ratio than Harmony Biosciences, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Harmony Biosciences$868.45M2.36$158.69M$2.4814.30
Prothena$9.68M54.19-$244.09M-$2.82N/A

Harmony Biosciences presently has a consensus target price of $40.89, suggesting a potential upside of 15.28%. Prothena has a consensus target price of $23.75, suggesting a potential upside of 137.03%. Given Prothena's stronger consensus rating and higher probable upside, analysts clearly believe Prothena is more favorable than Harmony Biosciences.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Harmony Biosciences
1 Sell rating(s)
6 Hold rating(s)
4 Buy rating(s)
0 Strong Buy rating(s)
2.27
Prothena
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
1 Strong Buy rating(s)
2.71

Harmony Biosciences has a net margin of 16.20% compared to Prothena's net margin of -260.92%. Harmony Biosciences' return on equity of 17.19% beat Prothena's return on equity.

Company Net Margins Return on Equity Return on Assets
Harmony Biosciences16.20% 17.19% 11.99%
Prothena -260.92%-43.44%-36.87%

Harmony Biosciences has a beta of 0.96, meaning that its stock price is 4% less volatile than the broader market. Comparatively, Prothena has a beta of -0.25, meaning that its stock price is 125% less volatile than the broader market.

Summary

Harmony Biosciences beats Prothena on 10 of the 16 factors compared between the two stocks.

How does Prothena compare to Nurix Therapeutics?

Nurix Therapeutics (NASDAQ:NRIX) and Prothena (NASDAQ:PRTA) are both medical companies, but which is the superior investment? We will contrast the two companies based on the strength of their media sentiment, dividends, analyst recommendations, valuation, profitability, institutional ownership, risk and earnings.

Prothena has a net margin of -260.92% compared to Nurix Therapeutics' net margin of -411.37%. Prothena's return on equity of -43.44% beat Nurix Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Nurix Therapeutics-411.37% -64.21% -48.44%
Prothena -260.92%-43.44%-36.87%

97.1% of Prothena shares are held by institutional investors. 6.7% of Nurix Therapeutics shares are held by company insiders. Comparatively, 10.4% of Prothena shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

Prothena has lower revenue, but higher earnings than Nurix Therapeutics. Nurix Therapeutics is trading at a lower price-to-earnings ratio than Prothena, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Nurix Therapeutics$83.98M28.20-$264.46M-$3.16N/A
Prothena$9.68M54.19-$244.09M-$2.82N/A

Nurix Therapeutics has a beta of 1.86, indicating that its share price is 86% more volatile than the broader market. Comparatively, Prothena has a beta of -0.25, indicating that its share price is 125% less volatile than the broader market.

Nurix Therapeutics presently has a consensus price target of $32.20, suggesting a potential upside of 40.61%. Prothena has a consensus price target of $23.75, suggesting a potential upside of 137.03%. Given Prothena's higher possible upside, analysts clearly believe Prothena is more favorable than Nurix Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Nurix Therapeutics
1 Sell rating(s)
1 Hold rating(s)
14 Buy rating(s)
0 Strong Buy rating(s)
2.81
Prothena
1 Sell rating(s)
1 Hold rating(s)
4 Buy rating(s)
1 Strong Buy rating(s)
2.71

In the previous week, Nurix Therapeutics had 5 more articles in the media than Prothena. MarketBeat recorded 7 mentions for Nurix Therapeutics and 2 mentions for Prothena. Prothena's average media sentiment score of 0.88 beat Nurix Therapeutics' score of 0.56 indicating that Prothena is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Nurix Therapeutics
2 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Prothena
0 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Prothena beats Nurix Therapeutics on 12 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding PRTA and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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PRTA vs. The Competition

MetricProthenaMED IndustryMedical SectorNASDAQ Exchange
Market Cap$524.58M$3.63B$7.04B$12.19B
Dividend YieldN/A2.21%2.66%6.24%
P/E Ratio-3.5521.5626.1324.17
Price / Sales54.19334.27600.51118.90
Price / CashN/A141.1447.9555.62
Price / Book1.928.3310.786.36
Net Income-$244.09M$23.91M$3.58B$337.99M
7 Day Performance12.21%3.42%2.22%0.10%
1 Month Performance0.40%0.39%-0.09%-1.28%
1 Year Performance64.80%65.22%34.39%27.68%

Prothena Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
PRTA
Prothena
2.7832 of 5 stars
$10.02
+8.1%
$23.75
+137.0%
+64.8%$524.58M$9.68MN/A130
MESO
Mesoblast
1.2647 of 5 stars
$15.37
-0.8%
N/A+20.8%$1.99B$65.38MN/A80
ADMA
ADMA Biologics
4.3901 of 5 stars
$8.58
+0.1%
$19.67
+129.3%
-51.8%$1.99B$509.86M12.61530
TSHA
Taysha Gene Therapies
3.0667 of 5 stars
$6.81
+4.2%
$11.91
+75.0%
+166.4%$1.95B$9.77MN/A180
HRMY
Harmony Biosciences
4.5056 of 5 stars
$33.61
+0.5%
$40.89
+21.7%
+10.9%$1.95B$868.45M13.55200

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This page (NASDAQ:PRTA) was last updated on 6/28/2026 by MarketBeat.com Staff.
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