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Prothena (PRTA) Competitors

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$8.63 +0.15 (+1.82%)
Closing price 03:59 PM Eastern
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$8.62 -0.01 (-0.16%)
As of 04:04 PM Eastern
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PRTA vs. ALVO, VIR, NVAX, ZBIO, and ABSI

Should you buy Prothena stock or one of its competitors? Prothena's main competitors and comparable companies include Alvotech (ALVO), Vir Biotechnology (VIR), Novavax (NVAX), Zenas BioPharma (ZBIO), and Absci (ABSI). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Prothena compare to Alvotech?

Prothena (NASDAQ:PRTA) and Alvotech (NASDAQ:ALVO) are both small-cap healthcare companies, but which is the better investment? We will contrast the two businesses based on the strength of their analyst recommendations, earnings, profitability, media sentiment, institutional ownership, dividends, valuation and risk.

Prothena currently has a consensus target price of $24.57, indicating a potential upside of 189.76%. Alvotech has a consensus target price of $8.50, indicating a potential upside of 45.30%. Given Prothena's stronger consensus rating and higher probable upside, research analysts clearly believe Prothena is more favorable than Alvotech.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Prothena
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.75
Alvotech
1 Sell rating(s)
2 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.50

Prothena has a beta of -0.29, indicating that its stock price is 129% less volatile than the broader market. Comparatively, Alvotech has a beta of 0.2, indicating that its stock price is 80% less volatile than the broader market.

97.1% of Prothena shares are owned by institutional investors. 10.4% of Prothena shares are owned by insiders. Comparatively, 0.5% of Alvotech shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company is poised for long-term growth.

Alvotech has higher revenue and earnings than Prothena. Prothena is trading at a lower price-to-earnings ratio than Alvotech, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Prothena$9.68M45.86-$244.09M-$0.84N/A
Alvotech$588.90M3.00$27.92M-$0.61N/A

Alvotech has a net margin of -36.31% compared to Prothena's net margin of -80.68%. Alvotech's return on equity of 0.00% beat Prothena's return on equity.

Company Net Margins Return on Equity Return on Assets
Prothena-80.68% -16.45% -14.51%
Alvotech -36.31%N/A -11.73%

In the previous week, Alvotech had 14 more articles in the media than Prothena. MarketBeat recorded 18 mentions for Alvotech and 4 mentions for Prothena. Prothena's average media sentiment score of 1.35 beat Alvotech's score of 0.78 indicating that Prothena is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Prothena
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Alvotech
6 Very Positive mention(s)
6 Positive mention(s)
6 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Alvotech beats Prothena on 9 of the 16 factors compared between the two stocks.

How does Prothena compare to Vir Biotechnology?

Vir Biotechnology (NASDAQ:VIR) and Prothena (NASDAQ:PRTA) are both small-cap healthcare companies, but which is the superior stock? We will compare the two businesses based on the strength of their analyst recommendations, dividends, valuation, institutional ownership, earnings, media sentiment, profitability and risk.

Vir Biotechnology has a net margin of 0.00% compared to Prothena's net margin of -80.68%. Prothena's return on equity of -16.45% beat Vir Biotechnology's return on equity.

Company Net Margins Return on Equity Return on Assets
Vir BiotechnologyN/A -29.99% -23.62%
Prothena -80.68%-16.45%-14.51%

In the previous week, Vir Biotechnology had 5 more articles in the media than Prothena. MarketBeat recorded 9 mentions for Vir Biotechnology and 4 mentions for Prothena. Prothena's average media sentiment score of 1.35 beat Vir Biotechnology's score of 0.12 indicating that Prothena is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Vir Biotechnology
0 Very Positive mention(s)
1 Positive mention(s)
7 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Prothena
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Vir Biotechnology presently has a consensus target price of $21.86, indicating a potential upside of 89.73%. Prothena has a consensus target price of $24.57, indicating a potential upside of 189.76%. Given Prothena's higher probable upside, analysts clearly believe Prothena is more favorable than Vir Biotechnology.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Vir Biotechnology
1 Sell rating(s)
0 Hold rating(s)
6 Buy rating(s)
1 Strong Buy rating(s)
2.88
Prothena
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.75

Vir Biotechnology has a beta of 1.59, indicating that its stock price is 59% more volatile than the broader market. Comparatively, Prothena has a beta of -0.29, indicating that its stock price is 129% less volatile than the broader market.

Prothena has lower revenue, but higher earnings than Vir Biotechnology. Prothena is trading at a lower price-to-earnings ratio than Vir Biotechnology, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Vir Biotechnology$68.56M28.43-$437.99M-$1.86N/A
Prothena$9.68M45.86-$244.09M-$0.84N/A

65.3% of Vir Biotechnology shares are held by institutional investors. Comparatively, 97.1% of Prothena shares are held by institutional investors. 2.9% of Vir Biotechnology shares are held by insiders. Comparatively, 10.4% of Prothena shares are held by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

Summary

Prothena beats Vir Biotechnology on 9 of the 16 factors compared between the two stocks.

How does Prothena compare to Novavax?

Novavax (NASDAQ:NVAX) and Prothena (NASDAQ:PRTA) are both small-cap healthcare companies, but which is the superior investment? We will contrast the two companies based on the strength of their analyst recommendations, media sentiment, institutional ownership, valuation, earnings, risk, profitability and dividends.

Novavax has higher revenue and earnings than Prothena. Prothena is trading at a lower price-to-earnings ratio than Novavax, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Novavax$1.12B1.65$440.30M-$1.52N/A
Prothena$9.68M45.86-$244.09M-$0.84N/A

Novavax currently has a consensus price target of $14.00, indicating a potential upside of 24.78%. Prothena has a consensus price target of $24.57, indicating a potential upside of 189.76%. Given Prothena's stronger consensus rating and higher probable upside, analysts plainly believe Prothena is more favorable than Novavax.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Novavax
2 Sell rating(s)
2 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.33
Prothena
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.75

53.0% of Novavax shares are owned by institutional investors. Comparatively, 97.1% of Prothena shares are owned by institutional investors. 1.6% of Novavax shares are owned by insiders. Comparatively, 10.4% of Prothena shares are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Novavax has a beta of 2.44, indicating that its share price is 144% more volatile than the broader market. Comparatively, Prothena has a beta of -0.29, indicating that its share price is 129% less volatile than the broader market.

In the previous week, Novavax had 22 more articles in the media than Prothena. MarketBeat recorded 26 mentions for Novavax and 4 mentions for Prothena. Prothena's average media sentiment score of 1.35 beat Novavax's score of 0.00 indicating that Prothena is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Novavax
7 Very Positive mention(s)
5 Positive mention(s)
4 Neutral mention(s)
5 Negative mention(s)
4 Very Negative mention(s)
Neutral
Prothena
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Novavax has a net margin of -59.87% compared to Prothena's net margin of -80.68%. Novavax's return on equity of -14.82% beat Prothena's return on equity.

Company Net Margins Return on Equity Return on Assets
Novavax-59.87% -14.82% -13.35%
Prothena -80.68%-16.45%-14.51%

Summary

Novavax and Prothena tied by winning 8 of the 16 factors compared between the two stocks.

How does Prothena compare to Zenas BioPharma?

Zenas BioPharma (NASDAQ:ZBIO) and Prothena (NASDAQ:PRTA) are both small-cap healthcare companies, but which is the better stock? We will compare the two businesses based on the strength of their risk, valuation, earnings, profitability, dividends, analyst recommendations, institutional ownership and media sentiment.

Zenas BioPharma has a beta of -0.9, suggesting that its share price is 190% less volatile than the broader market. Comparatively, Prothena has a beta of -0.29, suggesting that its share price is 129% less volatile than the broader market.

Zenas BioPharma has a net margin of 0.00% compared to Prothena's net margin of -80.68%. Prothena's return on equity of -16.45% beat Zenas BioPharma's return on equity.

Company Net Margins Return on Equity Return on Assets
Zenas BioPharmaN/A -122.45% -58.04%
Prothena -80.68%-16.45%-14.51%

Zenas BioPharma currently has a consensus price target of $46.71, indicating a potential upside of 65.77%. Prothena has a consensus price target of $24.57, indicating a potential upside of 189.76%. Given Prothena's stronger consensus rating and higher probable upside, analysts clearly believe Prothena is more favorable than Zenas BioPharma.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Zenas BioPharma
1 Sell rating(s)
2 Hold rating(s)
6 Buy rating(s)
0 Strong Buy rating(s)
2.56
Prothena
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.75

Prothena has lower revenue, but higher earnings than Zenas BioPharma. Prothena is trading at a lower price-to-earnings ratio than Zenas BioPharma, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Zenas BioPharma$10M183.68-$377.74M-$8.99N/A
Prothena$9.68M45.86-$244.09M-$0.84N/A

97.1% of Prothena shares are owned by institutional investors. 22.0% of Zenas BioPharma shares are owned by insiders. Comparatively, 10.4% of Prothena shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

In the previous week, Zenas BioPharma had 6 more articles in the media than Prothena. MarketBeat recorded 10 mentions for Zenas BioPharma and 4 mentions for Prothena. Prothena's average media sentiment score of 1.35 beat Zenas BioPharma's score of 0.32 indicating that Prothena is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Zenas BioPharma
0 Very Positive mention(s)
3 Positive mention(s)
7 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Prothena
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Summary

Prothena beats Zenas BioPharma on 10 of the 17 factors compared between the two stocks.

How does Prothena compare to Absci?

Prothena (NASDAQ:PRTA) and Absci (NASDAQ:ABSI) are both small-cap healthcare companies, but which is the superior business? We will compare the two businesses based on the strength of their dividends, media sentiment, analyst recommendations, earnings, risk, valuation, profitability and institutional ownership.

In the previous week, Absci had 1 more articles in the media than Prothena. MarketBeat recorded 5 mentions for Absci and 4 mentions for Prothena. Prothena's average media sentiment score of 1.35 beat Absci's score of 0.40 indicating that Prothena is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Prothena
2 Very Positive mention(s)
0 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Absci
1 Very Positive mention(s)
1 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Absci has lower revenue, but higher earnings than Prothena. Absci is trading at a lower price-to-earnings ratio than Prothena, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Prothena$9.68M45.86-$244.09M-$0.84N/A
Absci$2.80M565.09-$115.18M-$0.80N/A

Prothena currently has a consensus target price of $24.57, indicating a potential upside of 189.76%. Absci has a consensus target price of $13.71, indicating a potential upside of 48.74%. Given Prothena's higher possible upside, research analysts plainly believe Prothena is more favorable than Absci.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Prothena
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.75
Absci
1 Sell rating(s)
0 Hold rating(s)
8 Buy rating(s)
0 Strong Buy rating(s)
2.78

Prothena has a beta of -0.29, indicating that its share price is 129% less volatile than the broader market. Comparatively, Absci has a beta of 2.27, indicating that its share price is 127% more volatile than the broader market.

Prothena has a net margin of -80.68% compared to Absci's net margin of -7,756.38%. Prothena's return on equity of -16.45% beat Absci's return on equity.

Company Net Margins Return on Equity Return on Assets
Prothena-80.68% -16.45% -14.51%
Absci -7,756.38%-61.71%-54.52%

97.1% of Prothena shares are owned by institutional investors. Comparatively, 52.1% of Absci shares are owned by institutional investors. 10.4% of Prothena shares are owned by insiders. Comparatively, 10.5% of Absci shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

Summary

Prothena beats Absci on 9 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding PRTA and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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PRTA vs. The Competition

MetricProthenaBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$451.99M$3.82B$7.13B$13.20B
Dividend YieldN/A3.66%2.53%16.47%
P/E Ratio-10.2814.02275.1725.93
Price / Sales46.691,174.57566.3383.66
Price / CashN/A118.3777.4152.81
Price / Book1.6616.1010.806.27
Net Income-$244.09M-$22.69M$3.50B$382.13M
7 Day Performance1.10%-3.42%-1.96%-1.34%
1 Month Performance-9.50%-12.63%-7.50%-5.58%
1 Year Performance-16.58%9.66%3.41%-1.52%

Prothena Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
PRTA
Prothena
3.276 of 5 stars
$8.63
+1.8%
$24.57
+184.6%
-16.6%$451.99M$9.68MN/A67
ALVO
Alvotech
3.4187 of 5 stars
$5.95
-3.3%
$8.50
+43.0%
-32.3%$1.80B$588.90MN/A1,460
VIR
Vir Biotechnology
2.5976 of 5 stars
$10.41
-1.0%
$21.57
+107.3%
+103.5%$1.76B$68.56MN/A367
NVAX
Novavax
2.0406 of 5 stars
$10.59
-1.9%
$14.00
+32.2%
+21.7%$1.75B$1.12BN/A749
ZBIO
Zenas BioPharma
2.3669 of 5 stars
$26.27
-4.6%
$45.71
+74.0%
+35.2%$1.72B$10MN/A167

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This page (NASDAQ:PRTA) was last updated on 10/8/2026 by MarketBeat.com Staff.
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