Go Pro

Prothena (PRTA) Competitors

Prothena logo
$8.76 +0.18 (+2.10%)
Closing price 08/7/2026 04:00 PM Eastern
Extended Trading
$9.13 +0.37 (+4.27%)
As of 08/7/2026 07:42 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

PRTA vs. LKFT, RXRX, BCAX, SNDX, and TSHA

Should you buy Prothena stock or one of its competitors? MarketBeat compares Prothena with other companies and stocks that may be similar based on industry, sector, market capitalization, business model, investor interest, or shared news coverage. Companies and stocks commonly compared with Prothena include Lakefront Biotherapeutics American Depositary Shares (LKFT), Recursion Pharmaceuticals (RXRX), Bicara Therapeutics (BCAX), Syndax Pharmaceuticals (SNDX), and Taysha Gene Therapies (TSHA). These companies are all part of the "biotechnology" industry.

How does Prothena compare to Lakefront Biotherapeutics American Depositary Shares?

Lakefront Biotherapeutics American Depositary Shares (NASDAQ:LKFT) and Prothena (NASDAQ:PRTA) are both small-cap healthcare companies, but which is the superior business? We will compare the two companies based on the strength of their profitability, valuation, risk, dividends, earnings, analyst recommendations, institutional ownership and media sentiment.

Lakefront Biotherapeutics American Depositary Shares has a beta of 0.27, meaning that its stock price is 73% less volatile than the broader market. Comparatively, Prothena has a beta of -0.3, meaning that its stock price is 130% less volatile than the broader market.

Lakefront Biotherapeutics American Depositary Shares has higher revenue and earnings than Prothena. Lakefront Biotherapeutics American Depositary Shares is trading at a lower price-to-earnings ratio than Prothena, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Lakefront Biotherapeutics American Depositary Shares$1.04B1.70$363.05M-$1.41N/A
Prothena$9.68M47.37-$244.09M-$2.82N/A

Lakefront Biotherapeutics American Depositary Shares has a net margin of 0.00% compared to Prothena's net margin of -80.68%. Lakefront Biotherapeutics American Depositary Shares' return on equity of 0.00% beat Prothena's return on equity.

Company Net Margins Return on Equity Return on Assets
Lakefront Biotherapeutics American Depositary SharesN/A N/A N/A
Prothena -80.68%-16.33%-14.09%

32.5% of Lakefront Biotherapeutics American Depositary Shares shares are held by institutional investors. Comparatively, 97.1% of Prothena shares are held by institutional investors. 2.9% of Lakefront Biotherapeutics American Depositary Shares shares are held by company insiders. Comparatively, 10.4% of Prothena shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Lakefront Biotherapeutics American Depositary Shares presently has a consensus price target of $34.33, indicating a potential upside of 27.16%. Prothena has a consensus price target of $23.75, indicating a potential upside of 171.12%. Given Prothena's stronger consensus rating and higher possible upside, analysts clearly believe Prothena is more favorable than Lakefront Biotherapeutics American Depositary Shares.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Lakefront Biotherapeutics American Depositary Shares
0 Sell rating(s)
7 Hold rating(s)
0 Buy rating(s)
1 Strong Buy rating(s)
2.25
Prothena
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.75

In the previous week, Prothena had 6 more articles in the media than Lakefront Biotherapeutics American Depositary Shares. MarketBeat recorded 8 mentions for Prothena and 2 mentions for Lakefront Biotherapeutics American Depositary Shares. Lakefront Biotherapeutics American Depositary Shares' average media sentiment score of 0.62 beat Prothena's score of 0.35 indicating that Lakefront Biotherapeutics American Depositary Shares is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Lakefront Biotherapeutics American Depositary Shares
1 Very Positive mention(s)
1 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive
Prothena
1 Very Positive mention(s)
0 Positive mention(s)
5 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral

Summary

Lakefront Biotherapeutics American Depositary Shares and Prothena tied by winning 8 of the 16 factors compared between the two stocks.

How does Prothena compare to Recursion Pharmaceuticals?

Recursion Pharmaceuticals (NASDAQ:RXRX) and Prothena (NASDAQ:PRTA) are both small-cap healthcare companies, but which is the superior investment? We will contrast the two businesses based on the strength of their profitability, media sentiment, risk, institutional ownership, valuation, dividends, earnings and analyst recommendations.

Prothena has a net margin of -80.68% compared to Recursion Pharmaceuticals' net margin of -945.94%. Prothena's return on equity of -16.33% beat Recursion Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Recursion Pharmaceuticals-945.94% -50.41% -38.25%
Prothena -80.68%-16.33%-14.09%

89.1% of Recursion Pharmaceuticals shares are held by institutional investors. Comparatively, 97.1% of Prothena shares are held by institutional investors. 6.7% of Recursion Pharmaceuticals shares are held by insiders. Comparatively, 10.4% of Prothena shares are held by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock will outperform the market over the long term.

Recursion Pharmaceuticals has a beta of 1.03, suggesting that its stock price is 3% more volatile than the broader market. Comparatively, Prothena has a beta of -0.3, suggesting that its stock price is 130% less volatile than the broader market.

Recursion Pharmaceuticals currently has a consensus price target of $8.10, suggesting a potential upside of 151.55%. Prothena has a consensus price target of $23.75, suggesting a potential upside of 171.12%. Given Prothena's stronger consensus rating and higher probable upside, analysts plainly believe Prothena is more favorable than Recursion Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Recursion Pharmaceuticals
1 Sell rating(s)
2 Hold rating(s)
2 Buy rating(s)
0 Strong Buy rating(s)
2.20
Prothena
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.75

Prothena has lower revenue, but higher earnings than Recursion Pharmaceuticals. Prothena is trading at a lower price-to-earnings ratio than Recursion Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Recursion Pharmaceuticals$74.68M22.85-$644.76M-$1.20N/A
Prothena$9.68M47.37-$244.09M-$2.82N/A

In the previous week, Recursion Pharmaceuticals had 16 more articles in the media than Prothena. MarketBeat recorded 24 mentions for Recursion Pharmaceuticals and 8 mentions for Prothena. Prothena's average media sentiment score of 0.35 beat Recursion Pharmaceuticals' score of 0.28 indicating that Prothena is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Recursion Pharmaceuticals
8 Very Positive mention(s)
4 Positive mention(s)
8 Neutral mention(s)
1 Negative mention(s)
1 Very Negative mention(s)
Neutral
Prothena
1 Very Positive mention(s)
0 Positive mention(s)
5 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral

Summary

Prothena beats Recursion Pharmaceuticals on 12 of the 17 factors compared between the two stocks.

How does Prothena compare to Bicara Therapeutics?

Prothena (NASDAQ:PRTA) and Bicara Therapeutics (NASDAQ:BCAX) are both small-cap healthcare companies, but which is the better investment? We will compare the two businesses based on the strength of their dividends, media sentiment, risk, analyst recommendations, institutional ownership, profitability, valuation and earnings.

Prothena has a beta of -0.3, indicating that its share price is 130% less volatile than the broader market. Comparatively, Bicara Therapeutics has a beta of -0.75, indicating that its share price is 175% less volatile than the broader market.

Bicara Therapeutics has a net margin of 0.00% compared to Prothena's net margin of -80.68%. Prothena's return on equity of -16.33% beat Bicara Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Prothena-80.68% -16.33% -14.09%
Bicara Therapeutics N/A -35.89%-33.78%

Bicara Therapeutics has lower revenue, but higher earnings than Prothena. Bicara Therapeutics is trading at a lower price-to-earnings ratio than Prothena, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Prothena$9.68M47.37-$244.09M-$2.82N/A
Bicara TherapeuticsN/AN/A-$137.95M-$2.78N/A

Prothena presently has a consensus price target of $23.75, indicating a potential upside of 171.12%. Bicara Therapeutics has a consensus price target of $30.27, indicating a potential upside of 7.89%. Given Prothena's stronger consensus rating and higher probable upside, research analysts plainly believe Prothena is more favorable than Bicara Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Prothena
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.75
Bicara Therapeutics
1 Sell rating(s)
3 Hold rating(s)
10 Buy rating(s)
1 Strong Buy rating(s)
2.73

In the previous week, Prothena had 4 more articles in the media than Bicara Therapeutics. MarketBeat recorded 8 mentions for Prothena and 4 mentions for Bicara Therapeutics. Bicara Therapeutics' average media sentiment score of 0.61 beat Prothena's score of 0.35 indicating that Bicara Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Prothena
1 Very Positive mention(s)
0 Positive mention(s)
5 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral
Bicara Therapeutics
1 Very Positive mention(s)
1 Positive mention(s)
2 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

97.1% of Prothena shares are held by institutional investors. 10.4% of Prothena shares are held by insiders. Comparatively, 13.8% of Bicara Therapeutics shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Summary

Prothena beats Bicara Therapeutics on 8 of the 15 factors compared between the two stocks.

How does Prothena compare to Syndax Pharmaceuticals?

Syndax Pharmaceuticals (NASDAQ:SNDX) and Prothena (NASDAQ:PRTA) are both small-cap healthcare companies, but which is the better business? We will compare the two businesses based on the strength of their profitability, earnings, risk, valuation, institutional ownership, media sentiment, dividends and analyst recommendations.

97.1% of Prothena shares are owned by institutional investors. 4.8% of Syndax Pharmaceuticals shares are owned by company insiders. Comparatively, 10.4% of Prothena shares are owned by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company will outperform the market over the long term.

Prothena has a net margin of -80.68% compared to Syndax Pharmaceuticals' net margin of -87.52%. Prothena's return on equity of -16.33% beat Syndax Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Syndax Pharmaceuticals-87.52% -372.94% -39.11%
Prothena -80.68%-16.33%-14.09%

Prothena has lower revenue, but higher earnings than Syndax Pharmaceuticals. Syndax Pharmaceuticals is trading at a lower price-to-earnings ratio than Prothena, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Syndax Pharmaceuticals$172.35M10.49-$285.42M-$2.51N/A
Prothena$9.68M47.37-$244.09M-$2.82N/A

Syndax Pharmaceuticals has a beta of 0.4, indicating that its stock price is 60% less volatile than the broader market. Comparatively, Prothena has a beta of -0.3, indicating that its stock price is 130% less volatile than the broader market.

In the previous week, Syndax Pharmaceuticals had 18 more articles in the media than Prothena. MarketBeat recorded 26 mentions for Syndax Pharmaceuticals and 8 mentions for Prothena. Prothena's average media sentiment score of 0.35 beat Syndax Pharmaceuticals' score of -0.45 indicating that Prothena is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Syndax Pharmaceuticals
3 Very Positive mention(s)
1 Positive mention(s)
7 Neutral mention(s)
5 Negative mention(s)
1 Very Negative mention(s)
Neutral
Prothena
1 Very Positive mention(s)
0 Positive mention(s)
5 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral

Syndax Pharmaceuticals presently has a consensus price target of $42.36, indicating a potential upside of 107.66%. Prothena has a consensus price target of $23.75, indicating a potential upside of 171.12%. Given Prothena's higher probable upside, analysts plainly believe Prothena is more favorable than Syndax Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Syndax Pharmaceuticals
1 Sell rating(s)
0 Hold rating(s)
12 Buy rating(s)
0 Strong Buy rating(s)
2.85
Prothena
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.75

Summary

Prothena beats Syndax Pharmaceuticals on 10 of the 17 factors compared between the two stocks.

How does Prothena compare to Taysha Gene Therapies?

Prothena (NASDAQ:PRTA) and Taysha Gene Therapies (NASDAQ:TSHA) are both small-cap healthcare companies, but which is the superior investment? We will compare the two companies based on the strength of their earnings, media sentiment, valuation, dividends, risk, institutional ownership, analyst recommendations and profitability.

Prothena has a beta of -0.3, meaning that its stock price is 130% less volatile than the broader market. Comparatively, Taysha Gene Therapies has a beta of 1.22, meaning that its stock price is 22% more volatile than the broader market.

Taysha Gene Therapies has a net margin of 0.00% compared to Prothena's net margin of -80.68%. Prothena's return on equity of -16.33% beat Taysha Gene Therapies' return on equity.

Company Net Margins Return on Equity Return on Assets
Prothena-80.68% -16.33% -14.09%
Taysha Gene Therapies N/A -56.07%-40.16%

Taysha Gene Therapies has higher revenue and earnings than Prothena. Taysha Gene Therapies is trading at a lower price-to-earnings ratio than Prothena, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Prothena$9.68M47.37-$244.09M-$2.82N/A
Taysha Gene Therapies$9.77M192.95-$109M-$0.38N/A

In the previous week, Prothena had 3 more articles in the media than Taysha Gene Therapies. MarketBeat recorded 8 mentions for Prothena and 5 mentions for Taysha Gene Therapies. Prothena's average media sentiment score of 0.35 beat Taysha Gene Therapies' score of 0.33 indicating that Prothena is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Prothena
1 Very Positive mention(s)
0 Positive mention(s)
5 Neutral mention(s)
0 Negative mention(s)
1 Very Negative mention(s)
Neutral
Taysha Gene Therapies
1 Very Positive mention(s)
0 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Prothena currently has a consensus price target of $23.75, suggesting a potential upside of 171.12%. Taysha Gene Therapies has a consensus price target of $12.77, suggesting a potential upside of 94.65%. Given Prothena's higher possible upside, analysts plainly believe Prothena is more favorable than Taysha Gene Therapies.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Prothena
1 Sell rating(s)
1 Hold rating(s)
5 Buy rating(s)
1 Strong Buy rating(s)
2.75
Taysha Gene Therapies
1 Sell rating(s)
0 Hold rating(s)
11 Buy rating(s)
2 Strong Buy rating(s)
3.00

97.1% of Prothena shares are held by institutional investors. Comparatively, 77.7% of Taysha Gene Therapies shares are held by institutional investors. 10.4% of Prothena shares are held by insiders. Comparatively, 3.5% of Taysha Gene Therapies shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Summary

Taysha Gene Therapies beats Prothena on 9 of the 17 factors compared between the two stocks.

Get Prothena News Delivered to You Automatically

Sign up to receive the latest news and ratings for PRTA and its competitors with MarketBeat's FREE daily newsletter.

Subscribe Now
SMS is currently available in Australia, Belgium, Canada, France, Germany, Ireland, Italy, New Zealand, the Netherlands, Singapore, South Africa, Spain, Switzerland, the United Kingdom, and the United States. By entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy.

New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding PRTA and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
Skip Chart

Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
Skip Chart

PRTA vs. The Competition

MetricProthenaBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$458.61M$3.69B$7.03B$13.02B
Dividend YieldN/A3.76%2.58%10.20%
P/E Ratio-10.439.02271.3625.17
Price / Sales47.371,304.20603.5989.49
Price / CashN/A102.3571.8150.72
Price / Book1.6818.1013.256.22
Net Income-$244.09M-$13.25M$3.45B$342.66M
7 Day Performance7.88%6.24%4.67%4.41%
1 Month Performance-9.13%-3.50%-1.28%-1.10%
1 Year Performance13.91%61.28%77.33%23.99%

Prothena Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
PRTA
Prothena
2.8664 of 5 stars
$8.76
+2.1%
$23.75
+171.1%
+13.9%$458.61M$9.68MN/A130
LKFT
Lakefront Biotherapeutics American Depositary Shares
2.1936 of 5 stars
$26.67
-0.3%
$34.33
+28.7%
-17.1%$1.76B$1.26BN/A1,310
RXRX
Recursion Pharmaceuticals
1.9571 of 5 stars
$3.28
+3.0%
$8.10
+147.3%
-39.9%$1.74B$74.68MN/A400
BCAX
Bicara Therapeutics
1.5167 of 5 stars
$26.27
+2.1%
$30.27
+15.2%
+175.1%$1.73BN/AN/A32
SNDX
Syndax Pharmaceuticals
2.4976 of 5 stars
$19.12
-0.6%
$42.55
+122.5%
+63.5%$1.69B$172.35MN/A110

Related Companies and Tools


This page (NASDAQ:PRTA) was last updated on 8/9/2026 by MarketBeat.com Staff.
From Our Partners