Zymeworks (ZYME) Competitors $15.05 +0.97 (+6.89%) As of 09/5/2025 04:00 PM Eastern Add Compare Share Share Competitors Stock AnalysisChartCompetitorsEarningsFinancialsHeadlinesSEC FilingsShort InterestTrendsBuy This Stock ZYME vs. KRYS, PCVX, ACAD, ACLX, ADMA, ARWR, MENS, MIRM, MLTX, and MTSRShould you be buying Zymeworks stock or one of its competitors? The main competitors of Zymeworks include Krystal Biotech (KRYS), Vaxcyte (PCVX), ACADIA Pharmaceuticals (ACAD), Arcellx (ACLX), ADMA Biologics (ADMA), Arrowhead Pharmaceuticals (ARWR), Jyong Biotech (MENS), Mirum Pharmaceuticals (MIRM), MoonLake Immunotherapeutics (MLTX), and Metsera (MTSR). These companies are all part of the "pharmaceutical products" industry. Zymeworks vs. Its Competitors Krystal Biotech Vaxcyte ACADIA Pharmaceuticals Arcellx ADMA Biologics Arrowhead Pharmaceuticals Jyong Biotech Mirum Pharmaceuticals MoonLake Immunotherapeutics Metsera Krystal Biotech (NASDAQ:KRYS) and Zymeworks (NASDAQ:ZYME) are both pharmaceutical products companies, but which is the better stock? We will contrast the two businesses based on the strength of their risk, valuation, media sentiment, analyst recommendations, profitability, earnings, dividends and institutional ownership. Which has more volatility and risk, KRYS or ZYME? Krystal Biotech has a beta of 0.66, suggesting that its stock price is 34% less volatile than the S&P 500. Comparatively, Zymeworks has a beta of 1.27, suggesting that its stock price is 27% more volatile than the S&P 500. Do analysts rate KRYS or ZYME? Krystal Biotech currently has a consensus target price of $210.38, indicating a potential upside of 40.00%. Given Krystal Biotech's stronger consensus rating and higher probable upside, analysts clearly believe Krystal Biotech is more favorable than Zymeworks.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Krystal Biotech 0 Sell rating(s) 1 Hold rating(s) 7 Buy rating(s) 0 Strong Buy rating(s) 2.88Zymeworks 0 Sell rating(s) 0 Hold rating(s) 0 Buy rating(s) 0 Strong Buy rating(s) 0.00 Do insiders and institutionals believe in KRYS or ZYME? 86.3% of Krystal Biotech shares are owned by institutional investors. Comparatively, 92.9% of Zymeworks shares are owned by institutional investors. 13.7% of Krystal Biotech shares are owned by insiders. Comparatively, 1.9% of Zymeworks shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term. Is KRYS or ZYME more profitable? Krystal Biotech has a net margin of 40.85% compared to Zymeworks' net margin of -59.96%. Krystal Biotech's return on equity of 15.21% beat Zymeworks' return on equity.Company Net Margins Return on Equity Return on Assets Krystal Biotech40.85% 15.21% 13.81% Zymeworks -59.96%-21.59%-16.52% Does the media refer more to KRYS or ZYME? In the previous week, Krystal Biotech had 4 more articles in the media than Zymeworks. MarketBeat recorded 8 mentions for Krystal Biotech and 4 mentions for Zymeworks. Krystal Biotech's average media sentiment score of 1.22 beat Zymeworks' score of -0.07 indicating that Krystal Biotech is being referred to more favorably in the media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Krystal Biotech 7 Very Positive mention(s) 0 Positive mention(s) 1 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Positive Zymeworks 1 Very Positive mention(s) 0 Positive mention(s) 2 Neutral mention(s) 0 Negative mention(s) 1 Very Negative mention(s) Neutral Which has higher valuation & earnings, KRYS or ZYME? Krystal Biotech has higher revenue and earnings than Zymeworks. Zymeworks is trading at a lower price-to-earnings ratio than Krystal Biotech, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioKrystal Biotech$290.52M14.97$89.16M$4.9230.54Zymeworks$76.30M14.83-$122.69M-$0.97-15.52 SummaryKrystal Biotech beats Zymeworks on 14 of the 16 factors compared between the two stocks. Get Zymeworks News Delivered to You Automatically Sign up to receive the latest news and ratings for ZYME and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding ZYME and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart ZYME vs. The Competition Export to ExcelMetricZymeworks IndustryManufacturing SectorNASDAQ ExchangeMarket Cap$1.13B$2.37B$2.52B$9.94BDividend YieldN/A13.82%2.53%4.53%P/E Ratio-15.5225.1626.3226.13Price / Sales14.8316,002.65118.21121.74Price / CashN/A19.9723.1829.11Price / Book3.063.4231.486.09Net Income-$122.69M-$402.94M$16.40M$266.19M7 Day Performance1.62%0.50%0.45%0.44%1 Month Performance25.21%1.82%2.59%4.88%1 Year PerformanceN/A12.76%31.91%26.03% Zymeworks Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)ZYMEZymeworks0.1069 of 5 stars$15.05+6.9%N/AN/A$1.13B$76.30M-15.52460KRYSKrystal Biotech4.8917 of 5 stars$150.27+0.3%$210.38+40.0%-18.4%$4.35B$290.52M30.54210Positive NewsPCVXVaxcyte2.7082 of 5 stars$33.02+2.7%$130.00+293.7%-70.4%$4.29BN/A-8.03160Positive NewsACADACADIA Pharmaceuticals4.2183 of 5 stars$25.26-0.9%$28.88+14.3%+57.2%$4.26B$957.80M18.99510Positive NewsAnalyst DowngradeACLXArcellx2.6226 of 5 stars$72.62+0.6%$114.31+57.4%+1.9%$4.03B$56.98M-21.2380Positive NewsADMAADMA Biologics3.636 of 5 stars$16.87-0.2%$27.67+64.0%+3.8%$4.03B$426.45M19.62530Positive NewsARWRArrowhead Pharmaceuticals3.9411 of 5 stars$29.08+3.9%$43.14+48.4%+30.9%$4.02B$3.55M-22.72400Trending NewsAnalyst ForecastInsider TradeAnalyst RevisionMENSJyong BiotechN/A$52.31-5.1%N/AN/A$3.98BN/A0.0031News CoverageGap DownMIRMMirum Pharmaceuticals3.2401 of 5 stars$76.06+2.5%$74.13-2.5%+85.0%$3.82B$336.89M-62.86140Positive NewsMLTXMoonLake Immunotherapeutics2.7467 of 5 stars$59.44-0.5%$74.43+25.2%+29.2%$3.82BN/A-21.382High Trading VolumeMTSRMetseraN/A$35.87-1.2%$59.00+64.5%N/A$3.77BN/A0.0081News CoveragePositive NewsAnalyst Forecast Related Companies and Tools Related Companies Krystal Biotech Alternatives Vaxcyte Alternatives ACADIA Pharmaceuticals Alternatives Arcellx Alternatives ADMA Biologics Alternatives Arrowhead Pharmaceuticals Alternatives Jyong Biotech Alternatives Mirum Pharmaceuticals Alternatives MoonLake Immunotherapeutics Alternatives Metsera Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:ZYME) was last updated on 9/8/2025 by MarketBeat.com Staff From Our PartnersThis is my Christian duty“This land I will give to you…” — a 4,000-year-old line from Genesis may hold the key to unlocking a $150 tril...Paradigm Press | SponsoredWhat Steve Bannon revealed about Trump’s gold playA Trump advisor just said 3 words that could reset the dollar. 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