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Stocks to Compare Sections All Sections Selected Performance Chart Price & Volume MarketRank Analyst Ratings Sales & Book Value Profitability & Earnings Dividends Debt Ownership Miscellaneous Headlines About Compare NASDAQ:AXSM NASDAQ:CRSP NASDAQ:EWTX NASDAQ:RYTM On This Page Performance ChartPrice & VolumeMarketRank™Analyst RatingsSales & Book ValueProfitability & EarningsDividendsDebtOwnershipMiscellaneousHeadlinesAbout Comparison Ideas Stock Ideas Comparative Price Performance Over Time1 day7 days30 days90 days365 daysCompare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeAXSMAxsome Therapeutics$103.02+1.6%$105.84$72.21▼$139.13$4.99B0.51635,684 shs838,764 shsCRSPCRISPR Therapeutics$56.09-0.3%$49.63$30.04▼$71.13$4.86B1.83.67 million shs2.99 million shsEWTXEdgewise Therapeutics$14.31+0.4%$14.12$10.60▼$38.12$1.50B0.26567,776 shs647,574 shsRYTMRhythm Pharmaceuticals$88.30+3.6%$72.39$40.61▼$94.80$5.42B2.38901,449 shs666,964 shs The Best Nuclear Energy Stocks to BuyNuclear energy stocks are roaring. It's the hottest energy sector of the year. Cameco Corp, Paladin Energy, and BWX Technologies were all up more than 40% in 2024. The biggest market moves could still be ahead of us, and there are seven nuclear energy stocks that could rise much higher in the next several months. To unlock these tickers, enter your email address below.Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceAXSMAxsome Therapeutics+1.62%+2.17%-0.86%-8.19%+17.99%CRSPCRISPR Therapeutics-0.30%-13.39%+8.55%+46.64%-2.09%EWTXEdgewise Therapeutics+0.35%+1.35%+9.99%-15.38%-15.97%RYTMRhythm Pharmaceuticals+3.60%+2.14%+31.95%+37.95%+83.16%Compare MarketRank™CompanyOverall ScoreAnalyst's OpinionShort Interest ScoreDividend StrengthESG ScoreNews and Social Media SentimentCompany OwnershipEarnings & ValuationAXSMAxsome Therapeutics4.8236 of 5 stars4.53.00.04.52.94.20.6CRSPCRISPR Therapeutics2.7909 of 5 stars3.32.00.00.03.03.30.6EWTXEdgewise Therapeutics2.2917 of 5 stars3.52.00.00.02.62.50.0RYTMRhythm Pharmaceuticals3.4446 of 5 stars2.52.00.04.33.20.80.6Compare Analyst ForecastsCompanyConsensus Rating ScoreConsensus RatingConsensus Price Target% Upside from Current PriceAXSMAxsome Therapeutics 3.06Buy$172.3367.28% UpsideCRSPCRISPR Therapeutics 2.50Moderate Buy$70.0724.92% UpsideEWTXEdgewise Therapeutics 2.91Moderate Buy$40.55183.34% UpsideRYTMRhythm Pharmaceuticals 3.07Buy$91.934.11% UpsideCurrent Analyst Ratings BreakdownLatest EWTX, RYTM, CRSP, and AXSM Analyst RatingsDateCompanyBrokerageActionRatingPrice TargetDetails7/30/2025EWTXEdgewise TherapeuticsRaymond James FinancialSubscribe to MarketBeat All Access for the recommendation accuracy ratingInitiated CoverageStrong-Buy$46.007/22/2025CRSPCRISPR TherapeuticsBank of AmericaSubscribe to MarketBeat All Access for the recommendation accuracy ratingLower Price TargetBuy ➝ Buy$79.00 ➝ $78.007/18/2025RYTMRhythm PharmaceuticalsCanaccord Genuity GroupSubscribe to MarketBeat All Access for the recommendation accuracy ratingBoost Price TargetBuy ➝ Buy$92.00 ➝ $105.007/10/2025RYTMRhythm PharmaceuticalsGuggenheimSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingBuy ➝ Buy7/10/2025RYTMRhythm PharmaceuticalsOppenheimerSubscribe to MarketBeat All Access for the recommendation accuracy ratingBoost Price TargetOutperform ➝ Outperform$76.00 ➝ $110.007/10/2025RYTMRhythm PharmaceuticalsBank of AmericaSubscribe to MarketBeat All Access for the recommendation accuracy ratingBoost Price TargetBuy ➝ Buy$73.00 ➝ $95.007/10/2025RYTMRhythm PharmaceuticalsWells Fargo & CompanySubscribe to MarketBeat All Access for the recommendation accuracy ratingBoost Price TargetOverweight ➝ Overweight$91.00 ➝ $129.007/10/2025RYTMRhythm PharmaceuticalsThe Goldman Sachs GroupSubscribe to MarketBeat All Access for the recommendation accuracy ratingInitiated CoverageBuy$97.007/9/2025RYTMRhythm PharmaceuticalsMorgan StanleySubscribe to MarketBeat All Access for the recommendation accuracy ratingSet Price TargetOverweight ➝ Overweight$95.007/9/2025RYTMRhythm PharmaceuticalsNeedham & Company LLCSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingBuy ➝ Buy$72.00 ➝ $95.007/8/2025CRSPCRISPR TherapeuticsNeedham & Company LLCSubscribe to MarketBeat All Access for the recommendation accuracy ratingReiterated RatingBuy ➝ Buy$81.00(Data available from 8/2/2022 forward. View 10+ years of historical ratings with our analyst ratings screener.)Compare Sales & Book ValueCompanyAnnual RevenuePrice/SalesCashflowPrice/CashBook ValuePrice/BookAXSMAxsome Therapeutics$385.69M13.15N/AN/A$1.18 per share87.31CRSPCRISPR Therapeutics$37.31M129.83N/AN/A$22.64 per share2.48EWTXEdgewise TherapeuticsN/AN/AN/AN/A$4.84 per shareN/ARYTMRhythm Pharmaceuticals$130.13M43.17N/AN/A$0.35 per share252.29Compare Profitability & EarningsCompanyNet IncomeEPSTrailing P/E RatioForward P/E RatioP/E GrowthNet MarginsReturn on Equity (ROE)Return on Assets (ROA)Next Earnings DateAXSMAxsome Therapeutics-$287.22M-$5.77N/A36.53N/A-64.39%-272.80%-36.69%8/4/2025 (Estimated)CRSPCRISPR Therapeutics-$366.25M-$4.52N/AN/AN/A-1,023.64%-20.08%-17.13%8/4/2025 (Estimated)EWTXEdgewise Therapeutics-$133.81M-$1.55N/AN/AN/AN/A-30.95%-29.45%8/6/2025 (Estimated)RYTMRhythm Pharmaceuticals-$260.60M-$2.81N/AN/AN/A-123.26%-739.62%-44.27%8/5/2025 (Estimated)Latest EWTX, RYTM, CRSP, and AXSM EarningsDateQuarterCompanyConsensus EstimateReported EPSBeat/MissGap EPSRevenue EstimateActual RevenueDetails8/14/2025Q2 2025EWTXEdgewise Therapeutics-$0.42N/AN/AN/AN/AN/A8/5/2025Q2 2025RYTMRhythm Pharmaceuticals-$0.64N/AN/AN/A$43.72 millionN/A8/4/2025Q2 2025AXSMAxsome Therapeutics-$1.04N/AN/AN/A$140.02 millionN/A8/4/2025Q2 2025CRSPCRISPR Therapeutics-$1.54N/AN/AN/A$6.44 millionN/A5/8/2025Q1 2025EWTXEdgewise Therapeutics-$0.45-$0.43+$0.02-$0.43N/AN/A5/7/2025Q1 2025RYTMRhythm Pharmaceuticals-$0.69-$0.81-$0.12-$0.81$40.43 million$37.72 million5/6/2025Q1 2025CRSPCRISPR Therapeutics-$1.27-$1.58-$0.31-$1.58N/AN/ACompare DividendsCompanyAnnual PayoutDividend Yield3-Year Dividend GrowthPayout RatioYears of Consecutive GrowthAXSMAxsome TherapeuticsN/AN/AN/AN/AN/ACRSPCRISPR TherapeuticsN/AN/AN/AN/AN/AEWTXEdgewise TherapeuticsN/AN/AN/AN/AN/ARYTMRhythm PharmaceuticalsN/AN/AN/AN/AN/ACompare DebtCompanyDebt-to-Equity RatioCurrent RatioQuick RatioAXSMAxsome Therapeutics3.482.031.96CRSPCRISPR TherapeuticsN/A15.6415.64EWTXEdgewise TherapeuticsN/A20.9920.99RYTMRhythm PharmaceuticalsN/A3.303.13Compare OwnershipInstitutional OwnershipCompanyInstitutional OwnershipAXSMAxsome Therapeutics81.49%CRSPCRISPR Therapeutics69.20%EWTXEdgewise TherapeuticsN/ARYTMRhythm PharmaceuticalsN/AInsider OwnershipCompanyInsider OwnershipAXSMAxsome Therapeutics22.30%CRSPCRISPR Therapeutics4.30%EWTXEdgewise Therapeutics23.20%RYTMRhythm Pharmaceuticals6.10%Compare Miscellaneous StatsCompanyEmployeesShares OutstandingFree FloatOptionableAXSMAxsome Therapeutics38049.24 million38.26 millionOptionableCRSPCRISPR Therapeutics46086.36 million82.65 millionOptionableEWTXEdgewise Therapeutics60105.20 million80.79 millionOptionableRYTMRhythm Pharmaceuticals14063.62 million59.74 millionOptionableEWTX, RYTM, CRSP, and AXSM HeadlinesRecent News About These CompaniesBayforest Capital Ltd Acquires New Position in Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM)5 hours ago | marketbeat.comCanaccord Genuity Maintained a Buy Rating on Rhythm Pharmaceuticals (RYTM)August 1 at 7:42 AM | insidermonkey.comCanaccord Genuity Maintained a Buy Rating on Rhythm Pharmaceuticals (RYTM)August 1 at 7:31 AM | msn.comRhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) Shares Bought by XTX Topco LtdAugust 1 at 4:04 AM | marketbeat.comRhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) Given Average Recommendation of "Buy" by AnalystsAugust 1 at 3:11 AM | americanbankingnews.comRhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) Receives Consensus Rating of "Buy" from AnalystsAugust 1 at 3:10 AM | marketbeat.comInsider Selling: Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) Insider Sells 1,520 Shares of StockJuly 30 at 9:05 PM | marketbeat.comRhythm Pharmaceuticals (RYTM) Projected to Post Quarterly Earnings on TuesdayJuly 30 at 8:25 AM | marketbeat.comRhythm Pharmaceuticals, Inc. (NASDAQ:RYTM) Insider Sells $130,613.60 in StockJuly 30 at 5:46 AM | insidertrades.comFederated Hermes Inc. Increases Stake in Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM)July 30 at 4:19 AM | marketbeat.comEarnings Preview: Rhythm Pharmaceuticals, Inc. (RYTM) Q2 Earnings Expected to DeclineJuly 29, 2025 | zacks.comUniversal Beteiligungs und Servicegesellschaft mbH Boosts Stake in Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM)July 28, 2025 | marketbeat.comRhythm Pharmaceuticals (NASDAQ:RYTM) Rating Increased to Hold at Wall Street ZenJuly 26, 2025 | marketbeat.comRhythm Pharmaceuticals to Report Second Quarter 2025 Financial Results on Tuesday, August 5, 2025July 22, 2025 | globenewswire.comRhythm Pharmaceuticals (NASDAQ:RYTM) Lowered to Sell Rating by Wall Street ZenJuly 19, 2025 | marketbeat.comRhythm Pharmaceuticals CFO Sells 42,120 SharesJuly 18, 2025 | msn.comRhythm Pharmaceuticals (NASDAQ:RYTM) Given New $105.00 Price Target at Canaccord Genuity GroupJuly 18, 2025 | marketbeat.comQ2 Earnings Estimate for RYTM Issued By Leerink PartnrsJuly 16, 2025 | marketbeat.comAnalysts Set Expectations for RYTM Q4 EarningsJuly 15, 2025 | marketbeat.comLeo Wealth LLC Purchases New Shares in Rhythm Pharmaceuticals, Inc. (NASDAQ:RYTM)July 14, 2025 | marketbeat.comLeerink Partnrs Issues Optimistic Outlook for RYTM EarningsJuly 14, 2025 | marketbeat.comNew MarketBeat Followers Over TimeMedia Sentiment Over TimeEWTX, RYTM, CRSP, and AXSM Company DescriptionsAxsome Therapeutics NASDAQ:AXSM$103.02 +1.64 (+1.62%) Closing price 08/1/2025 04:00 PM EasternExtended Trading$104.02 +1.01 (+0.98%) As of 08/1/2025 07:59 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Axsome Therapeutics, Inc., a biopharmaceutical company, engages in the development of novel therapies for central nervous system (CNS) disorders in the United States. The company's commercial product portfolio includes Auvelity (dextromethorphan-bupropion), a N-methyl-D-aspartate receptor antagonist with multimodal activity indicated for the treatment of major depressive disorder; and Sunosi (solriamfetol), a medication indicated to the treatment of excessive daytime sleepiness in patients with narcolepsy or obstructive sleep apnea. It is also developing AXS-05, which is in Phase III clinical trial to treat Alzheimer's disease agitation, as well as that has completed phase II clinical trial for the treatment of smoking cessation; AXS-07, an investigational medicine that has completed Phase III trials for the acute treatment of migraine; AXS-12, an investigational medicine, which is in Phase III trial to treat narcolepsy; AXS-14, a selective and potent norepinephrine reuptake inhibitor that has completed Phase III trial for the treatment of fibromyalgia and other conditions; and solriamfetol, a dual-acting dopamine and norepinephrine reuptake inhibitor, which has completed a Phase 2 trial for treating attention-deficit/hyperactivity disorder, and is in phase 2 major depressive, binge eating, and shift work disorder. Axsome Therapeutics, Inc. has a research collaboration agreement with Duke University for evaluating AXS-05 in smoking cessation. The company was incorporated in 2012 and is based in New York, New York.CRISPR Therapeutics NASDAQ:CRSP$56.09 -0.17 (-0.30%) Closing price 08/1/2025 04:00 PM EasternExtended Trading$56.14 +0.05 (+0.09%) As of 08/1/2025 07:59 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.CRISPR Therapeutics is a gene-editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene-editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic collaborations with companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Cambridge, Massachusetts, and business offices in San Francisco, California and London, United Kingdom. For more information, please visit www.crisprtx.com.Edgewise Therapeutics NASDAQ:EWTX$14.31 +0.05 (+0.35%) Closing price 08/1/2025 04:00 PM EasternExtended Trading$14.30 -0.01 (-0.03%) As of 08/1/2025 06:04 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Edgewise Therapeutics, Inc., a biopharmaceutical company, discovers, develops, and commercializes therapies for the treatment of muscle disorders. Its lead product candidate, EDG-5506, an orally administered small molecule that is in Phase II clinical trials, designed to address the root cause of dystrophinopathies including Duchenne muscular dystrophy and Becker muscular dystrophy. The company develops EDG-7500, a small molecule for the treatment of hypertrophic cardiomyopathy and other severe cardiac disorders that is in Phase I clinical trials. In addition, it develops a pipeline of precision medicine product candidates that target key muscle proteins and modulators to address genetically defined muscle disorders. Edgewise Therapeutics, Inc. was incorporated in 2017 and is headquartered in Boulder, Colorado.Rhythm Pharmaceuticals NASDAQ:RYTM$88.30 +3.07 (+3.60%) Closing price 08/1/2025 04:00 PM EasternExtended Trading$86.20 -2.10 (-2.38%) As of 08/1/2025 07:43 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more.Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the rare neuroendocrine diseases. The company's lead product candidate is IMCIVREE (setmelanotide), a rare melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, and Bardet-Biedl and Alström syndrome. It is in Phase 3 clinical trials for treating POMC or LEPR heterozygous deficiency obesities, steroid receptor coactivator 1 deficiency obesity, SH2B1 deficiency obesity, MC4 receptor deficiency obesity, and other MC4R disorders. The company has licensing agreements with LG Chem, Ltd; Ipsen Pharma S.A.S; Camurus; RareStone Group Ltd.; and LG Chem, Ltd. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts. 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