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Stocks to Compare Sections All Sections Selected Performance Chart Price & Volume MarketRank Analyst Ratings Sales & Book Value Profitability & Earnings Dividends Debt Ownership Miscellaneous Headlines About Compare NASDAQ:CRNX NASDAQ:IOVA NASDAQ:PTGX NASDAQ:SYRE On This Page Performance ChartPrice & VolumeMarketRank™Analyst RatingsSales & Book ValueProfitability & EarningsDividendsDebtOwnershipMiscellaneousHeadlinesAbout Comparison Ideas Stock Ideas Comparative Price Performance Over Time1 day7 days30 days90 days365 daysCompare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeCRNXCrinetics Pharmaceuticals$83.72-0.2%$46.60$25.83▼$84.00$8.83B0.232.27 million shs4.93 million shsIOVAIovance Biotherapeutics$5.17-5.7%$4.12$1.76▼$5.64$2.31B0.715.25 million shs14.15 million shsPTGXProtagonist Therapeutics$135.44-2.1%$114.88$50.49▼$143.29$8.71B1.79761,175 shs710,437 shsSYRESpyre Therapeutics$99.17-3.4%$83.93$14.51▼$105.09$8.72B3.021.10 million shs596,141 shs The Best Nuclear Energy Stocks to BuyNuclear energy is entering a new growth cycle as rising power demand, expanding data centers, and renewed policy support bring the sector back into focus. After strong gains in recent years, the most impactful phase of nuclear investment may still be ahead. This report highlights seven nuclear energy stocks positioned across the value chain—combining near-term revenue with long-term upside as next-generation technologies scale. Click the link below to unlock the full list.Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceCRNXCrinetics Pharmaceuticals+0.04%+0.23%+133.90%+114.58%+171.08%IOVAIovance Biotherapeutics+9.16%+39.44%+40.12%+55.24%+120.08%PTGXProtagonist Therapeutics+3.01%+5.36%+22.55%+31.04%+150.47%SYRESpyre Therapeutics+5.52%+3.79%+16.26%+40.68%+528.13%Compare Price & VolumeCompanyCurrent Price50-Day Moving Average52-Week RangeMarket CapBetaAvg. VolumeToday's VolumeCRNXCrinetics Pharmaceuticals$83.72-0.2%$46.60$25.83▼$84.00$8.83B0.232.27 million shs4.93 million shsIOVAIovance Biotherapeutics$5.17-5.7%$4.12$1.76▼$5.64$2.31B0.715.25 million shs14.15 million shsPTGXProtagonist Therapeutics$135.44-2.1%$114.88$50.49▼$143.29$8.71B1.79761,175 shs710,437 shsSYRESpyre Therapeutics$99.17-3.4%$83.93$14.51▼$105.09$8.72B3.021.10 million shs596,141 shs The Best Nuclear Energy Stocks to BuyNuclear energy is entering a new growth cycle as rising power demand, expanding data centers, and renewed policy support bring the sector back into focus. After strong gains in recent years, the most impactful phase of nuclear investment may still be ahead. This report highlights seven nuclear energy stocks positioned across the value chain—combining near-term revenue with long-term upside as next-generation technologies scale. Click the link below to unlock the full list.Get This Free ReportCompare Price PerformanceCompany1-Day Performance7-Day Performance30-Day Performance90-Day Performance1-Year PerformanceCRNXCrinetics Pharmaceuticals+0.04%+0.23%+133.90%+114.58%+171.08%IOVAIovance Biotherapeutics+9.16%+39.44%+40.12%+55.24%+120.08%PTGXProtagonist Therapeutics+3.01%+5.36%+22.55%+31.04%+150.47%SYRESpyre Therapeutics+5.52%+3.79%+16.26%+40.68%+528.13%Compare Analyst ForecastsCompanyConsensus Rating ScoreConsensus RatingConsensus Price Target% Upside from Current PriceCRNXCrinetics Pharmaceuticals 2.29Hold$78.27-6.51% DownsideIOVAIovance Biotherapeutics 2.30Hold$8.4363.03% UpsidePTGXProtagonist Therapeutics 2.94Moderate Buy$123.00-9.18% DownsideSYRESpyre Therapeutics 2.92Moderate Buy$101.422.27% UpsideCurrent Analyst Ratings BreakdownLatest IOVA, CRNX, PTGX, and SYRE Analyst RatingsDateCompanyBrokerageActionRatingPrice TargetDetails7/17/2026CRNXCrinetics Pharmaceuticals Weiss RatingsSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingSell (D-)7/17/2026PTGXProtagonist Therapeutics Johnson RiceSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingSet Price Target$165.007/17/2026PTGXProtagonist Therapeutics CitigroupSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingReiterated RatingOutperform7/14/2026PTGXProtagonist Therapeutics BarclaysSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingBoost Price TargetOverweight$119.00 ➝ $151.007/13/2026SYRESpyre Therapeutics MizuhoSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingBoost Price TargetOutperform$84.00 ➝ $120.007/8/2026CRNXCrinetics Pharmaceuticals TD CowenSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingDowngradeBuy ➝ Hold7/8/2026PTGXProtagonist Therapeutics Zacks ResearchSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingUpgradeHold ➝ Strong-Buy7/7/2026CRNXCrinetics Pharmaceuticals EvercoreSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingDowngradeStrong-Buy ➝ Hold7/7/2026CRNXCrinetics Pharmaceuticals Citizens JmpSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingDowngradeStrong-Buy ➝ Hold7/7/2026CRNXCrinetics Pharmaceuticals Piper SandlerSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingDowngradeStrong-Buy ➝ Hold7/7/2026CRNXCrinetics Pharmaceuticals Lifesci CapitalSubscribe to MarketBeat All Access for the firm's recommendation accuracy ratingDowngradeStrong-Buy ➝ Hold(Data available from 7/22/2023 forward. View 10+ years of historical ratings with our analyst ratings screener.)Compare Sales & Book ValueCompanyAnnual RevenuePrice/SalesCashflowPrice/CashBook ValuePrice/BookCRNXCrinetics Pharmaceuticals$18.07M488.54N/AN/A$9.71 per share8.62IOVAIovance Biotherapeutics$263.50M8.76N/AN/A$1.76 per share2.94PTGXProtagonist Therapeutics$46.02M189.27N/AN/A$9.83 per share13.78SYRESpyre TherapeuticsN/AN/AN/AN/A$7.21 per shareN/ACompare Profitability & EarningsCompanyNet IncomeEPSTrailing P/E RatioForward P/E RatioP/E GrowthNet MarginsReturn on Equity (ROE)Return on Assets (ROA)Next Earnings DateCRNXCrinetics Pharmaceuticals-$465.32M-$5.13N/AN/AN/A-2,747.18%-43.96%-39.61%8/4/2026 (Estimated)IOVAIovance Biotherapeutics-$390.98M-$0.95N/AN/AN/A-123.92%-50.17%-38.77%8/6/2026 (Estimated)PTGXProtagonist Therapeutics-$130.15M-$1.81N/AN/AN/A-154.88%-17.76%-16.47%8/5/2026 (Estimated)SYRESpyre Therapeutics-$155.20M-$2.08N/AN/AN/AN/A-42.88%-27.76%8/4/2026 (Estimated)Latest IOVA, CRNX, PTGX, and SYRE EarningsDateQuarterCompanyConsensus EstimateReported EPSBeat/MissGap EPSRevenue EstimateActual RevenueDetails8/6/2026Q2 2026IOVAIovance Biotherapeutics-$0.17N/AN/AN/A$87.67 millionN/A8/5/2026Q2 2026PTGXProtagonist Therapeutics$2.11N/AN/AN/A$190.99 millionN/A8/4/2026Q2 2026CRNXCrinetics Pharmaceuticals-$1.23N/AN/AN/A$14.84 millionN/A8/4/2026Q2 2026SYRESpyre Therapeutics-$0.71N/AN/AN/AN/AN/A5/7/2026Q1 2026CRNXCrinetics Pharmaceuticals-$1.22-$1.23-$0.01-$1.23$8.51 million$10.73 million5/7/2026Q1 2026IOVAIovance Biotherapeutics-$0.19-$0.19N/A-$0.19$77.84 million$71.43 million5/5/2026Q1 2026PTGXProtagonist Therapeutics-$0.5004$0.05+$0.5504$0.05$11.70 million$56.37 million5/5/2026Q1 2026SYRESpyre Therapeutics-$0.66-$0.74-$0.08-$0.74$70.87 millionN/ACompare DividendsCompanyAnnual PayoutDividend Yield5-Year Annualized Dividend GrowthPayout RatioYears of Consecutive GrowthCRNXCrinetics PharmaceuticalsN/AN/AN/AN/AN/AIOVAIovance BiotherapeuticsN/AN/AN/AN/AN/APTGXProtagonist TherapeuticsN/AN/AN/AN/AN/ASYRESpyre TherapeuticsN/AN/AN/AN/AN/ACompare DebtCompanyDebt-to-Equity RatioCurrent RatioQuick RatioCRNXCrinetics PharmaceuticalsN/A18.6018.56IOVAIovance BiotherapeuticsN/A3.603.15PTGXProtagonist TherapeuticsN/A17.7617.76SYRESpyre TherapeuticsN/A8.978.97Compare OwnershipInstitutional OwnershipCompanyInstitutional OwnershipCRNXCrinetics Pharmaceuticals98.51%IOVAIovance Biotherapeutics77.03%PTGXProtagonist Therapeutics98.63%SYRESpyre Therapeutics80.39%Insider OwnershipCompanyInsider OwnershipCRNXCrinetics Pharmaceuticals3.80%IOVAIovance Biotherapeutics7.80%PTGXProtagonist Therapeutics5.19%SYRESpyre Therapeutics15.69%Compare Miscellaneous StatsCompanyEmployeesShares OutstandingFree FloatOptionableCRNXCrinetics Pharmaceuticals210105.44 million101.43 millionOptionableIOVAIovance Biotherapeutics500446.50 million411.68 millionOptionablePTGXProtagonist Therapeutics12064.31 million60.97 millionOptionableSYRESpyre Therapeutics7387.94 million74.14 millionOptionableIOVA, CRNX, PTGX, and SYRE HeadlinesRecent News About These CompaniesSpyre Therapeutics (NASDAQ:SYRE) Trading 5.7% Higher - Should You Buy?July 17, 2026 | marketbeat.comWhy Spyre Therapeutics, Inc.’s (SYRE) Stock Is Up 10.35%July 14, 2026 | aaii.comASpyre Therapeutics (NASDAQ:SYRE) Hits New 1-Year High After Analyst UpgradeJuly 14, 2026 | marketbeat.comEmerald Advisers LLC Sells 22,744 Shares of Spyre Therapeutics, Inc. $SYREJuly 14, 2026 | marketbeat.comSpyre Therapeutics Stock Dividends | NASDAQ:SYRE | BenzingaJuly 13, 2026 | benzinga.comSpyre Therapeutics (NASDAQ:SYRE) Stock Price Expected to Rise, Mizuho Analyst SaysJuly 13, 2026 | marketbeat.comCandriam S.C.A. Buys 184,748 Shares of Spyre Therapeutics, Inc. $SYREJuly 12, 2026 | marketbeat.comJefferies Sticks to Its Buy Rating for Spyre Therapeutics (SYRE)July 6, 2026 | theglobeandmail.comInsider Selling: Spyre Therapeutics (NASDAQ:SYRE) CFO Sells $658,050.00 in StockJuly 3, 2026 | insidertrades.comSpyre Therapeutics Announces Grants of Inducement AwardsJuly 2, 2026 | globenewswire.comSpyre Therapeutics, Inc. $SYRE Stock Holdings Decreased by Pictet Asset Management Holding SAJuly 2, 2026 | marketbeat.comSpyre Therapeutics: Deep And Diverse Immunology Pipeline Awaiting DataJune 30, 2026 | seekingalpha.comIs SYRE Stock a Buy Now or a Wait-and-See Biotech Story TodayJune 29, 2026 | zacks.comSpyre Therapeutics Stock Outlook Hinges on 2026 Study CatalystsJune 29, 2026 | zacks.comSYRE and Spyre Ride New IBD Trends in Biotech Drug DesignJune 29, 2026 | zacks.comSpyre Therapeutics (NASDAQ:SYRE) CFO Sells $1,306,950.00 in StockJune 27, 2026 | insidertrades.comSpyre Therapeutics: A Platform Where The Combination Strategy Is The Real AssetJune 26, 2026 | seekingalpha.comBiotech ETF Index Surges 10% After RebalanceJune 25, 2026 | etftrends.comESpyre Therapeutics Shares Slide Following Large Insider Stock Sales (SYRE)June 24, 2026 | finance.yahoo.comMichael Thomas Henderson Sells 20,000 Shares of Spyre Therapeutics (NASDAQ:SYRE) StockJune 24, 2026 | insidertrades.comStifel Nicolaus Remains a Buy on Spyre Therapeutics (SYRE)June 23, 2026 | theglobeandmail.comNew MarketBeat Followers Over TimeMedia Sentiment Over Time Top HeadlinesView All HeadlinesSK Hynix’s Nasdaq Listing Could Reset the AI Memory TradeBy Thomas Hughes | July 7, 20265 Tech Stocks to Buy on the July PullbackBy Thomas Hughes | June 29, 2026Micron’s Sudden Plunge May Be an AI Buying ChanceBy Jeffrey Neal Johnson | June 23, 2026Rocket Lab’s Stock Drop Comes With a Bullish TwistBy Ryan Hasson | July 10, 2026Vertex’s Crinetics Deal Balances Growth with Integration RiskBy Chris Markoch | July 8, 2026IOVA, CRNX, PTGX, and SYRE Company DescriptionsCrinetics Pharmaceuticals NASDAQ:CRNX$83.72 -0.18 (-0.21%) Closing price 04:00 PM EasternExtended Trading$83.69 -0.03 (-0.03%) As of 06:30 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.Crinetics Pharmaceuticals, Inc., a clinical-stage pharmaceutical company, focuses on the discovery, development, and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors. The company's lead product candidate is paltusotine, an oral selective nonpeptide somatostatin receptor type 2 agonist, which is in Phase 3 trial for the treatment of acromegaly; and Phase 2 trial for treating carcinoid syndrome associated with neuroendocrine tumors. It is also developing CRN04894, an investigational oral nonpeptide product candidate to antagonize the adrenocorticotrophic hormone (ACTH) receptor that has completed a Phase 1 study for the treatment of diseases caused by excess ACTH, including congenital adrenal hyperplasia and Cushing's disease. In addition, the company is developing antagonists of the parathyroid hormone (PTH) receptor for the treatment of primary hyperparathyroidism and humoral hypercalcemia of malignancy, and other diseases of excess PTH; identified investigational orally available somatostatin receptor type 3 targeted nonpeptide agonists for the treatment of autosomal dominant polycystic kidney disease; and developing thyroid-stimulating hormone receptor antagonists for the treatment of graves' disease and thyroid eye disease, as well as Oral GLP-1 and GIP nonpeptides for the treatment of diabetes and obesity. Crinetics Pharmaceuticals, Inc. was incorporated in 2008 and is headquartered in San Diego, California.Iovance Biotherapeutics NASDAQ:IOVA$5.17 -0.31 (-5.66%) Closing price 04:00 PM EasternExtended Trading$5.16 -0.01 (-0.21%) As of 06:30 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.Iovance Biotherapeutics, Inc., a commercial-stage biotechnology company, develops and commercializes cell therapies using autologous tumor infiltrating lymphocyte for the treatment of metastatic melanoma and other solid tumor cancers in the United States. The company offers Amtagvi, a tumor-derived autologous T cell immunotherapy used to treat adult patients with unresectable or metastatic melanoma; and Proleukin, an interleukin-2 product for the treatment of patients with metastatic renal cell carcinoma. It also develops lifileucel in combination with pembrolizumab to treat frontline advanced melanoma patients; LN-145 for the treatment of non-small cell lung cancer (NSCLC) and solid tumor cancers; IOV-4001, which is in Phase 1/2 IOV-GM1-201 clinical trial, for the treatment of NSCLC; and lifileucel for gynecological cancers. The company has collaborations and licensing agreements with WuXi Advanced Therapies, Inc.; National Institutes of Health; the National Cancer Institute; H. Lee Moffitt Cancer Center; The University of Texas M.D. Anderson Cancer Center; Cellectis S.A.; Novartis Pharma AG; and Boehringer Ingelheim Biopharmaceuticals GmbH. The company was formerly known as Lion Biotechnologies, Inc. and changed its name to Iovance Biotherapeutics, Inc. in June 2017. Iovance Biotherapeutics, Inc. was incorporated in 2007 and is headquartered in San Carlos, California.Protagonist Therapeutics NASDAQ:PTGX$135.44 -2.87 (-2.08%) Closing price 04:00 PM EasternExtended Trading$135.66 +0.22 (+0.16%) As of 04:46 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.Protagonist Therapeutics, Inc., a biopharmaceutical company, develops peptide-based drugs for hematology and blood disorders, and inflammatory and immunomodulatory diseases. It is developing Rusfertide (PTG-300), an injectable hepcidin mimetic that completed phase 2 clinical trials for the treatment of polycythemia vera and other blood disorders; and JNJ-2113, an orally delivered investigational drug to block biological pathways that completed phase 2b clinical trials for the treatment of moderate-to-severe plaque psoriasis; and PN-943, an orally delivered, gut-restricted alpha 4 beta 7 specific integrin antagonist completed a phase 2 clinical trials in patients with moderate to severe ulcerative colitis. The company has a license and collaboration agreement with Takeda to commercialize rusfertide; and JNJ Innovative Medicines to co-develop Interleukin-23 receptor antagonist compound JNJ-2113. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.Spyre Therapeutics NASDAQ:SYRE$99.17 -3.53 (-3.44%) Closing price 04:00 PM EasternExtended Trading$99.90 +0.73 (+0.74%) As of 06:16 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.Spyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts. 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