Compare Stocks: PTGX, BIIB, ALNY, and BNTX

Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
ALNY Alnylam Pharmaceuticals	$264.50 -1.1%	$259.76	$197.81 ▼ $495.55	$35.78B	0.31	1.75 million shs	1.71 million shs
BIIB Biogen	$224.51 +0.8%	$209.44	$135.39 ▼ $225.80	$32.90B	0.17	750,123 shs	550,678 shs
BNTX BioNTech	$102.88 -0.9%	$96.38	$79.52 ▼ $124.00	$26.25B	1.29	1.75 million shs	1.18 million shs
PTGX Protagonist Therapeutics	$148.80 +1.9%	$140.71	$54.50 ▼ $160.81	$9.45B	1.8	500,729 shs	353,886 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
ALNY Alnylam Pharmaceuticals	-1.08%	+11.81%	+20.79%	-12.72%	-40.88%
BIIB Biogen	+0.83%	+1.36%	+7.70%	+14.93%	+58.53%
BNTX BioNTech	-0.90%	-7.65%	+12.62%	+16.80%	+2.45%
PTGX Protagonist Therapeutics	+1.86%	-0.47%	+9.56%	+52.80%	+156.07%

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
ALNY Alnylam Pharmaceuticals	$264.50 -1.1%	$259.76	$197.81 ▼ $495.55	$35.78B	0.31	1.75 million shs	1.71 million shs
BIIB Biogen	$224.51 +0.8%	$209.44	$135.39 ▼ $225.80	$32.90B	0.17	750,123 shs	550,678 shs
BNTX BioNTech	$102.88 -0.9%	$96.38	$79.52 ▼ $124.00	$26.25B	1.29	1.75 million shs	1.18 million shs
PTGX Protagonist Therapeutics	$148.80 +1.9%	$140.71	$54.50 ▼ $160.81	$9.45B	1.8	500,729 shs	353,886 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
ALNY Alnylam Pharmaceuticals	-1.08%	+11.81%	+20.79%	-12.72%	-40.88%
BIIB Biogen	+0.83%	+1.36%	+7.70%	+14.93%	+58.53%
BNTX BioNTech	-0.90%	-7.65%	+12.62%	+16.80%	+2.45%
PTGX Protagonist Therapeutics	+1.86%	-0.47%	+9.56%	+52.80%	+156.07%

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
ALNY Alnylam Pharmaceuticals	2.88	Moderate Buy	$386.14	45.99% Upside
BIIB Biogen	2.58	Moderate Buy	$228.50	1.78% Upside
BNTX BioNTech	2.74	Moderate Buy	$127.44	23.87% Upside
PTGX Protagonist Therapeutics	2.89	Moderate Buy	$147.13	-1.12% Downside

Current Analyst Ratings Breakdown

Latest PTGX, BIIB, ALNY, and BNTX Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
9/3/2026	BIIB Biogen	Piper Sandler Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Overweight	$225.00 ➝ $245.00
9/2/2026	ALNY Alnylam Pharmaceuticals	HC Wainwright Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy	$455.00
9/1/2026	PTGX Protagonist Therapeutics	Barclays Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Overweight	$153.00 ➝ $180.00
9/1/2026	PTGX Protagonist Therapeutics	BMO Capital Markets Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Outperform	$178.00 ➝ $190.00
8/31/2026	PTGX Protagonist Therapeutics	Citigroup Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Buy	$175.00 ➝ $182.00
8/31/2026	PTGX Protagonist Therapeutics	Citigroup Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Outperform
8/31/2026	PTGX Protagonist Therapeutics	Wolfe Research Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Outperform
8/31/2026	ALNY Alnylam Pharmaceuticals	Sanford C. Bernstein Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy
8/31/2026	ALNY Alnylam Pharmaceuticals	TD Cowen Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy
8/31/2026	ALNY Alnylam Pharmaceuticals	BMO Capital Markets Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Outperform
8/31/2026	PTGX Protagonist Therapeutics	HC Wainwright Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Buy	$167.00 ➝ $170.00

(Data available from 9/4/2023 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
ALNY Alnylam Pharmaceuticals	$4.80B	7.37	$2.77 per share	95.63	$10.12 per share	26.14
BIIB Biogen	$10.03B	3.31	$22.82 per share	9.84	$127.56 per share	1.76
BNTX BioNTech	$3.25B	8.01	$1.32 per share	77.75	$81.64 per share	1.26
PTGX Protagonist Therapeutics	$46.02M	209.23	N/A	N/A	$13.01 per share	11.44

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
ALNY Alnylam Pharmaceuticals	$313.75M	$5.38	49.16	27.41	N/A	15.26%	84.93%	14.30%	10/29/2026 (Estimated)
BIIB Biogen	$1.29B	$5.65	39.74	13.95	2.46	8.32%	11.18%	6.88%	10/29/2026 (Estimated)
BNTX BioNTech	-$1.29B	-$7.83	N/A	N/A	N/A	-63.54%	-6.86%	-6.00%	11/3/2026 (Estimated)
PTGX Protagonist Therapeutics	-$130.15M	$1.03	144.47	N/A	N/A	29.40%	12.03%	11.23%	11/5/2026 (Estimated)

Latest PTGX, BIIB, ALNY, and BNTX Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
8/5/2026	Q2 2026	PTGX Protagonist Therapeutics	$2.27	$2.29	+$0.02	$2.29	$212.03 million	$213.48 million
8/4/2026	Q2 2026	BNTX BioNTech	-$2.3983	-$2.5340	-$0.1357	-$3.70	$180.18 million	$122.31 million
7/30/2026	Q2 2026	ALNY Alnylam Pharmaceuticals	$1.63	$1.84	+$0.21	$1.21	$1.32 billion	$1.29 billion
7/29/2026	Q2 2026	BIIB Biogen	$2.94	$3.60	+$0.66	$0.66	$2.46 billion	$2.74 billion

Compare Dividends

Company	Annual Payout	Dividend Yield	5-Year Annualized Dividend Growth	Payout Ratio	Years of Consecutive Growth
ALNY Alnylam Pharmaceuticals	N/A	N/A	N/A	N/A	N/A
BIIB Biogen	N/A	N/A	N/A	N/A	N/A
BNTX BioNTech	N/A	N/A	N/A	N/A	N/A
PTGX Protagonist Therapeutics	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
ALNY Alnylam Pharmaceuticals	0.75	3.05	2.99
BIIB Biogen	0.39	1.87	1.26
BNTX BioNTech	0.01	7.85	7.80
PTGX Protagonist Therapeutics	N/A	21.71	21.71

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
ALNY Alnylam Pharmaceuticals	92.97%
BIIB Biogen	87.93%
BNTX BioNTech	15.52%
PTGX Protagonist Therapeutics	98.63%

Insider Ownership

Company	Insider Ownership
ALNY Alnylam Pharmaceuticals	0.86%
BIIB Biogen	0.25%
BNTX BioNTech	19.20%
PTGX Protagonist Therapeutics	5.19%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
ALNY Alnylam Pharmaceuticals	2,770	133.81 million	132.66 million	Optionable
BIIB Biogen	7,500	147.75 million	147.39 million	Optionable
BNTX BioNTech	7,807	252.88 million	204.33 million	Optionable
PTGX Protagonist Therapeutics	120	64.71 million	61.35 million	Optionable

PTGX, BIIB, ALNY, and BNTX Headlines

Recent News About These Companies

Q1 Earnings Estimate for PTGX Issued By HC Wainwright

2 hours ago | americanbankingnews.com

BMO Capital Markets Boosts Protagonist Therapeutics (NASDAQ:PTGX) Price Target to $190.00

September 3 at 2:22 AM | americanbankingnews.com

Analysts Are Bullish on Top Healthcare Stocks: Palvella Therapeutics (PVLA), Protagonist Therapeutics (PTGX)

September 2 at 7:41 PM | theglobeandmail.com

Analysts Are Bullish on These Healthcare Stocks: Ascendis Pharma (ASND), Protagonist Therapeutics (PTGX)

September 2 at 9:40 AM | theglobeandmail.com

Research Analysts Offer Predictions for PTGX Q1 Earnings

September 2 at 7:26 AM | marketbeat.com

Protagonist Therapeutics to Participate in Two Investment Bank Conferences in September 2026

September 2 at 7:05 AM | accessnewswire.comA

Protagonist Therapeutics (PTGX) Stock Could Be Overvalued Following FDA Approval News

September 2 at 4:39 AM | uk.finance.yahoo.com

The Bull Case For Protagonist Therapeutics (PTGX) Could Change Following FDA Approval Of MIMRYLO And Takeda Milestones

September 1 at 1:37 PM | finance.yahoo.com

Protagonist Therapeutics (NASDAQ:PTGX) Given New $190.00 Price Target at BMO Capital Markets

September 1 at 8:41 AM | marketbeat.com

Why Is Protagonist Therapeutics (PTGX) In Focus After MIMRYLO FDA Approval?

September 1 at 3:34 AM | uk.finance.yahoo.com

Protagonist Therapeutics' Own Pipeline Seen as Main Long-Term Growth Driver, Wedbush Says

August 31, 2026 | finance.yahoo.com

Protagonist Therapeutics' Mimrylo Holds Commercial Potential After FDA Approval, Truist Says

August 31, 2026 | finance.yahoo.com

Protagonist Therapeutics, Inc. (PTGX) Discusses FDA Approval of Mimrylo for Erythrocytosis in Polycythemia Vera Transcript

August 31, 2026 | seekingalpha.com

Protagonist Wins FDA Approval for MIMRYLO in Rare Blood Cancer Treatment

August 31, 2026 | marketbeat.com

Protagonist Therapeutics, Inc. (PTGX) Discusses FDA Approval of Mimrylo for Erythrocytosis in Polycythemia Vera - Slideshow

August 31, 2026 | seekingalpha.com

132,351 Shares in Protagonist Therapeutics, Inc. $PTGX Acquired by Legal & General Group Plc

August 31, 2026 | marketbeat.com

Johnson & Johnson Owns Stakes in 15 Stocks. Here's the Best of the Bunch.

August 31, 2026 | fool.com

Wellington Management Group LLP Sells 182,863 Shares of Protagonist Therapeutics, Inc. $PTGX

August 30, 2026 | marketbeat.com

Hsbc Holdings PLC Acquires New Holdings in Protagonist Therapeutics, Inc. $PTGX

August 30, 2026 | marketbeat.com

Protagonist Therapeutics, Inc. $PTGX Shares Acquired by Alyeska Investment Group L.P.

August 30, 2026 | marketbeat.com

US FDA approves drug for rare blood cancer

August 29, 2026 | msn.com

New MarketBeat Followers Over Time

Media Sentiment Over Time

PTGX, BIIB, ALNY, and BNTX Company Descriptions

Alnylam Pharmaceuticals NASDAQ:ALNY

$264.50 -2.90 (-1.08%)

Closing price 09/3/2026 04:00 PM Eastern

Extended Trading

$261.14 -3.36 (-1.27%)

As of 04:23 AM Eastern

Alnylam Pharmaceuticals, Inc., a biopharmaceutical company, focuses on discovering, developing, and commercializing novel therapeutics based on ribonucleic acid interference. Its marketed products include ONPATTRO (patisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; AMVUTTRA for the treatment of hATTR amyloidosis with polyneuropathy in adults; GIVLAARI for the treatment of adults with acute hepatic porphyria; and OXLUMO for the treatment of primary hyperoxaluria type 1. In addition, the company develops patisiran for the treatment of transthyretin amyloidosis, or ATTR amyloidosis, with cardiomyopathy; cemdisiran to treat complement-mediated diseases; Belcesiran for the treatment of alpha-1 liver disease; Elebsiran to treat chronic HBV infection; Zilebesiran to treat hypertension; ALN-APP to treat Alzheimer's disease and cerebral amyloid angiopathy; and ALN-HSD to treat NASH. Further, it offers Fitusiran for the treatment of hemophilia, Inclisiran to treat hypercholesterolemia, lumasiran for the treatment of advanced PH1, and vutrisiran for the treatment of ATTR amyloidosis, which is in phase 3 clinical trial. Alnylam Pharmaceuticals, Inc. has strategic collaborations with Regeneron Pharmaceuticals, Inc. to discover, develop, and commercialize RNAi therapeutics for a range of diseases by addressing therapeutic targets expressed in the eye and CNS; and Roche to develop pharmaceutical products containing zilebesiran. It also has license and collaboration agreements with Novartis AG; Vir Biotechnology, Inc.; Dicerna Pharmaceuticals, Inc.; Ionis Pharmaceuticals, Inc.; and PeptiDream, Inc. The company was founded in 2002 and is headquartered in Cambridge, Massachusetts.

Biogen NASDAQ:BIIB

$224.51 +1.84 (+0.83%)

Closing price 09/3/2026 04:00 PM Eastern

Extended Trading

$224.80 +0.29 (+0.13%)

As of 04:12 AM Eastern

Biogen Inc. discovers, develops, manufactures, and delivers therapies for treating neurological and neurodegenerative diseases in the United States, Europe, Germany, Asia, and internationally. The company provides TECFIDERA, VUMERITY, AVONEX, PLEGRIDY, TYSABRI, and FAMPYRA for multiple sclerosis (MS); SPINRAZA for spinal muscular atrophy; ADUHELM to treat Alzheimer's disease; FUMADERM to treat plaque psoriasis; BENEPALI, an etanercept biosimilar referencing ENBREL; IMRALDI, an adalimumab biosimilar referencing HUMIRA; FLIXABI, an infliximab biosimilar referencing REMICADE; and BYOOVIZ, a ranibizumab biosimilar referencing LUCENTIS. It offers RITUXAN for treating non-Hodgkin's lymphoma, chronic lymphocytic leukemia (CLL), rheumatoid arthritis, two forms of ANCA-associated vasculitis, and pemphigus vulgaris; RITUXAN HYCELA for non-Hodgkin's lymphoma and CLL; GAZYVA to treat CLL and follicular lymphoma; OCREVUS for relapsing MS and primary progressive MS; LUNSUMIO to treat relapsed or refractory follicular lymphoma; glofitamab for non-Hodgkin's lymphoma; and other anti-CD20 therapies. In addition, the company is developing various products for the treatment of MS, Alzheimer's disease and dementia, neuromuscular disorders, Parkinson's disease and movement disorders, neuropsychiatry, genetic neurodevelopmental disorders, and biosimilars, which are under various stages of development. It has collaboration and license agreements with Acorda Therapeutics, Inc.; Alkermes Pharma Ireland Limited; Denali Therapeutics Inc.; Eisai Co., Ltd.; Genentech, Inc.; Neurimmune SubOne AG; Ionis Pharmaceuticals, Inc.; Samsung Bioepis Co., Ltd.; Sangamo Therapeutics, Inc.; and Sage Therapeutics, Inc., as well as collaboration with Fujirebio to potentially identify and develop blood-based biomarkers for tau pathology in the brain. The company was founded in 1978 and is headquartered in Cambridge, Massachusetts.

BioNTech NASDAQ:BNTX

$102.88 -0.93 (-0.90%)

Closing price 09/3/2026 04:00 PM Eastern

Extended Trading

$102.75 -0.13 (-0.13%)

As of 04:21 AM Eastern

BioNTech SE, a biotechnology company, develops and commercializes immunotherapies for cancer and other infectious diseases. The company is developing FixVac product candidates, including BNT111, which is in Phase II clinical trial for advance melanoma; BNT112 that is in Phase I/IIa clinical trial for prostate cancer; BNT113, which is in Phase II clinical trial to treat HPV 16+ head and neck cancers; BNT114 to treat triple negative breast cancer; BNT115, which is in Phase I clinical trial in ovarian cancer; and BNT116, which is in Phase I clinical trial for non-small cell lung cancer. It develops BNT122, which is in Phase II clinical trial for first-line melanoma and in Phase I clinical trial to treat multiple solid tumors; BNT131 that is in Phase I clinical trial for multiple solid tumors; BNT141 and BNT142 that are in Phase I clinical trial to treat multiple solid tumors; BNT151, BNT152, and BNT153 to treat solid tumors; BNT211 to treat multiple solid tumors, and BNT221 for pancreatic and other cancers; BNT311 which are in Phase II clinical trial to treat metastatic non-small cell lung cancer and Phase I/II clinical trial to treat multiple solid tumors; and BNT312, which is in Phase 2 clinical trial to treat multiple solid tumors, as well as ONC-392, which is in Phase III clinical trial to treat ovarian cancer and Phase I/II clinical trial to treat multiple solid tumors. It develops BNT321, an IgG1 monoclonal antibody in Phase I clinical trial for pancreatic cancer; BNT411, a small molecule immunomodulator product candidate in Phase I clinical trial for solid tumors; BNT322, which is in Phase I/Ib clinical trial for multiple solid tumors; and prophylactic vaccine for shingles, malaria, tuberculosis, HSV-2, and other infectious diseases. It has collaborations with Genentech, Inc.; Sanofi S.A.; Genmab A/S; Pfizer Inc.; Shanghai Fosun Pharmaceutical (Group) Co., Ltd; and Ryvu Therapeutics S.A. BioNTech SE was incorporated in 2008 and is based in Mainz, Germany.

Protagonist Therapeutics NASDAQ:PTGX

$148.80 +2.72 (+1.86%)

As of 09/3/2026 04:00 PM Eastern

Protagonist Therapeutics, Inc., a biopharmaceutical company, develops peptide-based drugs for hematology and blood disorders, and inflammatory and immunomodulatory diseases. It is developing Rusfertide (PTG-300), an injectable hepcidin mimetic that completed phase 2 clinical trials for the treatment of polycythemia vera and other blood disorders; and JNJ-2113, an orally delivered investigational drug to block biological pathways that completed phase 2b clinical trials for the treatment of moderate-to-severe plaque psoriasis; and PN-943, an orally delivered, gut-restricted alpha 4 beta 7 specific integrin antagonist completed a phase 2 clinical trials in patients with moderate to severe ulcerative colitis. The company has a license and collaboration agreement with Takeda to commercialize rusfertide; and JNJ Innovative Medicines to co-develop Interleukin-23 receptor antagonist compound JNJ-2113. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

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Compare Stocks

Comparative Price Performance Over Time

Compare Price & Volume

Compare Price Performance

Compare Price & Volume

Compare Price Performance

Compare Analyst Forecasts

Current Analyst Ratings Breakdown

Latest PTGX, BIIB, ALNY, and BNTX Analyst Ratings

Compare Sales & Book Value

Compare Profitability & Earnings

Latest PTGX, BIIB, ALNY, and BNTX Earnings

Compare Dividends

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Compare Ownership

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Insider Ownership

Compare Miscellaneous Stats

PTGX, BIIB, ALNY, and BNTX Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

PTGX, BIIB, ALNY, and BNTX Company Descriptions

Alnylam Pharmaceuticals NASDAQ:ALNY

Biogen NASDAQ:BIIB

BioNTech NASDAQ:BNTX

Protagonist Therapeutics NASDAQ:PTGX

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Latest PTGX, BIIB, ALNY, and BNTX Analyst Ratings

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Latest PTGX, BIIB, ALNY, and BNTX Earnings

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PTGX, BIIB, ALNY, and BNTX Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

PTGX, BIIB, ALNY, and BNTX Company Descriptions

Alnylam Pharmaceuticals NASDAQ:ALNY

Biogen NASDAQ:BIIB

BioNTech NASDAQ:BNTX

Protagonist Therapeutics NASDAQ:PTGX

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