Compare Stocks: SYRE, INSM, BNTX, and INCY

Comparative Price Performance Over Time

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
BNTX BioNTech	$103.76	$96.63	$79.52 ▼ $124.00	$26.24B	1.29	1.70 million shs	612,211 shs
INCY Incyte	$126.75	$120.87	$81.09 ▼ $132.60	$25.69B	0.77	1.21 million shs	1.03 million shs
INSM Insmed	$126.29	$115.86	$90.39 ▼ $212.75	$27.58B	0.82	1.91 million shs	1.80 million shs
SYRE Spyre Therapeutics	$88.98	$98.05	$14.51 ▼ $110.18	$7.82B	2.99	1.11 million shs	803,823 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
BNTX BioNTech	0.00%	+1.66%	+10.77%	+21.36%	-7.74%
INCY Incyte	0.00%	+1.91%	+5.13%	+25.94%	+46.30%
INSM Insmed	0.00%	+6.54%	-3.67%	+34.11%	-12.96%
SYRE Spyre Therapeutics	0.00%	-1.53%	-15.18%	+23.58%	+423.41%

Compare Price & Volume

Company	Current Price	50-Day Moving Average	52-Week Range	Market Cap	Beta	Avg. Volume	Today's Volume
BNTX BioNTech	$103.76	$96.63	$79.52 ▼ $124.00	$26.24B	1.29	1.70 million shs	612,211 shs
INCY Incyte	$126.75	$120.87	$81.09 ▼ $132.60	$25.69B	0.77	1.21 million shs	1.03 million shs
INSM Insmed	$126.29	$115.86	$90.39 ▼ $212.75	$27.58B	0.82	1.91 million shs	1.80 million shs
SYRE Spyre Therapeutics	$88.98	$98.05	$14.51 ▼ $110.18	$7.82B	2.99	1.11 million shs	803,823 shs

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Compare Price Performance

Company	1-Day Performance	7-Day Performance	30-Day Performance	90-Day Performance	1-Year Performance
BNTX BioNTech	0.00%	+1.66%	+10.77%	+21.36%	-7.74%
INCY Incyte	0.00%	+1.91%	+5.13%	+25.94%	+46.30%
INSM Insmed	0.00%	+6.54%	-3.67%	+34.11%	-12.96%
SYRE Spyre Therapeutics	0.00%	-1.53%	-15.18%	+23.58%	+423.41%

Compare Analyst Forecasts

Company	Consensus Rating Score	Consensus Rating	Consensus Price Target	% Upside from Current Price
BNTX BioNTech	2.74	Moderate Buy	$127.44	22.82% Upside
INCY Incyte	2.54	Moderate Buy	$124.05	-2.13% Downside
INSM Insmed	3.00	Buy	$205.52	62.74% Upside
SYRE Spyre Therapeutics	2.87	Moderate Buy	$109.69	23.28% Upside

Current Analyst Ratings Breakdown

Latest SYRE, INSM, BNTX, and INCY Analyst Ratings

Date	Company	Brokerage	Action	Rating	Price Target
9/1/2026	SYRE Spyre Therapeutics	Weiss Ratings Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Sell (D-)
9/1/2026	INCY Incyte	BMO Capital Markets Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Market Perform
8/31/2026	BNTX BioNTech	Canaccord Genuity Group Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Lower Price Target	Buy	$142.00 ➝ $136.00
8/26/2026	SYRE Spyre Therapeutics	Deutsche Bank Aktiengesellschaft Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Lower Price Target	Buy	$135.00 ➝ $127.00
8/26/2026	SYRE Spyre Therapeutics	Wedbush Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Lower Price Target	Outperform	$130.00 ➝ $123.00
8/26/2026	SYRE Spyre Therapeutics	BTIG Research Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Lower Price Target	Buy	$132.00 ➝ $121.00
8/24/2026	INCY Incyte	TD Cowen Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Upgrade	Strong-Buy
8/20/2026	INCY Incyte	Benchmark Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy
8/20/2026	INCY Incyte	Canaccord Genuity Group Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Initiated Coverage	Buy	$152.00
8/20/2026	INCY Incyte	HC Wainwright Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Reiterated Rating	Buy	$150.00
8/17/2026	INCY Incyte	Piper Sandler Subscribe to MarketBeat All Access for the firm's recommendation accuracy rating	Boost Price Target	Overweight	$110.00 ➝ $130.00

(Data available from 9/7/2023 forward. View 10+ years of historical ratings with our analyst ratings screener.)

Compare Sales & Book Value

Company	Annual Revenue	Price/Sales	Cashflow	Price/Cash	Book Value	Price/Book
BNTX BioNTech	$3.25B	8.08	$1.34 per share	77.72	$96.59 per share	1.07
INCY Incyte	$5.14B	5.00	$6.18 per share	20.51	$26.32 per share	4.82
INSM Insmed	$606.42M	45.48	N/A	N/A	$3.46 per share	36.50
SYRE Spyre Therapeutics	$890K	8,792.02	N/A	N/A	$7.21 per share	12.34

Compare Profitability & Earnings

Company	Net Income	EPS	Trailing P/E Ratio	Forward P/E Ratio	P/E Growth	Net Margins	Return on Equity (ROE)	Return on Assets (ROA)	Next Earnings Date
BNTX BioNTech	-$1.29B	-$7.83	N/A	N/A	N/A	-63.54%	-6.86%	-6.00%	11/3/2026 (Estimated)
INCY Incyte	$1.29B	$7.85	16.15	15.98	3.68	27.71%	29.93%	22.88%	10/27/2026 (Estimated)
INSM Insmed	-$1.28B	-$4.11	N/A	48.39	N/A	-76.94%	-123.94%	-44.30%	10/29/2026 (Estimated)
SYRE Spyre Therapeutics	-$155.20M	-$1.95	N/A	N/A	N/A	N/A	-30.74%	-22.23%	11/3/2026 (Estimated)

Latest SYRE, INSM, BNTX, and INCY Earnings

Date	Quarter	Company	Consensus Estimate	Reported EPS	Beat/Miss	Gap EPS	Revenue Estimate	Actual Revenue
8/6/2026	Q2 2026	INSM Insmed	-$0.6724	-$0.06	+$0.6124	-$0.06	$395.50 million	$425.49 million
8/4/2026	Q2 2026	BNTX BioNTech	-$2.3983	-$2.5340	-$0.1357	-$3.70	$180.18 million	$122.31 million
8/4/2026	Q2 2026	SYRE Spyre Therapeutics	-$0.7589	-$0.36	+$0.3989	-$0.36	N/A	N/A
7/28/2026	Q2 2026	INCY Incyte	$2.15	$3.09	+$0.94	$2.81	$1.50 billion	$1.67 billion

Compare Dividends

Company	Annual Payout	Dividend Yield	5-Year Annualized Dividend Growth	Payout Ratio	Years of Consecutive Growth
BNTX BioNTech	N/A	N/A	N/A	N/A	N/A
INCY Incyte	N/A	N/A	N/A	N/A	N/A
INSM Insmed	N/A	N/A	N/A	N/A	N/A
SYRE Spyre Therapeutics	N/A	N/A	N/A	N/A	N/A

Compare Debt

Company	Debt-to-Equity Ratio	Current Ratio	Quick Ratio
BNTX BioNTech	0.01	7.85	7.80
INCY Incyte	N/A	4.59	4.51
INSM Insmed	0.74	3.72	3.40
SYRE Spyre Therapeutics	N/A	18.53	18.53

Compare Ownership

Institutional Ownership

Company	Institutional Ownership
BNTX BioNTech	15.52%
INCY Incyte	96.97%
INSM Insmed	N/A
SYRE Spyre Therapeutics	80.39%

Insider Ownership

Company	Insider Ownership
BNTX BioNTech	19.20%
INCY Incyte	16.20%
INSM Insmed	2.10%
SYRE Spyre Therapeutics	15.69%

Compare Miscellaneous Stats

Company	Employees	Shares Outstanding	Free Float	Optionable
BNTX BioNTech	7,807	252.88 million	204.33 million	Optionable
INCY Incyte	2,844	202.70 million	169.86 million	Optionable
INSM Insmed	1,664	218.38 million	213.80 million	Optionable
SYRE Spyre Therapeutics	73	87.94 million	74.14 million	Optionable

SYRE, INSM, BNTX, and INCY Headlines

Recent News About These Companies

Spyre Therapeutics Announces Grants of Inducement Awards

September 4 at 4:01 PM | globenewswire.com

Spyre Therapeutics (NASDAQ:SYRE) Insider Heidy King-Jones Sells 400 Shares of Stock

September 4 at 7:22 AM | insidertrades.com

Insider Selling: Spyre Therapeutics (NASDAQ:SYRE) Insider Sells $36,000.00 in Stock

September 3, 2026 | marketbeat.com

Spyre Therapeutics (NASDAQ:SYRE) CFO Scott Burrows Sells 7,500 Shares

September 3, 2026 | marketbeat.com

Insider Selling: Spyre Therapeutics (NASDAQ:SYRE) CEO Sells 15,000 Shares of Stock

September 3, 2026 | marketbeat.com

Spyre Therapeutics (NASDAQ:SYRE) CFO Sells 18,232 Shares of Stock

September 3, 2026 | marketbeat.com

Heidy King-Jones Sells 27,999 Shares of Spyre Therapeutics (NASDAQ:SYRE) Stock

September 3, 2026 | marketbeat.com

Spyre Therapeutics to Participate in Upcoming September Investor Conferences

September 3, 2026 | globenewswire.com

Spyre Therapeutics (SYRE) Down 16.6% Since Last Earnings Report: Can It Rebound?

September 3, 2026 | zacks.com

Braidwell LP Decreases Stock Holdings in Spyre Therapeutics, Inc. $SYRE

September 3, 2026 | marketbeat.com

Wellington Management Group LLP Has $140.41 Million Stock Position in Spyre Therapeutics, Inc. $SYRE

September 1, 2026 | marketbeat.com

Spyre (SYRE) Fell 13% on Its Weakest Program. Its Best One Just Worked

September 1, 2026 | finance.yahoo.com

Bank of New York Mellon Corp Invests $21.77 Million in Spyre Therapeutics, Inc. $SYRE

August 31, 2026 | marketbeat.com

Analysts Offer Insights on Healthcare Companies: Revolution Medicines (RVMD) and Spyre Therapeutics (SYRE)

August 30, 2026 | theglobeandmail.com

Analysts Offer Insights on Healthcare Companies: Solventum Corporation (SOLV), Argenx Se (ARGX) and Spyre Therapeutics (SYRE)

August 28, 2026 | theglobeandmail.com

Spyre Therapeutics (NASDAQ:SYRE) Shares Gap Down After Analyst Downgrade

August 28, 2026 | americanbankingnews.com

Wedbush Lowers Spyre Therapeutics (NASDAQ:SYRE) Price Target to $123.00

August 28, 2026 | americanbankingnews.com

BTIG Research Has Lowered Expectations for Spyre Therapeutics (NASDAQ:SYRE) Stock Price

August 28, 2026 | americanbankingnews.com

Analysts Offer Insights on Healthcare Companies: Spyre Therapeutics (SYRE) and CVS Health (CVS)

August 27, 2026 | theglobeandmail.com

Spyre Therapeutics: Catalyst-Rich Period But Easiest Money May Have Been Made (Downgrade)

August 27, 2026 | seekingalpha.com

Spyre reveals mid-stage miss for TL1A antibody in rheumatoid arthritis

August 27, 2026 | thepharmaletter.comT

New MarketBeat Followers Over Time

Media Sentiment Over Time

SYRE, INSM, BNTX, and INCY Company Descriptions

BioNTech NASDAQ:BNTX

$103.76 0.00 (0.00%)

As of 09/4/2026 04:00 PM Eastern

BioNTech SE, a biotechnology company, develops and commercializes immunotherapies for cancer and other infectious diseases. The company is developing FixVac product candidates, including BNT111, which is in Phase II clinical trial for advance melanoma; BNT112 that is in Phase I/IIa clinical trial for prostate cancer; BNT113, which is in Phase II clinical trial to treat HPV 16+ head and neck cancers; BNT114 to treat triple negative breast cancer; BNT115, which is in Phase I clinical trial in ovarian cancer; and BNT116, which is in Phase I clinical trial for non-small cell lung cancer. It develops BNT122, which is in Phase II clinical trial for first-line melanoma and in Phase I clinical trial to treat multiple solid tumors; BNT131 that is in Phase I clinical trial for multiple solid tumors; BNT141 and BNT142 that are in Phase I clinical trial to treat multiple solid tumors; BNT151, BNT152, and BNT153 to treat solid tumors; BNT211 to treat multiple solid tumors, and BNT221 for pancreatic and other cancers; BNT311 which are in Phase II clinical trial to treat metastatic non-small cell lung cancer and Phase I/II clinical trial to treat multiple solid tumors; and BNT312, which is in Phase 2 clinical trial to treat multiple solid tumors, as well as ONC-392, which is in Phase III clinical trial to treat ovarian cancer and Phase I/II clinical trial to treat multiple solid tumors. It develops BNT321, an IgG1 monoclonal antibody in Phase I clinical trial for pancreatic cancer; BNT411, a small molecule immunomodulator product candidate in Phase I clinical trial for solid tumors; BNT322, which is in Phase I/Ib clinical trial for multiple solid tumors; and prophylactic vaccine for shingles, malaria, tuberculosis, HSV-2, and other infectious diseases. It has collaborations with Genentech, Inc.; Sanofi S.A.; Genmab A/S; Pfizer Inc.; Shanghai Fosun Pharmaceutical (Group) Co., Ltd; and Ryvu Therapeutics S.A. BioNTech SE was incorporated in 2008 and is based in Mainz, Germany.

Incyte NASDAQ:INCY

$126.75 0.00 (0.00%)

As of 09/4/2026 04:00 PM Eastern

Incyte Corporation, a biopharmaceutical company, engages in the discovery, development, and commercialization of therapeutics for hematology/oncology, and inflammation and autoimmunity areas in the United States and internationally. The company offers JAKAFI (ruxolitinib) for treatment of intermediate or high-risk myelofibrosis, polycythemia vera, and steroid-refractory acute graft-versus-host disease; MONJUVI (tafasitamab-cxix)/MINJUVI (tafasitamab) for relapsed or refractory diffuse large B-cell lymphoma; PEMAZYRE (pemigatinib), a fibroblast growth factor receptor kinase inhibitor that act as oncogenic drivers in liquid and solid tumor types; ICLUSIG (ponatinib) to treat chronic myeloid leukemia and Philadelphia-chromosome positive acute lymphoblastic leukemia; and ZYNYZ (retifanlimab-dlwr) to treat adults with metastatic or recurrent locally advanced Merkel cell carcinoma, as well as OPZELURA cream for treatment of atopic dermatitis. Its clinical stage products include retifanlimab under Phase 3 clinical trials for squamous cell carcinoma of the anal canal and non-small cell lung cancer; axatilimab, an anti-CSF-1R monoclonal antibody under Phase 2 that is being developed as a therapy for patients with chronic GVHD; INCA033989 to inhibit oncogenesis; INCB160058, which is being developed as a disease-modifying therapeutic; and INCB99280 and INCB99318 for the treatment solid tumors. The company also develops INCB123667, INCA32459, and INCA33890, as well as Ruxolitinib cream, Povorcitinib, and INCA034460. It has collaboration out-license agreements with Novartis and Lilly; in-license agreements with Agenus, Merus, MacroGenics, and Syndax; and collaboration and license agreement with China Medical System Holdings Limited for the development and commercialization of povorcitinib. The company sells its products to specialty, retail, and hospital pharmacies, distributors, and wholesalers. The company was formerly known as Incyte Genomics Inc and changed its name to Incyte Corporation in March 2003. Incyte Corporation was incorporated in 1991 and is headquartered in Wilmington, Delaware.

Insmed NASDAQ:INSM

$126.29 0.00 (0.00%)

As of 09/4/2026 04:00 PM Eastern

Insmed Incorporated is a global biopharmaceutical company on a mission to transform the lives of patients with serious and rare diseases. Insmed's first commercial product is ARIKAYCE® (amikacin liposome inhalation suspension), which is approved in the United States for the treatment of Mycobacterium avium complex (MAC) lung disease as part of a combination antibacterial drug regimen for adult patients with limited or no alternative treatment options. MAC lung disease is a rare and often chronic infection that can cause irreversible lung damage and can be fatal. Insmed's earlier-stage clinical pipeline includes INS1007, a novel oral reversible inhibitor of dipeptidyl peptidase 1 with therapeutic potential in non-cystic fibrosis bronchiectasis and other inflammatory diseases, and INS1009, an inhaled formulation of a treprostinil prodrug that may offer a differentiated product profile for rare pulmonary disorders, including pulmonary arterial hypertension.

Spyre Therapeutics NASDAQ:SYRE

$88.98 0.00 (0.00%)

As of 09/4/2026 04:00 PM Eastern

Spyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts.

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Compare Stocks

Comparative Price Performance Over Time

Compare Price & Volume

Compare Price Performance

Compare Price & Volume

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Compare Analyst Forecasts

Current Analyst Ratings Breakdown

Latest SYRE, INSM, BNTX, and INCY Analyst Ratings

Compare Sales & Book Value

Compare Profitability & Earnings

Latest SYRE, INSM, BNTX, and INCY Earnings

Compare Dividends

Compare Debt

Compare Ownership

Institutional Ownership

Insider Ownership

Compare Miscellaneous Stats

SYRE, INSM, BNTX, and INCY Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

SYRE, INSM, BNTX, and INCY Company Descriptions

BioNTech NASDAQ:BNTX

Incyte NASDAQ:INCY

Insmed NASDAQ:INSM

Spyre Therapeutics NASDAQ:SYRE

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Latest SYRE, INSM, BNTX, and INCY Analyst Ratings

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Compare Profitability & Earnings

Latest SYRE, INSM, BNTX, and INCY Earnings

Compare Dividends

Compare Debt

Compare Ownership

Institutional Ownership

Insider Ownership

Compare Miscellaneous Stats

SYRE, INSM, BNTX, and INCY Headlines

Recent News About These Companies

New MarketBeat Followers Over Time

Media Sentiment Over Time

SYRE, INSM, BNTX, and INCY Company Descriptions

BioNTech NASDAQ:BNTX

Incyte NASDAQ:INCY

Insmed NASDAQ:INSM

Spyre Therapeutics NASDAQ:SYRE

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