Alnylam Pharmaceuticals (ALNY) Competitors $453.56 +1.39 (+0.31%) Closing price 09/19/2025 04:00 PM EasternExtended Trading$455.25 +1.69 (+0.37%) As of 09/19/2025 06:09 PM Eastern Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Polygon.io. Learn more. Add Compare Share Share Competitors Stock AnalysisAnalyst ForecastsChartCompetitorsEarningsFDA EventsFinancialsHeadlinesInsider TradesOptions ChainOwnershipSEC FilingsShort InterestSustainabilityTrendsBuy This Stock ALNY vs. AMGN, GILD, VRTX, REGN, BIIB, UTHR, INCY, NBIX, EXEL, and BMRNShould you be buying Alnylam Pharmaceuticals stock or one of its competitors? The main competitors of Alnylam Pharmaceuticals include Amgen (AMGN), Gilead Sciences (GILD), Vertex Pharmaceuticals (VRTX), Regeneron Pharmaceuticals (REGN), Biogen (BIIB), United Therapeutics (UTHR), Incyte (INCY), Neurocrine Biosciences (NBIX), Exelixis (EXEL), and BioMarin Pharmaceutical (BMRN). These companies are all part of the "biotechnology" industry. Alnylam Pharmaceuticals vs. Its Competitors Amgen Gilead Sciences Vertex Pharmaceuticals Regeneron Pharmaceuticals Biogen United Therapeutics Incyte Neurocrine Biosciences Exelixis BioMarin Pharmaceutical Alnylam Pharmaceuticals (NASDAQ:ALNY) and Amgen (NASDAQ:AMGN) are both large-cap medical companies, but which is the superior business? We will contrast the two companies based on the strength of their analyst recommendations, valuation, earnings, profitability, media sentiment, institutional ownership, risk and dividends. Do institutionals & insiders believe in ALNY or AMGN? 93.0% of Alnylam Pharmaceuticals shares are held by institutional investors. Comparatively, 76.5% of Amgen shares are held by institutional investors. 1.5% of Alnylam Pharmaceuticals shares are held by insiders. Comparatively, 0.8% of Amgen shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth. Which has more risk and volatility, ALNY or AMGN? Alnylam Pharmaceuticals has a beta of 0.32, suggesting that its share price is 68% less volatile than the S&P 500. Comparatively, Amgen has a beta of 0.49, suggesting that its share price is 51% less volatile than the S&P 500. Does the media refer more to ALNY or AMGN? In the previous week, Amgen had 34 more articles in the media than Alnylam Pharmaceuticals. MarketBeat recorded 63 mentions for Amgen and 29 mentions for Alnylam Pharmaceuticals. Amgen's average media sentiment score of 1.50 beat Alnylam Pharmaceuticals' score of 0.90 indicating that Amgen is being referred to more favorably in the news media. Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment Alnylam Pharmaceuticals 13 Very Positive mention(s) 2 Positive mention(s) 10 Neutral mention(s) 1 Negative mention(s) 0 Very Negative mention(s) Positive Amgen 56 Very Positive mention(s) 0 Positive mention(s) 7 Neutral mention(s) 0 Negative mention(s) 0 Very Negative mention(s) Very Positive Do analysts prefer ALNY or AMGN? Alnylam Pharmaceuticals currently has a consensus target price of $439.58, indicating a potential downside of 3.08%. Amgen has a consensus target price of $304.43, indicating a potential upside of 6.66%. Given Amgen's higher probable upside, analysts plainly believe Amgen is more favorable than Alnylam Pharmaceuticals.Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score Alnylam Pharmaceuticals 0 Sell rating(s) 4 Hold rating(s) 24 Buy rating(s) 0 Strong Buy rating(s) 2.86Amgen 2 Sell rating(s) 12 Hold rating(s) 7 Buy rating(s) 0 Strong Buy rating(s) 2.24 Is ALNY or AMGN more profitable? Amgen has a net margin of 18.96% compared to Alnylam Pharmaceuticals' net margin of -12.96%. Amgen's return on equity of 174.71% beat Alnylam Pharmaceuticals' return on equity.Company Net Margins Return on Equity Return on Assets Alnylam Pharmaceuticals-12.96% -273.52% -7.39% Amgen 18.96%174.71%13.12% Which has higher valuation and earnings, ALNY or AMGN? Amgen has higher revenue and earnings than Alnylam Pharmaceuticals. Alnylam Pharmaceuticals is trading at a lower price-to-earnings ratio than Amgen, indicating that it is currently the more affordable of the two stocks. CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings RatioAlnylam Pharmaceuticals$2.25B26.44-$278.16M-$2.47-183.63Amgen$33.42B4.60$4.09B$12.2323.34 SummaryAmgen beats Alnylam Pharmaceuticals on 11 of the 16 factors compared between the two stocks. Get Alnylam Pharmaceuticals News Delivered to You Automatically Sign up to receive the latest news and ratings for ALNY and its competitors with MarketBeat's FREE daily newsletter. Subscribe Now View SMS TermsBy entering your phone number and clicking the sign-up button, you agree to receive periodic text messages from MarketBeat at the phone number you submitted, including texts that may be sent using an automatic telephone dialing system. Message and data rates may apply. Message frequency will vary. Messages will consist of stock alerts, news stories, and partner advertisements/offers. Consent is not a condition of the purchase of any goods or services. Text HELP for help/customer support. Unsubscribe at any time by replying "STOP" to any text message that you receive from MarketBeat or by visiting our mailing preferences page. Read our full terms of service and privacy policy. New MarketBeat Followers Over TimeWhat are MarkeBeat Followers?This chart shows the number of new MarketBeat users adding ALNY and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period. Skip ChartMedia Sentiment Over TimeWhat is Media Sentiment?This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.Skip Chart ALNY vs. The Competition Export to ExcelMetricAlnylam PharmaceuticalsMED IndustryMedical SectorNASDAQ ExchangeMarket Cap$59.27B$3.15B$5.80B$10.40BDividend YieldN/A2.37%5.63%4.60%P/E Ratio-183.6321.0580.5826.78Price / Sales26.44450.04534.44123.53Price / CashN/A46.6037.9961.55Price / Book872.239.6615.776.40Net Income-$278.16M-$53.22M$3.30B$271.80M7 Day Performance-2.65%3.11%5.36%3.49%1 Month Performance-1.04%7.56%8.10%9.90%1 Year Performance65.61%11.15%81.36%28.62% Alnylam Pharmaceuticals Competitors List Export to ExcelCompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)ALNYAlnylam Pharmaceuticals3.8654 of 5 stars$453.56+0.3%$439.58-3.1%+64.1%$59.27B$2.25B-183.632,230Trending NewsAnalyst ForecastAMGNAmgen4.5616 of 5 stars$274.40-0.7%$304.43+10.9%-15.0%$147.73B$34.92B22.4428,000Positive NewsGILDGilead Sciences4.9201 of 5 stars$112.54-1.8%$115.39+2.5%+36.0%$139.64B$28.75B22.4217,600Positive NewsAnalyst ForecastInsider TradeVRTXVertex Pharmaceuticals4.904 of 5 stars$393.21-0.3%$496.05+26.2%-19.8%$100.82B$11.02B28.116,100Positive NewsAnalyst RevisionREGNRegeneron Pharmaceuticals4.794 of 5 stars$572.59+2.2%$817.67+42.8%-48.5%$60.69B$14.21B14.4315,106Positive NewsShort Interest ↑BIIBBiogen4.6854 of 5 stars$143.32-1.1%$181.65+26.7%-29.3%$21.01B$10.00B13.707,605Positive NewsAnalyst DowngradeUTHRUnited Therapeutics4.6526 of 5 stars$403.11-0.5%$438.85+8.9%+18.9%$18.18B$3.08B15.731,305Trending NewsInsider TradeINCYIncyte4.7712 of 5 stars$83.14+0.0%$82.53-0.7%+29.5%$16.24B$4.24B18.902,617Trending NewsAnalyst ForecastShort Interest ↓NBIXNeurocrine Biosciences4.4912 of 5 stars$140.44-1.0%$160.00+13.9%+20.6%$13.93B$2.51B41.551,800Positive NewsEXELExelixis4.6628 of 5 stars$39.01-0.4%$44.06+12.9%+49.5%$10.50B$2.17B18.751,147Analyst UpgradeBMRNBioMarin Pharmaceutical4.9641 of 5 stars$53.14-1.8%$92.04+73.2%-23.9%$10.20B$2.85B15.773,040Positive NewsShort Interest ↑ Related Companies and Tools Related Companies Amgen Alternatives Gilead Sciences Alternatives Vertex Pharmaceuticals Alternatives Regeneron Pharmaceuticals Alternatives Biogen Alternatives United Therapeutics Alternatives Incyte Alternatives Neurocrine Biosciences Alternatives Exelixis Alternatives BioMarin Pharmaceutical Alternatives Top 10 Stock Comparisons Semiconductor Stocks Artificial Intelligence Stocks Growth Stocks Magnificent Seven Stocks Pharmaceutical Stocks Ecommerce Stocks Bitcoin Stocks Meme Stocks Cryptocurrency Stocks Cybersecurity Stocks This page (NASDAQ:ALNY) was last updated on 9/20/2025 by MarketBeat.com Staff From Our PartnersFront-Run Buffett's Shocking Gold MoveA Historic Gold Announcement Is About to Rock Wall Street? 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