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Ionis Pharmaceuticals (IONS) Competitors

Ionis Pharmaceuticals logo
$68.94 -0.08 (-0.12%)
Closing price 10/7/2025 04:00 PM Eastern
Extended Trading
$67.84 -1.10 (-1.59%)
As of 10/7/2025 07:58 PM Eastern
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IONS vs. BIIB, UTHR, INCY, NBIX, EXEL, BMRN, EXAS, MDGL, HALO, and RGEN

Should you be buying Ionis Pharmaceuticals stock or one of its competitors? The main competitors of Ionis Pharmaceuticals include Biogen (BIIB), United Therapeutics (UTHR), Incyte (INCY), Neurocrine Biosciences (NBIX), Exelixis (EXEL), BioMarin Pharmaceutical (BMRN), Exact Sciences (EXAS), Madrigal Pharmaceuticals (MDGL), Halozyme Therapeutics (HALO), and Repligen (RGEN). These companies are all part of the "biotechnology" industry.

Ionis Pharmaceuticals vs. Its Competitors

Ionis Pharmaceuticals (NASDAQ:IONS) and Biogen (NASDAQ:BIIB) are both large-cap medical companies, but which is the better investment? We will contrast the two companies based on the strength of their dividends, institutional ownership, analyst recommendations, valuation, media sentiment, profitability, earnings and risk.

Ionis Pharmaceuticals presently has a consensus target price of $75.29, suggesting a potential upside of 9.22%. Biogen has a consensus target price of $180.04, suggesting a potential upside of 18.28%. Given Biogen's higher possible upside, analysts plainly believe Biogen is more favorable than Ionis Pharmaceuticals.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ionis Pharmaceuticals
1 Sell rating(s)
4 Hold rating(s)
13 Buy rating(s)
1 Strong Buy rating(s)
2.74
Biogen
1 Sell rating(s)
20 Hold rating(s)
11 Buy rating(s)
0 Strong Buy rating(s)
2.31

In the previous week, Ionis Pharmaceuticals had 7 more articles in the media than Biogen. MarketBeat recorded 25 mentions for Ionis Pharmaceuticals and 18 mentions for Biogen. Biogen's average media sentiment score of 0.97 beat Ionis Pharmaceuticals' score of 0.21 indicating that Biogen is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Ionis Pharmaceuticals
11 Very Positive mention(s)
2 Positive mention(s)
4 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Biogen
9 Very Positive mention(s)
0 Positive mention(s)
8 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

Ionis Pharmaceuticals has a beta of 0.33, suggesting that its share price is 67% less volatile than the S&P 500. Comparatively, Biogen has a beta of 0.13, suggesting that its share price is 87% less volatile than the S&P 500.

Biogen has higher revenue and earnings than Ionis Pharmaceuticals. Ionis Pharmaceuticals is trading at a lower price-to-earnings ratio than Biogen, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Ionis Pharmaceuticals$705M15.59-$453.90M-$1.84-37.47
Biogen$9.68B2.31$1.63B$10.4614.55

Biogen has a net margin of 15.31% compared to Ionis Pharmaceuticals' net margin of -28.25%. Biogen's return on equity of 13.85% beat Ionis Pharmaceuticals' return on equity.

Company Net Margins Return on Equity Return on Assets
Ionis Pharmaceuticals-28.25% -45.29% -8.99%
Biogen 15.31%13.85%8.32%

93.9% of Ionis Pharmaceuticals shares are held by institutional investors. Comparatively, 87.9% of Biogen shares are held by institutional investors. 2.7% of Ionis Pharmaceuticals shares are held by company insiders. Comparatively, 0.2% of Biogen shares are held by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a stock is poised for long-term growth.

Summary

Biogen beats Ionis Pharmaceuticals on 9 of the 17 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding IONS and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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IONS vs. The Competition

MetricIonis PharmaceuticalsMED IndustryMedical SectorNASDAQ Exchange
Market Cap$11.00B$2.66B$6.12B$10.65B
Dividend YieldN/A56.92%5.69%4.75%
P/E Ratio-37.4723.8685.6026.85
Price / Sales15.59745.61612.81135.13
Price / CashN/A169.9037.7861.77
Price / Book18.485.5913.256.70
Net Income-$453.90M$32.78M$3.30B$276.44M
7 Day Performance4.77%4.01%3.87%2.48%
1 Month Performance13.02%10.63%8.33%8.79%
1 Year Performance82.38%-1.80%88.97%34.41%

Ionis Pharmaceuticals Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
IONS
Ionis Pharmaceuticals
3.409 of 5 stars
$68.94
-0.1%
$75.29
+9.2%
+82.1%$11.00B$705M-37.471,069Analyst Forecast
BIIB
Biogen
4.5652 of 5 stars
$138.52
+0.8%
$182.04
+31.4%
-17.0%$20.14B$9.68B8.587,605Analyst Forecast
UTHR
United Therapeutics
4.3203 of 5 stars
$424.31
-1.9%
$449.57
+6.0%
+30.6%$19.52B$2.88B16.891,305Insider Trade
INCY
Incyte
4.5088 of 5 stars
$83.89
+1.4%
$83.67
-0.3%
+32.6%$16.15B$4.24B20.572,617
NBIX
Neurocrine Biosciences
4.7811 of 5 stars
$140.27
-1.2%
$161.89
+15.4%
+22.1%$14.08B$2.36B42.011,800News Coverage
EXEL
Exelixis
4.8289 of 5 stars
$40.57
+3.9%
$44.42
+9.5%
+50.6%$10.51B$2.17B18.951,147Positive News
BMRN
BioMarin Pharmaceutical
4.9513 of 5 stars
$54.02
+0.3%
$92.60
+71.4%
-20.7%$10.34B$2.85B14.593,040
EXAS
Exact Sciences
4.5021 of 5 stars
$53.38
-0.4%
$68.05
+27.5%
-16.6%$10.14B$2.76B0.007,000Analyst Forecast
MDGL
Madrigal Pharmaceuticals
4.309 of 5 stars
$443.10
+4.4%
$495.88
+11.9%
+103.1%$9.42B$180.13M0.0090
HALO
Halozyme Therapeutics
4.6736 of 5 stars
$73.29
-0.6%
$69.89
-4.6%
+22.6%$8.63B$1.02B15.18390Analyst Revision
RGEN
Repligen
4.6142 of 5 stars
$124.09
-1.2%
$168.75
+36.0%
+6.8%$7.07B$634.44M77.061,778Analyst Forecast

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This page (NASDAQ:IONS) was last updated on 10/8/2025 by MarketBeat.com Staff
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