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Palvella Therapeutics (PVLA) Competitors

Palvella Therapeutics logo
$150.56 -3.76 (-2.44%)
Closing price 09/18/2026 04:00 PM Eastern
Extended Trading
$150.69 +0.13 (+0.09%)
As of 09/18/2026 07:30 PM Eastern
Extended trading is trading that happens on electronic markets outside of regular trading hours. This is a fair market value extended hours price provided by Massive. Learn more.

PVLA vs. CYTK, PRAX, TGTX, APGE, and SYRE

Should you buy Palvella Therapeutics stock or one of its competitors? Palvella Therapeutics's main competitors and comparable companies include Cytokinetics (CYTK), Praxis Precision Medicines (PRAX), TG Therapeutics (TGTX), Apogee Therapeutics (APGE), and Spyre Therapeutics (SYRE). Companies are selected based on similarities in market, industry, and size. These companies are all part of the "biotechnology" industry.

How does Palvella Therapeutics compare to Cytokinetics?

Cytokinetics (NASDAQ:CYTK) and Palvella Therapeutics (NASDAQ:PVLA) are both mid-cap healthcare companies, but which is the better stock? We will contrast the two companies based on the strength of their media sentiment, institutional ownership, dividends, risk, analyst recommendations, profitability, valuation and earnings.

Cytokinetics presently has a consensus price target of $103.37, indicating a potential upside of 50.29%. Palvella Therapeutics has a consensus price target of $209.14, indicating a potential upside of 38.91%. Given Cytokinetics' higher probable upside, analysts plainly believe Cytokinetics is more favorable than Palvella Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Cytokinetics
1 Sell rating(s)
1 Hold rating(s)
18 Buy rating(s)
0 Strong Buy rating(s)
2.85
Palvella Therapeutics
1 Sell rating(s)
0 Hold rating(s)
12 Buy rating(s)
2 Strong Buy rating(s)
3.00

Cytokinetics has a beta of 0.36, suggesting that its stock price is 64% less volatile than the broader market. Comparatively, Palvella Therapeutics has a beta of -0.25, suggesting that its stock price is 125% less volatile than the broader market.

In the previous week, Cytokinetics had 6 more articles in the media than Palvella Therapeutics. MarketBeat recorded 18 mentions for Cytokinetics and 12 mentions for Palvella Therapeutics. Cytokinetics' average media sentiment score of 0.34 beat Palvella Therapeutics' score of 0.24 indicating that Cytokinetics is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Cytokinetics
7 Very Positive mention(s)
2 Positive mention(s)
6 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Palvella Therapeutics
6 Very Positive mention(s)
2 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Palvella Therapeutics has lower revenue, but higher earnings than Cytokinetics. Palvella Therapeutics is trading at a lower price-to-earnings ratio than Cytokinetics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Cytokinetics$88.04M97.21-$784.96M-$7.22N/A
Palvella Therapeutics$42.81M50.68-$41.72M-$4.83N/A

40.1% of Palvella Therapeutics shares are owned by institutional investors. 2.6% of Cytokinetics shares are owned by company insiders. Comparatively, 17.2% of Palvella Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock will outperform the market over the long term.

Palvella Therapeutics has a net margin of 0.00% compared to Cytokinetics' net margin of -1,321.12%. Cytokinetics' return on equity of 0.00% beat Palvella Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Cytokinetics-1,321.12% N/A -51.01%
Palvella Therapeutics N/A -47.84%-38.33%

Summary

Cytokinetics beats Palvella Therapeutics on 9 of the 17 factors compared between the two stocks.

How does Palvella Therapeutics compare to Praxis Precision Medicines?

Praxis Precision Medicines (NASDAQ:PRAX) and Palvella Therapeutics (NASDAQ:PVLA) are both mid-cap healthcare companies, but which is the superior stock? We will contrast the two companies based on the strength of their analyst recommendations, earnings, valuation, dividends, media sentiment, risk, profitability and institutional ownership.

Praxis Precision Medicines has a beta of 2.76, indicating that its stock price is 176% more volatile than the broader market. Comparatively, Palvella Therapeutics has a beta of -0.25, indicating that its stock price is 125% less volatile than the broader market.

Praxis Precision Medicines' return on equity of -34.15% beat Palvella Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Praxis Precision MedicinesN/A -34.15% -32.42%
Palvella Therapeutics N/A -47.84%-38.33%

Praxis Precision Medicines currently has a consensus price target of $612.42, indicating a potential upside of 104.86%. Palvella Therapeutics has a consensus price target of $209.14, indicating a potential upside of 38.91%. Given Praxis Precision Medicines' higher probable upside, equities research analysts clearly believe Praxis Precision Medicines is more favorable than Palvella Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Praxis Precision Medicines
2 Sell rating(s)
0 Hold rating(s)
15 Buy rating(s)
3 Strong Buy rating(s)
2.95
Palvella Therapeutics
1 Sell rating(s)
0 Hold rating(s)
12 Buy rating(s)
2 Strong Buy rating(s)
3.00

Palvella Therapeutics has higher revenue and earnings than Praxis Precision Medicines. Palvella Therapeutics is trading at a lower price-to-earnings ratio than Praxis Precision Medicines, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Praxis Precision Medicines$8.55M976.22-$303.27M-$12.93N/A
Palvella Therapeutics$42.81M50.68-$41.72M-$4.83N/A

67.8% of Praxis Precision Medicines shares are owned by institutional investors. Comparatively, 40.1% of Palvella Therapeutics shares are owned by institutional investors. 3.0% of Praxis Precision Medicines shares are owned by company insiders. Comparatively, 17.2% of Palvella Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

In the previous week, Palvella Therapeutics had 11 more articles in the media than Praxis Precision Medicines. MarketBeat recorded 12 mentions for Palvella Therapeutics and 1 mentions for Praxis Precision Medicines. Praxis Precision Medicines' average media sentiment score of 1.62 beat Palvella Therapeutics' score of 0.24 indicating that Praxis Precision Medicines is being referred to more favorably in the media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Praxis Precision Medicines
1 Very Positive mention(s)
0 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Very Positive
Palvella Therapeutics
6 Very Positive mention(s)
2 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral

Summary

Praxis Precision Medicines beats Palvella Therapeutics on 10 of the 16 factors compared between the two stocks.

How does Palvella Therapeutics compare to TG Therapeutics?

Palvella Therapeutics (NASDAQ:PVLA) and TG Therapeutics (NASDAQ:TGTX) are both mid-cap healthcare companies, but which is the superior business? We will compare the two businesses based on the strength of their dividends, media sentiment, analyst recommendations, earnings, risk, valuation, profitability and institutional ownership.

In the previous week, Palvella Therapeutics had 1 more articles in the media than TG Therapeutics. MarketBeat recorded 12 mentions for Palvella Therapeutics and 11 mentions for TG Therapeutics. TG Therapeutics' average media sentiment score of 0.86 beat Palvella Therapeutics' score of 0.24 indicating that TG Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Palvella Therapeutics
6 Very Positive mention(s)
2 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
TG Therapeutics
7 Very Positive mention(s)
0 Positive mention(s)
3 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

TG Therapeutics has higher revenue and earnings than Palvella Therapeutics. Palvella Therapeutics is trading at a lower price-to-earnings ratio than TG Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Palvella Therapeutics$42.81M50.68-$41.72M-$4.83N/A
TG Therapeutics$616.29M14.12$447.18M$2.7420.76

Palvella Therapeutics currently has a consensus target price of $209.14, indicating a potential upside of 38.91%. TG Therapeutics has a consensus target price of $63.00, indicating a potential upside of 10.78%. Given Palvella Therapeutics' stronger consensus rating and higher possible upside, research analysts plainly believe Palvella Therapeutics is more favorable than TG Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Palvella Therapeutics
1 Sell rating(s)
0 Hold rating(s)
12 Buy rating(s)
2 Strong Buy rating(s)
3.00
TG Therapeutics
2 Sell rating(s)
2 Hold rating(s)
5 Buy rating(s)
0 Strong Buy rating(s)
2.33

Palvella Therapeutics has a beta of -0.25, indicating that its share price is 125% less volatile than the broader market. Comparatively, TG Therapeutics has a beta of 1.67, indicating that its share price is 67% more volatile than the broader market.

TG Therapeutics has a net margin of 55.22% compared to Palvella Therapeutics' net margin of 0.00%. TG Therapeutics' return on equity of 73.49% beat Palvella Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Palvella TherapeuticsN/A -47.84% -38.33%
TG Therapeutics 55.22%73.49%34.14%

40.1% of Palvella Therapeutics shares are owned by institutional investors. Comparatively, 58.6% of TG Therapeutics shares are owned by institutional investors. 17.2% of Palvella Therapeutics shares are owned by insiders. Comparatively, 8.9% of TG Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

Summary

TG Therapeutics beats Palvella Therapeutics on 10 of the 17 factors compared between the two stocks.

How does Palvella Therapeutics compare to Apogee Therapeutics?

Apogee Therapeutics (NASDAQ:APGE) and Palvella Therapeutics (NASDAQ:PVLA) are both mid-cap healthcare companies, but which is the better investment? We will compare the two companies based on the strength of their risk, institutional ownership, analyst recommendations, media sentiment, earnings, profitability, valuation and dividends.

Apogee Therapeutics presently has a consensus price target of $126.77, suggesting a potential downside of 6.14%. Palvella Therapeutics has a consensus price target of $209.14, suggesting a potential upside of 38.91%. Given Palvella Therapeutics' stronger consensus rating and higher possible upside, analysts plainly believe Palvella Therapeutics is more favorable than Apogee Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Apogee Therapeutics
1 Sell rating(s)
15 Hold rating(s)
2 Buy rating(s)
1 Strong Buy rating(s)
2.16
Palvella Therapeutics
1 Sell rating(s)
0 Hold rating(s)
12 Buy rating(s)
2 Strong Buy rating(s)
3.00

In the previous week, Palvella Therapeutics had 12 more articles in the media than Apogee Therapeutics. MarketBeat recorded 12 mentions for Palvella Therapeutics and 0 mentions for Apogee Therapeutics. Palvella Therapeutics' average media sentiment score of 0.24 beat Apogee Therapeutics' score of 0.00 indicating that Palvella Therapeutics is being referred to more favorably in the news media.

Company Overall Sentiment
Apogee Therapeutics Neutral
Palvella Therapeutics Neutral

Apogee Therapeutics has a beta of 0.33, meaning that its share price is 67% less volatile than the broader market. Comparatively, Palvella Therapeutics has a beta of -0.25, meaning that its share price is 125% less volatile than the broader market.

79.0% of Apogee Therapeutics shares are owned by institutional investors. Comparatively, 40.1% of Palvella Therapeutics shares are owned by institutional investors. 24.3% of Apogee Therapeutics shares are owned by company insiders. Comparatively, 17.2% of Palvella Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

Palvella Therapeutics has higher revenue and earnings than Apogee Therapeutics. Palvella Therapeutics is trading at a lower price-to-earnings ratio than Apogee Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Apogee TherapeuticsN/AN/A-$255.84M-$4.34N/A
Palvella Therapeutics$42.81M50.68-$41.72M-$4.83N/A

Apogee Therapeutics' return on equity of -29.88% beat Palvella Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Apogee TherapeuticsN/A -29.88% -28.08%
Palvella Therapeutics N/A -47.84%-38.33%

Summary

Palvella Therapeutics beats Apogee Therapeutics on 8 of the 15 factors compared between the two stocks.

How does Palvella Therapeutics compare to Spyre Therapeutics?

Palvella Therapeutics (NASDAQ:PVLA) and Spyre Therapeutics (NASDAQ:SYRE) are both mid-cap healthcare companies, but which is the better business? We will compare the two companies based on the strength of their valuation, media sentiment, dividends, analyst recommendations, risk, earnings, profitability and institutional ownership.

Palvella Therapeutics has a beta of -0.25, indicating that its stock price is 125% less volatile than the broader market. Comparatively, Spyre Therapeutics has a beta of 2.99, indicating that its stock price is 199% more volatile than the broader market.

Spyre Therapeutics' return on equity of -30.74% beat Palvella Therapeutics' return on equity.

Company Net Margins Return on Equity Return on Assets
Palvella TherapeuticsN/A -47.84% -38.33%
Spyre Therapeutics N/A -30.74%-22.23%

Palvella Therapeutics currently has a consensus target price of $209.14, indicating a potential upside of 38.91%. Spyre Therapeutics has a consensus target price of $109.69, indicating a potential upside of 21.54%. Given Palvella Therapeutics' stronger consensus rating and higher probable upside, equities analysts plainly believe Palvella Therapeutics is more favorable than Spyre Therapeutics.

Company Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Palvella Therapeutics
1 Sell rating(s)
0 Hold rating(s)
12 Buy rating(s)
2 Strong Buy rating(s)
3.00
Spyre Therapeutics
1 Sell rating(s)
1 Hold rating(s)
12 Buy rating(s)
1 Strong Buy rating(s)
2.87

Palvella Therapeutics has higher revenue and earnings than Spyre Therapeutics. Spyre Therapeutics is trading at a lower price-to-earnings ratio than Palvella Therapeutics, indicating that it is currently the more affordable of the two stocks.

CompanyGross RevenuePrice/Sales RatioNet IncomeEarnings Per SharePrice/Earnings Ratio
Palvella Therapeutics$42.81M50.68-$41.72M-$4.83N/A
Spyre Therapeutics$890K8,917.51-$155.20M-$1.95N/A

In the previous week, Palvella Therapeutics had 6 more articles in the media than Spyre Therapeutics. MarketBeat recorded 12 mentions for Palvella Therapeutics and 6 mentions for Spyre Therapeutics. Spyre Therapeutics' average media sentiment score of 0.95 beat Palvella Therapeutics' score of 0.24 indicating that Spyre Therapeutics is being referred to more favorably in the news media.

Company Very Positive Positive Neutral Negative Very Negative Overall Sentiment
Palvella Therapeutics
6 Very Positive mention(s)
2 Positive mention(s)
0 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Neutral
Spyre Therapeutics
4 Very Positive mention(s)
1 Positive mention(s)
1 Neutral mention(s)
0 Negative mention(s)
0 Very Negative mention(s)
Positive

40.1% of Palvella Therapeutics shares are owned by institutional investors. Comparatively, 80.4% of Spyre Therapeutics shares are owned by institutional investors. 17.2% of Palvella Therapeutics shares are owned by company insiders. Comparatively, 15.7% of Spyre Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

Summary

Palvella Therapeutics beats Spyre Therapeutics on 8 of the 15 factors compared between the two stocks.

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New MarketBeat Followers Over Time

This chart shows the number of new MarketBeat users adding PVLA and its top 5 competitors to their watchlist. Each company is represented with a line over a 90 day period.
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Media Sentiment Over Time

This chart shows the average media sentiment of NASDAQ and its competitors over the past 90 days as caculated by MarketBeat. The averaged score is equivalent to the following: Very Negative Sentiment <= -1.5, Negative Sentiment > -1.5 and <= -0.5, Neutral Sentiment > -0.5 and < 0.5, Positive Sentiment >= 0.5 and < 1.5, and Very Positive Sentiment >= 1.5.
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PVLA vs. The Competition

MetricPalvella TherapeuticsBiotechnology IndustryHealthcare SectorNASDAQ Exchange
Market Cap$2.22B$3.91B$7.25B$13.13B
Dividend YieldN/A3.65%2.57%12.94%
P/E Ratio-31.1714.08273.8125.39
Price / Sales50.681,407.75692.78109.00
Price / CashN/A110.7577.4251.66
Price / Book63.8015.4510.456.33
Net Income-$41.72M-$22.78M$3.48B$358.24M
7 Day Performance0.29%-1.22%0.88%1.17%
1 Month Performance0.40%-4.44%-1.59%-2.59%
1 Year Performance158.52%37.78%18.08%5.97%

Palvella Therapeutics Competitors List

CompanyMarketRankShare PriceAnalysts' Price Target1Y Price PerformanceMarket CapRevenueP/E RatioEmployee CountIndicator(s)
PVLA
Palvella Therapeutics
2.2398 of 5 stars
$150.56
-2.4%
$209.14
+38.9%
+155.0%$2.22B$42.81MN/A29
CYTK
Cytokinetics
2.8895 of 5 stars
$69.92
+0.8%
$103.37
+47.8%
+39.5%$8.70B$88.04MN/A673
PRAX
Praxis Precision Medicines
3.1019 of 5 stars
$310.47
+0.5%
$585.95
+88.7%
+561.0%$8.67B$8.55MN/A110
TGTX
TG Therapeutics
3.3775 of 5 stars
$56.47
+1.1%
$63.00
+11.6%
+74.4%$8.64B$616.29M20.61399
APGE
Apogee Therapeutics
1.0608 of 5 stars
$135.07
flat
$126.77
-6.1%
N/A$8.40BN/AN/A91

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This page (NASDAQ:PVLA) was last updated on 9/19/2026 by MarketBeat.com Staff.
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